JP2015502330A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015502330A5 JP2015502330A5 JP2014534836A JP2014534836A JP2015502330A5 JP 2015502330 A5 JP2015502330 A5 JP 2015502330A5 JP 2014534836 A JP2014534836 A JP 2014534836A JP 2014534836 A JP2014534836 A JP 2014534836A JP 2015502330 A5 JP2015502330 A5 JP 2015502330A5
- Authority
- JP
- Japan
- Prior art keywords
- tmg
- pyβpypyβpypypyβpyβ
- compound
- pypypyβpypypyβpyβ
- pypypyβpypyβpyim
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 11
- 150000003839 salts Chemical class 0.000 claims 3
- OGNSCSPNOLGXSM-UHFFFAOYSA-N (+/-)-DABA Natural products NCCC(N)C(O)=O OGNSCSPNOLGXSM-UHFFFAOYSA-N 0.000 claims 2
- LWXLPQFDIHLJGX-UHFFFAOYSA-N (4-amino-1-methyl-3h-pyrrol-2-ylidene)methanone Chemical compound CN1C=C(N)CC1=C=O LWXLPQFDIHLJGX-UHFFFAOYSA-N 0.000 claims 2
- UCMIRNVEIXFBKS-UHFFFAOYSA-N beta-alanine Chemical compound NCCC(O)=O UCMIRNVEIXFBKS-UHFFFAOYSA-N 0.000 claims 2
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical group NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 claims 2
- NSUPVLQQSPQZLZ-UHFFFAOYSA-N (5-amino-3-methyl-1h-imidazol-2-ylidene)methanone Chemical compound CN1C=C(N)NC1=C=O NSUPVLQQSPQZLZ-UHFFFAOYSA-N 0.000 claims 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims 1
- OGNSCSPNOLGXSM-GSVOUGTGSA-N D-2,4-diaminobutyric acid Chemical group NCC[C@@H](N)C(O)=O OGNSCSPNOLGXSM-GSVOUGTGSA-N 0.000 claims 1
- OGNSCSPNOLGXSM-VKHMYHEASA-N L-2,4-diaminobutyric acid Chemical group NCC[C@H](N)C(O)=O OGNSCSPNOLGXSM-VKHMYHEASA-N 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- 229940000635 beta-alanine Drugs 0.000 claims 1
- IUNMPGNGSSIWFP-UHFFFAOYSA-N dimethylaminopropylamine Chemical compound CN(C)CCCN IUNMPGNGSSIWFP-UHFFFAOYSA-N 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229960003692 gamma aminobutyric acid Drugs 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 1
- KMBPCQSCMCEPMU-UHFFFAOYSA-N n'-(3-aminopropyl)-n'-methylpropane-1,3-diamine Chemical compound NCCCN(C)CCCN KMBPCQSCMCEPMU-UHFFFAOYSA-N 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- -1 tetramethylguanidinyl Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161545311P | 2011-10-10 | 2011-10-10 | |
| US61/545,311 | 2011-10-10 | ||
| PCT/US2012/059604 WO2013055825A2 (en) | 2011-10-10 | 2012-10-10 | Guanidinyl-substituted polyamides useful for treating human papilloma virus |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015502330A JP2015502330A (ja) | 2015-01-22 |
| JP2015502330A5 true JP2015502330A5 (enExample) | 2015-12-03 |
Family
ID=48042465
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014534836A Pending JP2015502330A (ja) | 2011-10-10 | 2012-10-10 | ヒトパピローマウイルスを処置するのに有用なグアニジニル置換ポリアミド |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US9133228B2 (enExample) |
| EP (1) | EP2751096A4 (enExample) |
| JP (1) | JP2015502330A (enExample) |
| KR (1) | KR20140074996A (enExample) |
| CN (1) | CN104024247B (enExample) |
| AU (1) | AU2012322835A1 (enExample) |
| BR (1) | BR112014008464A2 (enExample) |
| CA (1) | CA2851516C (enExample) |
| HK (1) | HK1201064A1 (enExample) |
| RU (1) | RU2014113702A (enExample) |
| SG (1) | SG11201401226YA (enExample) |
| WO (1) | WO2013055825A2 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9982020B2 (en) * | 2011-10-10 | 2018-05-29 | Nanovir Llc | Antiviral compounds and methods for treating infections caused by double-stranded DNA viruses |
| WO2016022664A1 (en) * | 2014-08-05 | 2016-02-11 | Nanovir Llc | Antiviral compounds and methods for treating infections caused by double-stranded dna viruses |
| US20220193241A1 (en) * | 2019-03-20 | 2022-06-23 | Chiba-Prefecture | Agent targeting double-membrane organelle dna |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU7380294A (en) | 1993-08-06 | 1995-02-28 | Synphar Laboratories, Inc. | Oligopeptide antiretroviral agents |
| EP0973740A1 (en) | 1996-02-26 | 2000-01-26 | California Institute Of Technology | Design, synthesis and use of specific polyamide dna-binding ligands |
| CN1260006A (zh) | 1996-02-26 | 2000-07-12 | 加利福尼亚州技术学院 | 双链dna和杂环低聚物之间复合物的形成 |
| AU734715B2 (en) | 1996-02-26 | 2001-06-21 | California Institute Of Technology | Improved polyamides for binding in the minor groove of double stranded DNA |
| US5998140A (en) | 1996-07-31 | 1999-12-07 | The Scripps Research Institute | Complex formation between dsDNA and oligomer of cyclic heterocycles |
| JP2002515057A (ja) | 1996-08-01 | 2002-05-21 | カリフォルニア・インスティチュート・オブ・テクノロジー | ポリアミドｄｎａ結合リガンドによる遺伝子発現の阻害 |
| AU5910899A (en) | 1998-09-11 | 2000-04-03 | California Institute Of Technology | Inhibition of oncogene transcription by synthetic polyamides |
| US6673940B1 (en) | 1999-01-08 | 2004-01-06 | California Institute Of Technology | Compositions and methods relating to cyclic compounds that undergo nucleotide base pair-specific interactions with double-stranded nucleic acids |
| JP4012145B2 (ja) | 2001-06-25 | 2007-11-21 | 独立行政法人科学技術振興機構 | ピロール−イミダゾールポリアミドの固相合成法 |
| AU2002363523A1 (en) | 2001-11-07 | 2003-05-19 | Pharmacia Corporation | Methods of promoting uptake and nuclear accumulation of polyamides in eukaryotic cells |
| BR0213988A (pt) | 2001-11-07 | 2004-08-31 | Pharmacia Corp | Moduladores de poliamida de transcrição de cox2 |
| ATE468147T1 (de) | 2003-01-16 | 2010-06-15 | Femmepharma Holding Co Inc | Vaginaler oder rektaler applikator und verfahren |
| WO2004078943A2 (en) | 2003-03-04 | 2004-09-16 | California Institute Of Technology | Alternative heterocycles for dna recognition |
| MXPA05011642A (es) | 2003-04-30 | 2005-12-15 | Pharmacia Corp | Compuestos que tienen un resto biciclico condensado para unirse al surco menor del adn de doble hebra. |
| US8399013B2 (en) | 2003-06-26 | 2013-03-19 | Poly-Med, Inc. | Partially absorbable fiber-reinforced composites for controlled drug delivery |
| WO2005033282A2 (en) | 2003-10-01 | 2005-04-14 | Pharmacia & Upjohn Company Llc | Polyamide compositions and therapeutic methods for treatment of human papilloma virus |
| DE10357677A1 (de) * | 2003-12-10 | 2005-07-14 | Greiner Bio-One Gmbh | Primer und Sonden zum Nachweis genitaler HPV-Genotypen |
| WO2007045096A1 (en) * | 2005-10-21 | 2007-04-26 | University Of Saskatchewan | Oligoheteroaromatic luminiscent assemblies as high-affinity dna sequence-directed ligands |
| WO2007103584A2 (en) | 2006-03-09 | 2007-09-13 | Nanovir, Llc | Polyamides for treating human papilloma virus |
| US8993609B2 (en) | 2006-05-04 | 2015-03-31 | Nanovir, Llc | Compounds for treating papilloma virus infection |
| WO2007130616A2 (en) | 2006-05-04 | 2007-11-15 | Nanovir, Llc | Polyamides for treating human papilloma virus |
-
2012
- 2012-10-10 RU RU2014113702/04A patent/RU2014113702A/ru not_active Application Discontinuation
- 2012-10-10 JP JP2014534836A patent/JP2015502330A/ja active Pending
- 2012-10-10 US US13/649,000 patent/US9133228B2/en not_active Expired - Fee Related
- 2012-10-10 HK HK15101532.6A patent/HK1201064A1/xx unknown
- 2012-10-10 BR BR112014008464A patent/BR112014008464A2/pt not_active IP Right Cessation
- 2012-10-10 AU AU2012322835A patent/AU2012322835A1/en not_active Abandoned
- 2012-10-10 CA CA2851516A patent/CA2851516C/en active Active
- 2012-10-10 EP EP12840685.7A patent/EP2751096A4/en not_active Withdrawn
- 2012-10-10 KR KR1020147012415A patent/KR20140074996A/ko not_active Ceased
- 2012-10-10 SG SG11201401226YA patent/SG11201401226YA/en unknown
- 2012-10-10 WO PCT/US2012/059604 patent/WO2013055825A2/en not_active Ceased
- 2012-10-10 CN CN201280049712.1A patent/CN104024247B/zh not_active Expired - Fee Related