BR112014008464A2 - composto; composição farmacêutica; método para ligar dna de fita dupla com especificidade para sequência; método para reduzir ou inibir a proliferação de células de papiloma ou neoplásticas; método para tratar células infectadas por vírus; e método para tratar hpv em um indivíduo - Google Patents
composto; composição farmacêutica; método para ligar dna de fita dupla com especificidade para sequência; método para reduzir ou inibir a proliferação de células de papiloma ou neoplásticas; método para tratar células infectadas por vírus; e método para tratar hpv em um indivíduoInfo
- Publication number
- BR112014008464A2 BR112014008464A2 BR112014008464A BR112014008464A BR112014008464A2 BR 112014008464 A2 BR112014008464 A2 BR 112014008464A2 BR 112014008464 A BR112014008464 A BR 112014008464A BR 112014008464 A BR112014008464 A BR 112014008464A BR 112014008464 A2 BR112014008464 A2 BR 112014008464A2
- Authority
- BR
- Brazil
- Prior art keywords
- treating
- papilloma
- proliferation
- inhibiting
- individual
- Prior art date
Links
- 108020004414 DNA Proteins 0.000 title abstract 2
- 102000053602 DNA Human genes 0.000 title abstract 2
- 241000700605 Viruses Species 0.000 title abstract 2
- 210000004027 cell Anatomy 0.000 title abstract 2
- 230000002401 inhibitory effect Effects 0.000 title abstract 2
- 210000005170 neoplastic cell Anatomy 0.000 title abstract 2
- 208000003154 papilloma Diseases 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 230000035755 proliferation Effects 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title 1
- 239000004952 Polyamide Substances 0.000 abstract 2
- 229920002647 polyamide Polymers 0.000 abstract 2
- CZRCFAOMWRAFIC-UHFFFAOYSA-N 5-(tetradecyloxy)-2-furoic acid Chemical compound CCCCCCCCCCCCCCOC1=CC=C(C(O)=O)O1 CZRCFAOMWRAFIC-UHFFFAOYSA-N 0.000 abstract 1
- 208000009608 Papillomavirus Infections Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
- C07K14/003—Peptide-nucleic acids (PNAs)
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polyamides (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Materials For Medical Uses (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161545311P | 2011-10-10 | 2011-10-10 | |
| PCT/US2012/059604 WO2013055825A2 (en) | 2011-10-10 | 2012-10-10 | Guanidinyl-substituted polyamides useful for treating human papilloma virus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112014008464A2 true BR112014008464A2 (pt) | 2017-04-11 |
Family
ID=48042465
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112014008464A BR112014008464A2 (pt) | 2011-10-10 | 2012-10-10 | composto; composição farmacêutica; método para ligar dna de fita dupla com especificidade para sequência; método para reduzir ou inibir a proliferação de células de papiloma ou neoplásticas; método para tratar células infectadas por vírus; e método para tratar hpv em um indivíduo |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US9133228B2 (enExample) |
| EP (1) | EP2751096A4 (enExample) |
| JP (1) | JP2015502330A (enExample) |
| KR (1) | KR20140074996A (enExample) |
| CN (1) | CN104024247B (enExample) |
| AU (1) | AU2012322835A1 (enExample) |
| BR (1) | BR112014008464A2 (enExample) |
| CA (1) | CA2851516C (enExample) |
| HK (1) | HK1201064A1 (enExample) |
| RU (1) | RU2014113702A (enExample) |
| SG (1) | SG11201401226YA (enExample) |
| WO (1) | WO2013055825A2 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9982020B2 (en) * | 2011-10-10 | 2018-05-29 | Nanovir Llc | Antiviral compounds and methods for treating infections caused by double-stranded DNA viruses |
| WO2016022664A1 (en) * | 2014-08-05 | 2016-02-11 | Nanovir Llc | Antiviral compounds and methods for treating infections caused by double-stranded dna viruses |
| US20220193241A1 (en) * | 2019-03-20 | 2022-06-23 | Chiba-Prefecture | Agent targeting double-membrane organelle dna |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU7380294A (en) | 1993-08-06 | 1995-02-28 | Synphar Laboratories, Inc. | Oligopeptide antiretroviral agents |
| EP0973740A1 (en) | 1996-02-26 | 2000-01-26 | California Institute Of Technology | Design, synthesis and use of specific polyamide dna-binding ligands |
| CN1260006A (zh) | 1996-02-26 | 2000-07-12 | 加利福尼亚州技术学院 | 双链dna和杂环低聚物之间复合物的形成 |
| AU734715B2 (en) | 1996-02-26 | 2001-06-21 | California Institute Of Technology | Improved polyamides for binding in the minor groove of double stranded DNA |
| US5998140A (en) | 1996-07-31 | 1999-12-07 | The Scripps Research Institute | Complex formation between dsDNA and oligomer of cyclic heterocycles |
| JP2002515057A (ja) | 1996-08-01 | 2002-05-21 | カリフォルニア・インスティチュート・オブ・テクノロジー | ポリアミドｄｎａ結合リガンドによる遺伝子発現の阻害 |
| AU5910899A (en) | 1998-09-11 | 2000-04-03 | California Institute Of Technology | Inhibition of oncogene transcription by synthetic polyamides |
| US6673940B1 (en) | 1999-01-08 | 2004-01-06 | California Institute Of Technology | Compositions and methods relating to cyclic compounds that undergo nucleotide base pair-specific interactions with double-stranded nucleic acids |
| JP4012145B2 (ja) | 2001-06-25 | 2007-11-21 | 独立行政法人科学技術振興機構 | ピロール−イミダゾールポリアミドの固相合成法 |
| AU2002363523A1 (en) | 2001-11-07 | 2003-05-19 | Pharmacia Corporation | Methods of promoting uptake and nuclear accumulation of polyamides in eukaryotic cells |
| BR0213988A (pt) | 2001-11-07 | 2004-08-31 | Pharmacia Corp | Moduladores de poliamida de transcrição de cox2 |
| ATE468147T1 (de) | 2003-01-16 | 2010-06-15 | Femmepharma Holding Co Inc | Vaginaler oder rektaler applikator und verfahren |
| WO2004078943A2 (en) | 2003-03-04 | 2004-09-16 | California Institute Of Technology | Alternative heterocycles for dna recognition |
| MXPA05011642A (es) | 2003-04-30 | 2005-12-15 | Pharmacia Corp | Compuestos que tienen un resto biciclico condensado para unirse al surco menor del adn de doble hebra. |
| US8399013B2 (en) | 2003-06-26 | 2013-03-19 | Poly-Med, Inc. | Partially absorbable fiber-reinforced composites for controlled drug delivery |
| WO2005033282A2 (en) | 2003-10-01 | 2005-04-14 | Pharmacia & Upjohn Company Llc | Polyamide compositions and therapeutic methods for treatment of human papilloma virus |
| DE10357677A1 (de) * | 2003-12-10 | 2005-07-14 | Greiner Bio-One Gmbh | Primer und Sonden zum Nachweis genitaler HPV-Genotypen |
| WO2007045096A1 (en) * | 2005-10-21 | 2007-04-26 | University Of Saskatchewan | Oligoheteroaromatic luminiscent assemblies as high-affinity dna sequence-directed ligands |
| WO2007103584A2 (en) | 2006-03-09 | 2007-09-13 | Nanovir, Llc | Polyamides for treating human papilloma virus |
| US8993609B2 (en) | 2006-05-04 | 2015-03-31 | Nanovir, Llc | Compounds for treating papilloma virus infection |
| WO2007130616A2 (en) | 2006-05-04 | 2007-11-15 | Nanovir, Llc | Polyamides for treating human papilloma virus |
-
2012
- 2012-10-10 RU RU2014113702/04A patent/RU2014113702A/ru not_active Application Discontinuation
- 2012-10-10 JP JP2014534836A patent/JP2015502330A/ja active Pending
- 2012-10-10 US US13/649,000 patent/US9133228B2/en not_active Expired - Fee Related
- 2012-10-10 HK HK15101532.6A patent/HK1201064A1/xx unknown
- 2012-10-10 BR BR112014008464A patent/BR112014008464A2/pt not_active IP Right Cessation
- 2012-10-10 AU AU2012322835A patent/AU2012322835A1/en not_active Abandoned
- 2012-10-10 CA CA2851516A patent/CA2851516C/en active Active
- 2012-10-10 EP EP12840685.7A patent/EP2751096A4/en not_active Withdrawn
- 2012-10-10 KR KR1020147012415A patent/KR20140074996A/ko not_active Ceased
- 2012-10-10 SG SG11201401226YA patent/SG11201401226YA/en unknown
- 2012-10-10 WO PCT/US2012/059604 patent/WO2013055825A2/en not_active Ceased
- 2012-10-10 CN CN201280049712.1A patent/CN104024247B/zh not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2015502330A (ja) | 2015-01-22 |
| EP2751096A4 (en) | 2015-04-08 |
| WO2013055825A2 (en) | 2013-04-18 |
| US20130090362A1 (en) | 2013-04-11 |
| CN104024247A (zh) | 2014-09-03 |
| RU2014113702A (ru) | 2015-11-20 |
| AU2012322835A1 (en) | 2014-04-17 |
| CA2851516C (en) | 2016-08-02 |
| US9133228B2 (en) | 2015-09-15 |
| CA2851516A1 (en) | 2013-04-18 |
| EP2751096A2 (en) | 2014-07-09 |
| NZ623292A (en) | 2016-02-26 |
| CN104024247B (zh) | 2016-05-25 |
| HK1201064A1 (en) | 2015-08-21 |
| KR20140074996A (ko) | 2014-06-18 |
| WO2013055825A3 (en) | 2013-06-13 |
| SG11201401226YA (en) | 2014-05-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application fees: dismissal - article 86 of industrial property law | ||
| B08K | Lapse as no evidence of payment of the annual fee has been furnished to inpi (acc. art. 87) |