JP2015502330A - ヒトパピローマウイルスを処置するのに有用なグアニジニル置換ポリアミド - Google Patents

ヒトパピローマウイルスを処置するのに有用なグアニジニル置換ポリアミド Download PDF

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JP2015502330A
JP2015502330A JP2014534836A JP2014534836A JP2015502330A JP 2015502330 A JP2015502330 A JP 2015502330A JP 2014534836 A JP2014534836 A JP 2014534836A JP 2014534836 A JP2014534836 A JP 2014534836A JP 2015502330 A JP2015502330 A JP 2015502330A
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JP
Japan
Prior art keywords
tmg
compound
hpv
polyamide
pyβpypyβpypypyβpyβ
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JP2014534836A
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English (en)
Japanese (ja)
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JP2015502330A5 (enExample
Inventor
バシキン，ジェイムズ，ケイ．
エドワーズ，テリ，ジー．
フィッシャー，クリストファー
ジュニア，ジョージ，ディー． ハリス
ジュニア，ジョージ，ディー． ハリス
コラー，ケヴィン，ジェイ．
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Missouri System
NanoVir LLC
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University of Missouri System
NanoVir LLC
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Application filed by University of Missouri System, NanoVir LLC filed Critical University of Missouri System
Publication of JP2015502330A publication Critical patent/JP2015502330A/ja
Publication of JP2015502330A5 publication Critical patent/JP2015502330A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C07K14/003—Peptide-nucleic acids (PNAs)

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polyamides (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Materials For Medical Uses (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2014534836A 2011-10-10 2012-10-10 ヒトパピローマウイルスを処置するのに有用なグアニジニル置換ポリアミド Pending JP2015502330A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161545311P 2011-10-10 2011-10-10
US61/545,311 2011-10-10
PCT/US2012/059604 WO2013055825A2 (en) 2011-10-10 2012-10-10 Guanidinyl-substituted polyamides useful for treating human papilloma virus

Publications (2)

Publication Number Publication Date
JP2015502330A true JP2015502330A (ja) 2015-01-22
JP2015502330A5 JP2015502330A5 (enExample) 2015-12-03

Family

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JP2014534836A Pending JP2015502330A (ja) 2011-10-10 2012-10-10 ヒトパピローマウイルスを処置するのに有用なグアニジニル置換ポリアミド

Country Status (12)

Country Link
US (1) US9133228B2 (enExample)
EP (1) EP2751096A4 (enExample)
JP (1) JP2015502330A (enExample)
KR (1) KR20140074996A (enExample)
CN (1) CN104024247B (enExample)
AU (1) AU2012322835A1 (enExample)
BR (1) BR112014008464A2 (enExample)
CA (1) CA2851516C (enExample)
HK (1) HK1201064A1 (enExample)
RU (1) RU2014113702A (enExample)
SG (1) SG11201401226YA (enExample)
WO (1) WO2013055825A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024138360A (ja) * 2019-03-20 2024-10-08 学校法人順天堂 二重膜構造細胞内小器官ｄｎａ標的薬

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9982020B2 (en) * 2011-10-10 2018-05-29 Nanovir Llc Antiviral compounds and methods for treating infections caused by double-stranded DNA viruses
WO2016022664A1 (en) * 2014-08-05 2016-02-11 Nanovir Llc Antiviral compounds and methods for treating infections caused by double-stranded dna viruses

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009536680A (ja) * 2006-05-04 2009-10-15 ナノビール・リミテッド・ライアビリティ・カンパニー ヒトパピローマウイルスを処置するためのポリアミド類

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WO1995004732A1 (en) 1993-08-06 1995-02-16 Synphar Laboratories, Inc. Oligopeptide antiretroviral agents
EP0973740A1 (en) 1996-02-26 2000-01-26 California Institute Of Technology Design, synthesis and use of specific polyamide dna-binding ligands
CN1260006A (zh) 1996-02-26 2000-07-12 加利福尼亚州技术学院 双链dna和杂环低聚物之间复合物的形成
JP2001513759A (ja) 1996-02-26 2001-09-04 カリフォルニア・インスティチュート・オブ・テクノロジー 二本鎖ｄｎａの副溝において結合する改良されたポリアミド
US5998140A (en) 1996-07-31 1999-12-07 The Scripps Research Institute Complex formation between dsDNA and oligomer of cyclic heterocycles
JP2002515057A (ja) 1996-08-01 2002-05-21 カリフォルニア・インスティチュート・オブ・テクノロジー ポリアミドｄｎａ結合リガンドによる遺伝子発現の阻害
AU5910899A (en) 1998-09-11 2000-04-03 California Institute Of Technology Inhibition of oncogene transcription by synthetic polyamides
US6673940B1 (en) 1999-01-08 2004-01-06 California Institute Of Technology Compositions and methods relating to cyclic compounds that undergo nucleotide base pair-specific interactions with double-stranded nucleic acids
JP4012145B2 (ja) 2001-06-25 2007-11-21 独立行政法人科学技術振興機構 ピロール−イミダゾールポリアミドの固相合成法
CA2465886A1 (en) 2001-11-07 2003-05-15 Kathleen S. Crowley Methods of promoting uptake and nuclear accumulation of polyamides in eukaryotic cells
CA2466391A1 (en) 2001-11-07 2003-05-15 Dennis P. Phillion Polyamide modulators of cox2 transcription
WO2004064913A1 (en) 2003-01-16 2004-08-05 Femmepharma Holding Company, Inc. Vaginal or rectal applicator
WO2004078943A2 (en) 2003-03-04 2004-09-16 California Institute Of Technology Alternative heterocycles for dna recognition
CA2531869A1 (en) 2003-04-30 2004-11-18 Pharmacia Corporation Compounds having a fused, bicyclic moiety for binding to the minor groove of dsdna
US8399013B2 (en) 2003-06-26 2013-03-19 Poly-Med, Inc. Partially absorbable fiber-reinforced composites for controlled drug delivery
WO2005033282A2 (en) 2003-10-01 2005-04-14 Pharmacia & Upjohn Company Llc Polyamide compositions and therapeutic methods for treatment of human papilloma virus
DE10357677A1 (de) * 2003-12-10 2005-07-14 Greiner Bio-One Gmbh Primer und Sonden zum Nachweis genitaler HPV-Genotypen
WO2007045096A1 (en) * 2005-10-21 2007-04-26 University Of Saskatchewan Oligoheteroaromatic luminiscent assemblies as high-affinity dna sequence-directed ligands
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US8993609B2 (en) 2006-05-04 2015-03-31 Nanovir, Llc Compounds for treating papilloma virus infection

Patent Citations (1)

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JP2009536680A (ja) * 2006-05-04 2009-10-15 ナノビール・リミテッド・ライアビリティ・カンパニー ヒトパピローマウイルスを処置するためのポリアミド類

Non-Patent Citations (1)

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Title
JPN6015051494; Ｄｉａｎａ　Ｅ．　Ｗｅｔｚｌｅｒ，ｅｔ　ａｌ: 'Ｎｅｗ　Ｈｕｍａｎ　Ｐａｐｉｌｌｏｍａ　Ｖｉｒｕｓ　Ｅ２　Ｔｒａｎｓｃｒｉｐｔｉｏｎ　Ｆａｃｔｏｒ　Ｍｉｍｉｃｓ：　Ａ　Ｔｒｉｐｙｒｒｏｌｅ-Ｐｅｐｔｉｄｅ　Ｃｏｎｊｕｇａｔｅ　ｗｉｔｈ　Ｔｉｇｈｔ' ＰＬｏＳ　ＯＮＥ Ｖｏｌ．６，Ｎｏ．７, 201107, ｅ２２４０９　（ｐ．１-８） *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024138360A (ja) * 2019-03-20 2024-10-08 学校法人順天堂 二重膜構造細胞内小器官ｄｎａ標的薬
JP7851631B2 (ja) 2019-03-20 2026-04-27 学校法人順天堂 二重膜構造細胞内小器官ｄｎａ標的薬

Also Published As

Publication number Publication date
CN104024247B (zh) 2016-05-25
KR20140074996A (ko) 2014-06-18
US9133228B2 (en) 2015-09-15
WO2013055825A3 (en) 2013-06-13
CN104024247A (zh) 2014-09-03
BR112014008464A2 (pt) 2017-04-11
EP2751096A2 (en) 2014-07-09
NZ623292A (en) 2016-02-26
CA2851516A1 (en) 2013-04-18
EP2751096A4 (en) 2015-04-08
AU2012322835A1 (en) 2014-04-17
RU2014113702A (ru) 2015-11-20
WO2013055825A2 (en) 2013-04-18
US20130090362A1 (en) 2013-04-11
HK1201064A1 (en) 2015-08-21
SG11201401226YA (en) 2014-05-29
CA2851516C (en) 2016-08-02

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