RU2014113702A - Гуанидинил-замещенные полиамиды, пригодные для лечения инфекций, вызванных папилломавирусом человека - Google Patents
Гуанидинил-замещенные полиамиды, пригодные для лечения инфекций, вызванных папилломавирусом человека Download PDFInfo
- Publication number
- RU2014113702A RU2014113702A RU2014113702/04A RU2014113702A RU2014113702A RU 2014113702 A RU2014113702 A RU 2014113702A RU 2014113702/04 A RU2014113702/04 A RU 2014113702/04A RU 2014113702 A RU2014113702 A RU 2014113702A RU 2014113702 A RU2014113702 A RU 2014113702A
- Authority
- RU
- Russia
- Prior art keywords
- compound according
- pharmaceutically acceptable
- dna
- double
- compound
- Prior art date
Links
- 208000015181 infectious disease Diseases 0.000 title claims 4
- 241000701806 Human papillomavirus Species 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 21
- 238000000034 method Methods 0.000 claims abstract 18
- 108020004414 DNA Proteins 0.000 claims abstract 9
- 102000053602 DNA Human genes 0.000 claims abstract 7
- 150000003839 salts Chemical class 0.000 claims abstract 6
- OGNSCSPNOLGXSM-UHFFFAOYSA-N (+/-)-DABA Natural products NCCC(N)C(O)=O OGNSCSPNOLGXSM-UHFFFAOYSA-N 0.000 claims abstract 4
- LWXLPQFDIHLJGX-UHFFFAOYSA-N (4-amino-1-methyl-3h-pyrrol-2-ylidene)methanone Chemical compound CN1C=C(N)CC1=C=O LWXLPQFDIHLJGX-UHFFFAOYSA-N 0.000 claims abstract 4
- UCMIRNVEIXFBKS-UHFFFAOYSA-N beta-alanine Chemical compound NCCC(O)=O UCMIRNVEIXFBKS-UHFFFAOYSA-N 0.000 claims abstract 4
- 230000027455 binding Effects 0.000 claims abstract 4
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 claims abstract 4
- 239000003937 drug carrier Substances 0.000 claims abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract 3
- NSUPVLQQSPQZLZ-UHFFFAOYSA-N (5-amino-3-methyl-1h-imidazol-2-ylidene)methanone Chemical compound CN1C=C(N)NC1=C=O NSUPVLQQSPQZLZ-UHFFFAOYSA-N 0.000 claims abstract 2
- OGNSCSPNOLGXSM-GSVOUGTGSA-N D-2,4-diaminobutyric acid Chemical compound NCC[C@@H](N)C(O)=O OGNSCSPNOLGXSM-GSVOUGTGSA-N 0.000 claims abstract 2
- 230000004568 DNA-binding Effects 0.000 claims abstract 2
- OGNSCSPNOLGXSM-VKHMYHEASA-N L-2,4-diaminobutyric acid Chemical compound NCC[C@H](N)C(O)=O OGNSCSPNOLGXSM-VKHMYHEASA-N 0.000 claims abstract 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims abstract 2
- 229940000635 beta-alanine Drugs 0.000 claims abstract 2
- IUNMPGNGSSIWFP-UHFFFAOYSA-N dimethylaminopropylamine Chemical compound CN(C)CCCN IUNMPGNGSSIWFP-UHFFFAOYSA-N 0.000 claims abstract 2
- 229960003692 gamma aminobutyric acid Drugs 0.000 claims abstract 2
- 238000000338 in vitro Methods 0.000 claims abstract 2
- 238000001727 in vivo Methods 0.000 claims abstract 2
- KMBPCQSCMCEPMU-UHFFFAOYSA-N n'-(3-aminopropyl)-n'-methylpropane-1,3-diamine Chemical compound NCCCN(C)CCCN KMBPCQSCMCEPMU-UHFFFAOYSA-N 0.000 claims abstract 2
- -1 tetramethylguanidinyl Chemical group 0.000 claims abstract 2
- 210000004027 cell Anatomy 0.000 claims 10
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 241000700605 Viruses Species 0.000 claims 2
- 210000004881 tumor cell Anatomy 0.000 claims 2
- 241000701044 Human gammaherpesvirus 4 Species 0.000 claims 1
- 208000022361 Human papillomavirus infectious disease Diseases 0.000 claims 1
- 241000341655 Human papillomavirus type 16 Species 0.000 claims 1
- 241001631646 Papillomaviridae Species 0.000 claims 1
- 208000009608 Papillomavirus Infections Diseases 0.000 claims 1
- 241000700647 Variola virus Species 0.000 claims 1
- 210000000436 anus Anatomy 0.000 claims 1
- 210000003679 cervix uteri Anatomy 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 210000000214 mouth Anatomy 0.000 claims 1
- 210000003739 neck Anatomy 0.000 claims 1
- 210000003899 penis Anatomy 0.000 claims 1
- 210000003800 pharynx Anatomy 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- 241000701161 unidentified adenovirus Species 0.000 claims 1
- 241001529453 unidentified herpesvirus Species 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
- C07K14/003—Peptide-nucleic acids (PNAs)
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polyamides (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Materials For Medical Uses (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161545311P | 2011-10-10 | 2011-10-10 | |
| US61/545,311 | 2011-10-10 | ||
| PCT/US2012/059604 WO2013055825A2 (en) | 2011-10-10 | 2012-10-10 | Guanidinyl-substituted polyamides useful for treating human papilloma virus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2014113702A true RU2014113702A (ru) | 2015-11-20 |
Family
ID=48042465
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2014113702/04A RU2014113702A (ru) | 2011-10-10 | 2012-10-10 | Гуанидинил-замещенные полиамиды, пригодные для лечения инфекций, вызванных папилломавирусом человека |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US9133228B2 (enExample) |
| EP (1) | EP2751096A4 (enExample) |
| JP (1) | JP2015502330A (enExample) |
| KR (1) | KR20140074996A (enExample) |
| CN (1) | CN104024247B (enExample) |
| AU (1) | AU2012322835A1 (enExample) |
| BR (1) | BR112014008464A2 (enExample) |
| CA (1) | CA2851516C (enExample) |
| HK (1) | HK1201064A1 (enExample) |
| RU (1) | RU2014113702A (enExample) |
| SG (1) | SG11201401226YA (enExample) |
| WO (1) | WO2013055825A2 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9982020B2 (en) * | 2011-10-10 | 2018-05-29 | Nanovir Llc | Antiviral compounds and methods for treating infections caused by double-stranded DNA viruses |
| WO2016022664A1 (en) * | 2014-08-05 | 2016-02-11 | Nanovir Llc | Antiviral compounds and methods for treating infections caused by double-stranded dna viruses |
| EP4365590B1 (en) * | 2019-03-20 | 2025-09-24 | Juntendo Educational Foundation | Agent targeting double-membrane organelle dna |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995004732A1 (en) | 1993-08-06 | 1995-02-16 | Synphar Laboratories, Inc. | Oligopeptide antiretroviral agents |
| EP0973740A1 (en) | 1996-02-26 | 2000-01-26 | California Institute Of Technology | Design, synthesis and use of specific polyamide dna-binding ligands |
| CN1260006A (zh) | 1996-02-26 | 2000-07-12 | 加利福尼亚州技术学院 | 双链dna和杂环低聚物之间复合物的形成 |
| JP2001513759A (ja) | 1996-02-26 | 2001-09-04 | カリフォルニア・インスティチュート・オブ・テクノロジー | 二本鎖ｄｎａの副溝において結合する改良されたポリアミド |
| US5998140A (en) | 1996-07-31 | 1999-12-07 | The Scripps Research Institute | Complex formation between dsDNA and oligomer of cyclic heterocycles |
| JP2002515057A (ja) | 1996-08-01 | 2002-05-21 | カリフォルニア・インスティチュート・オブ・テクノロジー | ポリアミドｄｎａ結合リガンドによる遺伝子発現の阻害 |
| AU5910899A (en) | 1998-09-11 | 2000-04-03 | California Institute Of Technology | Inhibition of oncogene transcription by synthetic polyamides |
| US6673940B1 (en) | 1999-01-08 | 2004-01-06 | California Institute Of Technology | Compositions and methods relating to cyclic compounds that undergo nucleotide base pair-specific interactions with double-stranded nucleic acids |
| JP4012145B2 (ja) | 2001-06-25 | 2007-11-21 | 独立行政法人科学技術振興機構 | ピロール−イミダゾールポリアミドの固相合成法 |
| CA2465886A1 (en) | 2001-11-07 | 2003-05-15 | Kathleen S. Crowley | Methods of promoting uptake and nuclear accumulation of polyamides in eukaryotic cells |
| CA2466391A1 (en) | 2001-11-07 | 2003-05-15 | Dennis P. Phillion | Polyamide modulators of cox2 transcription |
| WO2004064913A1 (en) | 2003-01-16 | 2004-08-05 | Femmepharma Holding Company, Inc. | Vaginal or rectal applicator |
| WO2004078943A2 (en) | 2003-03-04 | 2004-09-16 | California Institute Of Technology | Alternative heterocycles for dna recognition |
| CA2531869A1 (en) | 2003-04-30 | 2004-11-18 | Pharmacia Corporation | Compounds having a fused, bicyclic moiety for binding to the minor groove of dsdna |
| US8399013B2 (en) | 2003-06-26 | 2013-03-19 | Poly-Med, Inc. | Partially absorbable fiber-reinforced composites for controlled drug delivery |
| WO2005033282A2 (en) | 2003-10-01 | 2005-04-14 | Pharmacia & Upjohn Company Llc | Polyamide compositions and therapeutic methods for treatment of human papilloma virus |
| DE10357677A1 (de) * | 2003-12-10 | 2005-07-14 | Greiner Bio-One Gmbh | Primer und Sonden zum Nachweis genitaler HPV-Genotypen |
| WO2007045096A1 (en) * | 2005-10-21 | 2007-04-26 | University Of Saskatchewan | Oligoheteroaromatic luminiscent assemblies as high-affinity dna sequence-directed ligands |
| WO2007103584A2 (en) | 2006-03-09 | 2007-09-13 | Nanovir, Llc | Polyamides for treating human papilloma virus |
| US7589171B2 (en) | 2006-05-04 | 2009-09-15 | Nanovir, Llc | Polyamides for treating human papilloma virus |
| US8993609B2 (en) | 2006-05-04 | 2015-03-31 | Nanovir, Llc | Compounds for treating papilloma virus infection |
-
2012
- 2012-10-10 CN CN201280049712.1A patent/CN104024247B/zh not_active Expired - Fee Related
- 2012-10-10 JP JP2014534836A patent/JP2015502330A/ja active Pending
- 2012-10-10 KR KR1020147012415A patent/KR20140074996A/ko not_active Ceased
- 2012-10-10 BR BR112014008464A patent/BR112014008464A2/pt not_active IP Right Cessation
- 2012-10-10 US US13/649,000 patent/US9133228B2/en not_active Expired - Fee Related
- 2012-10-10 CA CA2851516A patent/CA2851516C/en active Active
- 2012-10-10 EP EP12840685.7A patent/EP2751096A4/en not_active Withdrawn
- 2012-10-10 AU AU2012322835A patent/AU2012322835A1/en not_active Abandoned
- 2012-10-10 WO PCT/US2012/059604 patent/WO2013055825A2/en not_active Ceased
- 2012-10-10 HK HK15101532.6A patent/HK1201064A1/xx unknown
- 2012-10-10 SG SG11201401226YA patent/SG11201401226YA/en unknown
- 2012-10-10 RU RU2014113702/04A patent/RU2014113702A/ru not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CN104024247B (zh) | 2016-05-25 |
| KR20140074996A (ko) | 2014-06-18 |
| US9133228B2 (en) | 2015-09-15 |
| WO2013055825A3 (en) | 2013-06-13 |
| CN104024247A (zh) | 2014-09-03 |
| BR112014008464A2 (pt) | 2017-04-11 |
| EP2751096A2 (en) | 2014-07-09 |
| NZ623292A (en) | 2016-02-26 |
| CA2851516A1 (en) | 2013-04-18 |
| EP2751096A4 (en) | 2015-04-08 |
| AU2012322835A1 (en) | 2014-04-17 |
| WO2013055825A2 (en) | 2013-04-18 |
| US20130090362A1 (en) | 2013-04-11 |
| JP2015502330A (ja) | 2015-01-22 |
| HK1201064A1 (en) | 2015-08-21 |
| SG11201401226YA (en) | 2014-05-29 |
| CA2851516C (en) | 2016-08-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA94 | Acknowledgement of application withdrawn (non-payment of fees) |
Effective date: 20170417 |