BR112014008464A2 - composto; composição farmacêutica; método para ligar dna de fita dupla com especificidade para sequência; método para reduzir ou inibir a proliferação de células de papiloma ou neoplásticas; método para tratar células infectadas por vírus; e método para tratar hpv em um indivíduo - Google Patents
composto; composição farmacêutica; método para ligar dna de fita dupla com especificidade para sequência; método para reduzir ou inibir a proliferação de células de papiloma ou neoplásticas; método para tratar células infectadas por vírus; e método para tratar hpv em um indivíduoInfo
- Publication number
- BR112014008464A2 BR112014008464A2 BR112014008464A BR112014008464A BR112014008464A2 BR 112014008464 A2 BR112014008464 A2 BR 112014008464A2 BR 112014008464 A BR112014008464 A BR 112014008464A BR 112014008464 A BR112014008464 A BR 112014008464A BR 112014008464 A2 BR112014008464 A2 BR 112014008464A2
- Authority
- BR
- Brazil
- Prior art keywords
- treating
- papilloma
- proliferation
- inhibiting
- individual
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
- C07K14/003—Peptide-nucleic acids (PNAs)
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polyamides (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Materials For Medical Uses (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
resumo composto; composição farmacêutica; método para ligar dna de fita dupla com especificidade para sequência; método para reduzir ou inibir a proliferação de células de papiloma ou neoplásticas; método para tratar células infectadas por vírus; e método para tratar hpv em um indivíduo trata-se de composições de poliamida que contêm radicais de guanidinila, incluindo radicais de tetrametilguanidinila. essas poliamidas são úteis para aplicações médicas, por exemplo, para tratar infecções por vírus do papiloma humano. 1/1
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161545311P | 2011-10-10 | 2011-10-10 | |
PCT/US2012/059604 WO2013055825A2 (en) | 2011-10-10 | 2012-10-10 | Guanidinyl-substituted polyamides useful for treating human papilloma virus |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112014008464A2 true BR112014008464A2 (pt) | 2017-04-11 |
Family
ID=48042465
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112014008464A BR112014008464A2 (pt) | 2011-10-10 | 2012-10-10 | composto; composição farmacêutica; método para ligar dna de fita dupla com especificidade para sequência; método para reduzir ou inibir a proliferação de células de papiloma ou neoplásticas; método para tratar células infectadas por vírus; e método para tratar hpv em um indivíduo |
Country Status (12)
Country | Link |
---|---|
US (1) | US9133228B2 (pt) |
EP (1) | EP2751096A4 (pt) |
JP (1) | JP2015502330A (pt) |
KR (1) | KR20140074996A (pt) |
CN (1) | CN104024247B (pt) |
AU (1) | AU2012322835A1 (pt) |
BR (1) | BR112014008464A2 (pt) |
CA (1) | CA2851516C (pt) |
HK (1) | HK1201064A1 (pt) |
RU (1) | RU2014113702A (pt) |
SG (1) | SG11201401226YA (pt) |
WO (1) | WO2013055825A2 (pt) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9982020B2 (en) * | 2011-10-10 | 2018-05-29 | Nanovir Llc | Antiviral compounds and methods for treating infections caused by double-stranded DNA viruses |
WO2016022664A1 (en) | 2014-08-05 | 2016-02-11 | Nanovir Llc | Antiviral compounds and methods for treating infections caused by double-stranded dna viruses |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU7380294A (en) | 1993-08-06 | 1995-02-28 | Synphar Laboratories, Inc. | Oligopeptide antiretroviral agents |
WO1998037066A1 (en) | 1996-02-26 | 1998-08-27 | California Institute Of Technology | Improved polyamides for binding in the minor groove of double stranded dna |
CN1260006A (zh) | 1996-02-26 | 2000-07-12 | 加利福尼亚州技术学院 | 双链dna和杂环低聚物之间复合物的形成 |
AU6255298A (en) | 1996-02-26 | 1998-09-09 | California Institute Of Technology | Design, synthesis and use of specific polyamide dna-binding ligands |
US5998140A (en) | 1996-07-31 | 1999-12-07 | The Scripps Research Institute | Complex formation between dsDNA and oligomer of cyclic heterocycles |
WO1998035702A1 (en) | 1996-08-01 | 1998-08-20 | California Institute Of Technology | Inhibition of gene transcription by polyamide dna-binding ligands |
JP2003505521A (ja) | 1998-09-11 | 2003-02-12 | カリフォルニア・インスティテュート・オブ・テクノロジー | 合成ポリアミドによる癌遺伝子転写の阻害 |
US6673940B1 (en) | 1999-01-08 | 2004-01-06 | California Institute Of Technology | Compositions and methods relating to cyclic compounds that undergo nucleotide base pair-specific interactions with double-stranded nucleic acids |
WO2003000683A1 (en) | 2001-06-25 | 2003-01-03 | Japan Science And Technology Agency | Method of the solid phase synhesis of pyrrole-imidazole polyamide |
JP2005508181A (ja) | 2001-11-07 | 2005-03-31 | ファルマシア・コーポレーション | Cox2転写のポリアミド調節因子 |
AU2002363523A1 (en) | 2001-11-07 | 2003-05-19 | Pharmacia Corporation | Methods of promoting uptake and nuclear accumulation of polyamides in eukaryotic cells |
EP1585571B1 (en) | 2003-01-16 | 2010-05-19 | Femmepharma Holding Cpmpany, Inc. | Vaginal or rectal applicator and method |
US8524899B2 (en) | 2003-03-04 | 2013-09-03 | California Institute Of Technology | Alternative heterocycles for DNA recognition |
US20050009054A1 (en) | 2003-04-30 | 2005-01-13 | Pharmacia Corporation | Compounds having a fused, bicyclic moiety for binding to the minor groove of dsDNA |
US8399013B2 (en) | 2003-06-26 | 2013-03-19 | Poly-Med, Inc. | Partially absorbable fiber-reinforced composites for controlled drug delivery |
WO2005033282A2 (en) * | 2003-10-01 | 2005-04-14 | Pharmacia & Upjohn Company Llc | Polyamide compositions and therapeutic methods for treatment of human papilloma virus |
DE10357677A1 (de) | 2003-12-10 | 2005-07-14 | Greiner Bio-One Gmbh | Primer und Sonden zum Nachweis genitaler HPV-Genotypen |
WO2007045096A1 (en) * | 2005-10-21 | 2007-04-26 | University Of Saskatchewan | Oligoheteroaromatic luminiscent assemblies as high-affinity dna sequence-directed ligands |
WO2007103584A2 (en) | 2006-03-09 | 2007-09-13 | Nanovir, Llc | Polyamides for treating human papilloma virus |
US8993609B2 (en) | 2006-05-04 | 2015-03-31 | Nanovir, Llc | Compounds for treating papilloma virus infection |
EP2013200B1 (en) | 2006-05-04 | 2012-04-25 | Nanovir, LLC | Polyamides for treating human papilloma virus |
-
2012
- 2012-10-10 CA CA2851516A patent/CA2851516C/en active Active
- 2012-10-10 KR KR1020147012415A patent/KR20140074996A/ko not_active Application Discontinuation
- 2012-10-10 CN CN201280049712.1A patent/CN104024247B/zh not_active Expired - Fee Related
- 2012-10-10 US US13/649,000 patent/US9133228B2/en not_active Expired - Fee Related
- 2012-10-10 WO PCT/US2012/059604 patent/WO2013055825A2/en active Application Filing
- 2012-10-10 AU AU2012322835A patent/AU2012322835A1/en not_active Abandoned
- 2012-10-10 RU RU2014113702/04A patent/RU2014113702A/ru not_active Application Discontinuation
- 2012-10-10 SG SG11201401226YA patent/SG11201401226YA/en unknown
- 2012-10-10 JP JP2014534836A patent/JP2015502330A/ja active Pending
- 2012-10-10 BR BR112014008464A patent/BR112014008464A2/pt not_active IP Right Cessation
- 2012-10-10 EP EP12840685.7A patent/EP2751096A4/en not_active Withdrawn
-
2015
- 2015-02-11 HK HK15101532.6A patent/HK1201064A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
RU2014113702A (ru) | 2015-11-20 |
CA2851516A1 (en) | 2013-04-18 |
JP2015502330A (ja) | 2015-01-22 |
SG11201401226YA (en) | 2014-05-29 |
EP2751096A4 (en) | 2015-04-08 |
WO2013055825A2 (en) | 2013-04-18 |
HK1201064A1 (en) | 2015-08-21 |
CN104024247A (zh) | 2014-09-03 |
CN104024247B (zh) | 2016-05-25 |
KR20140074996A (ko) | 2014-06-18 |
NZ623292A (en) | 2016-02-26 |
WO2013055825A3 (en) | 2013-06-13 |
US20130090362A1 (en) | 2013-04-11 |
CA2851516C (en) | 2016-08-02 |
US9133228B2 (en) | 2015-09-15 |
AU2012322835A1 (en) | 2014-04-17 |
EP2751096A2 (en) | 2014-07-09 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application fees: dismissal - article 86 of industrial property law | ||
B08K | Lapse as no evidence of payment of the annual fee has been furnished to inpi (acc. art. 87) |