CA2851516C - Guanidinyl-substituted polyamides useful for treating human papilloma virus - Google Patents

Guanidinyl-substituted polyamides useful for treating human papilloma virus Download PDF

Info

Publication number
CA2851516C
CA2851516C CA2851516A CA2851516A CA2851516C CA 2851516 C CA2851516 C CA 2851516C CA 2851516 A CA2851516 A CA 2851516A CA 2851516 A CA2851516 A CA 2851516A CA 2851516 C CA2851516 C CA 2851516C
Authority
CA
Canada
Prior art keywords
beta
eta
pypy
tmg
pypypy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2851516A
Other languages
English (en)
French (fr)
Other versions
CA2851516A1 (en
Inventor
James K. Bashkin
Terri G. Edwards
Christopher Fisher
George D. Harris, Jr
Kevin J. Koeller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NanoVir LLC
University of Missouri–St. Louis
Original Assignee
NanoVir LLC
University of Missouri–St. Louis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NanoVir LLC, University of Missouri–St. Louis filed Critical NanoVir LLC
Publication of CA2851516A1 publication Critical patent/CA2851516A1/en
Application granted granted Critical
Publication of CA2851516C publication Critical patent/CA2851516C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C07K14/003—Peptide-nucleic acids (PNAs)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polyamides (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Materials For Medical Uses (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA2851516A 2011-10-10 2012-10-10 Guanidinyl-substituted polyamides useful for treating human papilloma virus Active CA2851516C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161545311P 2011-10-10 2011-10-10
US61/545,311 2011-10-10
PCT/US2012/059604 WO2013055825A2 (en) 2011-10-10 2012-10-10 Guanidinyl-substituted polyamides useful for treating human papilloma virus

Publications (2)

Publication Number Publication Date
CA2851516A1 CA2851516A1 (en) 2013-04-18
CA2851516C true CA2851516C (en) 2016-08-02

Family

ID=48042465

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2851516A Active CA2851516C (en) 2011-10-10 2012-10-10 Guanidinyl-substituted polyamides useful for treating human papilloma virus

Country Status (12)

Country Link
US (1) US9133228B2 (enExample)
EP (1) EP2751096A4 (enExample)
JP (1) JP2015502330A (enExample)
KR (1) KR20140074996A (enExample)
CN (1) CN104024247B (enExample)
AU (1) AU2012322835A1 (enExample)
BR (1) BR112014008464A2 (enExample)
CA (1) CA2851516C (enExample)
HK (1) HK1201064A1 (enExample)
RU (1) RU2014113702A (enExample)
SG (1) SG11201401226YA (enExample)
WO (1) WO2013055825A2 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9982020B2 (en) * 2011-10-10 2018-05-29 Nanovir Llc Antiviral compounds and methods for treating infections caused by double-stranded DNA viruses
WO2016022664A1 (en) * 2014-08-05 2016-02-11 Nanovir Llc Antiviral compounds and methods for treating infections caused by double-stranded dna viruses
EP4365590B1 (en) * 2019-03-20 2025-09-24 Juntendo Educational Foundation Agent targeting double-membrane organelle dna

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995004732A1 (en) 1993-08-06 1995-02-16 Synphar Laboratories, Inc. Oligopeptide antiretroviral agents
EP0973740A1 (en) 1996-02-26 2000-01-26 California Institute Of Technology Design, synthesis and use of specific polyamide dna-binding ligands
CN1260006A (zh) 1996-02-26 2000-07-12 加利福尼亚州技术学院 双链dna和杂环低聚物之间复合物的形成
JP2001513759A (ja) 1996-02-26 2001-09-04 カリフォルニア・インスティチュート・オブ・テクノロジー 二本鎖ｄｎａの副溝において結合する改良されたポリアミド
US5998140A (en) 1996-07-31 1999-12-07 The Scripps Research Institute Complex formation between dsDNA and oligomer of cyclic heterocycles
JP2002515057A (ja) 1996-08-01 2002-05-21 カリフォルニア・インスティチュート・オブ・テクノロジー ポリアミドｄｎａ結合リガンドによる遺伝子発現の阻害
AU5910899A (en) 1998-09-11 2000-04-03 California Institute Of Technology Inhibition of oncogene transcription by synthetic polyamides
US6673940B1 (en) 1999-01-08 2004-01-06 California Institute Of Technology Compositions and methods relating to cyclic compounds that undergo nucleotide base pair-specific interactions with double-stranded nucleic acids
JP4012145B2 (ja) 2001-06-25 2007-11-21 独立行政法人科学技術振興機構 ピロール−イミダゾールポリアミドの固相合成法
CA2465886A1 (en) 2001-11-07 2003-05-15 Kathleen S. Crowley Methods of promoting uptake and nuclear accumulation of polyamides in eukaryotic cells
CA2466391A1 (en) 2001-11-07 2003-05-15 Dennis P. Phillion Polyamide modulators of cox2 transcription
WO2004064913A1 (en) 2003-01-16 2004-08-05 Femmepharma Holding Company, Inc. Vaginal or rectal applicator
WO2004078943A2 (en) 2003-03-04 2004-09-16 California Institute Of Technology Alternative heterocycles for dna recognition
CA2531869A1 (en) 2003-04-30 2004-11-18 Pharmacia Corporation Compounds having a fused, bicyclic moiety for binding to the minor groove of dsdna
US8399013B2 (en) 2003-06-26 2013-03-19 Poly-Med, Inc. Partially absorbable fiber-reinforced composites for controlled drug delivery
WO2005033282A2 (en) 2003-10-01 2005-04-14 Pharmacia & Upjohn Company Llc Polyamide compositions and therapeutic methods for treatment of human papilloma virus
DE10357677A1 (de) * 2003-12-10 2005-07-14 Greiner Bio-One Gmbh Primer und Sonden zum Nachweis genitaler HPV-Genotypen
WO2007045096A1 (en) * 2005-10-21 2007-04-26 University Of Saskatchewan Oligoheteroaromatic luminiscent assemblies as high-affinity dna sequence-directed ligands
WO2007103584A2 (en) 2006-03-09 2007-09-13 Nanovir, Llc Polyamides for treating human papilloma virus
US7589171B2 (en) 2006-05-04 2009-09-15 Nanovir, Llc Polyamides for treating human papilloma virus
US8993609B2 (en) 2006-05-04 2015-03-31 Nanovir, Llc Compounds for treating papilloma virus infection

Also Published As

Publication number Publication date
CN104024247B (zh) 2016-05-25
KR20140074996A (ko) 2014-06-18
US9133228B2 (en) 2015-09-15
WO2013055825A3 (en) 2013-06-13
CN104024247A (zh) 2014-09-03
BR112014008464A2 (pt) 2017-04-11
EP2751096A2 (en) 2014-07-09
NZ623292A (en) 2016-02-26
CA2851516A1 (en) 2013-04-18
EP2751096A4 (en) 2015-04-08
AU2012322835A1 (en) 2014-04-17
RU2014113702A (ru) 2015-11-20
WO2013055825A2 (en) 2013-04-18
US20130090362A1 (en) 2013-04-11
JP2015502330A (ja) 2015-01-22
HK1201064A1 (en) 2015-08-21
SG11201401226YA (en) 2014-05-29

Similar Documents

Publication Publication Date Title
JP5796039B2 (ja) ヒトパピローマウイルスを処置するためのポリアミド類
US9066951B2 (en) Drugs to treat HPV infection
WO2007103584A2 (en) Polyamides for treating human papilloma virus
US9133228B2 (en) Guanidinyl-substituted polyamides useful for treating human papilloma virus
US9290551B2 (en) Compounds for treating papilloma virus infection
WO2005033282A2 (en) Polyamide compositions and therapeutic methods for treatment of human papilloma virus
US9982020B2 (en) Antiviral compounds and methods for treating infections caused by double-stranded DNA viruses
JP2877910B2 (ja) ２―オキソアルキル側鎖を有する抗ウイルスペプチド
NZ623292B2 (en) Guanidinyl-substituted polyamides useful for treating human papilloma virus
JP5547082B2 (ja) 新規なヒトパピローマウイルス阻害剤およびそれを含有する医薬組成物
Bashkin et al. Polyamides containing amino butyric acid-based building blocks
Bashkin et al. Polyamides for treating human papilloma virus
US20200360471A1 (en) Methods of treating and preventing viral infections
Edwards i, United States Patent (10) Patent No.: US 9.333. 232 B2
JPH03101696A (ja) 抗ヘルペスペンタペプチド類
WO2016022664A1 (en) Antiviral compounds and methods for treating infections caused by double-stranded dna viruses
Nanovir Bashkin et al.(43) Pub. Date: Sep. 6, 2012
WO2015161479A1 (zh) 一种嘧啶类化合物的抗宫颈癌用途
HK1236532A1 (en) Indoles for use in influenza virus infection

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20140423