JP2015500702A5 - - Google Patents
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- Publication number
- JP2015500702A5 JP2015500702A5 JP2014546138A JP2014546138A JP2015500702A5 JP 2015500702 A5 JP2015500702 A5 JP 2015500702A5 JP 2014546138 A JP2014546138 A JP 2014546138A JP 2014546138 A JP2014546138 A JP 2014546138A JP 2015500702 A5 JP2015500702 A5 JP 2015500702A5
- Authority
- JP
- Japan
- Prior art keywords
- taste
- containing composition
- substance
- gastrointestinal tract
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims description 67
- 210000001035 gastrointestinal tract Anatomy 0.000 claims description 25
- 240000007326 Thaumatococcus daniellii Species 0.000 claims description 8
- 235000005266 Thaumatococcus daniellii Nutrition 0.000 claims description 8
- 101710084933 Miraculin Proteins 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 2
- 239000000126 substance Substances 0.000 claims 30
- 239000001962 taste-modifying agent Substances 0.000 claims 12
- 235000019640 taste Nutrition 0.000 claims 11
- 235000019643 salty taste Nutrition 0.000 claims 6
- 235000011341 Sideroxylon dulcificum Nutrition 0.000 claims 4
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 3
- 238000001839 endoscopy Methods 0.000 claims 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- 239000002775 capsule Substances 0.000 claims 2
- 238000002052 colonoscopy Methods 0.000 claims 2
- 239000000284 extract Substances 0.000 claims 2
- 230000002496 gastric effect Effects 0.000 claims 2
- 239000008187 granular material Substances 0.000 claims 2
- 239000000463 material Substances 0.000 claims 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 claims 2
- 239000006187 pill Substances 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims 2
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims 2
- 235000017557 sodium bicarbonate Nutrition 0.000 claims 2
- 238000001356 surgical procedure Methods 0.000 claims 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 2
- 238000005406 washing Methods 0.000 claims 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims 1
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 claims 1
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 claims 1
- 241000792859 Enema Species 0.000 claims 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims 1
- 239000000908 ammonium hydroxide Substances 0.000 claims 1
- 150000003863 ammonium salts Chemical class 0.000 claims 1
- 239000011668 ascorbic acid Substances 0.000 claims 1
- 235000010323 ascorbic acid Nutrition 0.000 claims 1
- 229960005070 ascorbic acid Drugs 0.000 claims 1
- 229910052788 barium Inorganic materials 0.000 claims 1
- DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium atom Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 claims 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 claims 1
- 159000000007 calcium salts Chemical class 0.000 claims 1
- 239000001569 carbon dioxide Substances 0.000 claims 1
- 229910002092 carbon dioxide Inorganic materials 0.000 claims 1
- 210000001072 colon Anatomy 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 108010010165 curculin Proteins 0.000 claims 1
- 239000006185 dispersion Substances 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 239000007920 enema Substances 0.000 claims 1
- 229940095399 enema Drugs 0.000 claims 1
- 235000019253 formic acid Nutrition 0.000 claims 1
- 239000001530 fumaric acid Substances 0.000 claims 1
- 238000011902 gastrointestinal surgery Methods 0.000 claims 1
- 238000012239 gene modification Methods 0.000 claims 1
- 230000005017 genetic modification Effects 0.000 claims 1
- 235000013617 genetically modified food Nutrition 0.000 claims 1
- 210000000936 intestine Anatomy 0.000 claims 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims 1
- 239000011976 maleic acid Substances 0.000 claims 1
- 239000001630 malic acid Substances 0.000 claims 1
- 235000011090 malic acid Nutrition 0.000 claims 1
- -1 neocrine Proteins 0.000 claims 1
- 239000006072 paste Substances 0.000 claims 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims 1
- 229910000027 potassium carbonate Inorganic materials 0.000 claims 1
- 239000001103 potassium chloride Substances 0.000 claims 1
- 235000011164 potassium chloride Nutrition 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 235000019608 salt taste sensations Nutrition 0.000 claims 1
- 229910000029 sodium carbonate Inorganic materials 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 235000002639 sodium chloride Nutrition 0.000 claims 1
- 239000001488 sodium phosphate Substances 0.000 claims 1
- 229910000162 sodium phosphate Inorganic materials 0.000 claims 1
- 159000000000 sodium salts Chemical class 0.000 claims 1
- 229910052938 sodium sulfate Inorganic materials 0.000 claims 1
- 235000011152 sodium sulphate Nutrition 0.000 claims 1
- 239000008247 solid mixture Substances 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 239000003826 tablet Substances 0.000 claims 1
- 239000000892 thaumatin Substances 0.000 claims 1
- 235000010436 thaumatin Nutrition 0.000 claims 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims 1
- 238000002609 virtual colonoscopy Methods 0.000 claims 1
- 230000000112 colonic effect Effects 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161568131P | 2011-12-07 | 2011-12-07 | |
| US61/568,131 | 2011-12-07 | ||
| PCT/US2012/068528 WO2013086382A1 (en) | 2011-12-07 | 2012-12-07 | Method for bowel preparation |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018000258A Division JP6595017B2 (ja) | 2011-12-07 | 2018-01-04 | 腸管前処置のための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015500702A JP2015500702A (ja) | 2015-01-08 |
| JP2015500702A5 true JP2015500702A5 (enExample) | 2016-02-04 |
| JP6272776B2 JP6272776B2 (ja) | 2018-01-31 |
Family
ID=48572199
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014546138A Active JP6272776B2 (ja) | 2011-12-07 | 2012-12-07 | 腸管前処置のための方法 |
| JP2018000258A Active JP6595017B2 (ja) | 2011-12-07 | 2018-01-04 | 腸管前処置のための方法 |
| JP2019173861A Active JP6985349B2 (ja) | 2011-12-07 | 2019-09-25 | 腸管前処置のための方法 |
| JP2021191351A Active JP7405499B2 (ja) | 2011-12-07 | 2021-11-25 | 腸管前処置のための方法 |
| JP2023171429A Pending JP2023182719A (ja) | 2011-12-07 | 2023-10-02 | 腸管前処置のための方法 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018000258A Active JP6595017B2 (ja) | 2011-12-07 | 2018-01-04 | 腸管前処置のための方法 |
| JP2019173861A Active JP6985349B2 (ja) | 2011-12-07 | 2019-09-25 | 腸管前処置のための方法 |
| JP2021191351A Active JP7405499B2 (ja) | 2011-12-07 | 2021-11-25 | 腸管前処置のための方法 |
| JP2023171429A Pending JP2023182719A (ja) | 2011-12-07 | 2023-10-02 | 腸管前処置のための方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (9) | US9238075B2 (enExample) |
| EP (2) | EP2787982B1 (enExample) |
| JP (5) | JP6272776B2 (enExample) |
| CN (2) | CN108904439A (enExample) |
| CA (1) | CA2890540A1 (enExample) |
| DK (1) | DK2787982T3 (enExample) |
| ES (1) | ES2944285T3 (enExample) |
| PT (1) | PT2787982T (enExample) |
| WO (1) | WO2013086382A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI535461B (zh) | 2011-03-11 | 2016-06-01 | 諾金私人有限公司 | 結腸清潔溶液、用於製備該溶液之組成物、包含該組成物或溶液之套組、與製備該溶液之方法 |
| ES2944285T3 (es) * | 2011-12-07 | 2023-06-20 | Msm Innovations Inc | Composición de preparación intestinal |
| CA2919487A1 (en) | 2012-08-03 | 2014-02-06 | Msm Innovations, Inc. | Kits using miraculin to reduce salty taste of a liquid composition |
| NZ743984A (en) | 2012-09-11 | 2019-10-25 | Norgine Bv | Compositions comprising polyethylene glycol, alkali metal or alkaline earth metal sulphates and electrolytes for use as colon cleansing compositions |
| KR101420315B1 (ko) * | 2014-03-19 | 2014-07-17 | 남봉길 | 약학적 액제 조성물 |
| US20160263152A1 (en) * | 2015-03-14 | 2016-09-15 | Gavis Pharmaceuticals | Bowel cleansing composition with improved taste |
| US20160271120A1 (en) * | 2015-03-17 | 2016-09-22 | Oakdene Holdings Llc | Pharmaceutical composition for cleansing of the gastrointestinal tract |
| RU2018105869A (ru) | 2015-08-17 | 2019-09-19 | Ферринг Б.В. | Жидкие составы, содержащие пикосульфат и цитрат магния |
| WO2018009761A1 (en) | 2016-07-08 | 2018-01-11 | Ferring B.V. | Stabilized liquid formulations containing picosulfate |
| WO2018093890A1 (en) * | 2016-11-16 | 2018-05-24 | The Coca-Cola Company | Taste improvement for stevia sweetened beverages with miracle fruit |
| US10143656B1 (en) | 2017-08-04 | 2018-12-04 | Braintree Laboratories, Inc. | Solid oral sulfate salt formulations for cleaning a colon and methods of using same |
| US11324774B2 (en) * | 2018-01-05 | 2022-05-10 | Augusta University Research Institute, Inc. | Compositions of oral alkaline salts and metabolic acid inducers and uses thereof |
| CN109673855A (zh) * | 2019-01-29 | 2019-04-26 | 湖南江海环保实业有限公司 | 用于生产高适口性氯化铵的复合口味改良剂、高适口性氯化铵及其制备方法 |
| CN113974167A (zh) * | 2021-11-10 | 2022-01-28 | 海而思（郑州）科技有限公司 | 一种代餐食品及其制备方法 |
| US12239659B2 (en) | 2023-06-15 | 2025-03-04 | Braintree Laboratories, Inc. | Methods of administering safe colon cleansing compositions |
| CN119080899B (zh) * | 2024-09-14 | 2025-11-11 | 天津大学 | 高热稳定性的甜蛋白neoculin的突变体及基因与应用 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3849555A (en) * | 1970-04-15 | 1974-11-19 | Mirlin Corp | Method for modifying sour and bitter taste |
| US3898323A (en) * | 1970-04-15 | 1975-08-05 | Mirlin Corp | Taste modifying composition |
| JP2509993B2 (ja) * | 1988-06-21 | 1996-06-26 | 良枝 栗原 | 苦味、渋味またはえぐ味を有する物質の味覚修飾剤 |
| US6015792A (en) | 1993-05-26 | 2000-01-18 | Bioresearch, Inc. | Specific eatable taste modifiers |
| US5886155A (en) | 1997-06-18 | 1999-03-23 | Bioresources International Inc. | Purification of miraculin glycoprotein using tandem hydrophobic interaction chromatography |
| JPH11228423A (ja) | 1998-02-17 | 1999-08-24 | Ohara Yakuhin Kogyo Kk | 腸管洗浄液用組成物 |
| US8361452B2 (en) | 2002-07-15 | 2013-01-29 | Halow George M | Bowel cleansing composition |
| GB0224909D0 (en) * | 2002-10-25 | 2002-12-04 | Norgine Europe Bv | Colon cleansing compositions |
| US20040151771A1 (en) | 2003-02-04 | 2004-08-05 | Gin Jerry B. | Long-lasting, flavored dosage forms for sustained release of beneficial agents within the mouth |
| JP2005187448A (ja) * | 2004-04-02 | 2005-07-14 | Ajinomoto Co Inc | 腸管洗浄用組成物 |
| JP4757801B2 (ja) | 2004-08-06 | 2011-08-24 | 浩 江面 | ミラクリンを発現する遺伝子組換え植物の作成方法 |
| US20060051428A1 (en) | 2004-09-03 | 2006-03-09 | Nelson Ayala | Aspartame and citrate flavored phosphate salt laxative |
| US7851005B2 (en) | 2005-05-23 | 2010-12-14 | Cadbury Adams Usa Llc | Taste potentiator compositions and beverages containing same |
| ES2399059T3 (es) | 2005-05-23 | 2013-03-25 | Kraft Foods Global Brands Llc | Composiciones potenciadoras del dulzor |
| US20070082061A1 (en) * | 2005-10-07 | 2007-04-12 | Nelson Ayala | Reduction of saltiness with sweeteners |
| CA2636061C (en) | 2006-01-27 | 2015-06-02 | Cadbury Adams Usa Llc | Flavor-enhancing compositions, methods of manufacture, and methods of use |
| JP4544633B2 (ja) * | 2006-02-28 | 2010-09-15 | 正人 前田 | 甘味誘導物質 |
| KR100826193B1 (ko) | 2006-07-26 | 2008-04-30 | 엘지전자 주식회사 | 조명 장치 |
| US8778987B2 (en) | 2007-03-13 | 2014-07-15 | Symrise Ag | Use of 4-hydroxychalcone derivatives for masking an unpleasant taste |
| US20090053304A1 (en) | 2007-08-23 | 2009-02-26 | Jinling Chen | Composition and method of producing a taste masking formulation of laxatives for bowel cleaning preparation prior to colonoscopy |
| US20090252758A1 (en) | 2008-04-07 | 2009-10-08 | Mazed Mohammad A | Nutritional supplement for the prevention of cardiovascular disease, alzheimer's disease, diabetes, and regulation and reduction of blood sugar and insulin resistance |
| CN102369275A (zh) | 2009-02-02 | 2012-03-07 | 卓莫赛尔公司 | 新型细胞系和方法 |
| GB0912487D0 (en) * | 2009-07-17 | 2009-08-26 | Norgine Bv | Improvements in and relating to colon cleansing compositions |
| US10624372B2 (en) | 2009-08-28 | 2020-04-21 | Symrise Ag | Reduced-sweetener products, flavoring mixtures for said reduced-sweetener products and process for the production of products of this type |
| SI2322190T1 (sl) * | 2009-11-02 | 2013-08-30 | Promefarm S.R.L. | Sestavki za izpiranje äśrevesja in uporaba le-teh |
| EP2366292A1 (en) | 2010-03-15 | 2011-09-21 | Nestec S.A. | Artificial sweeteners and performance |
| WO2012016161A1 (en) | 2010-07-30 | 2012-02-02 | Kraft Foods Global Brands Llc | A delivery system for active components as part of an edible composition |
| US9149493B2 (en) * | 2011-11-28 | 2015-10-06 | Alfa Wassermann Spa | Compositions for bowel cleansing and use thereof |
| ES2944285T3 (es) | 2011-12-07 | 2023-06-20 | Msm Innovations Inc | Composición de preparación intestinal |
| CA2919487A1 (en) | 2012-08-03 | 2014-02-06 | Msm Innovations, Inc. | Kits using miraculin to reduce salty taste of a liquid composition |
-
2012
- 2012-12-07 ES ES12854622T patent/ES2944285T3/es active Active
- 2012-12-07 PT PT128546223T patent/PT2787982T/pt unknown
- 2012-12-07 CN CN201810869331.7A patent/CN108904439A/zh active Pending
- 2012-12-07 DK DK12854622.3T patent/DK2787982T3/da active
- 2012-12-07 EP EP12854622.3A patent/EP2787982B1/en active Active
- 2012-12-07 CA CA2890540A patent/CA2890540A1/en active Pending
- 2012-12-07 CN CN201280060592.5A patent/CN103987382A/zh active Pending
- 2012-12-07 JP JP2014546138A patent/JP6272776B2/ja active Active
- 2012-12-07 WO PCT/US2012/068528 patent/WO2013086382A1/en not_active Ceased
- 2012-12-07 US US13/708,430 patent/US9238075B2/en active Active
- 2012-12-07 EP EP23159485.4A patent/EP4215185A1/en active Pending
-
2015
- 2015-12-09 US US14/963,616 patent/US9352044B2/en active Active
-
2016
- 2016-05-26 US US15/165,948 patent/US9629917B2/en active Active
-
2017
- 2017-03-10 US US15/456,028 patent/US20170182169A1/en not_active Abandoned
- 2017-10-25 US US15/793,257 patent/US20180110859A1/en not_active Abandoned
-
2018
- 2018-01-04 JP JP2018000258A patent/JP6595017B2/ja active Active
-
2019
- 2019-04-25 US US16/394,877 patent/US11058774B2/en active Active
- 2019-09-25 JP JP2019173861A patent/JP6985349B2/ja active Active
-
2021
- 2021-06-09 US US17/342,983 patent/US11771768B2/en active Active
- 2021-11-25 JP JP2021191351A patent/JP7405499B2/ja active Active
-
2023
- 2023-08-25 US US18/455,930 patent/US12226486B2/en active Active
- 2023-10-02 JP JP2023171429A patent/JP2023182719A/ja active Pending
-
2025
- 2025-01-08 US US19/013,697 patent/US20250144219A1/en active Pending
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