JP2015198665A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015198665A5 JP2015198665A5 JP2015117465A JP2015117465A JP2015198665A5 JP 2015198665 A5 JP2015198665 A5 JP 2015198665A5 JP 2015117465 A JP2015117465 A JP 2015117465A JP 2015117465 A JP2015117465 A JP 2015117465A JP 2015198665 A5 JP2015198665 A5 JP 2015198665A5
- Authority
- JP
- Japan
- Prior art keywords
- enzyme
- cell
- seq
- nicotinamide
- nicotinamidase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40225402P | 2002-08-09 | 2002-08-09 | |
| US60/402,254 | 2002-08-09 | ||
| US42861402P | 2002-11-22 | 2002-11-22 | |
| US60/428,614 | 2002-11-22 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010162637A Division JP2011015682A (ja) | 2002-08-09 | 2010-07-20 | 細胞及び生物の寿命を延ばし、ストレス耐性を増す方法及び組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015198665A JP2015198665A (ja) | 2015-11-12 |
| JP2015198665A5 true JP2015198665A5 (enExample) | 2016-05-26 |
| JP6602561B2 JP6602561B2 (ja) | 2019-11-06 |
Family
ID=31720582
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004529297A Pending JP2005535342A (ja) | 2002-08-09 | 2003-08-08 | 細胞及び生物の寿命を延ばし、ストレス耐性を増す方法及び組成物 |
| JP2010162637A Pending JP2011015682A (ja) | 2002-08-09 | 2010-07-20 | 細胞及び生物の寿命を延ばし、ストレス耐性を増す方法及び組成物 |
| JP2015117465A Expired - Fee Related JP6602561B2 (ja) | 2002-08-09 | 2015-06-10 | 細胞及び生物の寿命を延ばし、ストレス耐性を増す方法及び組成物 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004529297A Pending JP2005535342A (ja) | 2002-08-09 | 2003-08-08 | 細胞及び生物の寿命を延ばし、ストレス耐性を増す方法及び組成物 |
| JP2010162637A Pending JP2011015682A (ja) | 2002-08-09 | 2010-07-20 | 細胞及び生物の寿命を延ばし、ストレス耐性を増す方法及び組成物 |
Country Status (5)
| Country | Link |
|---|---|
| EP (2) | EP1551964A4 (enExample) |
| JP (3) | JP2005535342A (enExample) |
| AU (2) | AU2003264037B2 (enExample) |
| CA (2) | CA2421269A1 (enExample) |
| WO (1) | WO2004016726A2 (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7977049B2 (en) * | 2002-08-09 | 2011-07-12 | President And Fellows Of Harvard College | Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms |
| EP2236131A3 (en) | 2003-07-01 | 2011-03-02 | President and Fellows of Harvard College | Sirt1 modulators for manipulating cell/organism lifespan/stress response |
| US20060025337A1 (en) | 2003-07-01 | 2006-02-02 | President And Fellows Of Harvard College | Sirtuin related therapeutics and diagnostics for neurodegenerative diseases |
| EP1727546A4 (en) * | 2003-10-31 | 2008-07-09 | Robarts Res Inst | METHOD AND FORMULATIONS FOR THE PROTECTION OF CELLS AND FOR THE TREATMENT OF ILLNESSES AND SUFFERING THROUGH OPTIMIZATION OF INTRA-CELLULAR NAD CONCENTRATION |
| US8017634B2 (en) | 2003-12-29 | 2011-09-13 | President And Fellows Of Harvard College | Compositions for treating obesity and insulin resistance disorders |
| JP2007527418A (ja) | 2003-12-29 | 2007-09-27 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | 肥満及びインシュリン耐性障害を治療又は防止するための組成物 |
| PT1755391E (pt) * | 2004-06-04 | 2016-02-03 | Univ Washington | Métodos e composições para o tratamento de neuropatias |
| DE602005018379D1 (de) | 2004-09-24 | 2010-01-28 | Bayer Bioscience Nv | Stressresistente pflanzen |
| EP1844157A4 (en) * | 2005-01-25 | 2009-11-25 | Univ Johns Hopkins | STRATEGIES FOR THE DESIGN OF SUBSTANCES TO BE TAKEN ON THE SIR2 FAMILY OF ENZYMES |
| WO2006105440A2 (en) | 2005-03-30 | 2006-10-05 | Sirtris Pharmaceuticals, Inc. | Nicotinamide riboside and analogues thereof |
| WO2006138418A2 (en) | 2005-06-14 | 2006-12-28 | President And Fellows Of Harvard College | Improvement of cognitive performance with sirtuin activators |
| KR20080036579A (ko) * | 2005-06-15 | 2008-04-28 | 바이엘 바이오사이언스 엔.브이. | 저산소 조건에 대한 식물의 내성을 증가시키는 방법 |
| US8158856B2 (en) | 2006-03-21 | 2012-04-17 | Bayer Cropscience Nv | Stress resistant plants |
| ES2513143T3 (es) | 2006-12-11 | 2014-10-24 | Japan Science And Technology Agency | Regulador del crecimiento vegetal y sus usos |
| JP5344621B2 (ja) | 2007-11-13 | 2013-11-20 | 独立行政法人科学技術振興機構 | 糖度が向上した植物体を作出するための組成物及びその利用 |
| JP5570731B2 (ja) * | 2008-02-28 | 2014-08-13 | 旭化成ファーマ株式会社 | ピロリン酸の測定方法 |
| EP2259782A4 (en) | 2008-03-03 | 2013-01-23 | Nad Life Pty Ltd | PHARMACEUTICAL FORMULATIONS OF RESVERATROL AND METHOD FOR THEIR USE IN THE TREATMENT OF CELL DISEASES |
| JP2011115098A (ja) * | 2009-12-04 | 2011-06-16 | Nippon Menaade Keshohin Kk | 加齢による皮膚明度の低下を予測する皮膚評価方法 |
| CN103987249B (zh) | 2011-12-12 | 2015-10-21 | 冈山县 | 用于提高植物的氨基酸含量的化合物及其应用 |
| US9877981B2 (en) | 2012-10-09 | 2018-01-30 | President And Fellows Of Harvard College | NAD biosynthesis and precursors for the treatment and prevention of cancer and proliferation |
| US20160287621A1 (en) * | 2013-11-06 | 2016-10-06 | President And Fellows Of Harvard College | Biological production of nad precursors and analogs |
| WO2015186068A1 (en) | 2014-06-02 | 2015-12-10 | Glaxosmithkline Intellectual Property (No.2) Limited | Preparation and use of crystalline beta-d-nicotinamide riboside |
| RU2016149767A (ru) | 2014-06-06 | 2018-07-16 | Глэксосмитклайн Интеллекчуал Проперти (Но.2) Лимитед | Аналоги никотинамидрибозида и фармацевтические композиции и их применение |
| JP6623015B2 (ja) * | 2014-09-29 | 2019-12-18 | 国立研究開発法人理化学研究所 | 植物の耐塩性向上剤 |
| WO2020097116A1 (en) * | 2018-11-05 | 2020-05-14 | Rejuvenation Therapeutics | Compositions and methods for culturing yeast cells |
| CN114555619A (zh) * | 2019-08-14 | 2022-05-27 | 麦德龙国际生物科技有限责任公司 | 用于烟酰胺腺嘌呤二核苷酸的差分调节的化合物和组合物 |
| CN111394268B (zh) | 2019-12-20 | 2021-06-18 | 合肥康诺生物制药有限公司 | 基因工程菌及其构建方法、应用,生产nad+的方法 |
| CN112451673A (zh) * | 2020-12-10 | 2021-03-09 | 汤臣倍健股份有限公司 | 线粒体功能干预材料在制备改善线粒体功能的保健品或药品中的应用及其筛选方法 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4980286A (en) | 1985-07-05 | 1990-12-25 | Whitehead Institute For Biomedical Research | In vivo introduction and expression of foreign genetic material in epithelial cells |
| DE3681787D1 (de) | 1985-07-05 | 1991-11-07 | Whitehead Biomedical Inst | Expression von fremdem genetischem material in epithelzellen. |
| JP3015383B2 (ja) | 1987-09-11 | 2000-03-06 | ホワイトヘツド・インスチチユート・フオー・バイオメデイカル・リサーチ | 形質導入した線維芽およびそれらの使用 |
| DE3851153T2 (de) | 1987-12-11 | 1995-01-05 | Hughes Howard Med Inst | Genetische modifizierung von endothelialen zellen. |
| DE68927996T2 (de) | 1988-02-05 | 1997-12-04 | Hughes Howard Med Inst | Modifizierte hepatozyten und deren anwendung |
| US5585362A (en) | 1989-08-22 | 1996-12-17 | The Regents Of The University Of Michigan | Adenovirus vectors for gene therapy |
| ATE163046T1 (de) | 1990-10-31 | 1998-02-15 | Somatix Therapy Corp | Genetische veränderung von endothelzellen |
| JPH07507689A (ja) | 1992-06-08 | 1995-08-31 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 特定組織のターゲティング方法及び組成物 |
| AU689755B2 (en) | 1992-09-22 | 1998-04-09 | Biofocus Discovery Limited | Recombinant viruses displaying a nonviral polypeptide on their external surface |
| ATE263252T1 (de) | 1992-11-09 | 2004-04-15 | Us Health | Erzielbare vektorenpartikel |
| FR2705686B1 (fr) | 1993-05-28 | 1995-08-18 | Transgene Sa | Nouveaux adénovirus défectifs et lignées de complémentation correspondantes. |
| KR100356615B1 (ko) | 1993-07-13 | 2003-04-03 | 아방티 파르마 소시에테 아노님 | 결함아데노바이러스벡터및유전자치료에서그의사용 |
| US5631236A (en) | 1993-08-26 | 1997-05-20 | Baylor College Of Medicine | Gene therapy for solid tumors, using a DNA sequence encoding HSV-Tk or VZV-Tk |
| US5698443A (en) | 1995-06-27 | 1997-12-16 | Calydon, Inc. | Tissue specific viral vectors |
| ATE336587T1 (de) | 1994-06-10 | 2006-09-15 | Genvec Inc | Adenoviren-vektor systeme und zelllinien |
| US5856152A (en) | 1994-10-28 | 1999-01-05 | The Trustees Of The University Of Pennsylvania | Hybrid adenovirus-AAV vector and methods of use therefor |
| PT787200E (pt) | 1994-10-28 | 2005-08-31 | Univ Pennsylvania | Adenovirus melhorado e metodos para a sua utilizacao |
| US5872005A (en) | 1994-11-03 | 1999-02-16 | Cell Genesys Inc. | Packaging cell lines for adeno-associated viral vectors |
| NZ300387A (en) | 1994-12-12 | 2001-07-27 | Genetic Therapy Inc | Adenoviral vector modified to reduce host immune and inflammatory responses and its use in gene therapy treatment |
| DK0811073T3 (da) | 1995-02-24 | 2007-05-21 | Univ Pennsylvania | Avendelse af immunmodulatorer til fremstilling af medikamenter til inhibering af immunresponser mod co-administrerede rekombinanter |
| US5688676A (en) | 1995-06-07 | 1997-11-18 | Research Foundation Of State University Of New York | In vitro packaging of adeno-associated virus DNA |
| AU722196B2 (en) | 1995-08-30 | 2000-07-27 | Genzyme Corporation | Chromatographic purification of adenovirus and AAV |
| GB9816781D0 (en) | 1998-07-31 | 1998-09-30 | Univ London | Herpes virus vectors for dendritic cells |
| AU2001294173A1 (en) * | 2000-10-03 | 2002-04-15 | Takara Bio Inc. | Method of screening physiologically active substance |
| US7977049B2 (en) * | 2002-08-09 | 2011-07-12 | President And Fellows Of Harvard College | Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms |
| DE602005018379D1 (de) * | 2004-09-24 | 2010-01-28 | Bayer Bioscience Nv | Stressresistente pflanzen |
| US9515947B1 (en) | 2013-03-15 | 2016-12-06 | EMC IP Holding Company LLC | Method and system for providing a virtual network-aware storage array |
| KR20160071054A (ko) | 2014-12-11 | 2016-06-21 | 에스케이하이닉스 주식회사 | 반도체 메모리 장치 및 그의 동작 방법 |
| US9609948B2 (en) | 2015-04-28 | 2017-04-04 | Qianglong Furniture Co., Ltd. | Rotating armrest apparatus |
-
2003
- 2003-03-07 CA CA002421269A patent/CA2421269A1/en not_active Abandoned
- 2003-08-08 JP JP2004529297A patent/JP2005535342A/ja active Pending
- 2003-08-08 EP EP03788377A patent/EP1551964A4/en not_active Withdrawn
- 2003-08-08 CA CA002495185A patent/CA2495185A1/en not_active Abandoned
- 2003-08-08 AU AU2003264037A patent/AU2003264037B2/en not_active Ceased
- 2003-08-08 WO PCT/US2003/025016 patent/WO2004016726A2/en not_active Ceased
- 2003-08-08 EP EP11179088A patent/EP2431480A3/en not_active Withdrawn
-
2010
- 2010-07-20 JP JP2010162637A patent/JP2011015682A/ja active Pending
- 2010-09-10 AU AU2010219395A patent/AU2010219395B2/en not_active Ceased
-
2015
- 2015-06-10 JP JP2015117465A patent/JP6602561B2/ja not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2015198665A5 (enExample) | ||
| Lv et al. | A Time Course Study Demonstrating m RNA, micro RNA, 18 S r RNA, and U 6 sn RNA Changes to Estimate PMI in Deceased Rat's Spleen | |
| Petri et al. | Changes in the rumen epimural bacterial diversity of beef cattle as affected by diet and induced ruminal acidosis | |
| Uehara et al. | Two RNase H2 mutants with differential rNMP processing activity reveal a threshold of ribonucleotide tolerance for embryonic development | |
| Li et al. | Genome-wide DNA methylome variation in two genetically distinct chicken lines using MethylC-seq | |
| WO2019183630A3 (en) | Gene editing for autosomal dominant diseases | |
| KR20200062198A (ko) | 다중-이펙터 crispr 기반 진단 시스템 | |
| JP2017500015A5 (enExample) | ||
| CN106661612A (zh) | 制备用于测序的核酸的方法 | |
| JP2013503642A5 (enExample) | ||
| WO2016201450A3 (en) | Cancer treatment and diagnosis | |
| Silvestre et al. | Contrasting genetic structures of two parasitic nematodes, determined on the basis of neutral microsatellite markers and selected anthelmintic resistance markers | |
| Dong et al. | Comparative inner ear transcriptome analysis between the Rickett’s big-footed bats (Myotis ricketti) and the greater short-nosed fruit bats (Cynopterus sphinx) | |
| Ma et al. | Detection of Enterocytozoon bieneusi in white yaks in Gansu Province, China | |
| Da-Anoy et al. | Species variability in the response to elevated temperature of select corals in north-western Philippines | |
| Poon et al. | PKR deficiency alters E. coli-induced sickness behaviors but does not exacerbate neuroimmune responses or bacterial load | |
| JP2013537515A5 (enExample) | ||
| Cattani et al. | The detection of viable vegetative cells of Bacillus sporothermodurans using propidium monoazide with semi-nested PCR | |
| Khachatryan et al. | The streptomycin-sulfadiazine-tetracycline antimicrobial resistance element of calf-adapted Escherichia coli is widely distributed among isolates from Washington state cattle | |
| CN105950748A (zh) | 一种基于rpoB基因鉴定高同源性海洋弧菌的方法 | |
| MX2009008788A (es) | Poliformismos de serpine1 son predictivos de respuesta a administracion de proteina c activada y riesgo de muerte. | |
| Verma et al. | Detection and genotyping of Leptospira spp. from the kidneys of a seemingly healthy pig slaughtered for human consumption | |
| NO344051B1 (en) | Novel virus in Fish and Method for detection | |
| Buller et al. | Understanding the molecular epidemiology of the footrot pathogen Dichelobacter nodosus to support control and eradication programs | |
| Shu et al. | An endemic frog harbors multiple expression loci with different patterns of variation in the MHC class II B gene |