CA2421269A1 - Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms - Google Patents
Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms Download PDFInfo
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- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
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| US20050096256A1 (en) | 2003-07-01 | 2005-05-05 | President And Fellows Of Harvard College | Compositions for manipulating the lifespan and stress response of cells and organisms |
| US20060025337A1 (en) | 2003-07-01 | 2006-02-02 | President And Fellows Of Harvard College | Sirtuin related therapeutics and diagnostics for neurodegenerative diseases |
| CN101247793B (zh) | 2003-12-29 | 2013-04-10 | 哈佛大学校长及研究员协会 | 治疗或预防肥胖和胰岛素抗性病症的组合物 |
| US8017634B2 (en) | 2003-12-29 | 2011-09-13 | President And Fellows Of Harvard College | Compositions for treating obesity and insulin resistance disorders |
| CN1964627B (zh) * | 2004-06-04 | 2011-10-19 | 华盛顿大学 | 治疗神经病变的方法和组合物 |
| EP1794306B1 (en) | 2004-09-24 | 2009-12-16 | Bayer BioScience N.V. | Stress resistant plants |
| US20090012130A1 (en) * | 2005-01-25 | 2009-01-08 | The Johns Hopkins University | Strategies for Designing Drugs that Target the Sir2 Family of Enzymes |
| EP1877054A2 (en) | 2005-03-30 | 2008-01-16 | Sirtris Pharmaceuticals, Inc. | Nicotinamide riboside and analogues thereof |
| WO2006138418A2 (en) | 2005-06-14 | 2006-12-28 | President And Fellows Of Harvard College | Improvement of cognitive performance with sirtuin activators |
| PL1893759T3 (pl) * | 2005-06-15 | 2010-01-29 | Bayer Bioscience Nv | Sposób zwiększania odporności roślin na warunki niedotlenienia |
| CA2646476A1 (en) * | 2006-03-21 | 2007-09-27 | Bayer Bioscience N.V. | Stress resistant plants |
| RU2415573C2 (ru) | 2006-12-11 | 2011-04-10 | Джапэн Сайенс Энд Текнолоджи Эйдженси | Регулятор роста растений и его применение |
| WO2009063806A1 (ja) * | 2007-11-13 | 2009-05-22 | Japan Science And Technology Agency | 糖度が向上した植物体を作出するための組成物及びその利用 |
| JP5570731B2 (ja) * | 2008-02-28 | 2014-08-13 | 旭化成ファーマ株式会社 | ピロリン酸の測定方法 |
| JP5684578B2 (ja) | 2008-03-03 | 2015-03-11 | エヌエーディー ライフ プロプライエタリー リミテッド | リスベラトロールの医薬製剤、および細胞障害を治療するためのその使用方法 |
| JP2011115098A (ja) * | 2009-12-04 | 2011-06-16 | Nippon Menaade Keshohin Kk | 加齢による皮膚明度の低下を予測する皮膚評価方法 |
| CN103987249B (zh) | 2011-12-12 | 2015-10-21 | 冈山县 | 用于提高植物的氨基酸含量的化合物及其应用 |
| WO2014059034A2 (en) | 2012-10-09 | 2014-04-17 | President And Fellows Of Harvard College | Nad biosynthesis and precursors for the treatment and prevention of cancer and proliferation |
| US20160287621A1 (en) * | 2013-11-06 | 2016-10-06 | President And Fellows Of Harvard College | Biological production of nad precursors and analogs |
| CN106536535A (zh) | 2014-06-02 | 2017-03-22 | 葛兰素史密斯克莱知识产权（第2 号）有限公司 | 结晶的β‑D‑烟酰胺核苷的制备和用途 |
| WO2015186114A1 (en) | 2014-06-06 | 2015-12-10 | Glaxosmithkline Intellectual Property (No.2) Limited | Nicotinamide riboside analogs and pharmaceutical compositions and uses thereof |
| JP6623015B2 (ja) * | 2014-09-29 | 2019-12-18 | 国立研究開発法人理化学研究所 | 植物の耐塩性向上剤 |
| WO2020097116A1 (en) * | 2018-11-05 | 2020-05-14 | Rejuvenation Therapeutics | Compositions and methods for culturing yeast cells |
| JP7702934B2 (ja) * | 2019-08-14 | 2025-07-04 | メトロ インターナショナル バイオテック，エルエルシー | ニコチンアミドアデニンジヌクレオチドの差次的モジュレーションのための化合物及び組成物 |
| CN111394268B (zh) * | 2019-12-20 | 2021-06-18 | 合肥康诺生物制药有限公司 | 基因工程菌及其构建方法、应用，生产nad+的方法 |
| CN112451673A (zh) * | 2020-12-10 | 2021-03-09 | 汤臣倍健股份有限公司 | 线粒体功能干预材料在制备改善线粒体功能的保健品或药品中的应用及其筛选方法 |
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| US4980286A (en) | 1985-07-05 | 1990-12-25 | Whitehead Institute For Biomedical Research | In vivo introduction and expression of foreign genetic material in epithelial cells |
| DE3852823T2 (de) | 1987-09-11 | 1995-05-24 | Hughes Howard Med Inst | Transduktionsveränderte fibroblasten und ihre anwendung. |
| JP2914692B2 (ja) | 1987-12-11 | 1999-07-05 | ホワイトヘツド・インスチチユート・フオー・バイオメデイカル・リサーチ | 内皮細胞の遺伝子修飾 |
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| US5585362A (en) | 1989-08-22 | 1996-12-17 | The Regents Of The University Of Michigan | Adenovirus vectors for gene therapy |
| EP0556345B2 (en) | 1990-10-31 | 2005-10-12 | Cell Genesys, Inc. | Retroviral vectors useful for gene therapy |
| JPH07507689A (ja) | 1992-06-08 | 1995-08-31 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 特定組織のターゲティング方法及び組成物 |
| AU689755B2 (en) | 1992-09-22 | 1998-04-09 | Biofocus Discovery Limited | Recombinant viruses displaying a nonviral polypeptide on their external surface |
| EP0746625B1 (en) | 1992-11-09 | 2004-03-31 | THE UNITED STATES GOVERNMENT as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES | Targetable vector particles |
| FR2705686B1 (fr) | 1993-05-28 | 1995-08-18 | Transgene Sa | Nouveaux adénovirus défectifs et lignées de complémentation correspondantes. |
| CN1115414C (zh) | 1993-07-13 | 2003-07-23 | 罗纳-布朗克罗莱尔股份有限公司 | 用于基因治疗的病毒载体 |
| US5631236A (en) | 1993-08-26 | 1997-05-20 | Baylor College Of Medicine | Gene therapy for solid tumors, using a DNA sequence encoding HSV-Tk or VZV-Tk |
| US5698443A (en) | 1995-06-27 | 1997-12-16 | Calydon, Inc. | Tissue specific viral vectors |
| CA2192442C (en) | 1994-06-10 | 2007-09-25 | Imre Kovesdi | Complementary adenoviral vector systems and cell lines |
| US5856152A (en) | 1994-10-28 | 1999-01-05 | The Trustees Of The University Of Pennsylvania | Hybrid adenovirus-AAV vector and methods of use therefor |
| DK0787200T3 (da) | 1994-10-28 | 2005-08-15 | Univ Pennsylvania | Forbedret adenovirus og fremgangsmåder til anvendelse heraf |
| US5872005A (en) | 1994-11-03 | 1999-02-16 | Cell Genesys Inc. | Packaging cell lines for adeno-associated viral vectors |
| CA2206683A1 (en) | 1994-12-12 | 1996-06-20 | Genetic Therapy, Inc. | Improved adenoviral vectors and producer cells |
| DK0811073T3 (da) | 1995-02-24 | 2007-05-21 | Univ Pennsylvania | Avendelse af immunmodulatorer til fremstilling af medikamenter til inhibering af immunresponser mod co-administrerede rekombinanter |
| US5688676A (en) | 1995-06-07 | 1997-11-18 | Research Foundation Of State University Of New York | In vitro packaging of adeno-associated virus DNA |
| AU722196B2 (en) | 1995-08-30 | 2000-07-27 | Genzyme Corporation | Chromatographic purification of adenovirus and AAV |
| GB9816781D0 (en) | 1998-07-31 | 1998-09-30 | Univ London | Herpes virus vectors for dendritic cells |
| KR20030040518A (ko) * | 2000-10-03 | 2003-05-22 | 다카라 바이오 가부시키가이샤 | 생리활성 물질의 스크리닝 방법 |
| US7977049B2 (en) * | 2002-08-09 | 2011-07-12 | President And Fellows Of Harvard College | Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms |
| EP1794306B1 (en) * | 2004-09-24 | 2009-12-16 | Bayer BioScience N.V. | Stress resistant plants |
| US9515947B1 (en) | 2013-03-15 | 2016-12-06 | EMC IP Holding Company LLC | Method and system for providing a virtual network-aware storage array |
| KR20160071054A (ko) | 2014-12-11 | 2016-06-21 | 에스케이하이닉스 주식회사 | 반도체 메모리 장치 및 그의 동작 방법 |
| US9609948B2 (en) | 2015-04-28 | 2017-04-04 | Qianglong Furniture Co., Ltd. | Rotating armrest apparatus |
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2003
- 2003-03-07 CA CA002421269A patent/CA2421269A1/en not_active Abandoned
- 2003-08-08 CA CA002495185A patent/CA2495185A1/en not_active Abandoned
- 2003-08-08 EP EP11179088A patent/EP2431480A3/en not_active Withdrawn
- 2003-08-08 EP EP03788377A patent/EP1551964A4/en not_active Withdrawn
- 2003-08-08 AU AU2003264037A patent/AU2003264037B2/en not_active Ceased
- 2003-08-08 WO PCT/US2003/025016 patent/WO2004016726A2/en not_active Ceased
- 2003-08-08 JP JP2004529297A patent/JP2005535342A/ja active Pending
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2010
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2015
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006072809A3 (en) * | 2003-10-31 | 2006-11-02 | Robarts Res Inst | Formulations that optimize intracellular concentration of nicotinamide adenine (nad+) and methods of use to protect cells and treat diseases and conditions |
Also Published As
| Publication number | Publication date |
|---|---|
| JP6602561B2 (ja) | 2019-11-06 |
| JP2015198665A (ja) | 2015-11-12 |
| JP2011015682A (ja) | 2011-01-27 |
| WO2004016726A3 (en) | 2005-05-19 |
| WO2004016726A9 (en) | 2005-08-04 |
| JP2005535342A (ja) | 2005-11-24 |
| EP2431480A3 (en) | 2012-09-05 |
| AU2003264037A1 (en) | 2004-03-03 |
| EP1551964A2 (en) | 2005-07-13 |
| AU2003264037B2 (en) | 2010-06-17 |
| AU2010219395B2 (en) | 2011-07-14 |
| AU2010219395A1 (en) | 2010-09-30 |
| WO2004016726A2 (en) | 2004-02-26 |
| EP1551964A4 (en) | 2010-07-28 |
| EP2431480A2 (en) | 2012-03-21 |
| CA2495185A1 (en) | 2004-02-26 |
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