EP1551964A4 - Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms - Google Patents
Methods and compositions for extending the life span and increasing the stress resistance of cells and organismsInfo
- Publication number
- EP1551964A4 EP1551964A4 EP03788377A EP03788377A EP1551964A4 EP 1551964 A4 EP1551964 A4 EP 1551964A4 EP 03788377 A EP03788377 A EP 03788377A EP 03788377 A EP03788377 A EP 03788377A EP 1551964 A4 EP1551964 A4 EP 1551964A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- organisms
- compositions
- cells
- increasing
- extending
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/45—Transferases (2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Zoology (AREA)
- Urology & Nephrology (AREA)
- Toxicology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11179088A EP2431480A3 (en) | 2002-08-09 | 2003-08-08 | Methods and compositions for increasing the stress resistance of cells and organisms |
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US40225402P | 2002-08-09 | 2002-08-09 | |
US402254P | 2002-08-09 | ||
US42861402P | 2002-11-22 | 2002-11-22 | |
US428614P | 2002-11-22 | ||
PCT/US2003/025016 WO2004016726A2 (en) | 2002-08-09 | 2003-08-08 | Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1551964A2 EP1551964A2 (en) | 2005-07-13 |
EP1551964A4 true EP1551964A4 (en) | 2010-07-28 |
Family
ID=31720582
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP11179088A Withdrawn EP2431480A3 (en) | 2002-08-09 | 2003-08-08 | Methods and compositions for increasing the stress resistance of cells and organisms |
EP03788377A Withdrawn EP1551964A4 (en) | 2002-08-09 | 2003-08-08 | Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP11179088A Withdrawn EP2431480A3 (en) | 2002-08-09 | 2003-08-08 | Methods and compositions for increasing the stress resistance of cells and organisms |
Country Status (5)
Country | Link |
---|---|
EP (2) | EP2431480A3 (en) |
JP (3) | JP2005535342A (en) |
AU (2) | AU2003264037B2 (en) |
CA (2) | CA2421269A1 (en) |
WO (1) | WO2004016726A2 (en) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7977049B2 (en) * | 2002-08-09 | 2011-07-12 | President And Fellows Of Harvard College | Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms |
US20060025337A1 (en) | 2003-07-01 | 2006-02-02 | President And Fellows Of Harvard College | Sirtuin related therapeutics and diagnostics for neurodegenerative diseases |
US20090035275A1 (en) * | 2003-10-31 | 2009-02-05 | John Geoffrey Pickering | Methods and formulations for protecting cells, and for treating diseases and conditions by optimizing the intracellular concentration of NAD |
JP2007527418A (en) | 2003-12-29 | 2007-09-27 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | Composition for treating or preventing obesity and insulin resistance disorders |
US8017634B2 (en) | 2003-12-29 | 2011-09-13 | President And Fellows Of Harvard College | Compositions for treating obesity and insulin resistance disorders |
WO2006001982A2 (en) * | 2004-06-04 | 2006-01-05 | Washington University | Methods and compositions for treating neuropathies |
DE602005018379D1 (en) * | 2004-09-24 | 2010-01-28 | Bayer Bioscience Nv | STRESS RESISTANT PLANTS |
EP1844157A4 (en) * | 2005-01-25 | 2009-11-25 | Univ Johns Hopkins | Strategies for designing drugs that target the sir2 family of enzymes |
US20060229265A1 (en) | 2005-03-30 | 2006-10-12 | Sirtris Pharmaceuticals, Inc. | Nicotinamide riboside and analogues thereof |
WO2006138418A2 (en) | 2005-06-14 | 2006-12-28 | President And Fellows Of Harvard College | Improvement of cognitive performance with sirtuin activators |
EP2311963A3 (en) * | 2005-06-15 | 2011-08-17 | Bayer BioScience N.V. | Methods for increasing the resistance of plants to hypoxic conditions |
WO2007107326A1 (en) * | 2006-03-21 | 2007-09-27 | Bayer Bioscience N.V. | Stress resistant plants |
CA2672275C (en) | 2006-12-11 | 2013-01-22 | Japan Science And Technology Agency | Plant growth regulator comprising glutathione and use thereof to increase harvest index |
CA2687249C (en) | 2007-11-13 | 2014-07-08 | Japan Science And Technology Agency | A method for increasing the sugar content of a plant body as compared to the wild strain by affecting glutathione levels |
JP5570731B2 (en) * | 2008-02-28 | 2014-08-13 | 旭化成ファーマ株式会社 | Method for measuring pyrophosphate |
WO2009108999A1 (en) | 2008-03-03 | 2009-09-11 | Ross Stewart Grant | Pharmaceutical formulations of resveratrol and methods of use thereof for treating cell disorders |
JP2011115098A (en) * | 2009-12-04 | 2011-06-16 | Nippon Menaade Keshohin Kk | Method for evaluating skin for predicting reduction of skin brightness by aging |
KR101703180B1 (en) | 2011-12-12 | 2017-02-06 | 오카야마켄 | Compound for increasing amino acid content in plant, and use thereof |
US9877981B2 (en) | 2012-10-09 | 2018-01-30 | President And Fellows Of Harvard College | NAD biosynthesis and precursors for the treatment and prevention of cancer and proliferation |
WO2015069860A1 (en) * | 2013-11-06 | 2015-05-14 | President And Fellows Of Harvard College | Biological production of nad precursors and analogs |
WO2015186068A1 (en) | 2014-06-02 | 2015-12-10 | Glaxosmithkline Intellectual Property (No.2) Limited | Preparation and use of crystalline beta-d-nicotinamide riboside |
AU2015270090A1 (en) | 2014-06-06 | 2016-12-22 | Glaxosmithkline Intellectual Property (No.2) Limited | Nicotinamide riboside analogs and pharmaceutical compositions and uses thereof |
WO2020097116A1 (en) * | 2018-11-05 | 2020-05-14 | Rejuvenation Therapeutics | Compositions and methods for culturing yeast cells |
CN111394268B (en) * | 2019-12-20 | 2021-06-18 | 合肥康诺生物制药有限公司 | Genetically engineered bacterium, construction method and application thereof, and NAD (nicotinamide adenine dinucleotide) production+Method (2) |
CN112451673A (en) * | 2020-12-10 | 2021-03-09 | 汤臣倍健股份有限公司 | Application of mitochondrial function intervention material in preparation of health-care product or medicine for improving mitochondrial function and screening method thereof |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4980286A (en) | 1985-07-05 | 1990-12-25 | Whitehead Institute For Biomedical Research | In vivo introduction and expression of foreign genetic material in epithelial cells |
ATE68013T1 (en) | 1985-07-05 | 1991-10-15 | Whitehead Biomedical Inst | EXPRESSION OF FOREIGN GENETIC MATERIAL IN EPITHELIAL CELLS. |
ATE117375T1 (en) | 1987-09-11 | 1995-02-15 | Whitehead Biomedical Inst | TRANSDUCTION ALTERED FIBROBLASS AND THEIR APPLICATION. |
DE3851153T2 (en) | 1987-12-11 | 1995-01-05 | Hughes Howard Med Inst | GENETIC MODIFICATION OF ENDOTHELIAL CELLS. |
DE68927996T2 (en) | 1988-02-05 | 1997-12-04 | Hughes Howard Med Inst | MODIFIED HEPATOCYTES AND THEIR USE |
US5585362A (en) | 1989-08-22 | 1996-12-17 | The Regents Of The University Of Michigan | Adenovirus vectors for gene therapy |
ATE163046T1 (en) | 1990-10-31 | 1998-02-15 | Somatix Therapy Corp | GENETIC MODIFICATION OF ENDOTHELIAL CELLS |
EP0650370A4 (en) | 1992-06-08 | 1995-11-22 | Univ California | Methods and compositions for targeting specific tissue. |
DE69333115D1 (en) | 1992-09-22 | 2003-08-28 | Biofocus Discovery Ltd | RECOMBINANT VIRUSES PRESENTING A NON-VIRAL POLYPEPTIDE ON THEIR OUTER SURFACE |
WO1994011524A1 (en) | 1992-11-09 | 1994-05-26 | The United States Government As Represented By The Secretary Of The Department Of Health And Human Services | Targetable vector particles |
FR2705686B1 (en) | 1993-05-28 | 1995-08-18 | Transgene Sa | New defective adenoviruses and corresponding complementation lines. |
SK282843B6 (en) | 1993-07-13 | 2002-12-03 | Rhone-Poulenc Rorer S. A. | Defective adenovirus vectors and use thereof in gene therapy |
US5631236A (en) | 1993-08-26 | 1997-05-20 | Baylor College Of Medicine | Gene therapy for solid tumors, using a DNA sequence encoding HSV-Tk or VZV-Tk |
US5698443A (en) | 1995-06-27 | 1997-12-16 | Calydon, Inc. | Tissue specific viral vectors |
DE69535178T2 (en) | 1994-06-10 | 2006-12-14 | Genvec, Inc. | ADENOVER VECTOR SYSTEMS AND CELL LINES |
DK0787200T3 (en) | 1994-10-28 | 2005-08-15 | Univ Pennsylvania | Improved adenovirus and methods for its use |
US5856152A (en) | 1994-10-28 | 1999-01-05 | The Trustees Of The University Of Pennsylvania | Hybrid adenovirus-AAV vector and methods of use therefor |
US5872005A (en) | 1994-11-03 | 1999-02-16 | Cell Genesys Inc. | Packaging cell lines for adeno-associated viral vectors |
AU709498B2 (en) | 1994-12-12 | 1999-09-02 | Genetic Therapy, Inc. | Improved adenoviral vectors and producer cells |
WO1996026285A2 (en) | 1995-02-24 | 1996-08-29 | The Trustees Of The University Of Pennsylvania | Methods and compositions for administering gene therapy vectors |
US5688676A (en) | 1995-06-07 | 1997-11-18 | Research Foundation Of State University Of New York | In vitro packaging of adeno-associated virus DNA |
EP0847442A1 (en) | 1995-08-30 | 1998-06-17 | Genzyme Corporation | Chromatographic purification of adenovirus and aav |
GB9816781D0 (en) | 1998-07-31 | 1998-09-30 | Univ London | Herpes virus vectors for dendritic cells |
JPWO2002029099A1 (en) * | 2000-10-03 | 2004-02-12 | タカラバイオ株式会社 | Screening method for bioactive substance |
US7977049B2 (en) * | 2002-08-09 | 2011-07-12 | President And Fellows Of Harvard College | Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms |
US9515947B1 (en) | 2013-03-15 | 2016-12-06 | EMC IP Holding Company LLC | Method and system for providing a virtual network-aware storage array |
KR20160071054A (en) | 2014-12-11 | 2016-06-21 | 에스케이하이닉스 주식회사 | Semiconductor memory device and operating method thereof |
US9609948B2 (en) | 2015-04-28 | 2017-04-04 | Qianglong Furniture Co., Ltd. | Rotating armrest apparatus |
-
2003
- 2003-03-07 CA CA002421269A patent/CA2421269A1/en not_active Abandoned
- 2003-08-08 AU AU2003264037A patent/AU2003264037B2/en not_active Ceased
- 2003-08-08 EP EP11179088A patent/EP2431480A3/en not_active Withdrawn
- 2003-08-08 CA CA002495185A patent/CA2495185A1/en not_active Abandoned
- 2003-08-08 WO PCT/US2003/025016 patent/WO2004016726A2/en active Search and Examination
- 2003-08-08 EP EP03788377A patent/EP1551964A4/en not_active Withdrawn
- 2003-08-08 JP JP2004529297A patent/JP2005535342A/en active Pending
-
2010
- 2010-07-20 JP JP2010162637A patent/JP2011015682A/en active Pending
- 2010-09-10 AU AU2010219395A patent/AU2010219395B2/en not_active Ceased
-
2015
- 2015-06-10 JP JP2015117465A patent/JP6602561B2/en not_active Expired - Fee Related
Non-Patent Citations (5)
Title |
---|
CROWLEY C L ET AL: "The NAD+ precursors, nicotinic acid and nicotinamide protect cells against apoptosis induced by a multiple stress inducer, deoxycholate", CELL DEATH AND DIFFERENTIATION, vol. 7, no. 3, March 2000 (2000-03-01), Great Britain, pages 314 - 326, XP000953224, ISSN: 1350-9047, DOI: 10.1038/sj.cdd.4400658 * |
DRAGOVIC J ET AL: "Phase I/II study of pentoxifylline and nicotinamide in combination with radiation therapy in locally advanced cancers", INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, vol. 24, no. SUPPL. 1, 1992, & 34TH ANNUAL MEETING OF THE AMERICAN SOCIETY FOR THERAPEUTIC RADIOLOGY AND ONCOLOGY, SAN DIEGO, CALIF, pages 272 - 273, XP026844395, ISSN: 0360-3016 * |
GOTOH HIROKO: "Inhibitory effects of nicotinamide on the growth of transplanted murine breast cancer and urethane-initiated lung tumorigenesis in mice", VITAMINS, vol. 67, no. 9, 1993, KYOTO, pages 469 - 479, XP008036628, ISSN: 0006-386X * |
KNIP M ET AL: "Safety of high-dose nicotinamide: A review", DIABETOLOGIA, vol. 43, no. 11, November 2000 (2000-11-01), Germany, pages 1337 - 1345, XP009134696, ISSN: 0012-186X, DOI: 10.1007/s001250051536 * |
SESTILI P ET AL.: "Structural requirements for inhibitors of poly(ADP-ribose) polymerase.", JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, LNKD- PUBMED:2123880, vol. 116, no. 6, 1990, GERMANY, pages 615 - 622, XP009134778, ISSN: 0171-5216 * |
Also Published As
Publication number | Publication date |
---|---|
CA2421269A1 (en) | 2004-02-09 |
EP1551964A2 (en) | 2005-07-13 |
AU2010219395A1 (en) | 2010-09-30 |
AU2003264037B2 (en) | 2010-06-17 |
JP2005535342A (en) | 2005-11-24 |
JP2015198665A (en) | 2015-11-12 |
JP2011015682A (en) | 2011-01-27 |
EP2431480A2 (en) | 2012-03-21 |
WO2004016726A2 (en) | 2004-02-26 |
EP2431480A3 (en) | 2012-09-05 |
JP6602561B2 (en) | 2019-11-06 |
WO2004016726A3 (en) | 2005-05-19 |
AU2003264037A1 (en) | 2004-03-03 |
AU2010219395B2 (en) | 2011-07-14 |
WO2004016726A9 (en) | 2005-08-04 |
CA2495185A1 (en) | 2004-02-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20050308 |
|
AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR |
|
AX | Request for extension of the european patent |
Extension state: AL LT LV MK |
|
DAX | Request for extension of the european patent (deleted) | ||
A4 | Supplementary search report drawn up and despatched |
Effective date: 20100628 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: G01N 33/50 20060101ALI20100622BHEP Ipc: C07K 14/47 20060101ALI20100622BHEP Ipc: A61K 38/45 20060101ALI20100622BHEP Ipc: A01N 25/00 20060101ALI20100622BHEP Ipc: C07H 21/04 20060101ALI20100622BHEP Ipc: C12Q 1/58 20060101ALI20100622BHEP Ipc: C12Q 1/00 20060101ALI20100622BHEP Ipc: C12N 1/20 20060101ALI20100622BHEP Ipc: C12N 9/12 20060101ALI20100622BHEP Ipc: G01N 33/573 20060101AFI20100622BHEP |
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