JP2013537515A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013537515A5 JP2013537515A5 JP2013515556A JP2013515556A JP2013537515A5 JP 2013537515 A5 JP2013537515 A5 JP 2013537515A5 JP 2013515556 A JP2013515556 A JP 2013515556A JP 2013515556 A JP2013515556 A JP 2013515556A JP 2013537515 A5 JP2013537515 A5 JP 2013537515A5
- Authority
- JP
- Japan
- Prior art keywords
- pla2g16
- composition
- cell
- virus
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 101000595800 Homo sapiens Phospholipase A and acyltransferase 3 Proteins 0.000 claims 38
- 102100036066 Phospholipase A and acyltransferase 3 Human genes 0.000 claims 38
- 238000000034 method Methods 0.000 claims 35
- 150000001875 compounds Chemical class 0.000 claims 26
- 210000004027 cell Anatomy 0.000 claims 23
- 241000700605 Viruses Species 0.000 claims 19
- 241000709664 Picornaviridae Species 0.000 claims 15
- 239000003112 inhibitor Substances 0.000 claims 14
- 208000015181 infectious disease Diseases 0.000 claims 9
- 229920001184 polypeptide Polymers 0.000 claims 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims 7
- 102000004196 processed proteins & peptides Human genes 0.000 claims 7
- 230000000840 anti-viral effect Effects 0.000 claims 6
- 241000251539 Vertebrata <Metazoa> Species 0.000 claims 5
- 208000036142 Viral infection Diseases 0.000 claims 5
- 230000000694 effects Effects 0.000 claims 5
- 230000002255 enzymatic effect Effects 0.000 claims 5
- 210000004962 mammalian cell Anatomy 0.000 claims 5
- 230000009385 viral infection Effects 0.000 claims 5
- 241000709661 Enterovirus Species 0.000 claims 4
- 241001465754 Metazoa Species 0.000 claims 4
- 241000709687 Coxsackievirus Species 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 2
- 241000709715 Hepatovirus Species 0.000 claims 2
- 230000003247 decreasing effect Effects 0.000 claims 2
- 210000005260 human cell Anatomy 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 150000003384 small molecules Chemical group 0.000 claims 2
- 241000283690 Bos taurus Species 0.000 claims 1
- 241000283707 Capra Species 0.000 claims 1
- 241000283073 Equus caballus Species 0.000 claims 1
- 241000287828 Gallus gallus Species 0.000 claims 1
- 102100037611 Lysophospholipase Human genes 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 241001494479 Pecora Species 0.000 claims 1
- 108010058864 Phospholipases A2 Proteins 0.000 claims 1
- 208000005155 Picornaviridae Infections Diseases 0.000 claims 1
- 241000282898 Sus scrofa Species 0.000 claims 1
- 230000003197 catalytic effect Effects 0.000 claims 1
- 244000144972 livestock Species 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35642610P | 2010-06-18 | 2010-06-18 | |
| US61/356,426 | 2010-06-18 | ||
| PCT/US2011/040920 WO2011160043A2 (en) | 2010-06-18 | 2011-06-17 | Pla2g16 as a target for antiviral compounds |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016153821A Division JP6285993B2 (ja) | 2010-06-18 | 2016-08-04 | 抗ウイルス化合物のためのターゲットとしてのｐｌａ２ｇ１６ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013537515A JP2013537515A (ja) | 2013-10-03 |
| JP2013537515A5 true JP2013537515A5 (enExample) | 2014-07-31 |
| JP6053675B2 JP6053675B2 (ja) | 2016-12-27 |
Family
ID=45348904
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013515556A Expired - Fee Related JP6053675B2 (ja) | 2010-06-18 | 2011-06-17 | 抗ウイルス化合物のためのターゲットとしてのｐｌａ２ｇ１６ |
| JP2016153821A Expired - Fee Related JP6285993B2 (ja) | 2010-06-18 | 2016-08-04 | 抗ウイルス化合物のためのターゲットとしてのｐｌａ２ｇ１６ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016153821A Expired - Fee Related JP6285993B2 (ja) | 2010-06-18 | 2016-08-04 | 抗ウイルス化合物のためのターゲットとしてのｐｌａ２ｇ１６ |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US9011821B2 (enExample) |
| EP (1) | EP2583099B1 (enExample) |
| JP (2) | JP6053675B2 (enExample) |
| KR (1) | KR101931628B1 (enExample) |
| AU (1) | AU2011268127B2 (enExample) |
| CA (1) | CA2805409A1 (enExample) |
| ES (1) | ES2611150T3 (enExample) |
| WO (1) | WO2011160043A2 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015018797A2 (en) * | 2013-08-05 | 2015-02-12 | Haplogen Gmbh | Antiviral compounds |
| GB2527364A (en) * | 2014-06-20 | 2015-12-23 | Imp Innovations Ltd | Treatment |
| EP3512836A1 (en) | 2016-09-13 | 2019-07-24 | Haplogen GmbH | Antiviral compounds |
| WO2019068841A1 (en) | 2017-10-05 | 2019-04-11 | Haplogen Gmbh | ANTIVIRAL COMPOUNDS |
| US20220273624A1 (en) * | 2019-06-28 | 2022-09-01 | Niklovir Ab | Novel antiviral therapies |
| EP4045920A4 (en) * | 2019-10-15 | 2023-10-11 | Jnana Therapeutics Inc. | INTERACTION DISCOVERY PLATFORM WITH A REACTIVE AFFINITY PROBE |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL107150A0 (en) * | 1992-09-29 | 1993-12-28 | Isis Pharmaceuticals Inc | Oligonucleotides having a conserved g4 core sequence |
| TW577875B (en) | 1997-01-31 | 2004-03-01 | Shionogi & Co | Pyrrolidine derivatives with inhibitory activity for phospholipase A2 |
| WO2000027824A1 (en) | 1998-11-12 | 2000-05-18 | Elan Pharmaceuticals | Substituted pyrimidine compositions and methods of use |
| SI1686119T1 (sl) | 2000-02-16 | 2009-12-31 | Smithkline Beecham Plc | Derivati pirimidin-5-ona kot inhibitorji ldl-pla2 |
| GB0024807D0 (en) | 2000-10-10 | 2000-11-22 | Smithkline Beecham Plc | Novel compounds |
| GB0024808D0 (en) | 2000-10-10 | 2000-11-22 | Smithkline Beecham Plc | Novel compounds |
| GB0127140D0 (en) | 2001-11-10 | 2002-01-02 | Smithkline Beecham | Novel compounds |
| GB0127143D0 (en) | 2001-11-10 | 2002-01-02 | Smithkline Beecham | Novel compounds |
| GB0127139D0 (en) | 2001-11-10 | 2002-01-02 | Smithkline Beecham | Novel compounds |
| US6797708B2 (en) | 2001-12-03 | 2004-09-28 | Wyeth | Inhibitors of cytosolic phospholipase A2 |
| FR2833261B1 (fr) | 2001-12-06 | 2004-07-02 | Yang Ji Chemical Company Ltd | Nouveaux composes inhibiteurs specifiques de la phospholipase a2 secretee non pancreatique humaine du groupe ii |
| GB0208279D0 (en) | 2002-04-10 | 2002-05-22 | Glaxo Group Ltd | Novel compounds |
| GB0208280D0 (en) | 2002-04-10 | 2002-05-22 | Glaxo Group Ltd | Novel compounds |
| TW200718687A (en) | 2005-05-27 | 2007-05-16 | Wyeth Corp | Inhibitors of cytosolic phospholipase A2 |
| CA2619641A1 (en) | 2005-08-17 | 2007-02-22 | The Regents Of The University Of California | Systemic and intrathecal effects of a novel series of phospholipase a2 inhibitors on hyperalgesia and spinal pge2 release |
| WO2009100035A2 (en) * | 2008-02-01 | 2009-08-13 | Wyeth | Interleukin-21 (il-21) and il-21 receptor (il-21r) modulation of regulatory t cells and forkhead box p3 (foxp3) |
| JP5366074B2 (ja) * | 2008-11-05 | 2013-12-11 | プライムテック株式会社 | 共通サイトカイン受容体γ鎖遺伝子ノックアウトブタ |
| JP5886195B2 (ja) | 2009-07-09 | 2016-03-16 | ホワイトヘッド・インスティチュート・フォア・バイオメディカル・リサーチ | 哺乳動物遺伝学のための組成物および方法、ならびにその使用 |
-
2011
- 2011-06-17 JP JP2013515556A patent/JP6053675B2/ja not_active Expired - Fee Related
- 2011-06-17 EP EP11796527.7A patent/EP2583099B1/en not_active Not-in-force
- 2011-06-17 US US13/805,201 patent/US9011821B2/en not_active Expired - Fee Related
- 2011-06-17 AU AU2011268127A patent/AU2011268127B2/en not_active Ceased
- 2011-06-17 US US13/704,951 patent/US20130211209A1/en active Pending
- 2011-06-17 WO PCT/US2011/040920 patent/WO2011160043A2/en not_active Ceased
- 2011-06-17 KR KR1020127033161A patent/KR101931628B1/ko not_active Expired - Fee Related
- 2011-06-17 ES ES11796527.7T patent/ES2611150T3/es active Active
- 2011-06-17 CA CA 2805409 patent/CA2805409A1/en not_active Abandoned
-
2016
- 2016-08-04 JP JP2016153821A patent/JP6285993B2/ja not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Sarkar et al. | Mouse models as resources for studying infectious diseases | |
| Cui et al. | Virus diversity, wildlife-domestic animal circulation and potential zoonotic viruses of small mammals, pangolins and zoo animals | |
| Sun et al. | Atlas of ACE2 gene expression reveals novel insights into transmission of SARS-CoV-2 | |
| Williams et al. | Viral diversity of house mice in New York City | |
| JP2013537515A5 (enExample) | ||
| Etebari et al. | Identification of Aedes aegypti long intergenic non-coding RNAs and their association with Wolbachia and dengue virus infection | |
| Gralinski et al. | Genome wide identification of SARS-CoV susceptibility loci using the collaborative cross | |
| Tian et al. | Genomic analyses reveal genetic adaptations to tropical climates in chickens | |
| Misra et al. | Detection of polyoma and corona viruses in bats of Canada | |
| Harbison et al. | Selection for long and short sleep duration in Drosophila melanogaster reveals the complex genetic network underlying natural variation in sleep | |
| Tse et al. | Identification of a novel bat papillomavirus by metagenomics | |
| Reuter et al. | Identification of a novel astrovirus in a domestic pig in Hungary | |
| Christiansen et al. | First field evidence of the evolution from a non-virulent HPR0 to a virulent HPR-deleted infectious salmon anaemia virus | |
| Burger et al. | Generation of a commercial-scale founder population of porcine reproductive and respiratory syndrome virus resistant pigs using CRISPR-Cas | |
| Giuliani et al. | The epigenetic side of human adaptation: hypotheses, evidences and theories | |
| Campana et al. | Genome sequence, population history, and pelage genetics of the endangered African wild dog (Lycaon pictus) | |
| Rodriguez et al. | Characterization in vitro and in vivo of a pandemic H1N1 influenza virus from a fatal case | |
| Li et al. | Genetic diversity, molecular phylogeny and selection evidence of the silkworm mitochondria implicated by complete resequencing of 41 genomes | |
| Power et al. | Taking flight: an ecological, evolutionary and genomic perspective on bat telomeres | |
| Tan et al. | SLAM-ITseq identifies that Nrf2 induces liver regeneration through the pentose phosphate pathway | |
| McCoy et al. | Identification and validation of genetic variants predictive of gait in standardbred horses | |
| Peng et al. | Identification of SNPs related to hypermelanosis of the blind side by transcriptome profiling in the Japanese flounder (Paralichthys olivaceus) | |
| Cossette et al. | Epigenetics and island‐mainland divergence in an insectivorous small mammal | |
| JP2012529892A5 (enExample) | ||
| Bryk et al. | Early gene expression divergence between allopatric populations of the house mouse (Mus musculus domesticus) |