JP2015187156A5 - - Google Patents

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JP2015187156A5
JP2015187156A5 JP2015125342A JP2015125342A JP2015187156A5 JP 2015187156 A5 JP2015187156 A5 JP 2015187156A5 JP 2015125342 A JP2015125342 A JP 2015125342A JP 2015125342 A JP2015125342 A JP 2015125342A JP 2015187156 A5 JP2015187156 A5 JP 2015187156A5
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JP6194335B2 (ja
JP2015187156A (ja
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JP2015125342A 2002-05-17 2015-06-23 癌および他の疾患を治療および管理するための免疫調節性化合物を用いた方法および組成物 Expired - Lifetime JP6194335B2 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US38084202P 2002-05-17 2002-05-17
US60/380,842 2002-05-17
US42460002P 2002-11-06 2002-11-06
US60/424,600 2002-11-06

Related Parent Applications (1)

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JP2009116367A Division JP5839770B2 (ja) 2002-05-17 2009-05-13 癌および他の疾患を治療および管理するための免疫調節性化合物を用いた方法および組成物

Related Child Applications (1)

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JP2017095838A Division JP2017132817A (ja) 2002-05-17 2017-05-12 癌および他の疾患を治療および管理するための免疫調節性化合物を用いた方法および組成物

Publications (3)

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JP2015187156A JP2015187156A (ja) 2015-10-29
JP2015187156A5 true JP2015187156A5 (cg-RX-API-DMAC10.html) 2016-02-04
JP6194335B2 JP6194335B2 (ja) 2017-09-06

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JP2004505051A Pending JP2005530784A (ja) 2002-05-17 2003-05-16 癌および他の疾患を治療および管理するための免疫調節性化合物を用いた方法および組成物
JP2006288966A Pending JP2007008966A (ja) 2002-05-17 2006-10-24 癌および他の疾患を治療および管理するための免疫調節性化合物を用いた方法および組成物
JP2009116367A Expired - Lifetime JP5839770B2 (ja) 2002-05-17 2009-05-13 癌および他の疾患を治療および管理するための免疫調節性化合物を用いた方法および組成物
JP2009116363A Withdrawn JP2009191072A (ja) 2002-05-17 2009-05-13 癌および他の疾患を治療および管理するための免疫調節性化合物を用いた方法および組成物
JP2012273326A Expired - Lifetime JP5830005B2 (ja) 2002-05-17 2012-12-14 癌および他の疾患を治療および管理するための免疫調節性化合物を用いた方法および組成物
JP2013038222A Withdrawn JP2013126999A (ja) 2002-05-17 2013-02-28 癌および他の疾患を治療および管理するための免疫調節性化合物を用いた方法および組成物
JP2015125342A Expired - Lifetime JP6194335B2 (ja) 2002-05-17 2015-06-23 癌および他の疾患を治療および管理するための免疫調節性化合物を用いた方法および組成物
JP2017095838A Pending JP2017132817A (ja) 2002-05-17 2017-05-12 癌および他の疾患を治療および管理するための免疫調節性化合物を用いた方法および組成物

Family Applications Before (6)

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JP2004505051A Pending JP2005530784A (ja) 2002-05-17 2003-05-16 癌および他の疾患を治療および管理するための免疫調節性化合物を用いた方法および組成物
JP2006288966A Pending JP2007008966A (ja) 2002-05-17 2006-10-24 癌および他の疾患を治療および管理するための免疫調節性化合物を用いた方法および組成物
JP2009116367A Expired - Lifetime JP5839770B2 (ja) 2002-05-17 2009-05-13 癌および他の疾患を治療および管理するための免疫調節性化合物を用いた方法および組成物
JP2009116363A Withdrawn JP2009191072A (ja) 2002-05-17 2009-05-13 癌および他の疾患を治療および管理するための免疫調節性化合物を用いた方法および組成物
JP2012273326A Expired - Lifetime JP5830005B2 (ja) 2002-05-17 2012-12-14 癌および他の疾患を治療および管理するための免疫調節性化合物を用いた方法および組成物
JP2013038222A Withdrawn JP2013126999A (ja) 2002-05-17 2013-02-28 癌および他の疾患を治療および管理するための免疫調節性化合物を用いた方法および組成物

Family Applications After (1)

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JP2017095838A Pending JP2017132817A (ja) 2002-05-17 2017-05-12 癌および他の疾患を治療および管理するための免疫調節性化合物を用いた方法および組成物

Country Status (19)

Country Link
EP (9) EP1505973B1 (cg-RX-API-DMAC10.html)
JP (8) JP2005530784A (cg-RX-API-DMAC10.html)
KR (2) KR100822149B1 (cg-RX-API-DMAC10.html)
CN (13) CN1981761B (cg-RX-API-DMAC10.html)
AT (1) ATE459357T1 (cg-RX-API-DMAC10.html)
AU (1) AU2003234626B2 (cg-RX-API-DMAC10.html)
CA (10) CA2752127A1 (cg-RX-API-DMAC10.html)
CY (3) CY1110013T1 (cg-RX-API-DMAC10.html)
DE (1) DE60331537D1 (cg-RX-API-DMAC10.html)
DK (1) DK1505973T3 (cg-RX-API-DMAC10.html)
ES (2) ES2340027T3 (cg-RX-API-DMAC10.html)
IL (9) IL165254A0 (cg-RX-API-DMAC10.html)
LU (1) LU92642I2 (cg-RX-API-DMAC10.html)
MX (1) MXPA04011311A (cg-RX-API-DMAC10.html)
NZ (5) NZ549175A (cg-RX-API-DMAC10.html)
PT (2) PT1505973E (cg-RX-API-DMAC10.html)
SI (1) SI1505973T1 (cg-RX-API-DMAC10.html)
WO (1) WO2003097052A2 (cg-RX-API-DMAC10.html)
ZA (3) ZA200503656B (cg-RX-API-DMAC10.html)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU228769B1 (en) 1996-07-24 2013-05-28 Celgene Corp Substituted 2(2,6-dioxopiperidin-3-yl)phthalimides and -1-oxoisoindolines and their use for production of pharmaceutical compositions for mammals to reduce the level of tnf-alpha
DE60234585D1 (cg-RX-API-DMAC10.html) 2001-02-27 2010-01-14 Us Government
US7323479B2 (en) * 2002-05-17 2008-01-29 Celgene Corporation Methods for treatment and management of brain cancer using 1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-methylisoindoline
CN1981761B (zh) 2002-05-17 2011-10-12 细胞基因公司 使用免疫调节性化合物用于制备治疗和控制癌症和其它疾病药物中的应用及组合物
US7393862B2 (en) * 2002-05-17 2008-07-01 Celgene Corporation Method using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for treatment of certain leukemias
US11116782B2 (en) 2002-10-15 2021-09-14 Celgene Corporation Methods of treating myelodysplastic syndromes with a combination therapy using lenalidomide and azacitidine
US8404716B2 (en) 2002-10-15 2013-03-26 Celgene Corporation Methods of treating myelodysplastic syndromes with a combination therapy using lenalidomide and azacitidine
US7189740B2 (en) 2002-10-15 2007-03-13 Celgene Corporation Methods of using 3-(4-amino-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myelodysplastic syndromes
JP2006508950A (ja) * 2002-10-31 2006-03-16 セルジーン・コーポレーション 黄斑変性の治療用組成物
US7785601B2 (en) * 2002-12-31 2010-08-31 Sygnis Bioscience Gmbh & Co. Kg Methods of treating neurological conditions with hematopoietic growth factors
WO2005016326A2 (en) * 2003-07-11 2005-02-24 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Analogs of thalidomide as potential angiogenesis inhibitors
UA83504C2 (en) 2003-09-04 2008-07-25 Селджин Корпорейшн Polymorphic forms of 3-(4-amino-1-oxo-1,3 dihydro-isoindol-2-yl)-piperidine-2,6-dione
WO2005028436A2 (en) 2003-09-17 2005-03-31 The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Thalidomide analogs as tnf-alpha modulators
US8952895B2 (en) 2011-06-03 2015-02-10 Apple Inc. Motion-based device operations
US20050100529A1 (en) * 2003-11-06 2005-05-12 Zeldis Jerome B. Methods of using and compositions comprising immunomodulatory compounds for the treatment and management of asbestos-related diseases and disorders
JP5089170B2 (ja) * 2003-12-02 2012-12-05 セルジーン コーポレイション 異常ヘモグロビン症及び貧血症の治療及び管理のための方法及び組成物
US20050143344A1 (en) * 2003-12-30 2005-06-30 Zeldis Jerome B. Methods and compositions using immunomodulatory compounds for the treatment and management of central nervous system disorders or diseases
JP2007529434A (ja) 2004-03-17 2007-10-25 ラース マイケル ラーセン, 視覚サイクルの阻害による網膜症の予防
EP1737453A4 (en) * 2004-03-22 2008-11-26 Celgene Corp METHOD FOR THE USE OF IMMUNOMODULATORY COMPOUNDS AND COMPOSITIONS CONTAINING THEREOF FOR THE TREATMENT AND SUPPLY OF SKIN DISEASES OR DISORDERS
AU2004319758A1 (en) * 2004-04-14 2005-11-24 Celgene Corporation Methods of using and compositions comprising immunomodulatory compounds for the treatment and management of myelodysplastic syndromes
CA2586950A1 (en) * 2004-11-12 2006-05-18 Celgene Corporation Methods and compositions using immunomodulatory compounds for treatment and management of parasitic diseases
CA2588597A1 (en) * 2004-11-23 2006-06-01 Celgene Corporation Methods and compositions using immunomodulatory compounds for treatment and management of central nervous system injury
ES2359162T3 (es) * 2005-09-01 2011-05-19 Celgene Corporation Usos inmunologicos de compuestos inmunomoduladores para vacunas y terapia de enfermedades anti-infecciosas.
WO2007072225A2 (en) * 2005-12-01 2007-06-28 Medical Prognosis Institute Methods and devices for identifying biomarkers of treatment response and use thereof to predict treatment efficacy
AU2007238785B2 (en) 2006-04-13 2013-02-07 Agnieszka Ambrozak Tetrahalogenated compounds useful as inhibitors of angiogenesis
RU2426542C2 (ru) * 2006-05-26 2011-08-20 Селджин Корпорейшн Способы и композиции с применением иммуномодулирующих соединений при комбинированном лечении
CL2007002218A1 (es) * 2006-08-03 2008-03-14 Celgene Corp Soc Organizada Ba Uso de 3-(4-amino-1-oxo-1,3-dihidro-isoindol-2-il)-piperidina 2,6-diona para la preparacion de un medicamento util para el tratamiento de linfoma de celula de capa.
MX2009001441A (es) * 2006-08-07 2009-07-06 Facet Biotech Corp Metodos para tratar mieloma multiple usando terapias de combinacion basadas en anticuerpos anti-cs1.
AP2009004834A0 (en) * 2006-10-19 2009-04-30 Celgene Corp Methods and compositions using immunomodulatory c ompounds for the treatment and management of spirochete and other obligate intracellular bacterial diseases
RU2348420C2 (ru) * 2007-04-17 2009-03-10 ФГУ Ростовский научно-исследовательский онкологический институт Росздрава Способ лечения местно-распространенного рака легкого
KR20230065354A (ko) * 2007-09-28 2023-05-11 셀룰래리티 인코포레이티드 인간 태반 관류액 및 인간 태반-유래 중간체 천연 킬러 세포를 사용한 종양 억제 방법
UA104579C2 (uk) * 2007-12-10 2014-02-25 Байокрист Фармасьютикалз, Инк. Спосіб лікування раку кровотворної системи із застосуванням фородезину у комбінації з ритуксимабом
CA2712724A1 (en) * 2008-01-29 2009-08-06 Celgene Corporation Use of lenalidomide or pomalidomide for treating a disease associated with cd59 deficiency
RU2398525C1 (ru) * 2009-03-25 2010-09-10 Федеральное государственное учреждение "Ростовский научно-исследовательский онкологический институт Росмедтехнологий" Способ лечения рака легкого
CN101696205B (zh) 2009-11-02 2011-10-19 南京卡文迪许生物工程技术有限公司 3-(取代二氢异吲哚-2-基)-2,6-哌啶二酮多晶型物和药用组合物
CA2780998C (en) * 2009-11-24 2016-07-12 Celgene Corporation Immunomodulatory compounds for the restoration of vitamin d sensitivity in vitamin d resistant tumor cells
EP4289838A3 (en) 2010-02-11 2024-03-13 Celgene Corporation Arylmethoxy isoindoline derivatives and compositions comprising and methods of using the same
AU2011224166B2 (en) * 2010-03-12 2014-08-21 Celgene Corporation Methods for the treatment of non-Hodgkin's lymphomas using lenalidomide, and gene and protein biomarkers as a predictor
US10426740B1 (en) 2010-08-18 2019-10-01 Avm Biotechnology, Llc Compositions and methods to inhibit stem cell and progenitor cell binding to lymphoid tissue and for regenerating germinal centers in lymphatic tissues
KR20190017065A (ko) * 2010-08-18 2019-02-19 테레사 데이셔 림프양 조직에 줄기 세포와 조상 세포 결합을 저해하고, 그리고 림프 조직에서 배 중심을 재생하기 위한 조성물과 방법
WO2012062366A1 (en) * 2010-11-11 2012-05-18 Ingo Schmidt-Wolf Compositions comprising wnt inhibitors for treating cancer
US8927725B2 (en) 2011-12-02 2015-01-06 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Thio compounds
US9694015B2 (en) * 2012-09-10 2017-07-04 Celgene Corporation Methods for the treatment of locally advanced breast cancer
SG11201507759WA (en) * 2013-04-02 2015-10-29 Celgene Corp Methods and compositions using 4-amino-2-(2,6-dioxo-piperidine-3-yl)-isoindoline-1,3-dione for treatment and management of central nervous system cancers
GB201322626D0 (en) 2013-12-19 2014-02-05 Immutep S A Combined preparations for the treatment of cancer
CN104231068A (zh) * 2014-01-27 2014-12-24 苏州发士达生物科技有限公司 人白细胞介素ii突变体及其应用
JP6616934B2 (ja) * 2014-05-22 2019-12-04 株式会社 資生堂 レナリドミドの光学分割方法
US10034872B2 (en) 2014-08-22 2018-07-31 Celgene Corporation Methods of treating multiple myeloma with immunomodulatory compounds in combination with antibodies
DK3198035T3 (da) 2014-09-26 2023-01-30 Allarity Therapeutics Europe ApS Fremgangsmåder til forudsigelse af medicinrespons
GB201500374D0 (en) 2015-01-09 2015-02-25 Immutep S A Combined preparations for the treatment of cancer
CN107249502A (zh) * 2015-01-20 2017-10-13 斯里瓦特桑·拉加万 自照明式面颊牵开器
US11000536B2 (en) 2015-04-30 2021-05-11 Nant Holdings Ip, Llc Patient treatment via teratogenic pharmaceutical compounds
HRP20211478T1 (hr) * 2015-06-29 2021-12-24 Bristol-Myers Squibb Company Imunoterapijski režimi doziranja koji obuhvaćaju pomalidomid i anti-cs1 antitijelo za liječenje raka
CA3002381A1 (en) * 2015-10-21 2017-04-27 Teclison Limited Compositions and methods for immune-mediated cancer therapy
CN105388237B (zh) * 2015-12-28 2017-02-01 成都百裕金阁莱药业有限公司 阿普斯特中3‑乙酰氨基邻苯二甲酸的检测方法
US9725769B1 (en) 2016-10-07 2017-08-08 Oncology Venture ApS Methods for predicting drug responsiveness in cancer patients
AU2017258901A1 (en) 2016-12-30 2018-07-19 Allarity Therapeutics Europe ApS Methods for predicting drug responsiveness in cancer patients
IL312367A (en) 2017-01-31 2024-06-01 Arvinas Operations Inc Cereblon ligands and bifunctional compounds comprising the same
MX2019011679A (es) 2017-04-01 2019-11-01 Avm Biotechnology Llc Reemplazo de un pre-acondicionamiento citotoxico antes de una inmunoterapia celular.
EA201992765A1 (ru) 2017-05-24 2020-03-25 Новартис Аг Белки на основе антител с привитым цитокином и способы их применения в лечении рака
RU2020110236A (ru) * 2017-10-26 2021-11-26 Синбиас Фарма АГ Состав леналидомида с немедленным высвобождением
EA202092248A1 (ru) 2018-04-23 2021-02-04 Селджин Корпорейшн Замещенные соединения 4-аминоизоиндолин-1,3-диона, их композиции и способы лечения ими
JP7495886B2 (ja) * 2018-05-23 2024-06-05 セルジーン コーポレイション 多発性骨髄腫を治療すること及び4-(4-(4-(((2-(2,6-ジオキソピペリジン-3-イル)-1-オキソイソインドリン-4-イル)オキシ)メチル)ベンジル)ピペラジン-1-イル)-3-フルオロベンゾニトリルのバイオマーカーの使用
JP7098825B2 (ja) * 2018-09-07 2022-07-11 メッドシャイン ディスカバリー インコーポレイテッド 三環式置換ピペリジンジオン類化合物
EP3488851A1 (en) 2018-10-03 2019-05-29 AVM Biotechnology, LLC Immunoablative therapies
WO2021067546A1 (en) * 2019-10-04 2021-04-08 Dana-Farber Cancer Institute, Inc. Immunomodulatory imide drugs as zeta-chain-associated protein kinase 70 (zap70) agonists and uses thereof
MX2022004688A (es) * 2019-10-21 2022-05-10 Celgene Corp Métodos para tratar un cáncer hematológico y uso de biomarcadores compañeros para 2-(2,6-dioxopiperidin-3-il)-4-((2-fluoro-4-((3-mor folinoazetidin-1-il)metil)bencil)amino)isoindolin-1,3-diona.
DK4048278T3 (da) * 2019-10-21 2024-01-08 Celgene Corp Fremgangsmåder til behandling af hæmatologiske maligniteter under anvendelse af 2-(2,6-dioxopiperidin-3-yl)-4-((2-fluor-4-((3-morpholinoazetidin-1-yl)methyl)benzyl)amino)isoindolin-1,3-dion
CA3165168A1 (en) 2019-12-19 2021-06-24 Arvinas Operations, Inc. Compounds and methods for the targeted degradation of androgen receptor

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3228601A (en) 1964-02-20 1966-01-11 Monarch Marking Systems Inc Controls for marking machine
US3536809A (en) 1969-02-17 1970-10-27 Alza Corp Medication method
US3598123A (en) 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US3916899A (en) 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
US4008719A (en) 1976-02-02 1977-02-22 Alza Corporation Osmotic system having laminar arrangement for programming delivery of active agent
US5001116A (en) 1982-12-20 1991-03-19 The Children's Medical Center Corporation Inhibition of angiogenesis
US4994443A (en) 1982-12-20 1991-02-19 The Children's Medical Center Corporation Inhibition of angiogenesis
IE58110B1 (en) 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation
US5391485A (en) 1985-08-06 1995-02-21 Immunex Corporation DNAs encoding analog GM-CSF molecules displaying resistance to proteases which cleave at adjacent dibasic residues
US4810643A (en) 1985-08-23 1989-03-07 Kirin- Amgen Inc. Production of pluripotent granulocyte colony-stimulating factor
JPS63500636A (ja) 1985-08-23 1988-03-10 麒麟麦酒株式会社 多分化能性顆粒球コロニー刺激因子をコードするdna
US5073543A (en) 1988-07-21 1991-12-17 G. D. Searle & Co. Controlled release formulations of trophic factors in ganglioside-lipsome vehicle
IT1229203B (it) 1989-03-22 1991-07-25 Bioresearch Spa Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative.
US5120548A (en) 1989-11-07 1992-06-09 Merck & Co., Inc. Swelling modulated polymeric drug delivery device
KR0166088B1 (ko) 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
US5733566A (en) 1990-05-15 1998-03-31 Alkermes Controlled Therapeutics Inc. Ii Controlled release of antiparasitic agents in animals
US5580578A (en) 1992-01-27 1996-12-03 Euro-Celtique, S.A. Controlled release formulations coated with aqueous dispersions of acrylic polymers
US5360352A (en) 1992-12-24 1994-11-01 The Whitaker Corporation Wire retainer for current mode coupler
US5591767A (en) 1993-01-25 1997-01-07 Pharmetrix Corporation Liquid reservoir transdermal patch for the administration of ketorolac
US6114355A (en) 1993-03-01 2000-09-05 D'amato; Robert Methods and compositions for inhibition of angiogenesis
US5629327A (en) 1993-03-01 1997-05-13 Childrens Hospital Medical Center Corp. Methods and compositions for inhibition of angiogenesis
US5698579A (en) 1993-07-02 1997-12-16 Celgene Corporation Cyclic amides
IT1270594B (it) 1994-07-07 1997-05-07 Recordati Chem Pharm Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida
US6281230B1 (en) 1996-07-24 2001-08-28 Celgene Corporation Isoindolines, method of use, and pharmaceutical compositions
HU228769B1 (en) 1996-07-24 2013-05-28 Celgene Corp Substituted 2(2,6-dioxopiperidin-3-yl)phthalimides and -1-oxoisoindolines and their use for production of pharmaceutical compositions for mammals to reduce the level of tnf-alpha
US5798368A (en) 1996-08-22 1998-08-25 Celgene Corporation Tetrasubstituted 2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolines and method of reducing TNFα levels
US5635517B1 (en) 1996-07-24 1999-06-29 Celgene Corp Method of reducing TNFalpha levels with amino substituted 2-(2,6-dioxopiperidin-3-YL)-1-oxo-and 1,3-dioxoisoindolines
DE69739802D1 (de) 1996-07-24 2010-04-22 Celgene Corp Substituierte 2-(2,6-Dioxopiperidine-3-yl)-phthalimide -1-oxoisoindoline und Verfahren zur Reduzierung des TNF-alpha Spiegels
EP1361210B1 (en) 1996-08-12 2008-12-24 Celgene Corporation Novel immunotherapeutic agents and their use in the reduction of cytokine levels
ES2313154T3 (es) * 1996-11-05 2009-03-01 The Children's Medical Center Corporation Composiciones que comprenden talodimina y dexametasona para el tratamiento de cancer.
US5874448A (en) 1997-11-18 1999-02-23 Celgene Corporation Substituted 2-(2,6 dioxo-3-fluoropiperidin-3-yl)-isoindolines and method of reducing TNFα levels
US6020358A (en) * 1998-10-30 2000-02-01 Celgene Corporation Substituted phenethylsulfones and method of reducing TNFα levels
DK1169021T3 (da) * 1999-04-01 2010-01-11 Hana Biosciences Inc Sammensætninger og fremgangsmåder til behandling af lymfom
CN1429121A (zh) * 2000-03-17 2003-07-09 细胞治疗公司 聚谷氨酸-喜树碱结合物及其制备方法
KR100790589B1 (ko) * 2000-05-15 2008-01-02 셀겐코포레이션 암 치료용 조성물 및 치료 방법
US6458810B1 (en) * 2000-11-14 2002-10-01 George Muller Pharmaceutically active isoindoline derivatives
PT1353672E (pt) 2000-11-30 2008-01-11 Childrens Medical Center Síntese da 4-amino talidomida enantiómeros
US20030045552A1 (en) 2000-12-27 2003-03-06 Robarge Michael J. Isoindole-imide compounds, compositions, and uses thereof
CN1981761B (zh) * 2002-05-17 2011-10-12 细胞基因公司 使用免疫调节性化合物用于制备治疗和控制癌症和其它疾病药物中的应用及组合物
US7323479B2 (en) * 2002-05-17 2008-01-29 Celgene Corporation Methods for treatment and management of brain cancer using 1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-methylisoindoline

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