|
US5591855A
(en)
|
1994-10-14 |
1997-01-07 |
Cephalon, Inc. |
Fused pyrrolocarbazoles
|
|
US5628984A
(en)
|
1995-07-31 |
1997-05-13 |
University Of North Carolina At Chapel Hill |
Method of detecting lung disease
|
|
BR9807305A
(pt)
|
1997-02-05 |
2000-05-02 |
Warner Lambert Co |
Pirido [2,3-d] pirimidinas e 4-aminopirimidinas como inibidores de proliferação celular.
|
|
GB9718913D0
(en)
|
1997-09-05 |
1997-11-12 |
Glaxo Group Ltd |
Substituted oxindole derivatives
|
|
US20040006074A1
(en)
|
1998-04-28 |
2004-01-08 |
The Government Of The United States Of America |
Cyclin dependent kinase (CDK)4 inhibitors and their use for treating cancer
|
|
EP1086105B1
(en)
|
1998-06-16 |
2006-03-01 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES |
Fused azepinone cyclin dependent kinase inhibitors
|
|
US6593353B1
(en)
|
1999-01-29 |
2003-07-15 |
Board Of Trustees Of The University Of Illinois |
p53 inhibitors and therapeutic use of the same
|
|
WO2001007411A1
(en)
|
1999-07-26 |
2001-02-01 |
Banyu Pharmaceutical Co., Ltd. |
Biarylurea derivatives
|
|
US6387900B1
(en)
|
1999-08-12 |
2002-05-14 |
Pharmacia & Upjohn S.P.A. |
3(5)-ureido-pyrazole derivatives process for their preparation and their use as antitumor agents
|
|
US6291504B1
(en)
|
1999-10-20 |
2001-09-18 |
Dupont Pharmaceuticals Company |
Acylsemicarbazides and their uses
|
|
WO2001044247A2
(en)
|
1999-12-16 |
2001-06-21 |
Eli Lilly And Company |
Agents and methods for the treatment of proliferative diseases
|
|
US7053070B2
(en)
|
2000-01-25 |
2006-05-30 |
Warner-Lambert Company |
Pyrido[2,3-d]pyrimidine-2,7-diamine kinase inhibitors
|
|
CA2412560C
(en)
|
2000-06-26 |
2008-12-30 |
Pfizer Products Inc. |
Pyrrolo[2,3-d]pyrimidine compounds as immunosuppressive agents
|
|
US7109229B2
(en)
|
2000-09-29 |
2006-09-19 |
Eli Lilly And Company |
Methods and compounds for treating proliferative diseases
|
|
AU2002228692A1
(en)
|
2000-12-01 |
2002-06-11 |
Bristol-Myers Squibb Pharma Company |
3-(2,4-dimethylthiazol-5-yl) indeno(1,2-c)pyrazol-4-one derivatives as cdk inhibitors
|
|
ATE406881T1
(de)
|
2001-02-28 |
2008-09-15 |
Univ Temple |
Verwendung von alpha, beta ungesättigten arylsulfonen zum schutz von zellen und geweben vor toxizität ionischer strahlung
|
|
JP2004533449A
(ja)
*
|
2001-05-11 |
2004-11-04 |
ボード オブ リージェンツ， ザ ユニバーシティ オブ テキサス システム |
Ｃｄ２６を発現している細胞に関連する疾患の治療としての抗ｃｄ２６モノクローナル抗体
|
|
GEP20063909B
(en)
|
2002-01-22 |
2006-08-25 |
Warner Lambert Co |
2-(PYRIDIN-2-YLAMINO)-PYRIDO[2,3d] PYRIMIDIN-7-ONES
|
|
WO2003093469A2
(en)
|
2002-05-01 |
2003-11-13 |
Chromos Molecular Systems, Inc. |
Methods for delivering nucleic acid molecules into cells and assessment thereof
|
|
ATE433967T1
(de)
|
2003-01-17 |
2009-07-15 |
Warner Lambert Co |
2-aminopyridin-substituierteheterocyclen als inhibitoren der zellulären proliferation
|
|
ME00142B
(me)
|
2003-05-22 |
2010-10-10 |
Nerviano Medical Sciences Srl |
Derivati pirazolo-hinazolina, postupci za njihovo dobijanje i njihova upotreba kao inhibitora kinaze
|
|
NZ544609A
(en)
|
2003-07-11 |
2008-07-31 |
Warner Lambert Co |
Isethionate salt of 6-acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one
|
|
JP4490434B2
(ja)
|
2003-10-23 |
2010-06-23 |
エフ．ホフマン−ラ ロシュ アーゲー |
神経及び神経精神疾患の処置においてＧｌｙＴ−１阻害剤として使用するためのトリアザ−スピロピペリジン誘導体
|
|
GB0327380D0
(en)
|
2003-11-25 |
2003-12-31 |
Cyclacel Ltd |
Method
|
|
EP1740184A1
(en)
|
2004-03-30 |
2007-01-10 |
Pfizer Products Incorporated |
Combinations of signal transduction inhibitors
|
|
US8603763B2
(en)
|
2004-04-08 |
2013-12-10 |
Cornell Research Foundation, Inc. |
Functional immunohistochemical cell cycle analysis as a prognostic indicator for cancer
|
|
ITMI20040874A1
(it)
|
2004-04-30 |
2004-07-30 |
Ist Naz Stud Cura Dei Tumori |
Derivati indolici ed azaindolici con azione antitumorale
|
|
WO2006074985A1
(en)
|
2005-01-14 |
2006-07-20 |
Janssen Pharmaceutica N.V. |
5-membered annelated heterocyclic pyrimidines as kinase inhibitors
|
|
RU2007131101A
(ru)
|
2005-01-21 |
2009-02-27 |
Астекс Терапьютикс Лимитед (Gb) |
Комбинации пиразольных ингибиторов киназы и других средств против злокачественных новообразований
|
|
US8921376B2
(en)
|
2005-05-20 |
2014-12-30 |
Vertex Pharmaceuticals Incorporated |
Pyrrolopyridines useful as inhibitors of protein kinase
|
|
WO2007025090A2
(en)
|
2005-08-25 |
2007-03-01 |
Kalypsys, Inc. |
Heterobicyclic and - tricyclic inhibitors of mapk/erk kinase
|
|
EP1779848A1
(en)
|
2005-10-28 |
2007-05-02 |
Nikem Research S.R.L. |
V-ATPase inhibitors for the treatment of inflammatory and autoimmune diseases
|
|
CA2631128A1
(en)
|
2005-12-09 |
2007-06-14 |
F. Hoffmann-La Roche Ag |
Tricyclic amide derivatives useful for treating obesity
|
|
JP2009524589A
(ja)
|
2005-12-22 |
2009-07-02 |
ワイス |
置換されたイソキノリン−１，３（２ｈ，４ｈ）−ジオン、１−チオキソ−１，４−ジヒドロ−２ｈ−イソキノリン−３−オン誘導体、および１，４−ジヒドロ−３（２ｈ）−イソキノロン、ならびにキナーゼインヒビターとしてのそれらの使用
|
|
RU2447891C2
(ru)
|
2006-04-05 |
2012-04-20 |
Новартис Аг |
Комбинации терапевтических средств, предназначенные для лечения рака
|
|
US20070270362A1
(en)
|
2006-05-18 |
2007-11-22 |
The University Of Washington |
Methods and compositions for prevention or treatment of inflammatory-related diseases and disorders
|
|
AU2007269540B2
(en)
|
2006-07-05 |
2013-06-27 |
Exelixis, Inc. |
Methods of using IGF1R and Abl kinase modulators
|
|
CA2672898A1
(en)
|
2006-12-14 |
2008-06-26 |
Panacea Pharmaceuticals, Inc. |
Methods of neuroprotection by cyclin-dependent kinase inhibition
|
|
WO2008079933A2
(en)
|
2006-12-22 |
2008-07-03 |
Novartis Ag |
Heteroaryl-heteroaryl compounds as cdk inhibitors for the treatment of cancer, inflammation and viral infections
|
|
EP2162451A4
(en)
|
2007-06-25 |
2012-04-18 |
Neurogen Corp |
PIPERAZINYL-OXOALKYL-TETRAHYDRO-BETA-CARBOLINE AND RELATED ANALOGUE
|
|
WO2009061345A2
(en)
|
2007-11-07 |
2009-05-14 |
Cornell Research Foundation, Inc. |
Targeting cdk4 and cdk6 in cancer therapy
|
|
AU2008343932B2
(en)
|
2007-12-19 |
2013-08-15 |
Amgen Inc. |
Fused pyridine, pyrimidine and triazine compounds as cell cycle inhibitors
|
|
CN102105152B
(zh)
|
2008-07-29 |
2012-10-17 |
内尔维阿诺医学科学有限公司 |
包含cdks抑制剂和抗肿瘤剂的治疗组合
|
|
PT2331547E
(pt)
|
2008-08-22 |
2014-10-29 |
Novartis Ag |
Compostos de pirrolopirimidina como inibidores de cdk
|
|
AU2009298367A1
(en)
|
2008-10-01 |
2010-04-08 |
The University Of North Carolina At Chapel Hill |
Hematopoietic protection against chemotherapeutic compounds using selective cyclin-dependent kinase 4/6 inhibitors
|
|
AU2009310352A1
(en)
|
2008-10-01 |
2010-05-06 |
The University Of North Carolina At Chapel Hill |
Hematopoietic protection against ionizing radiation using selective cyclin-dependent kinase 4/6 inhibitors
|
|
PA8852901A1
(es)
|
2008-12-22 |
2010-07-27 |
Lilly Co Eli |
Inhibidores de proteina cinasa
|
|
EP3025724B1
(en)
|
2009-05-13 |
2018-07-11 |
The University of North Carolina At Chapel Hill |
Cyclin dependent kinase inhibitors and methods of use
|
|
US9040519B2
(en)
|
2010-02-18 |
2015-05-26 |
Medivation Technologies, Inc. |
Fused tetracyclic pyrido [4,3-B] indole and pyrido [3,4-B] indole derivatives and methods of use
|
|
UY33226A
(es)
*
|
2010-02-19 |
2011-09-30 |
Novartis Ag |
Compuestos de pirrolopirimidina deuterada como inhibidores de la cdk4/6
|
|
UY33227A
(es)
|
2010-02-19 |
2011-09-30 |
Novartis Ag |
Compuestos de pirrolopirimidina como inhibidores de la cdk4/6
|
|
US8691830B2
(en)
|
2010-10-25 |
2014-04-08 |
G1 Therapeutics, Inc. |
CDK inhibitors
|
|
EP2955183A1
(en)
|
2010-10-25 |
2015-12-16 |
G1 Therapeutics, Inc. |
Cdk inhibitors
|
|
JP6040157B2
(ja)
|
2010-11-02 |
2016-12-07 |
プロメガ コーポレイションＰｒｏｍｅｇａ Ｃｏｒｐｏｒａｔｉｏｎ |
セレンテラジン誘導体およびその使用方法
|
|
CN103501789A
(zh)
|
2010-11-17 |
2014-01-08 |
北卡罗来纳大学查珀尔希尔分校 |
通过抑制增殖性激酶cdk4和cdk6保护肾组织免于局部缺血
|
|
US8815853B2
(en)
|
2010-12-23 |
2014-08-26 |
Sanofi |
Pyrimidinone derivatives, preparation thereof and pharmaceutical use thereof
|
|
WO2012129344A1
(en)
*
|
2011-03-23 |
2012-09-27 |
Amgen Inc. |
Fused tricyclic dual inhibitors of cdk 4/6 and flt3
|
|
WO2013006532A1
(en)
|
2011-07-01 |
2013-01-10 |
Novartis Ag |
Combination therapy comprising a cdk4/6 inhibitor and a pi3k inhibitor for use in the treatment of cancer
|
|
WO2013148748A1
(en)
|
2012-03-29 |
2013-10-03 |
Francis Xavier Tavares |
Lactam kinase inhibitors
|
|
EP2841417A1
(en)
|
2012-04-26 |
2015-03-04 |
Francis Xavier Tavares |
Synthesis of lactams
|
|
US9241941B2
(en)
|
2012-09-20 |
2016-01-26 |
Memorial Sloan-Kettering Cancer Center |
Methods for treatment of lymphomas with mutations in cell cycle genes
|
|
WO2014144326A1
(en)
|
2013-03-15 |
2014-09-18 |
G1 Therapeutics, Inc. |
Transient protection of normal cells during chemotherapy
|
|
US20140274896A1
(en)
|
2013-03-15 |
2014-09-18 |
G1 Therapeutics, Inc. |
Transient Protection of Hematopoietic Stem and Progenitor Cells Against Ionizing Radiation
|
|
CN105407723A
(zh)
|
2013-03-15 |
2016-03-16 |
G1治疗公司 |
高效的抗赘生剂和抗增生剂
|
|
MX369503B
(es)
|
2013-04-08 |
2019-11-11 |
Pharmacyclics Llc |
Combinaciones que comprenden ibrutinib y abt-199 para tratar trastornos proliferativos de células b y métodos de uso de las mismas.
|
|
WO2015061407A1
(en)
|
2013-10-24 |
2015-04-30 |
Francis Xavier Tavares |
Process for synthesis of lactams
|
|
WO2015084892A1
(en)
|
2013-12-02 |
2015-06-11 |
Cornell University |
Methods for treating b cell proliferative disorders
|
|
US20150297608A1
(en)
|
2014-04-17 |
2015-10-22 |
G1 Therapeutics, Inc. |
Tricyclic Lactams for Use as Anti-Neoplastic and Anti-Proliferative Agents
|
|
WO2016040848A1
(en)
|
2014-09-12 |
2016-03-17 |
G1 Therapeutics, Inc. |
Treatment of rb-negative tumors using topoisomerase inhibitors in combination with cyclin dependent kinase 4/6 inhibitors
|
|
WO2016040858A1
(en)
|
2014-09-12 |
2016-03-17 |
G1 Therapeutics, Inc. |
Combinations and dosing regimes to treat rb-positive tumors
|
|
WO2016126889A1
(en)
|
2015-02-03 |
2016-08-11 |
G1 Therapeutics, Inc. |
Cdk4/6 inhibitor dosage formulations for the protection of hematopoietic stem and progenitor cells during chemotherapy
|