JP2015154787A5 - - Google Patents

Download PDF

Info

Publication number
JP2015154787A5
JP2015154787A5 JP2015111259A JP2015111259A JP2015154787A5 JP 2015154787 A5 JP2015154787 A5 JP 2015154787A5 JP 2015111259 A JP2015111259 A JP 2015111259A JP 2015111259 A JP2015111259 A JP 2015111259A JP 2015154787 A5 JP2015154787 A5 JP 2015154787A5
Authority
JP
Japan
Prior art keywords
polymerase
seq
amino acid
domain
chimeric
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2015111259A
Other languages
English (en)
Japanese (ja)
Other versions
JP6150847B2 (ja
JP2015154787A (ja
Filing date
Publication date
Application filed filed Critical
Publication of JP2015154787A publication Critical patent/JP2015154787A/ja
Publication of JP2015154787A5 publication Critical patent/JP2015154787A5/ja
Application granted granted Critical
Publication of JP6150847B2 publication Critical patent/JP6150847B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2015111259A 2008-11-03 2015-06-01 キメラdnaポリメラーゼ Active JP6150847B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11086208P 2008-11-03 2008-11-03
US61/110,862 2008-11-03

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2011534889A Division JP2012507986A (ja) 2008-11-03 2009-11-03 キメラdnaポリメラーゼ

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2016219403A Division JP2017029172A (ja) 2008-11-03 2016-11-10 キメラdnaポリメラーゼ

Publications (3)

Publication Number Publication Date
JP2015154787A JP2015154787A (ja) 2015-08-27
JP2015154787A5 true JP2015154787A5 (OSRAM) 2016-02-18
JP6150847B2 JP6150847B2 (ja) 2017-06-21

Family

ID=42226349

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2011534889A Withdrawn JP2012507986A (ja) 2008-11-03 2009-11-03 キメラdnaポリメラーゼ
JP2015111259A Active JP6150847B2 (ja) 2008-11-03 2015-06-01 キメラdnaポリメラーゼ
JP2016219403A Pending JP2017029172A (ja) 2008-11-03 2016-11-10 キメラdnaポリメラーゼ

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2011534889A Withdrawn JP2012507986A (ja) 2008-11-03 2009-11-03 キメラdnaポリメラーゼ

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2016219403A Pending JP2017029172A (ja) 2008-11-03 2016-11-10 キメラdnaポリメラーゼ

Country Status (7)

Country Link
US (2) US9023633B2 (OSRAM)
EP (2) EP2352818B1 (OSRAM)
JP (3) JP2012507986A (OSRAM)
CN (1) CN102257136A (OSRAM)
CA (1) CA2742593C (OSRAM)
ES (2) ES2716402T3 (OSRAM)
WO (1) WO2010062776A2 (OSRAM)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2352818B1 (en) 2008-11-03 2016-02-10 Kapa Biosystems, Inc. Chimeric dna polymerases
CA2742594C (en) 2008-11-03 2020-03-24 William Bourn Modified type a dna polymerases
US9315787B2 (en) 2011-01-14 2016-04-19 Kapa Biosystems, Inc. Modified DNA polymerases for improved amplification
CN102392000A (zh) * 2011-11-07 2012-03-28 李志茹 一种耐高温Pyrolobus聚合酶及其高效表达质粒和应用
CN103898077B (zh) 2012-12-24 2017-01-11 财团法人工业技术研究院 单离的脱氧核糖核酸聚合酶、套组及其应用
CN104250641B (zh) * 2013-06-28 2017-09-01 北京福安华生物科技有限公司 一种高保真dna聚合酶及其制备和应用
JP6428997B2 (ja) * 2013-08-06 2018-11-28 東洋紡株式会社 核酸増幅法
US9765309B2 (en) * 2014-06-27 2017-09-19 Illumina, Inc. Modified polymerases for improved incorporation of nucleotide analogues
US9963687B2 (en) 2014-08-27 2018-05-08 New England Biolabs, Inc. Fusion polymerase and method for using the same
CN113584015B (zh) * 2014-08-27 2025-05-02 新英格兰生物实验室公司 合成子的形成
EP3218471A1 (en) * 2014-11-14 2017-09-20 Illumina, Inc. Polymerases
JP6619152B2 (ja) * 2015-05-08 2019-12-11 国立研究開発法人産業技術総合研究所 フラビンアデニンジヌクレオチド依存型グルコース脱水素酵素活性を有するキメラタンパク質
CN106867978A (zh) * 2015-12-10 2017-06-20 江苏众红生物工程创药研究院有限公司 一种重组高保真dna聚合酶及其编码基因和表达方法
JP6980375B2 (ja) * 2015-12-11 2021-12-15 東洋紡株式会社 核酸増幅用試薬及び核酸増幅法
JP6969089B2 (ja) * 2015-12-11 2021-11-24 東洋紡株式会社 核酸増幅用組成物及び核酸増幅法
EP3402880B1 (en) 2016-01-15 2024-01-03 Thermo Fisher Scientific Baltics UAB Thermophilic dna polymerase mutants
JP6934477B2 (ja) 2016-01-19 2021-09-15 ボード オブ リージェンツ ザ ユニヴァーシティ オブ テキサス システム 熱安定逆転写酵素
US20190176153A1 (en) 2016-05-18 2019-06-13 Roche Sequencing Solutions, Inc. Quantitative real time pcr amplification using an electrowetting-based device
FR3052462A1 (fr) * 2016-06-14 2017-12-15 Dna Script Variants d'une adn polymerase de la famille polx
CN106011100A (zh) * 2016-08-08 2016-10-12 吴江近岸蛋白质科技有限公司 一种Pfu DNA聚合酶及其制备方法
US11312944B2 (en) * 2016-12-19 2022-04-26 Quantum-Si Incorporated Polymerizing enzymes for sequencing reactions
CN106754816B (zh) * 2017-02-24 2020-10-27 依科赛生物科技(太仓)有限公司 一种高保真快速扩增融合酶及其制备方法
EP3645710A1 (en) 2017-06-26 2020-05-06 Thermo Fisher Scientific Baltics Uab Thermophilic dna polymerase mutants
AU2018292105B2 (en) 2017-06-30 2024-12-12 Codexis, Inc. T7 RNA polymerase variants
RU2020103727A (ru) 2017-06-30 2021-07-30 Кодексис, Инк. Варианты рнк-полимеразы т7
JP6986299B2 (ja) * 2017-07-12 2021-12-22 ジーンキャスト カンパニー リミテッドGenecast Co., Ltd. 遺伝子変異特異性が増加したdna重合酵素およびその活性増加用pcrバッファー組成物
US11866785B2 (en) 2017-10-27 2024-01-09 Board Of Regents, The University Of Texas System Tumor specific antibodies and T-cell receptors and methods of identifying the same
CN111684064A (zh) 2018-01-19 2020-09-18 生物辐射实验室股份有限公司 突变dna聚合酶
WO2020047695A1 (zh) * 2018-09-03 2020-03-12 深圳华大生命科学研究院 重组型kod聚合酶
AU2019374098B2 (en) * 2018-10-31 2025-10-16 Illumina Singapore Pte. Ltd. Polymerases, compositions, and methods of use
KR20210098844A (ko) 2018-12-05 2021-08-11 일루미나, 인코포레이티드 중합효소, 조성물, 및 사용 방법
CN109628424B (zh) * 2018-12-31 2022-04-26 苏州近岸蛋白质科技股份有限公司 一种新型嵌合dna聚合酶及其制备方法
WO2020144480A1 (en) * 2019-01-09 2020-07-16 3Cr Bioscience Ltd. Method for detecting a nucleic acid sequence
GB2587177A (en) * 2019-01-09 2021-03-24 3Cr Bioscience Ltd Polymerase
BR112021026484A2 (pt) 2019-06-28 2022-04-12 Quantum Si Inc Polimerização de enzimas para reações de sequenciamento
US20240200040A1 (en) * 2019-12-23 2024-06-20 Bgi Shenzhen Chimeric dna polymerase and application thereof
US20230086471A1 (en) * 2020-02-15 2023-03-23 Agency For Science, Technology And Research A method to amplify a nucleic acid
CN113604450B (zh) * 2021-08-18 2023-08-18 华南理工大学 一种kod dna聚合酶突变体及其制备方法与应用
CN113755465A (zh) * 2021-09-23 2021-12-07 武汉爱博泰克生物科技有限公司 嵌合体dna聚合酶及其制备方法
WO2023082266A1 (zh) * 2021-11-15 2023-05-19 深圳华大生命科学研究院 嵌合dna聚合酶及其应用
CN119736271A (zh) * 2024-12-27 2025-04-01 安序源生物科技(深圳)有限公司 一种phi29 DNA聚合酶突变体及其用途

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4800159A (en) 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences
US5079352A (en) 1986-08-22 1992-01-07 Cetus Corporation Purified thermostable enzyme
US4889818A (en) 1986-08-22 1989-12-26 Cetus Corporation Purified thermostable enzyme
US5075216A (en) 1988-09-23 1991-12-24 Cetus Corporation Methods for dna sequencing with thermus aquaticus dna polymerase
US5066584A (en) 1988-09-23 1991-11-19 Cetus Corporation Methods for generating single stranded dna by the polymerase chain reaction
US5091310A (en) 1988-09-23 1992-02-25 Cetus Corporation Structure-independent dna amplification by the polymerase chain reaction
US5023171A (en) 1989-08-10 1991-06-11 Mayo Foundation For Medical Education And Research Method for gene splicing by overlap extension using the polymerase chain reaction
US5104792A (en) 1989-12-21 1992-04-14 The United States Of America As Represented By The Department Of Health And Human Services Method for amplifying unknown nucleic acid sequences
US5948663A (en) 1990-12-03 1999-09-07 Stratagene Purified thermostable pyrococcus furiosus DNA polymerase I
US5866395A (en) 1990-12-03 1999-02-02 Stratagene Purified thermostable pyrococcus furiosus DNA polymerase I
US5545552A (en) 1990-12-03 1996-08-13 Stratagene Purified thermostable pyrococcus furiosus DNA polymerase I
EP0547359B1 (en) 1991-12-18 2002-03-27 New England Biolabs, Inc. Purified thermostable dna polymerase obtainable from pyrococcus species
US5556772A (en) 1993-12-08 1996-09-17 Stratagene Polymerase compositions and uses thereof
JP3132624B2 (ja) 1994-05-09 2001-02-05 東洋紡績株式会社 超好熱始原菌由来のdnaポリメラーゼ遺伝子およびその用途
US6033859A (en) * 1996-05-24 2000-03-07 Toyo Boseki Kabushiki Kaisha Thermostable DNA polymerase from a hyperthermophilic archaeon strain KOD1
EP1564288B1 (en) 1997-01-31 2010-04-07 Japan Science and Technology Agency Function-modified thermophilic DNA polymerase
DE19810879A1 (de) 1998-03-13 1999-09-16 Roche Diagnostics Gmbh Polymerasenchimären
PT1112077E (pt) 1998-08-18 2011-03-16 Dermtech Int Método para detecção de factores biológicos na epiderme
GB9921318D0 (en) * 1999-09-09 1999-11-10 Kristensen Tom Chimeric molecules
US20050123940A1 (en) 1999-10-29 2005-06-09 Stratagene California Compositions and methods for synthesizing cDNA
EP1226255B1 (en) 1999-10-29 2006-03-29 Stratagene California Compositions and methods utilizing dna polymerases
EP1259624B1 (en) * 2000-02-17 2008-05-14 Qiagen GmbH Thermostable chimeric nucleic acid polymerases and uses thereof
EP1154017B1 (en) 2000-05-11 2010-01-20 Toyo Boseki Kabushiki Kaisha Modified thermostable dna polymerase from pyrococcus kodakarensis
US6627424B1 (en) 2000-05-26 2003-09-30 Mj Bioworks, Inc. Nucleic acid modifying enzymes
JP2004502443A (ja) 2000-07-12 2004-01-29 インヴィトロジェン コーポレーション 高忠実度ポリメラーゼおよびその使用方法
GB2382321A (en) 2001-11-21 2003-05-28 Doyen Medipharm Ltd Process and apparatus for cutting sheets
US7960157B2 (en) * 2002-12-20 2011-06-14 Agilent Technologies, Inc. DNA polymerase blends and uses thereof
US7704712B2 (en) 2003-03-25 2010-04-27 Stratagene California DNA polymerase fusions and uses thereof
US20040244310A1 (en) 2003-03-28 2004-12-09 Blumberg Marvin R. Data center
CA2567563A1 (en) * 2004-05-20 2005-12-01 The Government Of The United States Of America, As Represented By The Se Cretary Of The Department Of Health And Human Services Thermostable y-family polymerases and chimeras
EP1888743B1 (en) 2005-05-10 2011-08-03 Illumina Cambridge Limited Improved polymerases
US20070190538A1 (en) 2005-07-29 2007-08-16 Applera Corporation Chimeric polymerases
US8921086B2 (en) 2005-12-22 2014-12-30 Pacific Biosciences Of California, Inc. Polymerases for nucleotide analogue incorporation
JP2007298879A (ja) 2006-05-02 2007-11-15 C & C:Kk ストロボ装置
US8962293B2 (en) 2006-10-18 2015-02-24 Roche Molecular Systems, Inc. DNA polymerases and related methods
WO2008051530A2 (en) 2006-10-23 2008-05-02 Pacific Biosciences Of California, Inc. Polymerase enzymes and reagents for enhanced nucleic acid sequencing
EP2352818B1 (en) 2008-11-03 2016-02-10 Kapa Biosystems, Inc. Chimeric dna polymerases
WO2010062779A2 (en) 2008-11-03 2010-06-03 Kapabiosystems Modified dna polymerases
JP5328696B2 (ja) 2010-03-01 2013-10-30 淀川ヒューテック株式会社 複層ベルト

Similar Documents

Publication Publication Date Title
JP2015154787A5 (OSRAM)
FI3526323T3 (fi) Hepatiitti B -viruksen genomissa oleville tunnistussekvensseille spesifisiä muokattuja meganukleaaseja
CA3062698A1 (en) Nucleic acid molecules encoding an engineered antigen receptor and an inhibitory nucleic acid molecule and methods of use thereof
JP2019519216A5 (OSRAM)
SA517381912B1 (ar) "عناصر تنظيمية معدلة بعد الانتساخ لعلاج الالتهاب الكبدي pre
JP2019530462A5 (OSRAM)
WO2014202616A3 (en) Rasamsonia gene and use thereof
JP2018138049A5 (OSRAM)
WO2013182910A3 (en) Transcription activator-like effector (tale) fusion protein
JP2017518750A5 (OSRAM)
JP2017518072A5 (OSRAM)
JP2013048638A5 (OSRAM)
JP2018531624A5 (OSRAM)
WO2013082519A3 (en) Nucleotide-specific recognition sequences for designer tal effectors
WO2010062776A3 (en) Chimeric dna polymerases
JP2013530689A5 (OSRAM)
MX2018006471A (es) Polipeptidos que tienen actividad de beta-glucanasa, polinucleotidos que los codifican y usos de los mismos en composiciones de limpieza y detergentes.
JP2014000092A5 (OSRAM)
JP2016185981A5 (OSRAM)
JP2015524422A5 (OSRAM)
JP2018046876A5 (OSRAM)
EA201990884A1 (ru) АНТИ-C1s АНТИТЕЛА И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
EA201792080A1 (ru) Гуманизированные анти-c1s антитела и способы их применения
CN109937252A (zh) 重组dna聚合酶
JP2015509091A5 (OSRAM)