JP2015078203A5 - - Google Patents
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- JP2015078203A5 JP2015078203A5 JP2014237428A JP2014237428A JP2015078203A5 JP 2015078203 A5 JP2015078203 A5 JP 2015078203A5 JP 2014237428 A JP2014237428 A JP 2014237428A JP 2014237428 A JP2014237428 A JP 2014237428A JP 2015078203 A5 JP2015078203 A5 JP 2015078203A5
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- JP
- Japan
- Prior art keywords
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- Prior art date
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- 239000000203 mixture Substances 0.000 claims 18
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 claims 4
- 241000193998 Streptococcus pneumoniae Species 0.000 claims 4
- 229940031000 streptococcus pneumoniae Drugs 0.000 claims 4
- 229960004099 azithromycin Drugs 0.000 claims 3
- MQTOSJVFKKJCRP-BICOPXKESA-N azithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 MQTOSJVFKKJCRP-BICOPXKESA-N 0.000 claims 3
- 229910052731 fluorine Inorganic materials 0.000 claims 3
- 239000011737 fluorine Chemical group 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 3
- 239000003835 ketolide antibiotic agent Substances 0.000 claims 3
- 241000894006 Bacteria Species 0.000 claims 2
- 229930186147 Cephalosporin Natural products 0.000 claims 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 2
- 229930182555 Penicillin Natural products 0.000 claims 2
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 claims 2
- 102000002278 Ribosomal Proteins Human genes 0.000 claims 2
- 108010000605 Ribosomal Proteins Proteins 0.000 claims 2
- 241000194017 Streptococcus Species 0.000 claims 2
- 239000004098 Tetracycline Substances 0.000 claims 2
- 108010059993 Vancomycin Proteins 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 229940124587 cephalosporin Drugs 0.000 claims 2
- 150000001780 cephalosporins Chemical class 0.000 claims 2
- 229960002227 clindamycin Drugs 0.000 claims 2
- KDLRVYVGXIQJDK-AWPVFWJPSA-N clindamycin Chemical compound CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@H](C)Cl)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O1 KDLRVYVGXIQJDK-AWPVFWJPSA-N 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 229960003276 erythromycin Drugs 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 230000035772 mutation Effects 0.000 claims 2
- 229940049954 penicillin Drugs 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical compound C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 claims 2
- 125000003107 substituted aryl group Chemical group 0.000 claims 2
- 229960005404 sulfamethoxazole Drugs 0.000 claims 2
- JLKIGFTWXXRPMT-UHFFFAOYSA-N sulphamethoxazole Chemical compound O1C(C)=CC(NS(=O)(=O)C=2C=CC(N)=CC=2)=N1 JLKIGFTWXXRPMT-UHFFFAOYSA-N 0.000 claims 2
- 229960002180 tetracycline Drugs 0.000 claims 2
- 229930101283 tetracycline Natural products 0.000 claims 2
- 235000019364 tetracycline Nutrition 0.000 claims 2
- 150000003522 tetracyclines Chemical class 0.000 claims 2
- 229960001082 trimethoprim Drugs 0.000 claims 2
- IEDVJHCEMCRBQM-UHFFFAOYSA-N trimethoprim Chemical compound COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 IEDVJHCEMCRBQM-UHFFFAOYSA-N 0.000 claims 2
- 229960003165 vancomycin Drugs 0.000 claims 2
- MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 claims 2
- MYPYJXKWCTUITO-LYRMYLQWSA-O vancomycin(1+) Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C([O-])=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)[NH2+]C)[C@H]1C[C@](C)([NH3+])[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-O 0.000 claims 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 241000606161 Chlamydia Species 0.000 claims 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 1
- 241000204031 Mycoplasma Species 0.000 claims 1
- 241000331201 Nocardia pneumoniae Species 0.000 claims 1
- 241000295644 Staphylococcaceae Species 0.000 claims 1
- 206010041925 Staphylococcal infections Diseases 0.000 claims 1
- 241000202898 Ureaplasma Species 0.000 claims 1
- KPCZJLGGXRGYIE-UHFFFAOYSA-N [C]1=CC=CN=C1 Chemical group [C]1=CC=CN=C1 KPCZJLGGXRGYIE-UHFFFAOYSA-N 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 125000004423 acyloxy group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000002877 alkyl aryl group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000005001 aminoaryl group Chemical group 0.000 claims 1
- 230000000844 anti-bacterial effect Effects 0.000 claims 1
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 1
- 229910052794 bromium Inorganic materials 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 239000000460 chlorine Chemical group 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 125000004404 heteroalkyl group Chemical group 0.000 claims 1
- 206010022000 influenza Diseases 0.000 claims 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical group II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 208000015688 methicillin-resistant staphylococcus aureus infectious disease Diseases 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- -1 ureido, carbamoyl Chemical group 0.000 claims 1
Applications Claiming Priority (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10813408P | 2008-10-24 | 2008-10-24 | |
| US10811008P | 2008-10-24 | 2008-10-24 | |
| US10813708P | 2008-10-24 | 2008-10-24 | |
| US10811208P | 2008-10-24 | 2008-10-24 | |
| US10816808P | 2008-10-24 | 2008-10-24 | |
| US61/108,168 | 2008-10-24 | ||
| US61/108,110 | 2008-10-24 | ||
| US61/108,112 | 2008-10-24 | ||
| US61/108,137 | 2008-10-24 | ||
| US61/108,134 | 2008-10-24 | ||
| US16210909P | 2009-03-20 | 2009-03-20 | |
| US61/162,109 | 2009-03-20 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011533398A Division JP5715569B2 (ja) | 2008-10-24 | 2009-10-24 | トリアゾール含有マクロライドを用いた耐性疾患の治療方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016080557A Division JP6309995B2 (ja) | 2008-10-24 | 2016-04-13 | トリアゾール含有マクロライドを用いた耐性疾患の治療方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015078203A JP2015078203A (ja) | 2015-04-23 |
| JP2015078203A5 true JP2015078203A5 (OSRAM) | 2015-07-09 |
| JP5922210B2 JP5922210B2 (ja) | 2016-05-24 |
Family
ID=42119711
Family Applications (10)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011533397A Expired - Fee Related JP5711135B2 (ja) | 2008-10-24 | 2009-10-24 | 胃腸疾患を治療するための方法 |
| JP2011533398A Active JP5715569B2 (ja) | 2008-10-24 | 2009-10-24 | トリアゾール含有マクロライドを用いた耐性疾患の治療方法 |
| JP2011533399A Expired - Fee Related JP5602748B2 (ja) | 2008-10-24 | 2009-10-24 | トリアゾール含有マクロライドを用いた生体防御 |
| JP2014167991A Expired - Fee Related JP6002185B2 (ja) | 2008-10-24 | 2014-08-20 | トリアゾール含有マクロライドを用いた生体防御 |
| JP2014237428A Active JP5922210B2 (ja) | 2008-10-24 | 2014-11-25 | トリアゾール含有マクロライドを用いた耐性疾患の治療方法 |
| JP2014237346A Active JP5908569B2 (ja) | 2008-10-24 | 2014-11-25 | 胃腸疾患を治療するための方法 |
| JP2016080557A Active JP6309995B2 (ja) | 2008-10-24 | 2016-04-13 | トリアゾール含有マクロライドを用いた耐性疾患の治療方法 |
| JP2018047869A Pending JP2018115177A (ja) | 2008-10-24 | 2018-03-15 | トリアゾール含有マクロライドを用いた耐性疾患の治療方法 |
| JP2019189322A Pending JP2020023544A (ja) | 2008-10-24 | 2019-10-16 | トリアゾール含有マクロライドを用いた耐性疾患の治療方法 |
| JP2021146793A Active JP7171860B2 (ja) | 2008-10-24 | 2021-09-09 | トリアゾール含有マクロライドを用いた耐性疾患の治療方法 |
Family Applications Before (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011533397A Expired - Fee Related JP5711135B2 (ja) | 2008-10-24 | 2009-10-24 | 胃腸疾患を治療するための方法 |
| JP2011533398A Active JP5715569B2 (ja) | 2008-10-24 | 2009-10-24 | トリアゾール含有マクロライドを用いた耐性疾患の治療方法 |
| JP2011533399A Expired - Fee Related JP5602748B2 (ja) | 2008-10-24 | 2009-10-24 | トリアゾール含有マクロライドを用いた生体防御 |
| JP2014167991A Expired - Fee Related JP6002185B2 (ja) | 2008-10-24 | 2014-08-20 | トリアゾール含有マクロライドを用いた生体防御 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014237346A Active JP5908569B2 (ja) | 2008-10-24 | 2014-11-25 | 胃腸疾患を治療するための方法 |
| JP2016080557A Active JP6309995B2 (ja) | 2008-10-24 | 2016-04-13 | トリアゾール含有マクロライドを用いた耐性疾患の治療方法 |
| JP2018047869A Pending JP2018115177A (ja) | 2008-10-24 | 2018-03-15 | トリアゾール含有マクロライドを用いた耐性疾患の治療方法 |
| JP2019189322A Pending JP2020023544A (ja) | 2008-10-24 | 2019-10-16 | トリアゾール含有マクロライドを用いた耐性疾患の治療方法 |
| JP2021146793A Active JP7171860B2 (ja) | 2008-10-24 | 2021-09-09 | トリアゾール含有マクロライドを用いた耐性疾患の治療方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (7) | US9072759B2 (OSRAM) |
| EP (4) | EP2365747B1 (OSRAM) |
| JP (10) | JP5711135B2 (OSRAM) |
| CN (4) | CN102223794B (OSRAM) |
| AU (4) | AU2009308181B2 (OSRAM) |
| DK (1) | DK2358379T3 (OSRAM) |
| ES (3) | ES2677007T3 (OSRAM) |
| HK (1) | HK1252140A1 (OSRAM) |
| HR (1) | HRP20160222T1 (OSRAM) |
| SI (1) | SI2358379T1 (OSRAM) |
| WO (3) | WO2010048599A1 (OSRAM) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3738591A3 (en) | 2003-03-10 | 2021-03-24 | Merck Sharp & Dohme Corp. | Novel antibacterial agents |
| AU2008316830B2 (en) | 2007-10-25 | 2016-03-17 | Cempra Pharmaceuticals, Inc. | Process for the preparation of macrolide antibacterial agents |
| US9072759B2 (en) | 2008-10-24 | 2015-07-07 | Cempra Pharmaceuticals, Inc. | Biodefenses using triazole-containing macrolides |
| US9937194B1 (en) | 2009-06-12 | 2018-04-10 | Cempra Pharmaceuticals, Inc. | Compounds and methods for treating inflammatory diseases |
| ES2608285T3 (es) | 2009-09-10 | 2017-04-07 | Cempra Pharmaceuticals, Inc. | Procedimientos para el tratamiento de paludismo, tuberculosis y enfermedades por MAC |
| ES2564097T3 (es) * | 2010-03-22 | 2016-03-17 | Cempra Pharmaceuticals, Inc. | Formas cristalinas de un macrólido, y usos de las mismas |
| ES2636948T3 (es) * | 2010-05-20 | 2017-10-10 | Cempra Pharmaceuticals, Inc. | Procesos para preparar macrólidos y cetólidos e intermediarios para los mismos |
| WO2012034058A1 (en) * | 2010-09-10 | 2012-03-15 | Cempra Pharmaceuticals, Inc. | Hydrogen bond forming fluoro ketolides for treating diseases |
| IN2014DN08939A (OSRAM) | 2012-03-27 | 2015-05-22 | Cempra Pharmaceuticals Inc | |
| CN105163785A (zh) | 2013-03-14 | 2015-12-16 | 森普拉制药公司 | 用于治疗呼吸道疾病的方法及其制剂 |
| RU2015138797A (ru) | 2013-03-15 | 2017-04-24 | Семпра Фармасьютикалс, Инк. | Конвергентные способы получения макролидных антибактериальных агентов |
| MX377459B (es) | 2013-04-04 | 2025-03-10 | Harvard College | Macrolidos y metodos para su preparacion y uso. |
| CN104151382B (zh) * | 2014-08-08 | 2016-09-14 | 广东东阳光药业有限公司 | 一种固态大环内酯的晶型 |
| CN104311611B (zh) * | 2014-08-13 | 2017-01-18 | 广东东阳光药业有限公司 | 一种制备固态大环内酯的方法 |
| WO2016057798A1 (en) | 2014-10-08 | 2016-04-14 | President And Fellows Of Harvard College | 14-membered ketolides and methods of their preparation and use |
| CN107530365A (zh) * | 2015-03-25 | 2018-01-02 | 哈佛大学的校长及成员们 | 具有修饰的脱氧糖胺糖的大环内酯及其用途 |
| CN106554992A (zh) * | 2015-09-28 | 2017-04-05 | 中国疾病预防控制中心传染病预防控制所 | 检测耐红霉素弯曲菌的试剂盒 |
| BR112019017223A2 (pt) * | 2017-02-17 | 2020-04-14 | Cempra Pharmaceuticals Inc | macrolídeos contendo triazol e seus usos oftálmicos |
| US10706191B2 (en) * | 2017-08-31 | 2020-07-07 | Google Llc | Systems and methods for generating a geo-level hierarchical Bayesian model |
| US11145299B2 (en) | 2018-04-19 | 2021-10-12 | X Development Llc | Managing voice interface devices |
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