JP2014534218A5 - - Google Patents
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- JP2014534218A5 JP2014534218A5 JP2014538927A JP2014538927A JP2014534218A5 JP 2014534218 A5 JP2014534218 A5 JP 2014534218A5 JP 2014538927 A JP2014538927 A JP 2014538927A JP 2014538927 A JP2014538927 A JP 2014538927A JP 2014534218 A5 JP2014534218 A5 JP 2014534218A5
- Authority
- JP
- Japan
- Prior art keywords
- binding protein
- tnf
- fragment
- seq
- region
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 102000024070 binding proteins Human genes 0.000 claims 39
- 108091007650 binding proteins Proteins 0.000 claims 39
- 102100009534 TNF Human genes 0.000 claims 26
- 108010001801 Tumor Necrosis Factor-alpha Proteins 0.000 claims 21
- 230000001809 detectable Effects 0.000 claims 9
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- 230000001419 dependent Effects 0.000 claims 5
- 201000010099 disease Diseases 0.000 claims 5
- 230000000694 effects Effects 0.000 claims 4
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 3
- 230000001363 autoimmune Effects 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 201000009910 diseases by infectious agent Diseases 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- -1 scFv Proteins 0.000 claims 3
- 208000006673 Asthma Diseases 0.000 claims 2
- 206010011401 Crohn's disease Diseases 0.000 claims 2
- 230000035693 Fab Effects 0.000 claims 2
- 206010016654 Fibrosis Diseases 0.000 claims 2
- 206010061218 Inflammation Diseases 0.000 claims 2
- 206010021972 Inflammatory bowel disease Diseases 0.000 claims 2
- 210000004185 Liver Anatomy 0.000 claims 2
- 241000725643 Respiratory syncytial virus Species 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 2
- 102000004965 antibodies Human genes 0.000 claims 2
- 108090001123 antibodies Proteins 0.000 claims 2
- 201000008937 atopic dermatitis Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000004761 fibrosis Effects 0.000 claims 2
- NTYJJOPFIAHURM-UHFFFAOYSA-N histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 claims 2
- 230000028993 immune response Effects 0.000 claims 2
- 238000003018 immunoassay Methods 0.000 claims 2
- 230000002757 inflammatory Effects 0.000 claims 2
- 230000004054 inflammatory process Effects 0.000 claims 2
- 230000000051 modifying Effects 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 230000001681 protective Effects 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 201000004681 psoriasis Diseases 0.000 claims 2
- 108020003175 receptors Proteins 0.000 claims 2
- 102000005962 receptors Human genes 0.000 claims 2
- 230000001629 suppression Effects 0.000 claims 2
- PMATZTZNYRCHOR-CGLBZJNRSA-N (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-[(E,1R,2R)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17 Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 1
- XEYBRNLFEZDVAW-ARSRFYASSA-N (5Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-5-oxocyclopentyl]hept-5-enoic acid Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O XEYBRNLFEZDVAW-ARSRFYASSA-N 0.000 claims 1
- 206010002368 Anger Diseases 0.000 claims 1
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- 108060001001 BRK1 Proteins 0.000 claims 1
- 206010060945 Bacterial infection Diseases 0.000 claims 1
- 206010051728 Bone erosion Diseases 0.000 claims 1
- QXZGBUJJYSLZLT-FDISYFBBSA-N Bradykinin Chemical compound NC(=N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(=O)NCC(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CO)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)CCC1 QXZGBUJJYSLZLT-FDISYFBBSA-N 0.000 claims 1
- 101700017623 CALCA Proteins 0.000 claims 1
- 101700041770 CALCR Proteins 0.000 claims 1
- 206010007710 Cartilage injury Diseases 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 229940119017 Cyclosporine Drugs 0.000 claims 1
- 108010036949 Cyclosporine Proteins 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- STQGQHZAVUOBTE-VGBVRHCVSA-N DAUNOMYCIN Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 claims 1
- 206010012438 Dermatitis atopic Diseases 0.000 claims 1
- 230000035687 Dissociation Rate Constant Effects 0.000 claims 1
- 230000036947 Dissociation constant Effects 0.000 claims 1
- 208000005679 Eczema Diseases 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 206010014950 Eosinophilia Diseases 0.000 claims 1
- 208000005577 Gastroenteritis Diseases 0.000 claims 1
- 210000001035 Gastrointestinal Tract Anatomy 0.000 claims 1
- 208000005017 Glioblastoma Diseases 0.000 claims 1
- 102000003676 Glucocorticoid Receptors Human genes 0.000 claims 1
- 108090000079 Glucocorticoid Receptors Proteins 0.000 claims 1
- 208000002672 Hepatitis B Diseases 0.000 claims 1
- 208000005176 Hepatitis C Diseases 0.000 claims 1
- 206010073071 Hepatocellular carcinoma Diseases 0.000 claims 1
- 102000000543 Histamine receptors Human genes 0.000 claims 1
- 108010002059 Histamine receptors Proteins 0.000 claims 1
- 206010020243 Hodgkin's disease Diseases 0.000 claims 1
- 201000006743 Hodgkin's lymphoma Diseases 0.000 claims 1
- 241000714260 Human T-lymphotropic virus 1 Species 0.000 claims 1
- 206010048643 Hypereosinophilic syndrome Diseases 0.000 claims 1
- 102100018955 IL1A Human genes 0.000 claims 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
- 108060003951 Immunoglobulins Proteins 0.000 claims 1
- 102000018358 Immunoglobulins Human genes 0.000 claims 1
- 108010082786 Interleukin-1alpha Proteins 0.000 claims 1
- 208000003456 Juvenile Arthritis Diseases 0.000 claims 1
- 206010059176 Juvenile idiopathic arthritis Diseases 0.000 claims 1
- 102100011311 KNG1 Human genes 0.000 claims 1
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 206010025310 Other lymphomas Diseases 0.000 claims 1
- 102100012897 PGF Human genes 0.000 claims 1
- 101710014083 PGF Proteins 0.000 claims 1
- 208000006551 Parasitic Disease Diseases 0.000 claims 1
- 206010037162 Psoriatic arthropathy Diseases 0.000 claims 1
- 208000005069 Pulmonary Fibrosis Diseases 0.000 claims 1
- 206010039073 Rheumatoid arthritis Diseases 0.000 claims 1
- 206010039085 Rhinitis allergic Diseases 0.000 claims 1
- 102100003386 S100A12 Human genes 0.000 claims 1
- 101710023382 S100A12 Proteins 0.000 claims 1
- 206010039710 Scleroderma Diseases 0.000 claims 1
- QFJCIRLUMZQUOT-HPLJOQBZSA-N Sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims 1
- QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 claims 1
- 231100000765 Toxin Toxicity 0.000 claims 1
- 206010046736 Urticarias Diseases 0.000 claims 1
- 102100015249 VEGFA Human genes 0.000 claims 1
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 claims 1
- 239000002168 alkylating agent Substances 0.000 claims 1
- 230000000172 allergic Effects 0.000 claims 1
- 201000010105 allergic rhinitis Diseases 0.000 claims 1
- 239000004037 angiogenesis inhibitor Substances 0.000 claims 1
- 230000000340 anti-metabolite Effects 0.000 claims 1
- 239000002256 antimetabolite Substances 0.000 claims 1
- 230000001640 apoptogenic Effects 0.000 claims 1
- 201000009596 autoimmune hypersensitivity disease Diseases 0.000 claims 1
- 230000003115 biocidal Effects 0.000 claims 1
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 1
- 229960002685 biotin Drugs 0.000 claims 1
- 235000020958 biotin Nutrition 0.000 claims 1
- 239000011616 biotin Substances 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 108091006028 chimera Proteins 0.000 claims 1
- 229960001265 ciclosporin Drugs 0.000 claims 1
- 239000002872 contrast media Substances 0.000 claims 1
- 230000002596 correlated Effects 0.000 claims 1
- 239000003246 corticosteroid Substances 0.000 claims 1
- 201000003883 cystic fibrosis Diseases 0.000 claims 1
- 239000002254 cytotoxic agent Substances 0.000 claims 1
- 201000004624 dermatitis Diseases 0.000 claims 1
- 230000001627 detrimental Effects 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 229960002986 dinoprostone Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 231100001003 eczema Toxicity 0.000 claims 1
- 239000007850 fluorescent dye Substances 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 1
- 229960001340 histamine Drugs 0.000 claims 1
- 200000000018 inflammatory disease Diseases 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 201000002215 juvenile rheumatoid arthritis Diseases 0.000 claims 1
- 229960000485 methotrexate Drugs 0.000 claims 1
- 230000000394 mitotic Effects 0.000 claims 1
- 102000005614 monoclonal antibodies Human genes 0.000 claims 1
- 108010045030 monoclonal antibodies Proteins 0.000 claims 1
- 230000003843 mucus production Effects 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 230000036281 parasite infection Effects 0.000 claims 1
- OZAIFHULBGXAKX-UHFFFAOYSA-N precursor Substances N#CC(C)(C)N=NC(C)(C)C#N OZAIFHULBGXAKX-UHFFFAOYSA-N 0.000 claims 1
- 238000004393 prognosis Methods 0.000 claims 1
- 201000001263 psoriatic arthritis Diseases 0.000 claims 1
- 230000002285 radioactive Effects 0.000 claims 1
- 210000002345 respiratory system Anatomy 0.000 claims 1
- 229960002930 sirolimus Drugs 0.000 claims 1
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 claims 1
- 230000001225 therapeutic Effects 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 201000006704 ulcerative colitis Diseases 0.000 claims 1
- 238000002255 vaccination Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161550587P | 2011-10-24 | 2011-10-24 | |
| US61/550,587 | 2011-10-24 | ||
| PCT/US2012/061690 WO2013063114A1 (en) | 2011-10-24 | 2012-10-24 | Immunobinders directed against tnf |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014534218A JP2014534218A (ja) | 2014-12-18 |
| JP2014534218A5 true JP2014534218A5 (US20080131398A1-20080605-C00009.png) | 2015-12-17 |
Family
ID=47144149
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014538927A Pending JP2014534218A (ja) | 2011-10-24 | 2012-10-24 | Ｔｎｆを標的とする免疫結合剤 |
Country Status (25)
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102741288B (zh) | 2009-08-29 | 2015-08-19 | Abbvie公司 | 治疗用dll4结合蛋白 |
| AU2011223919B2 (en) | 2010-03-02 | 2015-03-19 | Abbvie Inc. | Therapeutic DLL4 binding proteins |
| WO2012018790A2 (en) | 2010-08-03 | 2012-02-09 | Abbott Laboratories | Dual variable domain immunoglobulins and uses thereof |
| AR083495A1 (es) | 2010-10-22 | 2013-02-27 | Esbatech Alcon Biomed Res Unit | Anticuerpos estables y solubles |
| AR084210A1 (es) | 2010-12-08 | 2013-05-02 | Abbott Lab | PROTEINAS DE UNION AL TNF-a |
| RU2014120981A (ru) | 2011-10-24 | 2015-12-10 | Эббви Инк. | Иммунные связывающие агенты против склеростина |
| EP2771361A1 (en) | 2011-10-24 | 2014-09-03 | AbbVie Inc. | Bispecific immunobinders directed against tnf and il-17 |
| IN2014CN03936A (US20080131398A1-20080605-C00009.png) | 2011-10-24 | 2015-09-04 | Abbvie Inc | |
| KR20210111353A (ko) | 2012-11-01 | 2021-09-10 | 애브비 인코포레이티드 | 항-ｖｅｇｆ／ｄｌｌ4 이원 가변 도메인 면역글로불린 및 이의 용도 |
| US9458244B2 (en) | 2012-12-28 | 2016-10-04 | Abbvie Inc. | Single chain multivalent binding protein compositions and methods |
| MX2015008446A (es) | 2012-12-28 | 2016-10-26 | Abbvie Inc | Composiciones de proteinas de union multivalentes. |
| WO2015057910A1 (en) | 2013-10-16 | 2015-04-23 | Oncobiologics, Inc. | Buffer formulations for enhanced antibody stability |
| WO2015191760A2 (en) | 2014-06-10 | 2015-12-17 | Abbvie, Inc. | Compositions and methods for treating rheumatoid arthritis |
| WO2016094881A2 (en) | 2014-12-11 | 2016-06-16 | Abbvie Inc. | Lrp-8 binding proteins |
| WO2016118707A1 (en) | 2015-01-21 | 2016-07-28 | Oncobiologics, Inc. | Modulation of charge variants in a monoclonal antibody composition |
| TW201710286A (zh) | 2015-06-15 | 2017-03-16 | 艾伯維有限公司 | 抗ｖｅｇｆ、ｐｄｇｆ及／或其受體之結合蛋白 |
| AR104847A1 (es) | 2015-06-17 | 2017-08-16 | Lilly Co Eli | Formulación de anticuerpo anti-cgrp |
| JP2018533620A (ja) * | 2015-09-14 | 2018-11-15 | ギャラクシー・バイオテック・リミテッド・ライアビリティ・カンパニーＧａｌａｘｙ Ｂｉｏｔｅｃｈ， ＬＬＣ | 血管新生因子に対する高力価のモノクローナル抗体 |
| US10988543B2 (en) | 2015-11-11 | 2021-04-27 | Opi Vi—Ip Holdco Llc | Humanized anti-tumor necrosis factor alpha receptor 2 (anti-TNFR2) antibodies and methods of use thereof to elicit an immune response against a tumor |
| GB201522394D0 (en) | 2015-12-18 | 2016-02-03 | Ucb Biopharma Sprl | Antibodies |
| WO2017136433A1 (en) | 2016-02-03 | 2017-08-10 | Oncobiologics, Inc. | Buffer formulations for enhanced antibody stability |
| KR20220119529A (ko) | 2016-06-02 | 2022-08-29 | 애브비 인코포레이티드 | 글루코코르티코이드 수용체 작용제 및 이의 면역접합체 |
| KR20190082263A (ko) | 2016-11-02 | 2019-07-09 | 나노프로테아젠 | 중합체 나노입자 |
| CN107903323B (zh) * | 2017-11-15 | 2020-04-17 | 中国药科大学 | 抗hTNF-α全人源抗体及其用途 |
| ES2877659T3 (es) | 2017-12-01 | 2021-11-17 | Abbvie Inc | Agonista del receptor de glucocorticoides y sus inmunoconjugados |
| WO2023205739A2 (en) * | 2022-04-20 | 2023-10-26 | Senti Biosciences, Inc. | Antigen-binding domains and methods of use thereof |
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- 2012-10-24 PE PE2014000587A patent/PE20141545A1/es not_active Application Discontinuation
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- 2012-10-24 US US13/659,658 patent/US9803009B2/en not_active Expired - Fee Related
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2013
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2014
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2015
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