JP2014533259A - カリウムチャネル阻害剤として有用なチエノおよびフロピリミジンならびにピリジン - Google Patents

カリウムチャネル阻害剤として有用なチエノおよびフロピリミジンならびにピリジン Download PDF

Info

Publication number
JP2014533259A
JP2014533259A JP2014540560A JP2014540560A JP2014533259A JP 2014533259 A JP2014533259 A JP 2014533259A JP 2014540560 A JP2014540560 A JP 2014540560A JP 2014540560 A JP2014540560 A JP 2014540560A JP 2014533259 A JP2014533259 A JP 2014533259A
Authority
JP
Japan
Prior art keywords
alkyl
optionally substituted
thieno
pyrimidin
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2014540560A
Other languages
English (en)
Japanese (ja)
Other versions
JP2014533259A5 (OSRAM
Inventor
マッジ デービッド
マッジ デービッド
チャン フィオナ
チャン フィオナ
エドワード ジョン デレク
エドワード ジョン デレク
ディー エドワーズ サイモン
ディー エドワーズ サイモン
ブラント リチャード
ブラント リチャード
ハートゾウラキス バジル
ハートゾウラキス バジル
ブラウン リンジー
ブラウン リンジー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Xention Ltd
Original Assignee
Xention Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1119703.5A external-priority patent/GB201119703D0/en
Priority claimed from GBGB1214250.1A external-priority patent/GB201214250D0/en
Application filed by Xention Ltd filed Critical Xention Ltd
Publication of JP2014533259A publication Critical patent/JP2014533259A/ja
Publication of JP2014533259A5 publication Critical patent/JP2014533259A5/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2014540560A 2011-11-15 2012-11-15 カリウムチャネル阻害剤として有用なチエノおよびフロピリミジンならびにピリジン Pending JP2014533259A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB1119703.5A GB201119703D0 (en) 2011-11-15 2011-11-15 Compounds
GB1119703.5 2011-11-15
GB1214250.1 2012-08-09
GBGB1214250.1A GB201214250D0 (en) 2012-08-09 2012-08-09 Compounds
PCT/GB2012/052842 WO2013072694A1 (en) 2011-11-15 2012-11-15 Thieno- and furo - pyrimidines and pyridines, useful as potassium channel inhibitors

Publications (2)

Publication Number Publication Date
JP2014533259A true JP2014533259A (ja) 2014-12-11
JP2014533259A5 JP2014533259A5 (OSRAM) 2016-01-14

Family

ID=47222145

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014540560A Pending JP2014533259A (ja) 2011-11-15 2012-11-15 カリウムチャネル阻害剤として有用なチエノおよびフロピリミジンならびにピリジン

Country Status (15)

Country Link
US (2) US9290511B2 (OSRAM)
EP (1) EP2780343A1 (OSRAM)
JP (1) JP2014533259A (OSRAM)
KR (1) KR20140094603A (OSRAM)
CN (1) CN104011054B (OSRAM)
AR (1) AR090037A1 (OSRAM)
AU (1) AU2012338570A1 (OSRAM)
BR (1) BR112014011671A2 (OSRAM)
CA (1) CA2855346A1 (OSRAM)
IN (1) IN2014MN01183A (OSRAM)
MX (1) MX2014005935A (OSRAM)
RU (1) RU2014124101A (OSRAM)
TW (1) TWI498331B (OSRAM)
WO (1) WO2013072694A1 (OSRAM)
ZA (1) ZA201403503B (OSRAM)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018522856A (ja) * 2015-06-23 2018-08-16 レ ラボラトワール セルヴィエ 新規なアミノ酸誘導体、その製造方法、及びそれを含有する医薬組成物
JP2018522855A (ja) * 2015-06-23 2018-08-16 レ ラボラトワール セルヴィエ 新規なヒドロキシエステル誘導体、その調製方法及びそれを含有する医薬組成物
JP2018527297A (ja) * 2015-06-23 2018-09-20 レ ラボラトワール セルヴィエ 新規な二環式誘導体、それらを調製するためのプロセス及びそれらを含有する医薬組成物
JP2018527296A (ja) * 2015-06-23 2018-09-20 レ ラボラトワール セルヴィエ 新規なヒドロキシ酸誘導体、その製造方法、及びそれを含有する医薬組成物
JP2023512113A (ja) * 2019-11-29 2023-03-23 大鵬薬品工業株式会社 Ｋｒａｓ ｇ１２ｄ変異に対して阻害活性を有する化合物
JP2024511101A (ja) * 2021-03-22 2024-03-12 アセシオン ファーマ エイピーエス 新規カリウムチャネル阻害剤

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE038920T2 (hu) 2013-06-06 2018-12-28 Astellas Pharma Inc Benzotiofén vegyület
FR3015483B1 (fr) * 2013-12-23 2016-01-01 Servier Lab Nouveaux derives de thienopyrimidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
RU2545758C1 (ru) * 2014-03-20 2015-04-10 Общество с ограниченной ответственностью "Алион" Бициклические пиримидины или их фармацевтически приемлемые соли-активаторы антиоксидантной программы и их применение в качестве цитопротекторов
US10246464B2 (en) 2014-09-09 2019-04-02 The Regents Of The University Of Michigan Thienopyrimidine and thienopyridine compounds and methods of use thereof
AR104020A1 (es) 2015-06-04 2017-06-21 Kura Oncology Inc Métodos y composiciones para inhibir la interacción de menina con proteínas mill
WO2016197027A1 (en) 2015-06-04 2016-12-08 Kura Oncology, Inc. Methods and compositions for inhibiting the interaction of menin with mll proteins
AU2016378723B2 (en) 2015-12-22 2021-09-30 SHY Therapeutics LLC Compounds for the treatment of cancer and inflammatory disease
MX387806B (es) 2016-03-16 2025-03-19 Kura Oncology Inc Inhibidores biciclicos con puente sustituidos de menina-mll y metodos de uso
SMT202300273T1 (it) * 2016-03-16 2023-09-06 Kura Oncology Inc Derivati di tieno[2,3–d]pirimidina sostituiti come inibitori di menina–mll e metodi d’uso
CN106727587A (zh) * 2016-11-28 2017-05-31 李娜 一种治疗心律失常的药物组合物
KR102590848B1 (ko) 2016-12-28 2023-10-19 다트 뉴로사이언스, 엘엘씨 Pde2 억제제로서 치환된 피라졸로피리미디논 화합물
EA038388B1 (ru) * 2017-01-16 2021-08-19 Кура Онколоджи, Инк. Замещенные ингибиторы менина-mll и способы применения
WO2018175746A1 (en) 2017-03-24 2018-09-27 Kura Oncology, Inc. Methods for treating hematological malignancies and ewing's sarcoma
US11542248B2 (en) 2017-06-08 2023-01-03 Kura Oncology, Inc. Methods and compositions for inhibiting the interaction of menin with MLL proteins
MX2019014875A (es) 2017-06-21 2021-01-29 SHY Therapeutics LLC Compuestos que interaccionan con la superfamilia ras para el tratamiento de cancer, enfermedades inflamatorias, rasopatias y enfermedad fibrotica.
US11098018B2 (en) * 2017-08-14 2021-08-24 Acesion Pharma Aps Potassium channel inhibitors
TW201920170A (zh) 2017-09-20 2019-06-01 美商庫拉腫瘤技術股份有限公司 經取代之menin-mll 抑制劑及使用方法
ES2902365T3 (es) 2017-11-27 2022-03-28 Dart Neuroscience Llc Compuestos de furanopirimidina sustituidos como inhibidores de PDE1
CN108117556A (zh) * 2018-01-15 2018-06-05 王山川 一种细胞周期检查点激酶1抑制剂的合成方法
EP3871673B1 (en) 2018-10-26 2024-01-03 Taiho Pharmaceutical Co., Ltd. Novel indazole compound or salt thereof
US12391705B2 (en) 2018-12-19 2025-08-19 Shy Therapeutics, Llc Compounds that interact with the Ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease
JP7458406B2 (ja) 2018-12-21 2024-03-29 セルジーン コーポレーション Ｒｉｐｋ２のチエノピリジン阻害剤
MX2022005053A (es) 2019-10-28 2022-05-18 Merck Sharp & Dohme Llc Inhibidores de peque?as moleculas de mutante g12c de kras.
US12479834B2 (en) 2019-11-29 2025-11-25 Taiho Pharmaceutical Co., Ltd. Phenol compound or salt thereof
WO2022194191A1 (en) * 2021-03-16 2022-09-22 Guangdong Newopp Biopharmaceuticals Co., Ltd. Heterocyclic compounds as inhibitors of kras g12d
TW202304925A (zh) * 2021-03-26 2023-02-01 美商住友製藥腫瘤公司 （呋喃并嘧啶—４—基）哌𠯤化合物及其用途
CN115006468B (zh) * 2022-06-28 2023-06-06 西安外事学院 一种复方中草药生发液及制备方法
TW202535891A (zh) 2023-10-20 2025-09-16 美商默沙東有限責任公司 Ｋｒａｓ蛋白之小分子抑制劑

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004014850A2 (en) * 2002-08-08 2004-02-19 Predix Pharmaceuticals Holdings, Inc. Substituted aminopyrimidines as neurokinin antagonists
WO2004065391A1 (en) * 2003-01-23 2004-08-05 Almirall Prodesfarma S.A. 4-AMINOTHIENO[2,3-d]PYRIMIDINE-6-CARBONITRILE DERIVATIVES AS PDE7 INHIBITORS
WO2004111057A1 (en) * 2003-06-11 2004-12-23 Xention Discovery Limited Thienopyrimidine derivatives as potassium channel inhibitors
WO2005100365A1 (ja) * 2004-04-12 2005-10-27 Sankyo Company, Limited チエノピリジン誘導体
WO2005121149A1 (en) * 2004-06-10 2005-12-22 Xention Discovery Limited Furanopyrimidine compounds effective as potassium channel inhibitors
WO2006061642A1 (en) * 2004-12-09 2006-06-15 Xention Discovery Limited Compounds
WO2006135639A1 (en) * 2005-06-10 2006-12-21 Janssen Pharmaceutica N.V. Thiξnopyrimidine and thienopyridine derivatives as flt-3 kinase inhibitors
WO2007066127A2 (en) * 2005-12-09 2007-06-14 Xention Limited Thieno ( 3 , 2-c) pyridine compounds
WO2007146284A2 (en) * 2006-06-12 2007-12-21 Vertex Pharmaceuticals Incorporated Thienopyrimidines useful as modulators of ion channels

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4008726A1 (de) 1990-03-19 1991-09-26 Basf Ag Thieno(2,3-d)pyrimidinderivate
EP0452002A3 (en) * 1990-03-30 1992-02-26 Dowelanco Thienopyrimidine derivatives
WO1998008845A1 (en) 1996-08-27 1998-03-05 Novartis Ag Herbicidal s-substituted 1,2,4,6-thiatriazines
WO2004011057A1 (en) 1998-02-07 2004-02-05 Advanced Cardiovascular Systems, Inc. Perfusion dilatation catherer with expanded support coil
JP2001097979A (ja) 1999-07-28 2001-04-10 Takeda Chem Ind Ltd 縮合複素環化合物、その製造法および用途
CZ2002802A3 (cs) 1999-09-17 2003-02-12 Nissan Chemical Industries, Ltd. Benzopyranové deriváty
US6887870B1 (en) 1999-10-12 2005-05-03 Bristol-Myers Squibb Company Heterocyclic sodium/proton exchange inhibitors and method
SE9904738D0 (sv) 1999-12-22 1999-12-22 Astra Pharma Prod Novel compounds
DE10031585A1 (de) * 2000-06-29 2002-01-10 Merck Patent Gmbh 2-Aminoalkyl-thieno[2,3-d]pyrimidine
TW589305B (en) 2001-02-14 2004-06-01 Nissan Chemical Ind Ltd 4-aminobenzopyran derivatives
EP1401823B1 (en) 2001-06-25 2005-10-05 Nissan Chemical Industries, Ltd. Substituted benzopyran derivatives against arrhythmia
WO2003022214A2 (en) 2001-09-06 2003-03-20 Millennium Pharmaceuticals, Inc. Piperazine and homopiperazine compounds
US7427623B2 (en) * 2001-09-11 2008-09-23 Smithkline Beecham Corporation 4-Amino-2,3-disubstituted thieno[2,3-d]pyrimidines and pharmacetical compositions thereof
US20050222175A1 (en) 2004-03-31 2005-10-06 Dhanoa Dale S New piperidinylamino-thieno[2,3-D] pyrimidine compounds
GB0315950D0 (en) * 2003-06-11 2003-08-13 Xention Discovery Ltd Compounds
US7594219B2 (en) 2003-07-24 2009-09-22 International Business Machines Corporation Method and apparatus for monitoring compatibility of software combinations
TWI346112B (en) 2004-02-25 2011-08-01 Nissan Chemical Ind Ltd Benzopyran compound
GB0420719D0 (en) 2004-09-17 2004-10-20 Addex Pharmaceuticals Sa Novel allosteric modulators
KR20140008471A (ko) 2004-10-21 2014-01-21 다우 아그로사이언시즈 엘엘씨 살진균 활성을 갖는 티에노-피리미딘 화합물
US7576212B2 (en) * 2004-12-09 2009-08-18 Xention Limited Thieno[2,3-B] pyridines as potassium channel inhibitors
US7576080B2 (en) 2004-12-23 2009-08-18 Memory Pharmaceuticals Corporation Certain thienopyrimidine derivatives as phosphodiesterase 10 inhibitors
EP1844052A1 (en) 2005-01-26 2007-10-17 Pharmacia & Upjohn Company LLC Thieno[2,3-d]pyrimidine compounds as inhibitors of adp-mediated platelets aggregation
US20080176857A1 (en) 2005-03-25 2008-07-24 Michael Dalton Ennis 4-Piperazinnylthieno[2,3-d]Pyrimidine Compounds as Platelet Aggregation Inhibitors
EP1866317A1 (en) 2005-03-28 2007-12-19 Pharmacia & Upjohn Company LLC 4-piperazinothieno [2, 3-d] pyrimidine compounds as platelet aggregation inhibitors
US20080194590A1 (en) 2005-03-28 2008-08-14 Pfizer Inc 4-Piperazinylthieno [2,3-D] Pyrimidine Compounds as Platelet Aggregation Inhibitors
WO2006103544A2 (en) 2005-03-28 2006-10-05 Pharmacia & Upjohn Company Llc 4-piperazinylthieno [2, 3-d] pyrimidine compounds as platelet aggregation inhibitors
WO2006136402A1 (en) * 2005-06-22 2006-12-28 Develogen Aktiengesellschaft Thienopyrimidines for pharmaceutical compositions
DE602005018972D1 (de) * 2005-09-23 2010-03-04 Equispharm Co Ltd 5,6-dimethylthienoä2,3-diüpyrimidinderivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzung für die bekämpfung von viren
US20070213305A1 (en) * 2005-11-02 2007-09-13 Cytovia, Inc. N-alkyl-N-aryl-thienopyrimidin-4-amines and analogs as activators of caspases and inducers of apoptosis and the use thereof
CA2651898A1 (en) * 2006-04-07 2007-10-18 Develogen Aktiengesellschaft Thienopyrimidines having mnk1/mnk2 inhibiting activity for pharmaceutical compositions
DE102006030236A1 (de) 2006-06-30 2008-01-03 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Direktoxidationsbrennstoffzelle für den konvektionsfreien Transport des Brennstoffs und Verfahren zum Betreiben der Brennstoffzelle
EP1947103A1 (en) 2007-01-22 2008-07-23 4Sc Ag Aryloxypropanolamines, methods of preparation thereof and use of aryloxypropanolamines as medicaments
GB0713602D0 (en) 2007-07-12 2007-08-22 Syngenta Participations Ag Chemical compounds
MX2010002926A (es) * 2007-09-14 2010-03-31 Janssen Pharmaceutica Nv Moduladores de tieno y furo-pirimidina del receptor h4 de histamina.
WO2009086303A2 (en) 2007-12-21 2009-07-09 University Of Rochester Method for altering the lifespan of eukaryotic organisms
TWI413522B (zh) 2008-02-22 2013-11-01 Otsuka Pharma Co Ltd 苯并二氮呯化合物及藥學組成物
US20100227853A1 (en) 2008-04-18 2010-09-09 Trustees Of Boston College Inhibitors of cyclic amp phosphodiesterases
US7863291B2 (en) 2008-04-23 2011-01-04 Bristol-Myers Squibb Company Quinuclidine compounds as alpha-7 nicotinic acetylcholine receptor ligands
ES2593495T3 (es) * 2008-08-26 2016-12-09 Evotec International Gmbh Tienopirimidinas para composiciones farmacéuticas
TWI334124B (en) * 2008-08-28 2010-12-01 Au Optronics Corp Display drive circuit for flat panel display and driving method for gate lines
TWI389913B (zh) 2008-09-08 2013-03-21 Lg Life Sciences Ltd 并合雜環化合物
CN102186479A (zh) 2008-09-10 2011-09-14 凯利普西斯公司 用于治疗疾病的组胺受体的氨基嘧啶抑制剂
WO2010033127A1 (en) 2008-09-22 2010-03-25 Sionyx, Inc. Response-enhanced monolithic-hybrid pixel
JP5792171B2 (ja) 2009-09-04 2015-10-07 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 白血病を治療するための組成物および方法
WO2011053292A1 (en) 2009-10-29 2011-05-05 Bristol-Myers Squibb Company Quinuclidine compounds as alpha-7 nicotinic acetylcholine receptor ligands
US8173808B2 (en) 2009-12-30 2012-05-08 Arqule, Inc. Substituted naphthalenyl-pyrimidine compounds
TW201219401A (en) * 2010-09-14 2012-05-16 Lexicon Pharmaceuticals Inc Bicyclic inhibitors of Notum Pectinacetylesterase and methods of their use
DK2835131T3 (en) 2010-12-14 2017-12-04 Electrophoretics Ltd Casein kinase 1 delta inhibitors (CK1 delta)
EP2663312B1 (en) 2011-01-10 2017-10-11 Nimbus Iris, Inc. Irak inhibitors and uses thereof

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004014850A2 (en) * 2002-08-08 2004-02-19 Predix Pharmaceuticals Holdings, Inc. Substituted aminopyrimidines as neurokinin antagonists
WO2004065391A1 (en) * 2003-01-23 2004-08-05 Almirall Prodesfarma S.A. 4-AMINOTHIENO[2,3-d]PYRIMIDINE-6-CARBONITRILE DERIVATIVES AS PDE7 INHIBITORS
WO2004111057A1 (en) * 2003-06-11 2004-12-23 Xention Discovery Limited Thienopyrimidine derivatives as potassium channel inhibitors
WO2005100365A1 (ja) * 2004-04-12 2005-10-27 Sankyo Company, Limited チエノピリジン誘導体
WO2005121149A1 (en) * 2004-06-10 2005-12-22 Xention Discovery Limited Furanopyrimidine compounds effective as potassium channel inhibitors
WO2006061642A1 (en) * 2004-12-09 2006-06-15 Xention Discovery Limited Compounds
WO2006135639A1 (en) * 2005-06-10 2006-12-21 Janssen Pharmaceutica N.V. Thiξnopyrimidine and thienopyridine derivatives as flt-3 kinase inhibitors
WO2007066127A2 (en) * 2005-12-09 2007-06-14 Xention Limited Thieno ( 3 , 2-c) pyridine compounds
WO2007146284A2 (en) * 2006-06-12 2007-12-21 Vertex Pharmaceuticals Incorporated Thienopyrimidines useful as modulators of ion channels

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JPN5015000625; ＨＯＺＩＥＮ　Ｚ　Ａ: 'ＳＹＮＴＨＥＳＩＳ　ＡＮＤ　ＡＰＰＬＩＣＡＴＩＯＮ　ＯＦ　ＳＯＭＥ　ＮＥＷ　ＴＨＩＥＮＯＰＹＲＩＭＩＤＩＮＥ　ＤＥＲＩＶＡＴＩＶＥＳ　ＡＳ　ＡＮＴＩＭＩＣＲＯＢＩＡＬ　ＡＧＥＮＴＳ' ＳＹＮＴＨＥＴＩＣ　ＣＯＭＭＵＮＩＣＡＴＩＯＮＳ Ｖｏｌ．２６　Ｎｏ．２０, 19960101, ｐ．３７３３-５５, ＴＡＹＬＯＲ　＆　ＦＲＡＮＣＩＳ　ＩＮＣ． *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018522856A (ja) * 2015-06-23 2018-08-16 レ ラボラトワール セルヴィエ 新規なアミノ酸誘導体、その製造方法、及びそれを含有する医薬組成物
JP2018522855A (ja) * 2015-06-23 2018-08-16 レ ラボラトワール セルヴィエ 新規なヒドロキシエステル誘導体、その調製方法及びそれを含有する医薬組成物
JP2018527297A (ja) * 2015-06-23 2018-09-20 レ ラボラトワール セルヴィエ 新規な二環式誘導体、それらを調製するためのプロセス及びそれらを含有する医薬組成物
JP2018527296A (ja) * 2015-06-23 2018-09-20 レ ラボラトワール セルヴィエ 新規なヒドロキシ酸誘導体、その製造方法、及びそれを含有する医薬組成物
JP2023512113A (ja) * 2019-11-29 2023-03-23 大鵬薬品工業株式会社 Ｋｒａｓ ｇ１２ｄ変異に対して阻害活性を有する化合物
JP7707189B2 (ja) 2019-11-29 2025-07-14 大鵬薬品工業株式会社 Ｋｒａｓ ｇ１２ｄ変異に対して阻害活性を有する化合物
JP2024511101A (ja) * 2021-03-22 2024-03-12 アセシオン ファーマ エイピーエス 新規カリウムチャネル阻害剤

Also Published As

Publication number Publication date
CN104011054B (zh) 2016-08-24
BR112014011671A2 (pt) 2017-05-30
RU2014124101A (ru) 2015-12-27
US20140371203A1 (en) 2014-12-18
MX2014005935A (es) 2014-09-04
KR20140094603A (ko) 2014-07-30
AU2012338570A1 (en) 2014-07-03
TWI498331B (zh) 2015-09-01
US9290511B2 (en) 2016-03-22
NZ626199A (en) 2015-04-24
US20160152634A1 (en) 2016-06-02
TW201326178A (zh) 2013-07-01
AR090037A1 (es) 2014-10-15
ZA201403503B (en) 2016-09-28
WO2013072694A1 (en) 2013-05-23
EP2780343A1 (en) 2014-09-24
CA2855346A1 (en) 2013-05-23
IN2014MN01183A (OSRAM) 2015-07-03
CN104011054A (zh) 2014-08-27

Similar Documents

Publication Publication Date Title
CN104011054B (zh) 用作钾通道抑制剂的噻吩并和呋喃并嘧啶类和吡啶类
WO2023066350A1 (zh) Crbn e3连接酶配体化合物、基于该配体化合物开发的蛋白降解剂及它们的应用
JP4719317B2 (ja) 縮合複素環誘導体およびその用途
EP2943485B1 (en) Bicyclic aromatic carboxamide compounds useful as pim kinase inhibitors
JP2023530320A (ja) Ｎａｖ１．８阻害剤としての５－オキソピロリジン－３－カルボキサミド
KR102517352B1 (ko) Nik 억제제로서의 헤테로방향족 유도체
CN104755083B (zh) 氨基烷基哌嗪的脲和酰胺衍生物及其用途
JP2008514643A (ja) 新規ピペリジニルアミノ−チエノ［２，３−ｄ］ピリミジン化合物
EA036592B1 (ru) Замещенные трициклические соединения как ингибиторы fgfr
TWI843949B (zh) 黑皮質素4(melanocortin 4)受體拮抗劑及其用途
KR20180014433A (ko) 핵 수용체 조절제
JP7716777B2 (ja) 窒素含有多環式縮合環系化合物、その医薬組成物、製造方法及び用途
KR20180100441A (ko) Nik 억제제로서 신규 치환된 시아노인돌린 유도체
KR20160086404A (ko) Mknk1 및 mknk2 억제제로서의 티에노피리미딘
TWI869674B (zh) 雜芳基衍生化合物及其用途
US20250214989A1 (en) Naphthyridinone derivatives for the treatment of a disease or disorder
JP2014533258A (ja) カリウムチャネル阻害剤としてのチエノ［２，３−ｃ］ピラゾールの使用
JP2002504883A (ja) コリン受容体リガンドとしての７−アザビシクロ［２．２．１］−ヘプタン及び−ヘプテン誘導体
NZ626199B2 (en) Thieno- and furo - pyrimidines and pyridines, useful as potassium channel inhibitors
OA21024A (en) Spiro compounds as melanocortin 4 receptor antagonists and uses thereof.

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20151116

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20151116

A871 Explanation of circumstances concerning accelerated examination

Free format text: JAPANESE INTERMEDIATE CODE: A871

Effective date: 20151116

A975 Report on accelerated examination

Free format text: JAPANESE INTERMEDIATE CODE: A971005

Effective date: 20151208

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20160609

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20160621

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20170228