|
US2488564A
(en)
|
1947-06-03 |
1949-11-22 |
Orthe Pharmaecutlcal Corp |
Preparation of hyaluronidase
|
|
US2488565A
(en)
|
1947-06-04 |
1949-11-22 |
Ortho Pharma Corp |
Preparation of hyaluronidase
|
|
US2676139A
(en)
|
1950-09-01 |
1954-04-20 |
American Home Prod |
Hyaluronidase
|
|
US2808362A
(en)
|
1952-05-02 |
1957-10-01 |
Armour & Co |
Preparation of hyaluronidase
|
|
US2795529A
(en)
|
1954-06-17 |
1957-06-11 |
American Home Prod |
Stabilized hyaluronidase solution containing calcium chloride
|
|
US2806815A
(en)
|
1955-04-12 |
1957-09-17 |
Ortho Pharma Corp |
Stabilized hyaluronidase
|
|
US4179337A
(en)
|
1973-07-20 |
1979-12-18 |
Davis Frank F |
Non-immunogenic polypeptides
|
|
US4002531A
(en)
|
1976-01-22 |
1977-01-11 |
Pierce Chemical Company |
Modifying enzymes with polyethylene glycol and product produced thereby
|
|
US4952496A
(en)
|
1984-03-30 |
1990-08-28 |
Associated Universities, Inc. |
Cloning and expression of the gene for bacteriophage T7 RNA polymerase
|
|
US4751180A
(en)
|
1985-03-28 |
1988-06-14 |
Chiron Corporation |
Expression using fused genes providing for protein product
|
|
US4935233A
(en)
|
1985-12-02 |
1990-06-19 |
G. D. Searle And Company |
Covalently linked polypeptide cell modulators
|
|
CA1319593C
(en)
|
1987-03-03 |
1993-06-29 |
Kenji Chichibu |
Method of assaying high molecular hyaluronic acid and kit of reagents for such assay
|
|
US5116964A
(en)
|
1989-02-23 |
1992-05-26 |
Genentech, Inc. |
Hybrid immunoglobulins
|
|
US5324844A
(en)
|
1989-04-19 |
1994-06-28 |
Enzon, Inc. |
Active carbonates of polyalkylene oxides for modification of polypeptides
|
|
US5122614A
(en)
|
1989-04-19 |
1992-06-16 |
Enzon, Inc. |
Active carbonates of polyalkylene oxides for modification of polypeptides
|
|
DE69026306T2
(de)
|
1989-05-27 |
1996-10-17 |
Seikagaku Kogyo Co Ltd |
Verfahren für die Herstellung von Polyethylenglykolderivate und modifizierte Proteine.
|
|
ATE193551T1
(de)
|
1991-03-18 |
2000-06-15 |
Scripps Research Inst |
Oligosaccharide als enzymsubstrate und - inhibitoren: verfahren und zusammensetzungen
|
|
US5262522A
(en)
|
1991-11-22 |
1993-11-16 |
Immunex Corporation |
Receptor for oncostatin M and leukemia inhibitory factor
|
|
US5872094A
(en)
|
1993-01-06 |
1999-02-16 |
The General Hospital Corporation |
Method for attaching cartilaginous tissue, cartilage matrix protein or link protein to a surface
|
|
WO1994028024A1
(en)
|
1993-06-01 |
1994-12-08 |
Enzon, Inc. |
Carbohydrate-modified polymer conjugates with erythropoietic activity
|
|
US5457035A
(en)
|
1993-07-23 |
1995-10-10 |
Immunex Corporation |
Cytokine which is a ligand for OX40
|
|
US5643575A
(en)
|
1993-10-27 |
1997-07-01 |
Enzon, Inc. |
Non-antigenic branched polymer conjugates
|
|
US5919455A
(en)
|
1993-10-27 |
1999-07-06 |
Enzon, Inc. |
Non-antigenic branched polymer conjugates
|
|
US5446090A
(en)
|
1993-11-12 |
1995-08-29 |
Shearwater Polymers, Inc. |
Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules
|
|
US5795569A
(en)
|
1994-03-31 |
1998-08-18 |
Amgen Inc. |
Mono-pegylated proteins that stimulate megakaryocyte growth and differentiation
|
|
CN1229385C
(zh)
|
1994-03-31 |
2005-11-30 |
安姆根有限公司 |
刺激巨核细胞生长和分化的组合物及方法
|
|
US6093563A
(en)
|
1994-07-08 |
2000-07-25 |
Ibex Technologies R And D, Inc. |
Chondroitin lyase enzymes
|
|
US5824784A
(en)
|
1994-10-12 |
1998-10-20 |
Amgen Inc. |
N-terminally chemically modified protein compositions and methods
|
|
US5932462A
(en)
|
1995-01-10 |
1999-08-03 |
Shearwater Polymers, Inc. |
Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
|
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
|
US5747027A
(en)
|
1995-04-07 |
1998-05-05 |
The Regents Of The University Of California |
BH55 hyaluronidase
|
|
US5672662A
(en)
|
1995-07-07 |
1997-09-30 |
Shearwater Polymers, Inc. |
Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications
|
|
US6214966B1
(en)
|
1996-09-26 |
2001-04-10 |
Shearwater Corporation |
Soluble, degradable poly(ethylene glycol) derivatives for controllable release of bound molecules into solution
|
|
US6193963B1
(en)
|
1996-10-17 |
2001-02-27 |
The Regents Of The University Of California |
Method of treating tumor-bearing patients with human plasma hyaluronidase
|
|
US6103525A
(en)
|
1996-10-17 |
2000-08-15 |
The Regents Of The University Of California |
Hybridoma cell lines producing monoclonal antibodies that bind to human plasma hyaluronidase
|
|
US6258351B1
(en)
|
1996-11-06 |
2001-07-10 |
Shearwater Corporation |
Delivery of poly(ethylene glycol)-modified molecules from degradable hydrogels
|
|
JP4213224B2
(ja)
|
1997-05-02 |
2009-01-21 |
ジェネンテック，インコーポレーテッド |
ヘテロマルチマー及び共通成分を有する多重特異性抗体の製造方法
|
|
US5990237A
(en)
|
1997-05-21 |
1999-11-23 |
Shearwater Polymers, Inc. |
Poly(ethylene glycol) aldehyde hydrates and related polymers and applications in modifying amines
|
|
US6448369B1
(en)
|
1997-11-06 |
2002-09-10 |
Shearwater Corporation |
Heterobifunctional poly(ethylene glycol) derivatives and methods for their preparation
|
|
US5985263A
(en)
|
1997-12-19 |
1999-11-16 |
Enzon, Inc. |
Substantially pure histidine-linked protein polymer conjugates
|
|
CA2237051A1
(en)
|
1997-12-19 |
1999-06-19 |
Eva A. Turley |
Enhanced affinity hyaluronan binding peptides
|
|
DK1411075T3
(da)
|
1998-03-12 |
2008-10-27 |
Nektar Therapeutics Al Corp |
Fremgangsmåde til fremstilling af polymerkonjugater
|
|
EP1064011A1
(en)
|
1998-03-13 |
2001-01-03 |
EntreMed, Inc. |
Metastatin and hyaluronate binding proteins and methods of use
|
|
WO2000002017A2
(en)
|
1998-07-03 |
2000-01-13 |
Neles Field Controls Oy |
Method and arrangement for measuring fluid
|
|
US6420339B1
(en)
|
1998-10-14 |
2002-07-16 |
Amgen Inc. |
Site-directed dual pegylation of proteins for improved bioactivity and biocompatibility
|
|
US6872546B1
(en)
|
1998-12-23 |
2005-03-29 |
Human Genome Sciences, Inc. |
Hyaluronan-binding proteins and encoding genes
|
|
US6852696B2
(en)
*
|
1999-03-26 |
2005-02-08 |
The University Of Texas System |
Inhibitors of glycosaminoglycans
|
|
JO2291B1
(en)
|
1999-07-02 |
2005-09-12 |
اف . هوفمان لاروش ايه جي |
Erythropoietin derivatives
|
|
CZ299516B6
(cs)
|
1999-07-02 |
2008-08-20 |
F. Hoffmann-La Roche Ag |
Konjugát erythropoetinového glykoproteinu, zpusobjeho výroby a použití a farmaceutická kompozice sjeho obsahem
|
|
CA2380203A1
(en)
|
1999-07-23 |
2001-02-01 |
The Secretary Of State For The Home Department |
A two stage method for detecting single nucleotide polymorphisms (snps)
|
|
US6461802B1
(en)
|
1999-08-02 |
2002-10-08 |
Agfa-Gevaert |
Adhesive layer for polyester film
|
|
AU781839B2
(en)
|
1999-12-22 |
2005-06-16 |
Nektar Therapeutics |
Sterically hindered derivatives of water soluble polymers
|
|
US6413507B1
(en)
|
1999-12-23 |
2002-07-02 |
Shearwater Corporation |
Hydrolytically degradable carbamate derivatives of poly (ethylene glycol)
|
|
WO2001062827A2
(en)
|
2000-02-22 |
2001-08-30 |
Shearwater Corporation |
N-maleimidyl polymer derivatives
|
|
US6586398B1
(en)
|
2000-04-07 |
2003-07-01 |
Amgen, Inc. |
Chemically modified novel erythropoietin stimulating protein compositions and methods
|
|
IL152804A0
(en)
|
2000-05-16 |
2003-06-24 |
Bolder Biotechnology Inc |
Methods for refolding proteins containing free cysteine residues
|
|
DE60144439D1
(de)
|
2000-12-20 |
2011-05-26 |
Hoffmann La Roche |
Konjugate von erythropoietin (epo) mit polyethylenglykol (peg)
|
|
TWI246524B
(en)
|
2001-01-19 |
2006-01-01 |
Shearwater Corp |
Multi-arm block copolymers as drug delivery vehicles
|
|
US7219016B2
(en)
|
2001-04-20 |
2007-05-15 |
Yale University |
Systems and methods for automated analysis of cells and tissues
|
|
US6908963B2
(en)
|
2001-10-09 |
2005-06-21 |
Nektar Therapeutics Al, Corporation |
Thioester polymer derivatives and method of modifying the N-terminus of a polypeptide therewith
|
|
AU2002352524B2
(en)
|
2001-11-07 |
2007-10-04 |
Nektar Therapeutics |
Branched polymers and their conjugates
|
|
US8188231B2
(en)
|
2002-09-27 |
2012-05-29 |
Xencor, Inc. |
Optimized FC variants
|
|
KR20040040782A
(ko)
|
2002-11-08 |
2004-05-13 |
선바이오(주) |
신규한 헥사-암 폴리에틸렌글리콜과 유도체 및 그의합성방법
|
|
WO2004043397A2
(en)
|
2002-11-12 |
2004-05-27 |
Genentech, Inc. |
Compositions and methods for the treatment of rheumatoid arthritis
|
|
GB0229734D0
(en)
|
2002-12-23 |
2003-01-29 |
Qinetiq Ltd |
Grading oestrogen and progesterone receptors expression
|
|
AU2004208962B2
(en)
|
2003-02-10 |
2010-07-15 |
To-Bbb Holding B.V. |
Differentially expressed nucleic acids in the blood-brain barrier under inflammatory conditions
|
|
WO2004075923A2
(en)
|
2003-02-26 |
2004-09-10 |
Nektar Therapeutics Al, Corporation |
Polymer-factor viii moiety conjugates
|
|
US7257268B2
(en)
|
2003-02-28 |
2007-08-14 |
Aperio Technologies, Inc. |
Systems and methods for image pattern recognition
|
|
US20090123367A1
(en)
|
2003-03-05 |
2009-05-14 |
Delfmems |
Soluble Glycosaminoglycanases and Methods of Preparing and Using Soluble Glycosaminoglycanases
|
|
US7871607B2
(en)
|
2003-03-05 |
2011-01-18 |
Halozyme, Inc. |
Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases
|
|
US20060104968A1
(en)
|
2003-03-05 |
2006-05-18 |
Halozyme, Inc. |
Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases
|
|
ES2532399T3
(es)
|
2003-03-05 |
2015-03-26 |
Halozyme, Inc. |
Glicoproteína hialuronidasa soluble (sHASEGP), proceso para prepararla, usos y composiciones farmacéuticas que la comprenden
|
|
US7610156B2
(en)
|
2003-03-31 |
2009-10-27 |
Xencor, Inc. |
Methods for rational pegylation of proteins
|
|
KR100512483B1
(ko)
|
2003-05-07 |
2005-09-05 |
선바이오(주) |
신규한 폴리에틸렌글리콜-말레이미드 유도체의 합성방법
|
|
TR201907313T4
(tr)
|
2003-05-23 |
2019-06-21 |
Nektar Therapeutics |
İki PEG zinciri içeren PEG türevleri.
|
|
ES2437491T3
(es)
|
2003-10-10 |
2014-01-10 |
Alchemia Oncology Pty Limited |
Modulación de la síntesis y degradación de hialuronano en el tratamiento de enfermedad
|
|
KR100956913B1
(ko)
|
2003-12-19 |
2010-05-11 |
제넨테크, 인크. |
치료제로서 유용한 일가 항체 단편
|
|
GB0408351D0
(en)
|
2004-04-15 |
2004-05-19 |
Plasso Technology Ltd |
Reversible binding surface
|
|
WO2005118799A1
(en)
|
2004-04-15 |
2005-12-15 |
Ista Pharmaceuticals, Inc. |
Ovine hyaluronidase
|
|
US7112687B2
(en)
|
2004-07-15 |
2006-09-26 |
Indena, S.P.A. |
Methods for obtaining paclitaxel from taxus plants
|
|
US7723472B2
(en)
|
2005-02-28 |
2010-05-25 |
The Regents Of The University Of California |
Extracellular matrix binding chimeric proteins and methods of use thereof
|
|
EP1896386B1
(en)
|
2005-06-08 |
2012-09-05 |
Cangene Corporation |
Hyaluronic acid binding peptides enhance host defense against pathogenic bacteria
|
|
AU2007249805B2
(en)
|
2006-05-12 |
2013-01-10 |
University Of Miami |
Biomarkers for detection and diagnosis of head and neck squamous cell carcinoma
|
|
US8023714B2
(en)
|
2007-06-06 |
2011-09-20 |
Aperio Technologies, Inc. |
System and method for assessing image interpretability in anatomic pathology
|
|
KR20140130512A
(ko)
|
2008-03-06 |
2014-11-10 |
할로자임, 아이엔씨 |
가용성 히알루로니다아제의 대규모 제조
|
|
TWI489994B
(zh)
|
2008-03-17 |
2015-07-01 |
Baxter Healthcare Sa |
供免疫球蛋白及玻尿酸酶之皮下投藥之用的組合及方法
|
|
KR20100135291A
(ko)
|
2008-04-14 |
2010-12-24 |
할로자임, 아이엔씨 |
히알루로난 관련 질환 및 상태 치료용 변형된 히알루로니다제 및 그 용도
|
|
EP2270145B1
(en)
|
2008-04-15 |
2013-01-16 |
Wako Pure Chemical Industries, Ltd. |
Novel protein capable of binding to hyaluronic acid, and method for measurement of hyaluronic acid using the same
|
|
TWI394580B
(zh)
|
2008-04-28 |
2013-05-01 |
Halozyme Inc |
超快起作用胰島素組成物
|
|
WO2010033508A1
(en)
|
2008-09-16 |
2010-03-25 |
Historx, Inc. |
Reproducible quantification of biomarker expression
|
|
CN103205407B
(zh)
|
2008-12-09 |
2016-03-16 |
哈洛齐梅公司 |
延长的可溶性ph20多肽及其用途
|
|
ES2559029T3
(es)
|
2009-04-24 |
2016-02-10 |
Tissue Tech, Inc. |
Composiciones que contienen al complejo HC.HA y metodos de uso de las mismas
|
|
MX2012003282A
(es)
|
2009-09-17 |
2012-04-30 |
Baxter Healthcare Sa |
Co-formulacion estable de hialuronidasa e inmunoglobulina, y metodos de su uso.
|
|
US20110111435A1
(en)
|
2009-11-06 |
2011-05-12 |
SlidePath Limited |
Detecting Cell Surface Markers
|
|
CN101899118B
(zh)
|
2010-04-22 |
2012-05-30 |
曹利民 |
一种融合蛋白HABP-mKate及其制备方法和应用
|
|
MX348420B
(es)
|
2010-07-20 |
2017-06-12 |
Halozyme Inc |
Efectos secundarios adversos asociados con la administracion de agentes anti-hialuronano y metodos para mejorar o prevenir los efectos secundarios.
|
|
EP2907504B1
(en)
|
2011-02-08 |
2017-06-28 |
Halozyme, Inc. |
Composition and lipid formulation of a hyaluronan-degrading enzyme and the use thereof for treatment of benign prostatic hyperplasia
|
|
JP5890516B2
(ja)
|
2011-06-17 |
2016-03-22 |
ハロザイム インコーポレイテッド |
ヒアルロナン分解酵素を用いる連続的皮下インスリン注入方法
|
|
US9993529B2
(en)
|
2011-06-17 |
2018-06-12 |
Halozyme, Inc. |
Stable formulations of a hyaluronan-degrading enzyme
|
|
AU2012328880B2
(en)
|
2011-10-24 |
2017-02-23 |
Halozyme, Inc. |
Companion diagnostic for anti-hyaluronan agent therapy and methods of use thereof
|
|
EP3130347B1
(en)
|
2011-12-30 |
2019-09-18 |
Halozyme, Inc. |
Ph20 polypeptide variants, formulations and uses thereof
|
|
HRP20181187T1
(hr)
|
2012-04-04 |
2018-09-21 |
Halozyme, Inc. |
Kombinirana terapija s hijaluronidazom i taksanom koji ciljano djeluje na tumor
|
|
WO2014062856A1
(en)
|
2012-10-16 |
2014-04-24 |
Halozyme, Inc. |
Hypoxia and hyaluronan and markers thereof for diagnosis and monitoring of diseases and conditions and related methods
|
|
TW201534726A
(zh)
|
2013-07-03 |
2015-09-16 |
Halozyme Inc |
熱穩定ｐｈ２０玻尿酸酶變異體及其用途
|