JP2014530810A - ゲラニルゲラニルアセトン誘導体 - Google Patents

ゲラニルゲラニルアセトン誘導体 Download PDF

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JP2014530810A
JP2014530810A JP2014534556A JP2014534556A JP2014530810A JP 2014530810 A JP2014530810 A JP 2014530810A JP 2014534556 A JP2014534556 A JP 2014534556A JP 2014534556 A JP2014534556 A JP 2014534556A JP 2014530810 A JP2014530810 A JP 2014530810A
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alkyl
compound according
hexane
etoac
compound
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JP2014530810A5 (enExample
Inventor
宏明 芹沢
宏明 芹沢
アルゲイド，アンカシュ
ダトワニ，アカーシュ
スペンサー，ナタリー
Original Assignee
コヨーテ ファーマシューティカルズ インコーポレイテッド
コヨーテ ファーマシューティカルズ インコーポレイテッド
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Publication of JP2014530810A publication Critical patent/JP2014530810A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/203—Unsaturated compounds containing keto groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32—Oximes
    • C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C251/36—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atoms of the oxyimino groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C251/40—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atoms of the oxyimino groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
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    • C07C251/50—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals
    • C07C251/60—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals of hydrocarbon radicals substituted by carboxyl groups
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    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/12—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
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    • C07C271/06—Esters of carbamic acids
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    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
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    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/24—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C07C309/66—Methanesulfonates
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/20—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
    • C07C47/21—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/527—Unsaturated compounds containing keto groups bound to rings other than six-membered aromatic rings
    • C07C49/557—Unsaturated compounds containing keto groups bound to rings other than six-membered aromatic rings having unsaturation outside the rings
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/647—Unsaturated compounds containing a keto groups being part of a ring having unsaturation outside the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
    • C07C69/22—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety
    • C07C69/24—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety esterified with monohydroxylic compounds
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/52—Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
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    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
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    • C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C69/75—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring of acids with a six-membered ring
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/12—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
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    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Furan Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2014534556A 2011-10-04 2012-02-29 ゲラニルゲラニルアセトン誘導体 Pending JP2014530810A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161543182P 2011-10-04 2011-10-04
US61/543,182 2011-10-04

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JP2014530810A true JP2014530810A (ja) 2014-11-20
JP2014530810A5 JP2014530810A5 (enExample) 2015-04-23

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US (1) US20130085283A1 (enExample)
EP (1) EP2763949A4 (enExample)
JP (1) JP2014530810A (enExample)
AU (1) AU2012319143A1 (enExample)
CA (1) CA2850716A1 (enExample)
IL (1) IL231823A0 (enExample)
IN (1) IN2014CN02585A (enExample)
WO (1) WO2013052148A1 (enExample)

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Publication number Priority date Publication date Assignee Title
US9045403B2 (en) 2012-02-29 2015-06-02 Coyote Pharmaceuticals, Inc. Geranyl geranyl acetone (GGA) derivatives and compositions thereof
US9119808B1 (en) 2012-10-08 2015-09-01 Coyote Pharmaceuticals, Inc. Treating neurodegenerative diseases with GGA or a derivative thereof
WO2014150171A1 (en) * 2013-03-15 2014-09-25 The Procter & Gamble Company Specific unsaturated and branched functional materials for use in consumer products
WO2015006614A2 (en) * 2013-07-11 2015-01-15 Coyote Pharmaceuticals, Inc. Gga derivatives
WO2015038680A1 (en) * 2013-09-11 2015-03-19 Coyote Pharmaceuticals, Inc. Drug conjugates of gga and gga derivatives
CN104447256A (zh) * 2014-11-13 2015-03-25 岳阳新华达制药有限公司 替普瑞酮中间体(5e,9e)-金合欢丙酮的制备方法
CN114031491B (zh) * 2021-11-26 2023-10-24 安徽先和医药研究有限公司 一种全反式替普瑞酮的制备方法
CN117466724B (zh) * 2023-09-20 2025-11-25 浙江工业大学 一种2-戊基-2-环戊烯-1-酮的制备方法

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JPN6015037624; Ｍｉｇｎａｎｉ，　Ｇ．；　Ｍｏｒｅｌ，　Ｄ．；　Ｇｒａｓｓ，　Ｆ．: 'Ａ　ｏｎｅ-ｐｏｔ　ｐｒｅｐａｒａｔｉｏｎ　ｏｆ　alpha-ｈａｌｏ　ｃａｒｂｏｎｙｌ　ａｎｄ　alpha-ｈａｌｏ　ｓｕｌｆｏｎｙｌ　ｃｏｍｐｏｕｎｄｓ　ｂｙ　ｈａｌｏｄｅａｃｙｌａｔｉｏｎ' ＴＥＴＲＡＨＥＤＲＯＮ　ＬＥＴＴＥＲＳ ２８（４５）, 1987, ５５０５-８ *
JPN6015037628; Ｘｕ，　Ｄａｑｉａｎｇ；　Ｐａｒｋ，　Ｃｈｒｉｓｔｉｎｅ　Ｙ．；　Ｓｈａｒｐｌｅｓｓ，　Ｋ．　Ｂａｒｒｙ: 'Ｓｔｕｄｙ　ｏｆ　ｔｈｅ　ｒｅｇｉｏ-　ａｎｄ　ｅｎａｎｔｉｏｓｅｌｅｃｔｉｖｉｔｙ　ｏｆ　ｔｈｅ　ｒｅａｃｔｉｏｎｓ　ｏｆ　ｏｓｍｉｕｍ　ｔｅｔｒｏｘｉｄｅ　ｗｉｔｈ　ａｌｌｙｌｉｃ　ａｌｃｏｈｏｌ' ＴＥＴＲＡＨＥＤＲＯＮ　ＬＥＴＴＥＲＳ ３５（１６）, 1994, ２４９５-８ *
JPN6015037631; Ｋｒｙｓｈｔａｌ，　Ｇ．　Ｖ．；　Ｚｈｄａｎｋｉｎａ，　Ｇ．　Ｍ．；　Ｚｌｏｔｉｎ，　Ｓ．　Ｇ．: 'Ｓｙｎｔｈｅｓｉｓ　ｏｆ　ｄｅｒｉｖａｔｉｖｅｓ　ｏｆ　ｐｒｅｎｙｌａｃｅｔｉｃ　ａｃｉｄｓ　ｂｙ　ｒｅａｃｔｉｏｎｓ　ｏｆ　ａｌｋｙｌ　ｍａｌｏｎａｔｅ，　ｃｙａｎｏａｃｅｔａｔｅ，　ａｎｄ　ａｃｅ' ＲＵＳＳＩＡＮ　ＣＨＥＭＩＣＡＬ　ＢＵＬＬＥＴＩＮ　（ＴＲＡＮＳＬＡＴＩＯＮ　ＯＦ　ＩＺＶＥＳＴＩＹＡ　ＡＫＡＤＥＭＩＩ　ＮＡＵＫ，　ＳＥＲＩＹＡ　ＫＨＩＭＩＣＨＥＳＫＡＹＡ） ５３（３）, 2004, ６５２-６５８ *
JPN6015037633; Ｒａｗａｔ，　Ｄｉｗａｎ　Ｓ．；　Ｋｒｚｙｓｉａｋ，　Ａｍａｎｄａ　Ｊ．；　Ｇｉｂｂｓ，　Ｒｉｃｈａｒｄ　Ａ．: 'Ｓｙｎｔｈｅｓｉｓ　ａｎｄ　Ｂｉｏｃｈｅｍｉｃａｌ　Ｅｖａｌｕａｔｉｏｎ　ｏｆ　３，７-Ｄｉｓｕｂｓｔｉｔｕｔｅｄ　Ｆａｒｎｅｓｙｌ　Ｄｉｐｈｏｓｐｈａｔｅ　Ａｎａｌｏｇｕｅｓ' ＪＯＵＲＮＡＬ　ＯＦ　ＯＲＧＡＮＩＣ　ＣＨＥＭＩＳＴＲＹ ７３（５）, 2008, １８８１-１８８７ *
JPN6015037636; Ｓｅｎ，　Ｓ．　Ｅ．；　Ｓｐｅｒｒｙ，　Ａ．　Ｅ．；　Ｃｈｉｌｄｒｅｓｓ，　Ｍ．；　Ｈａｎｎｅｍａｎｎ，　Ｄ．　Ｅ．: 'Ｊｕｖｅｎｉｌｅ　ｈｏｒｍｏｎｅ　ｂｉｏｓｙｎｔｈｅｓｉｓ　ｉｎ　ｍｏｔｈｓ：　ｓｙｎｔｈｅｓｉｓ　ａｎｄ　ｅｖａｌｕａｔｉｏｎ　ｏｆ　ｆａｒｎｅｓｏｌ　ｈｏｍｏｌｏｇｓ　ａｓ　ａｌｔｅｒｎａｔｅ　ｓ' ＩＮＳＥＣＴ　ＢＩＯＣＨＥＭＩＳＴＲＹ　ＡＮＤ　ＭＯＬＥＣＵＬＡＲ　ＢＩＯＬＯＧＹ ３３（６）, 2003, ６０１-６０７ *
JPN6015037639; Ｏｈｋｉ， Ｍａｓａｈｉｋｏ； Ｍｏｒｉ， Ｋｅｎｊｉ； Ｍａｔｓｕｉ， Ｍａｓａｎａｏ； Ｓａｋｉｍａｅ， Ａｋｉｈｉｒｏ: 'Ｓｙｎｔｈｅｓｉｓ ｏｆ ｃｏｍｐｏｕｎｄｓ ｗｉｔｈ ｊｕｖｅｎｉｌｅ ｈｏｒｍｏｎｅ ａｃｔｉｖｉｔｙ． Ｘ． Ｓｙｎｔｈｅｓｉｓ ｏｆ ｎｅｗ ａｎａｌｏｇｓ ｏｆ ｔｈｅ Ｃｅｃｒｏｐｉａ' ＡＧＲＩＣＵＬＴＵＲＡＬ ＡＮＤ ＢＩＯＬＯＧＩＣＡＬ ＣＨＥＭＩＳＴＲＹ ３６（６）, 1972, ９７９-８３ *
JPN6015037641; Ｇｎａｎａｄｅｓｉｋａｎ，　Ｖｉｊａｙ；　Ｃｏｒｅｙ，　Ｅ．　Ｊ．: 'Ａ　Ｓｔｒａｔｅｇｙ　ｆｏｒ　Ｐｏｓｉｔｉｏｎ-Ｓｅｌｅｃｔｉｖｅ　Ｅｐｏｘｉｄａｔｉｏｎ　ｏｆ　Ｐｏｌｙｐｒｅｎｏｌｓ' ＪＯＵＲＮＡＬ　ＯＦ　ＴＨＥ　ＡＭＥＲＩＣＡＮ　ＣＨＥＭＩＣＡＬ　ＳＯＣＩＥＴＹ １３０（２５）, 2008, ８０８９-８０９３ *

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