JP2014530810A5 - - Google Patents
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- Publication number
- JP2014530810A5 JP2014530810A5 JP2014534556A JP2014534556A JP2014530810A5 JP 2014530810 A5 JP2014530810 A5 JP 2014530810A5 JP 2014534556 A JP2014534556 A JP 2014534556A JP 2014534556 A JP2014534556 A JP 2014534556A JP 2014530810 A5 JP2014530810 A5 JP 2014530810A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- optionally substituted
- cycloalkyl
- groups
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229910052739 hydrogen Inorganic materials 0.000 claims 10
- 125000000753 cycloalkyl group Chemical group 0.000 claims 9
- 239000001257 hydrogen Substances 0.000 claims 9
- 210000002569 neuron Anatomy 0.000 claims 9
- 150000001875 compounds Chemical class 0.000 claims 7
- 125000000623 heterocyclic group Chemical group 0.000 claims 7
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 5
- 125000003118 aryl group Chemical group 0.000 claims 5
- 150000002431 hydrogen Chemical class 0.000 claims 5
- 230000001537 neural effect Effects 0.000 claims 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 230000002708 enhancing effect Effects 0.000 claims 3
- 150000002148 esters Chemical class 0.000 claims 3
- 206010001497 Agitation Diseases 0.000 claims 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 2
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 2
- 108091006027 G proteins Proteins 0.000 claims 2
- 102000030782 GTP binding Human genes 0.000 claims 2
- 108091000058 GTP-Binding Proteins 0.000 claims 2
- 125000004429 atom Chemical group 0.000 claims 2
- 230000028600 axonogenesis Effects 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 239000002858 neurotransmitter agent Substances 0.000 claims 2
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical group [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 2
- 230000000638 stimulation Effects 0.000 claims 2
- 210000000225 synapse Anatomy 0.000 claims 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 208000028389 Nerve injury Diseases 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 230000030833 cell death Effects 0.000 claims 1
- 230000034994 death Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 125000002573 ethenylidene group Chemical group [*]=C=C([H])[H] 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 125000000879 imine group Chemical group 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000008764 nerve damage Effects 0.000 claims 1
- 230000016273 neuron death Effects 0.000 claims 1
- 230000014511 neuron projection development Effects 0.000 claims 1
- 230000004112 neuroprotection Effects 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 125000003544 oxime group Chemical group 0.000 claims 1
- 125000004043 oxo group Chemical group O=* 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161543182P | 2011-10-04 | 2011-10-04 | |
| US61/543,182 | 2011-10-04 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014530810A JP2014530810A (ja) | 2014-11-20 |
| JP2014530810A5 true JP2014530810A5 (enExample) | 2015-04-23 |
Family
ID=48044061
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014534556A Pending JP2014530810A (ja) | 2011-10-04 | 2012-02-29 | ゲラニルゲラニルアセトン誘導体 |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP2763949A4 (enExample) |
| JP (1) | JP2014530810A (enExample) |
| AU (1) | AU2012319143A1 (enExample) |
| CA (1) | CA2850716A1 (enExample) |
| IL (1) | IL231823A0 (enExample) |
| IN (1) | IN2014CN02585A (enExample) |
| WO (1) | WO2013052148A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9045403B2 (en) | 2012-02-29 | 2015-06-02 | Coyote Pharmaceuticals, Inc. | Geranyl geranyl acetone (GGA) derivatives and compositions thereof |
| US9119808B1 (en) | 2012-10-08 | 2015-09-01 | Coyote Pharmaceuticals, Inc. | Treating neurodegenerative diseases with GGA or a derivative thereof |
| CN104447256A (zh) * | 2014-11-13 | 2015-03-25 | 岳阳新华达制药有限公司 | 替普瑞酮中间体(5e,9e)-金合欢丙酮的制备方法 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS53145922A (en) * | 1977-05-26 | 1978-12-19 | Eisai Co Ltd | Remedy for peptic ulcer containing prenyl ketone compound |
| JPS5520713A (en) * | 1978-08-01 | 1980-02-14 | Eisai Co Ltd | Drug for external use for accelerating heal of skin injury |
| JPS5522632A (en) * | 1978-08-07 | 1980-02-18 | Eisai Co Ltd | Preparation of stable composition comprising prenyl ketone compound |
| US4281019A (en) * | 1979-02-01 | 1981-07-28 | American Cyanamid Company | 4-[(Unsaturated or cyclopropylated alkyl)amino]phenyl compounds useful as hypolipidemic and antiatherosclerotic agents |
| JPS591474A (ja) * | 1982-06-07 | 1984-01-06 | Nippon Iyakuhin Kogyo Kk | ピペラジン環を有するゲラニルゲラニル酢酸アミド化合物またはその塩類 |
| FR2555162B1 (fr) * | 1983-11-18 | 1986-09-26 | Rhone Poulenc Sante | Procede de preparation de derives ethyleniques chlores |
| US5212164A (en) * | 1988-08-29 | 1993-05-18 | E. R. Squibb & Sons, Inc. | Phosphorus-containing squalene synthetase inhibitors |
| JP2907640B2 (ja) * | 1992-06-29 | 1999-06-21 | 高砂香料工業株式会社 | 尋常性ざ瘡用皮膚外用剤 |
| JPH06192073A (ja) * | 1992-12-24 | 1994-07-12 | Eisai Co Ltd | 細胞分化誘導剤 |
| JPH0971525A (ja) * | 1995-09-07 | 1997-03-18 | Pola Chem Ind Inc | メラニン産生抑制剤及び皮膚外用剤 |
| JPH10158194A (ja) * | 1996-11-27 | 1998-06-16 | Pola Chem Ind Inc | 経皮吸収促進剤 |
| US6172057B1 (en) * | 1997-02-27 | 2001-01-09 | American Cyanamid Company | N-Hydroxy-2-(alkyl, aryl, or heteroaryl sulfanyl, sulfinyl or sulfonyl)-3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors |
| CA2336201A1 (en) * | 1998-06-24 | 1999-12-29 | Merck & Co., Inc. | Compositions and methods for inhibiting bone resorption |
| US20050009772A1 (en) * | 2003-05-06 | 2005-01-13 | The Regents Of The University Of California | Methods and compositions for the treatment of glaucoma and other retinal diseases |
| US10201510B2 (en) * | 2005-02-05 | 2019-02-12 | Oregon Health & Science University | Compositions and methods for treatment of neurological symptoms associated with alcohol-withdrawal and for convulsive seizure |
| US20060270742A1 (en) * | 2005-05-02 | 2006-11-30 | Jane Staunton | Compositions and methods for the treatment of neurodegenerative diseases |
| EP2093222A1 (en) * | 2008-02-22 | 2009-08-26 | Newbiotechnic, S.A. | Polyisoprenoid epoxides useful for decreasing cholesterol and/or increasing coenzyme Q biosynthesis |
| CA2732784C (en) * | 2008-08-13 | 2018-09-18 | Neuroquest Inc. | Compositions comprising terpene compounds for treating negative sensory phenomena |
| JP5467795B2 (ja) * | 2009-04-23 | 2014-04-09 | 学校法人近畿大学 | β−セクレターゼ阻害剤 |
| EP2423177A1 (en) * | 2010-08-25 | 2012-02-29 | Nyken Holding B.V. | Analogs of geranylgeranylacetone (GGA) |
| BR112013003682A2 (pt) * | 2010-09-01 | 2016-09-06 | Coyote Pharmaceuticals Inc | métodos para tratar doenças neurodegenerativas |
-
2012
- 2012-02-29 IN IN2585CHN2014 patent/IN2014CN02585A/en unknown
- 2012-02-29 EP EP12838765.1A patent/EP2763949A4/en not_active Withdrawn
- 2012-02-29 WO PCT/US2012/027147 patent/WO2013052148A1/en not_active Ceased
- 2012-02-29 AU AU2012319143A patent/AU2012319143A1/en not_active Abandoned
- 2012-02-29 CA CA2850716A patent/CA2850716A1/en not_active Abandoned
- 2012-02-29 JP JP2014534556A patent/JP2014530810A/ja active Pending
-
2014
- 2014-03-31 IL IL231823A patent/IL231823A0/en unknown
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