JP2014527056A5 - - Google Patents
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- Publication number
- JP2014527056A5 JP2014527056A5 JP2014526363A JP2014526363A JP2014527056A5 JP 2014527056 A5 JP2014527056 A5 JP 2014527056A5 JP 2014526363 A JP2014526363 A JP 2014526363A JP 2014526363 A JP2014526363 A JP 2014526363A JP 2014527056 A5 JP2014527056 A5 JP 2014527056A5
- Authority
- JP
- Japan
- Prior art keywords
- inhalant composition
- total weight
- inhalant
- composition
- preparing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000000203 mixture Substances 0.000 claims description 19
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 4
- YFMFNYKEUDLDTL-UHFFFAOYSA-N 1,1,1,2,3,3,3-heptafluoropropane Chemical compound FC(F)(F)C(F)C(F)(F)F YFMFNYKEUDLDTL-UHFFFAOYSA-N 0.000 claims description 2
- KUVIULQEHSCUHY-XYWKZLDCSA-N Beclometasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)COC(=O)CC)(OC(=O)CC)[C@@]1(C)C[C@@H]2O KUVIULQEHSCUHY-XYWKZLDCSA-N 0.000 claims description 2
- 229940057282 albuterol sulfate Drugs 0.000 claims description 2
- BNPSSFBOAGDEEL-UHFFFAOYSA-N albuterol sulfate Chemical compound OS(O)(=O)=O.CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1.CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 BNPSSFBOAGDEEL-UHFFFAOYSA-N 0.000 claims description 2
- 229950000210 beclometasone dipropionate Drugs 0.000 claims description 2
- 150000005828 hydrofluoroalkanes Chemical class 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 239000002202 Polyethylene glycol Substances 0.000 claims 3
- 229940124748 beta 2 agonist Drugs 0.000 claims 3
- 239000003246 corticosteroid Substances 0.000 claims 3
- 229920001223 polyethylene glycol Polymers 0.000 claims 3
- 239000003380 propellant Substances 0.000 claims 3
- 239000004094 surface-active agent Substances 0.000 claims 2
- OBRNDARFFFHCGE-PERKLWIXSA-N (S,S)-formoterol fumarate Chemical compound OC(=O)\C=C\C(O)=O.C1=CC(OC)=CC=C1C[C@H](C)NC[C@@H](O)C1=CC=C(O)C(NC=O)=C1.C1=CC(OC)=CC=C1C[C@H](C)NC[C@@H](O)C1=CC=C(O)C(NC=O)=C1 OBRNDARFFFHCGE-PERKLWIXSA-N 0.000 claims 1
- VOVIALXJUBGFJZ-KWVAZRHASA-N Budesonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3OC(CCC)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O VOVIALXJUBGFJZ-KWVAZRHASA-N 0.000 claims 1
- LUKZNWIVRBCLON-GXOBDPJESA-N Ciclesonide Chemical compound C1([C@H]2O[C@@]3([C@H](O2)C[C@@H]2[C@@]3(C[C@H](O)[C@@H]3[C@@]4(C)C=CC(=O)C=C4CC[C@H]32)C)C(=O)COC(=O)C(C)C)CCCCC1 LUKZNWIVRBCLON-GXOBDPJESA-N 0.000 claims 1
- NDAUXUAQIAJITI-UHFFFAOYSA-N albuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 claims 1
- NBMKJKDGKREAPL-DVTGEIKXSA-N beclomethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O NBMKJKDGKREAPL-DVTGEIKXSA-N 0.000 claims 1
- 229940092705 beclomethasone Drugs 0.000 claims 1
- 229960004436 budesonide Drugs 0.000 claims 1
- 229960003728 ciclesonide Drugs 0.000 claims 1
- 229960002714 fluticasone Drugs 0.000 claims 1
- MGNNYOODZCAHBA-GQKYHHCASA-N fluticasone Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(O)[C@@]2(C)C[C@@H]1O MGNNYOODZCAHBA-GQKYHHCASA-N 0.000 claims 1
- 229960000289 fluticasone propionate Drugs 0.000 claims 1
- WMWTYOKRWGGJOA-CENSZEJFSA-N fluticasone propionate Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(OC(=O)CC)[C@@]2(C)C[C@@H]1O WMWTYOKRWGGJOA-CENSZEJFSA-N 0.000 claims 1
- 229960002848 formoterol Drugs 0.000 claims 1
- BPZSYCZIITTYBL-UHFFFAOYSA-N formoterol Chemical compound C1=CC(OC)=CC=C1CC(C)NCC(O)C1=CC=C(O)C(NC=O)=C1 BPZSYCZIITTYBL-UHFFFAOYSA-N 0.000 claims 1
- 229960000193 formoterol fumarate Drugs 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- LZULAZTXJLWELL-UHFFFAOYSA-N methyl hex-5-ynoate Chemical compound COC(=O)CCCC#C LZULAZTXJLWELL-UHFFFAOYSA-N 0.000 claims 1
- 229960002288 procaterol Drugs 0.000 claims 1
- FKNXQNWAXFXVNW-BLLLJJGKSA-N procaterol Chemical compound N1C(=O)C=CC2=C1C(O)=CC=C2[C@@H](O)[C@@H](NC(C)C)CC FKNXQNWAXFXVNW-BLLLJJGKSA-N 0.000 claims 1
- 229960002789 procaterol hydrochloride Drugs 0.000 claims 1
- 229960002052 salbutamol Drugs 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
- 238000009472 formulation Methods 0.000 description 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TW100109223A TWI399202B (zh) | 2011-03-17 | 2011-03-17 | 製備用於治療呼吸道疾病之定量噴霧吸入劑的製程方法 |
| CN201110239124.1A CN102670505B (zh) | 2011-03-17 | 2011-08-19 | 制备用于治疗呼吸道疾病的定量喷雾吸入剂的工艺方法 |
| CN201110239124.1 | 2011-08-19 | ||
| PCT/CN2012/071129 WO2013026269A1 (zh) | 2011-03-17 | 2012-02-14 | 制备用于治疗呼吸道疾病的定量喷雾吸入剂的工艺方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014527056A JP2014527056A (ja) | 2014-10-09 |
| JP2014527056A5 true JP2014527056A5 (https=) | 2015-11-12 |
| JP5938476B2 JP5938476B2 (ja) | 2016-06-22 |
Family
ID=54253387
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014526363A Expired - Fee Related JP5938476B2 (ja) | 2011-03-17 | 2012-02-14 | 呼吸器疾患を治療するための定量噴霧式吸入剤を調製する方法 |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP2749275A4 (https=) |
| JP (1) | JP5938476B2 (https=) |
| KR (1) | KR101586273B1 (https=) |
| CN (1) | CN102670505B (https=) |
| AU (1) | AU2012300082B2 (https=) |
| CA (1) | CA2845258C (https=) |
| RU (1) | RU2582218C2 (https=) |
| SG (1) | SG2014011597A (https=) |
| TW (1) | TWI399202B (https=) |
| WO (1) | WO2013026269A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6739343B2 (ja) * | 2014-09-30 | 2020-08-12 | 株式会社エンビジョンＡｅｓｃエナジーデバイス | リチウムイオン二次電池の製造方法 |
| CN109464429B (zh) * | 2018-12-13 | 2021-04-27 | 上海方予健康医药科技有限公司 | 一种吸入压力定量气雾剂药物组合物及其制备方法 |
| CN110025578B (zh) * | 2019-04-10 | 2021-06-15 | 深圳市新阳唯康科技有限公司 | 一种治疗哮喘类肺部疾病的共无定形粉末及其制备方法 |
| WO2021195328A1 (en) * | 2020-03-25 | 2021-09-30 | Insmed Incorporated | Pharmaceutical formulations of treprostinil prodrugs and methods of use thereof |
| FR3137830A1 (fr) * | 2022-07-13 | 2024-01-19 | Aptar France Sas | Composition pharmaceutique comprenant du salbutamol |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5225183A (en) | 1988-12-06 | 1993-07-06 | Riker Laboratories, Inc. | Medicinal aerosol formulations |
| US5776434A (en) | 1988-12-06 | 1998-07-07 | Riker Laboratories, Inc. | Medicinal aerosol formulations |
| GB8828477D0 (en) * | 1988-12-06 | 1989-01-05 | Riker Laboratories Inc | Medical aerosol formulations |
| US5439670A (en) | 1989-11-28 | 1995-08-08 | Riker Laboratories, Inc. | Medicinal aerosol formulations |
| MX9203481A (es) | 1990-10-18 | 1992-07-01 | Minnesota Mining & Mfg | Formulaciones. |
| ZA924164B (en) | 1991-06-10 | 1993-02-24 | Schering Corp | Non-chlorofluorocarbon aerosol formulations |
| US6123924A (en) | 1991-09-25 | 2000-09-26 | Fisons Plc | Pressurized aerosol inhalation compositions |
| US5658549A (en) | 1991-12-12 | 1997-08-19 | Glaxo Group Limited | Aerosol formulations containing propellant 134a and fluticasone propionate |
| US5916540A (en) | 1994-10-24 | 1999-06-29 | Glaxo Group Limited | Aerosol formulations containing P134A and/or P227 and particulate medicament |
| DK0616524T3 (da) | 1991-12-12 | 1999-06-21 | Glaxo Group Ltd | Lægemidler |
| US5744123A (en) | 1991-12-12 | 1998-04-28 | Glaxo Group Limited | Aerosol formulations containing P134a and particulate medicaments |
| US5736124A (en) | 1991-12-12 | 1998-04-07 | Glaxo Group Limited | Aerosol formulations containing P134a and particulate medicament |
| IL104068A (en) | 1991-12-12 | 1998-10-30 | Glaxo Group Ltd | Surfactant-free pharmaceutical aerosol formulation comprising 1,1,1,2-tetrafluoroethane or 1,1,1,2,3,3,3-heptafluoro-n- propane as propellant |
| ES2079210T3 (es) | 1991-12-12 | 1996-01-01 | Glaxo Group Ltd | Formulacion farmaceutica de aerosol. |
| US5683676A (en) | 1991-12-12 | 1997-11-04 | Glaxo Group Limited | Canister containing aerosol formulations containing P134a and particulate medicaments |
| EP0617610B1 (en) | 1991-12-18 | 1997-03-19 | Minnesota Mining And Manufacturing Company | Suspension aerosol formulations |
| US5833950A (en) | 1992-07-31 | 1998-11-10 | Glaxo Group Limited | Aerosol formulations containing beclomethasone dipropionate-1, 1, 1, 2-tetrafluoroethane solvate |
| ES2119219T5 (es) | 1993-07-15 | 2011-05-11 | Minnesota Mining And Manufacturing Company | Cierres estancos para uso en un dispositivo para suministrar un aerosol. |
| EP0806940B1 (en) | 1994-12-22 | 2003-04-09 | AstraZeneca AB | Aerosol drug formulations |
| US6013245A (en) | 1995-01-26 | 2000-01-11 | Glaxo Group Limited | Aerosol formulation containing beclomethasone dipropionate and 1,1,1,2,3,3,3-heptafluoro-n-propane as propellant |
| GB9626960D0 (en) | 1996-12-27 | 1997-02-12 | Glaxo Group Ltd | Valve for aerosol container |
| AU718967B2 (en) * | 1997-02-05 | 2000-05-04 | Jagotec Ag | Medical aerosol formulations |
| US5891420A (en) | 1997-04-21 | 1999-04-06 | Aeropharm Technology Limited | Environmentally safe triancinolone acetonide aerosol formulations for oral inhalation |
| US5891419A (en) | 1997-04-21 | 1999-04-06 | Aeropharm Technology Limited | Environmentally safe flunisolide aerosol formulations for oral inhalation |
| US6309623B1 (en) | 1997-09-29 | 2001-10-30 | Inhale Therapeutic Systems, Inc. | Stabilized preparations for use in metered dose inhalers |
| GB9807232D0 (en) | 1998-04-03 | 1998-06-03 | Univ Cardiff | Aerosol composition |
| JP3610426B2 (ja) | 1998-06-04 | 2005-01-12 | 東京エレクトロン株式会社 | 基板姿勢制御装置 |
| JP4570251B2 (ja) * | 1998-07-24 | 2010-10-27 | ヤゴテック アーゲー | 医薬用エーロゾル製剤 |
| US6458338B1 (en) | 1998-09-22 | 2002-10-01 | Aeropharm Technology Incorporated | Amino acid stabilized medicinal aerosol formulations |
| DZ2947A1 (fr) | 1998-11-25 | 2004-03-15 | Chiesi Farma Spa | Inhalateur à compteur de dose sous pression. |
| US6004537A (en) | 1998-12-18 | 1999-12-21 | Baker Norton Pharmaceuticals, Inc. | Pharmaceutical solution aerosol formulations containing fluoroalkanes, budesonide and formoterol |
| AU7026800A (en) | 1999-09-11 | 2001-04-17 | Glaxo Group Limited | Pharmaceutical formulation of fluticasone propionate |
| ES2238334T3 (es) * | 1999-12-24 | 2005-09-01 | Glaxo Group Limited | Formulacion farmaceutica en aerosol de salmeterol y propionato de fluticasona. |
| US6540983B1 (en) | 2000-01-25 | 2003-04-01 | Aeropharm Technology Incorporated | Medical aerosol formulation |
| US6540982B1 (en) | 2000-01-25 | 2003-04-01 | Aeropharm Technology Incorporated | Medical aerosol formulation |
| US6464959B1 (en) | 2000-05-01 | 2002-10-15 | Aeropharm Technology Incorporated | Non-aqueous aerosol suspension comprising troglitazone, a fluid propellant, and an amino acid stabilizer |
| US6548049B1 (en) | 2000-05-01 | 2003-04-15 | Aeropharm Technology Incorporated | Medicinal aerosol formulation |
| US6447750B1 (en) | 2000-05-01 | 2002-09-10 | Aeropharm Technology Incorporated | Medicinal aerosol formulation |
| US6532684B1 (en) * | 2000-10-12 | 2003-03-18 | General Electric Company | System for cleaning pressurized containers |
| SE0200312D0 (sv) * | 2002-02-01 | 2002-02-01 | Astrazeneca Ab | Novel composition |
| EP3384931B1 (en) | 2002-03-01 | 2019-07-24 | Chiesi Farmaceutici S.p.A. | Formoterol superfine formulation |
| SE0203376D0 (sv) * | 2002-11-15 | 2002-11-15 | Astrazeneca Ab | New process |
| EP1452179A1 (en) * | 2003-02-27 | 2004-09-01 | CHIESI FARMACEUTICI S.p.A. | Novel medicament combination of a highly potent long-lasting beta2-agonist and a corticosteroid |
| GB0323685D0 (en) * | 2003-10-09 | 2003-11-12 | Jagotec Ag | Improvements in or relating to organic compounds |
| CN103462894A (zh) * | 2005-03-16 | 2013-12-25 | 霍尼韦尔国际公司 | 药物递送制剂、装置和方法 |
| CN101384248A (zh) * | 2006-02-09 | 2009-03-11 | 贝林格尔英格海姆法玛两合公司 | 用于具有二种或多种活性剂以及至少一种表面活性剂的气雾剂的药物制剂 |
| US20070286814A1 (en) * | 2006-06-12 | 2007-12-13 | Medispray Laboratories Pvt. Ltd. | Stable aerosol pharmaceutical formulations |
| TWI495466B (zh) * | 2010-09-23 | 2015-08-11 | Intech Biopharm Ltd | 用於氣喘之吸入性複方組合物 |
| CN102416179B (zh) * | 2010-09-28 | 2014-05-07 | 益得生物科技股份有限公司 | 用于哮喘的吸入性复方组合物 |
-
2011
- 2011-03-17 TW TW100109223A patent/TWI399202B/zh active
- 2011-08-19 CN CN201110239124.1A patent/CN102670505B/zh active Active
-
2012
- 2012-02-14 RU RU2014104996/15A patent/RU2582218C2/ru not_active IP Right Cessation
- 2012-02-14 WO PCT/CN2012/071129 patent/WO2013026269A1/zh not_active Ceased
- 2012-02-14 JP JP2014526363A patent/JP5938476B2/ja not_active Expired - Fee Related
- 2012-02-14 EP EP12825882.9A patent/EP2749275A4/en not_active Withdrawn
- 2012-02-14 CA CA2845258A patent/CA2845258C/en not_active Expired - Fee Related
- 2012-02-14 KR KR1020147004283A patent/KR101586273B1/ko not_active Expired - Fee Related
- 2012-02-14 SG SG2014011597A patent/SG2014011597A/en unknown
- 2012-02-14 AU AU2012300082A patent/AU2012300082B2/en not_active Ceased
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