JP2003518484A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2003518484A5 JP2003518484A5 JP2001548088A JP2001548088A JP2003518484A5 JP 2003518484 A5 JP2003518484 A5 JP 2003518484A5 JP 2001548088 A JP2001548088 A JP 2001548088A JP 2001548088 A JP2001548088 A JP 2001548088A JP 2003518484 A5 JP2003518484 A5 JP 2003518484A5
- Authority
- JP
- Japan
- Prior art keywords
- salmeterol
- formulation
- concentration
- formulation according
- fluticasone propionate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000009472 formulation Methods 0.000 description 28
- 239000000203 mixture Substances 0.000 description 28
- GIIZNNXWQWCKIB-UHFFFAOYSA-N Serevent Chemical compound C1=C(O)C(CO)=CC(C(O)CNCCCCCCOCCCCC=2C=CC=CC=2)=C1 GIIZNNXWQWCKIB-UHFFFAOYSA-N 0.000 description 19
- 229960004017 salmeterol Drugs 0.000 description 19
- 238000002360 preparation method Methods 0.000 description 10
- 229960000289 fluticasone propionate Drugs 0.000 description 9
- WMWTYOKRWGGJOA-CENSZEJFSA-N fluticasone propionate Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(OC(=O)CC)[C@@]2(C)C[C@@H]1O WMWTYOKRWGGJOA-CENSZEJFSA-N 0.000 description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 8
- 150000005828 hydrofluoroalkanes Chemical class 0.000 description 8
- 239000002585 base Substances 0.000 description 6
- 239000003380 propellant Substances 0.000 description 6
- 150000003839 salts Chemical class 0.000 description 6
- 239000008249 pharmaceutical aerosol Substances 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- YFMFNYKEUDLDTL-UHFFFAOYSA-N 1,1,1,2,3,3,3-heptafluoropropane Chemical group FC(F)(F)C(F)C(F)(F)F YFMFNYKEUDLDTL-UHFFFAOYSA-N 0.000 description 2
- LVGUZGTVOIAKKC-UHFFFAOYSA-N 1,1,1,2-tetrafluoroethane Chemical group FCC(F)(F)F LVGUZGTVOIAKKC-UHFFFAOYSA-N 0.000 description 2
- 229920000604 Polyethylene Glycol 200 Polymers 0.000 description 2
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- JLFNLZLINWHATN-UHFFFAOYSA-N pentaethylene glycol Chemical compound OCCOCCOCCOCCOCCO JLFNLZLINWHATN-UHFFFAOYSA-N 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 229950000339 xinafoate Drugs 0.000 description 2
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 230000005465 channeling Effects 0.000 description 1
- 238000002144 chemical decomposition reaction Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000012458 free base Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229940071648 metered dose inhaler Drugs 0.000 description 1
- 208000023504 respiratory system disease Diseases 0.000 description 1
- 229960005018 salmeterol xinafoate Drugs 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9930878.5A GB9930878D0 (en) | 1999-12-24 | 1999-12-24 | Pharmaceutical formulation |
| GB9930878.5 | 1999-12-24 | ||
| GB0018686.6 | 2000-07-28 | ||
| GB0018686A GB0018686D0 (en) | 2000-07-28 | 2000-07-28 | Pharmaceutical formulation |
| PCT/GB2000/004939 WO2001047493A1 (en) | 1999-12-24 | 2000-12-21 | Pharmaceutical aerosol formulation of salmeterol and fluticasone propionate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003518484A JP2003518484A (ja) | 2003-06-10 |
| JP2003518484A5 true JP2003518484A5 (https=) | 2007-12-27 |
Family
ID=26244762
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001548088A Pending JP2003518484A (ja) | 1999-12-24 | 2000-12-21 | サルメテロールおよびプロピオン酸フルチカゾンの医薬用エアゾル製剤 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20030032632A1 (https=) |
| EP (1) | EP1248597B1 (https=) |
| JP (1) | JP2003518484A (https=) |
| AT (1) | ATE291898T1 (https=) |
| AU (1) | AU2206801A (https=) |
| DE (1) | DE60019167T2 (https=) |
| ES (1) | ES2238334T3 (https=) |
| WO (1) | WO2001047493A1 (https=) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20010031244A1 (en) | 1997-06-13 | 2001-10-18 | Chiesi Farmaceutici S.P.A. | Pharmaceutical aerosol composition |
| DZ2947A1 (fr) | 1998-11-25 | 2004-03-15 | Chiesi Farma Spa | Inhalateur à compteur de dose sous pression. |
| IT1313553B1 (it) | 1999-07-23 | 2002-09-09 | Chiesi Farma Spa | Formulazioni ottimizzate costituite da soluzioni di steroidi dasomministrare per inalazione. |
| US20050048001A1 (en) * | 1999-11-23 | 2005-03-03 | Cripps Alan Leslie | Pharmaceutical formulations of salmeterol |
| DE60017450T2 (de) * | 1999-11-23 | 2006-03-02 | Glaxo Group Ltd., Greenford | Pharmazeutische formulierungen enthaltend salmeterol |
| IT1317846B1 (it) | 2000-02-22 | 2003-07-15 | Chiesi Farma Spa | Formulazioni contenenti un farmaco anticolinergico per il trattamentodella broncopneumopatia cronica ostruttiva. |
| JP5392880B2 (ja) | 2000-05-22 | 2014-01-22 | キエシ・フアルマチエウテイチ・ソチエタ・ペル・アチオニ | 加圧式定量吸入器のための安定な製薬学的溶液製剤 |
| US20060257324A1 (en) | 2000-05-22 | 2006-11-16 | Chiesi Farmaceutici S.P.A. | Pharmaceutical solution formulations for pressurised metered dose inhalers |
| GB2367011A (en) * | 2000-08-26 | 2002-03-27 | Glaxo Group Ltd | Metered dose inhaler for salmeterol |
| AR030516A1 (es) * | 2000-08-31 | 2003-08-20 | Glaxo Group Ltd | Uso de una combinacion de salmeterol y fluticasona |
| GB0021927D0 (en) * | 2000-09-07 | 2000-10-25 | Glaxo Group Ltd | Use of pharmaceutical combination |
| GB0105560D0 (en) * | 2001-03-07 | 2001-04-25 | Glaxo Group Ltd | Pharmaceutical formulations |
| GB0106031D0 (en) * | 2001-03-12 | 2001-05-02 | Glaxo Group Ltd | Use |
| WO2003059884A1 (en) | 2001-12-21 | 2003-07-24 | X-Ceptor Therapeutics, Inc. | Modulators of lxr |
| US7482366B2 (en) | 2001-12-21 | 2009-01-27 | X-Ceptor Therapeutics, Inc. | Modulators of LXR |
| EP1415647A1 (en) * | 2002-10-23 | 2004-05-06 | CHIESI FARMACEUTICI S.p.A. | "Long-acting beta-2 agonists ultrafine formulations" |
| DK1542904T3 (da) * | 2002-08-27 | 2008-04-21 | Schering Corp | Fremgangsmåde til fremstilling af formuleringer til en inhalator med målte doser |
| EP1595531A1 (en) | 2004-05-13 | 2005-11-16 | CHIESI FARMACEUTICI S.p.A. | Stable pharmaceutical solution formulations for pressurized metered dose inhalers |
| EP1811981B1 (en) * | 2004-10-12 | 2008-08-13 | Merck Generics (UK) Limited | Process for the preparation of suspension aerosol formulations, wherein the particles are formed by precipitation inside an aerosol canister |
| US7680778B2 (en) * | 2007-01-19 | 2010-03-16 | Microsoft Corporation | Support for reverse and stemmed hit-highlighting |
| GB0712454D0 (en) * | 2007-06-27 | 2007-08-08 | Generics Uk Ltd | Pharmaceutical compositions |
| EP2571486A4 (en) * | 2010-05-20 | 2013-12-04 | Sun Pharma Advanced Res Co Ltd | DRY POWDER INHALATION COMPOSITION |
| TWI399202B (zh) * | 2011-03-17 | 2013-06-21 | Intech Biopharm Ltd | 製備用於治療呼吸道疾病之定量噴霧吸入劑的製程方法 |
| PH12014500440A1 (en) | 2011-08-19 | 2014-04-28 | Intech Biopharm Ltd | Method for preparing metered dose sprayed inhaler for treating respiratory disease |
| CN102379846B (zh) * | 2011-10-21 | 2014-07-02 | 江苏长风药业有限公司 | 以氢氟烷烃和聚乙二醇为辅料氟替卡松丙酸酯气雾剂制剂 |
| AU2013259872B2 (en) | 2012-05-08 | 2018-06-28 | Nicox Ophthalmics, Inc. | Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof |
| US8765725B2 (en) | 2012-05-08 | 2014-07-01 | Aciex Therapeutics, Inc. | Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof |
| US9815865B2 (en) | 2013-01-07 | 2017-11-14 | Nicox Ophthalmics, Inc. | Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof |
| US11554229B2 (en) | 2013-03-26 | 2023-01-17 | OptiNose Inc. | Nasal administration |
| MX390453B (es) * | 2014-06-25 | 2025-03-19 | Optinose Inc | Administracion nasal. |
| US20170189329A1 (en) | 2014-07-29 | 2017-07-06 | 3M Innovative Properties Company | Method of preparing a pharmaceutical composition |
| US11260052B2 (en) | 2016-09-19 | 2022-03-01 | Mexichem Fluor S.A. De C.V. | Pharmaceutical composition |
| MX387723B (es) | 2016-09-19 | 2025-03-18 | Mexichem Fluor Sa De Cv | Composición farmacéutica que comprende bromuro de glicopirronio, propionato de fluticasona y 1,1-difluoroetano. |
| MX384545B (es) | 2016-09-19 | 2025-03-14 | Mexichem Fluor Sa De Cv | Composicion farmaceutica |
| WO2021195328A1 (en) * | 2020-03-25 | 2021-09-30 | Insmed Incorporated | Pharmaceutical formulations of treprostinil prodrugs and methods of use thereof |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE629985A (https=) * | 1962-11-29 | |||
| CH634480A5 (de) * | 1977-11-25 | 1983-02-15 | Schwarzkopf Gmbh Hans | Unter druck stehendes aerosolpraeparat. |
| IL95590A (en) * | 1989-09-08 | 1996-06-18 | Glaxo Group Ltd | Medicinal preparations containing Salmetrol and Pluticasone Propionate |
| US5919827A (en) * | 1990-07-11 | 1999-07-06 | Sepracor Inc. | Method for treating asthma using optically pure R(-) salmeterol |
| JP2769925B2 (ja) * | 1990-10-18 | 1998-06-25 | ミネソタ マイニング アンド マニュファクチャリング カンパニー | ベクロメタゾン１７，２１ジプロピオネートを含んで成るエアロゾル製剤 |
| MX9203481A (es) * | 1990-10-18 | 1992-07-01 | Minnesota Mining & Mfg | Formulaciones. |
| US5683676A (en) * | 1991-12-12 | 1997-11-04 | Glaxo Group Limited | Canister containing aerosol formulations containing P134a and particulate medicaments |
| IL104068A (en) * | 1991-12-12 | 1998-10-30 | Glaxo Group Ltd | Surfactant-free pharmaceutical aerosol formulation comprising 1,1,1,2-tetrafluoroethane or 1,1,1,2,3,3,3-heptafluoro-n- propane as propellant |
| US5736124A (en) * | 1991-12-12 | 1998-04-07 | Glaxo Group Limited | Aerosol formulations containing P134a and particulate medicament |
| SK280911B6 (sk) * | 1992-12-09 | 2000-09-12 | Boehringer Ingelheim Pharmaceuticals, Inc. | Farmaceutický prostriedok |
| DE4446891A1 (de) * | 1994-12-27 | 1996-07-04 | Falk Pharma Gmbh | Stabile wäßrige Budesonid-Lösung |
| NZ336049A (en) * | 1996-12-04 | 2000-09-29 | Bioglan Ireland R & D Ltd | Aersol device for administering pharmaceutical active agents in a solution of propellant, carrier and valve means for delivering this to the exterior of the container |
| AU718967B2 (en) * | 1997-02-05 | 2000-05-04 | Jagotec Ag | Medical aerosol formulations |
| GB2326334A (en) * | 1997-06-13 | 1998-12-23 | Chiesi Farma Spa | Pharmaceutical aerosol compositions |
| US6309623B1 (en) * | 1997-09-29 | 2001-10-30 | Inhale Therapeutic Systems, Inc. | Stabilized preparations for use in metered dose inhalers |
| GB2332372B (en) * | 1997-12-08 | 2002-08-14 | Minnesota Mining & Mfg | Pharmaceutical aerosol compositions |
| GB9808802D0 (en) * | 1998-04-24 | 1998-06-24 | Glaxo Group Ltd | Pharmaceutical formulations |
| CN1161104C (zh) * | 1998-06-18 | 2004-08-11 | 贝林格尔·英格海姆药物公司 | 有二种或多种活性物质的气溶胶药物制剂 |
| US6241969B1 (en) * | 1998-06-26 | 2001-06-05 | Elan Corporation Plc | Aqueous compositions containing corticosteroids for nasal and pulmonary delivery |
| IT1303788B1 (it) * | 1998-11-25 | 2001-02-23 | Chiesi Farma Spa | Formulazioni di aerosol medicinali. |
| US6004537A (en) * | 1998-12-18 | 1999-12-21 | Baker Norton Pharmaceuticals, Inc. | Pharmaceutical solution aerosol formulations containing fluoroalkanes, budesonide and formoterol |
| US6231519B1 (en) * | 1999-05-04 | 2001-05-15 | Nokia Corporation | Method and apparatus for providing air quality analysis based on human reactions and clustering methods |
| US6315985B1 (en) * | 1999-06-18 | 2001-11-13 | 3M Innovative Properties Company | C-17/21 OH 20-ketosteroid solution aerosol products with enhanced chemical stability |
| AU7026800A (en) * | 1999-09-11 | 2001-04-17 | Glaxo Group Limited | Pharmaceutical formulation of fluticasone propionate |
| EE200200426A (et) * | 2000-01-31 | 2003-12-15 | Pfizer Products Inc. | PDE4 isosüümide inhibiitoritena kasulikud pürimidiinkarboksamiidid |
-
2000
- 2000-12-21 ES ES00985666T patent/ES2238334T3/es not_active Expired - Lifetime
- 2000-12-21 WO PCT/GB2000/004939 patent/WO2001047493A1/en not_active Ceased
- 2000-12-21 JP JP2001548088A patent/JP2003518484A/ja active Pending
- 2000-12-21 DE DE60019167T patent/DE60019167T2/de not_active Expired - Lifetime
- 2000-12-21 US US10/168,672 patent/US20030032632A1/en not_active Abandoned
- 2000-12-21 AT AT00985666T patent/ATE291898T1/de not_active IP Right Cessation
- 2000-12-21 AU AU22068/01A patent/AU2206801A/en not_active Abandoned
- 2000-12-21 EP EP00985666A patent/EP1248597B1/en not_active Expired - Lifetime
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2003518484A5 (https=) | ||
| EP0789557B1 (en) | Propellant mixture for aerosol formulation | |
| JP5392880B2 (ja) | 加圧式定量吸入器のための安定な製薬学的溶液製剤 | |
| JP3280974B2 (ja) | 医 薬 | |
| JP4794701B2 (ja) | エアゾール製剤 | |
| JP2786493B2 (ja) | 医薬エアゾール製剤 | |
| JP3026841B2 (ja) | 医 薬 | |
| US20150250713A1 (en) | Pharmaceutical Composition | |
| RS52387B (sr) | Formoterol najfiniji preparat | |
| JPH10506887A (ja) | 医薬品 | |
| ME00333B (me) | Farmaceutski aerosolni preparat | |
| JPH07509475A (ja) | 医薬 | |
| JP2003509359A (ja) | プロピオン酸フルチカゾンの医薬製剤 | |
| AU2009312598A1 (en) | Pharmaceutical aerosol composition | |
| MX2012003303A (es) | Formulaciones medicinales en aerosol que no dañan la capa de ozono y con bajo efecto invernadero. | |
| AU2008269528B2 (en) | Pharmaceutical aerosol compositions comprising fluticasone | |
| US20130160761A1 (en) | Pharmaceutical Aerosol Composition | |
| US20110182830A1 (en) | Inhalation drug products, systems and uses | |
| JP5409594B2 (ja) | 加圧式定量吸入器のための安定な製薬学的溶液製剤 | |
| WO2007034207A2 (en) | Troventol formulation | |
| EP2911649A2 (en) | Pharmaceutical composition comprising tiotropium and a hydrofluoroalkane | |
| RS50233B (sr) | Stabilne farmaceutske formulacije rastvora za inhalatore odmerene doze pod pritiskom |