RU2582218C2 - Способ получения дозирующего распыляющего ингалятора для лечения респираторного заболевания - Google Patents
Способ получения дозирующего распыляющего ингалятора для лечения респираторного заболевания Download PDFInfo
- Publication number
- RU2582218C2 RU2582218C2 RU2014104996/15A RU2014104996A RU2582218C2 RU 2582218 C2 RU2582218 C2 RU 2582218C2 RU 2014104996/15 A RU2014104996/15 A RU 2014104996/15A RU 2014104996 A RU2014104996 A RU 2014104996A RU 2582218 C2 RU2582218 C2 RU 2582218C2
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- RU
- Russia
- Prior art keywords
- composition
- mixture
- hfa
- dose inhaler
- metered dose
- Prior art date
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- 238000000034 method Methods 0.000 title claims description 50
- 208000023504 respiratory system disease Diseases 0.000 title description 3
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- AEQDBKHAAWUCMT-CVHDTDHSSA-N hydron;8-hydroxy-5-[(1r,2s)-1-hydroxy-2-(propan-2-ylamino)butyl]-1h-quinolin-2-one;chloride Chemical compound Cl.N1C(=O)C=CC2=C1C(O)=CC=C2[C@@H](O)[C@@H](NC(C)C)CC AEQDBKHAAWUCMT-CVHDTDHSSA-N 0.000 description 1
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- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Otolaryngology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TW100109223A TWI399202B (zh) | 2011-03-17 | 2011-03-17 | 製備用於治療呼吸道疾病之定量噴霧吸入劑的製程方法 |
| CN201110239124.1A CN102670505B (zh) | 2011-03-17 | 2011-08-19 | 制备用于治疗呼吸道疾病的定量喷雾吸入剂的工艺方法 |
| CN201110239124.1 | 2011-08-19 | ||
| PCT/CN2012/071129 WO2013026269A1 (zh) | 2011-03-17 | 2012-02-14 | 制备用于治疗呼吸道疾病的定量喷雾吸入剂的工艺方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2014104996A RU2014104996A (ru) | 2015-09-27 |
| RU2582218C2 true RU2582218C2 (ru) | 2016-04-20 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2014104996/15A RU2582218C2 (ru) | 2011-03-17 | 2012-02-14 | Способ получения дозирующего распыляющего ингалятора для лечения респираторного заболевания |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP2749275A4 (https=) |
| JP (1) | JP5938476B2 (https=) |
| KR (1) | KR101586273B1 (https=) |
| CN (1) | CN102670505B (https=) |
| AU (1) | AU2012300082B2 (https=) |
| CA (1) | CA2845258C (https=) |
| RU (1) | RU2582218C2 (https=) |
| SG (1) | SG2014011597A (https=) |
| TW (1) | TWI399202B (https=) |
| WO (1) | WO2013026269A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6739343B2 (ja) * | 2014-09-30 | 2020-08-12 | 株式会社エンビジョンＡｅｓｃエナジーデバイス | リチウムイオン二次電池の製造方法 |
| CN109464429B (zh) * | 2018-12-13 | 2021-04-27 | 上海方予健康医药科技有限公司 | 一种吸入压力定量气雾剂药物组合物及其制备方法 |
| CN110025578B (zh) * | 2019-04-10 | 2021-06-15 | 深圳市新阳唯康科技有限公司 | 一种治疗哮喘类肺部疾病的共无定形粉末及其制备方法 |
| WO2021195328A1 (en) * | 2020-03-25 | 2021-09-30 | Insmed Incorporated | Pharmaceutical formulations of treprostinil prodrugs and methods of use thereof |
| FR3137830A1 (fr) * | 2022-07-13 | 2024-01-19 | Aptar France Sas | Composition pharmaceutique comprenant du salbutamol |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030032632A1 (en) * | 1999-12-24 | 2003-02-13 | Crispps Leslie Alan | Pharmaceutical aerosol formulation of salmeterol and fluticasone propionate |
Family Cites Families (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5225183A (en) | 1988-12-06 | 1993-07-06 | Riker Laboratories, Inc. | Medicinal aerosol formulations |
| US5776434A (en) | 1988-12-06 | 1998-07-07 | Riker Laboratories, Inc. | Medicinal aerosol formulations |
| GB8828477D0 (en) * | 1988-12-06 | 1989-01-05 | Riker Laboratories Inc | Medical aerosol formulations |
| US5439670A (en) | 1989-11-28 | 1995-08-08 | Riker Laboratories, Inc. | Medicinal aerosol formulations |
| MX9203481A (es) | 1990-10-18 | 1992-07-01 | Minnesota Mining & Mfg | Formulaciones. |
| ZA924164B (en) | 1991-06-10 | 1993-02-24 | Schering Corp | Non-chlorofluorocarbon aerosol formulations |
| US6123924A (en) | 1991-09-25 | 2000-09-26 | Fisons Plc | Pressurized aerosol inhalation compositions |
| US5658549A (en) | 1991-12-12 | 1997-08-19 | Glaxo Group Limited | Aerosol formulations containing propellant 134a and fluticasone propionate |
| US5916540A (en) | 1994-10-24 | 1999-06-29 | Glaxo Group Limited | Aerosol formulations containing P134A and/or P227 and particulate medicament |
| DK0616524T3 (da) | 1991-12-12 | 1999-06-21 | Glaxo Group Ltd | Lægemidler |
| US5744123A (en) | 1991-12-12 | 1998-04-28 | Glaxo Group Limited | Aerosol formulations containing P134a and particulate medicaments |
| US5736124A (en) | 1991-12-12 | 1998-04-07 | Glaxo Group Limited | Aerosol formulations containing P134a and particulate medicament |
| IL104068A (en) | 1991-12-12 | 1998-10-30 | Glaxo Group Ltd | Surfactant-free pharmaceutical aerosol formulation comprising 1,1,1,2-tetrafluoroethane or 1,1,1,2,3,3,3-heptafluoro-n- propane as propellant |
| ES2079210T3 (es) | 1991-12-12 | 1996-01-01 | Glaxo Group Ltd | Formulacion farmaceutica de aerosol. |
| US5683676A (en) | 1991-12-12 | 1997-11-04 | Glaxo Group Limited | Canister containing aerosol formulations containing P134a and particulate medicaments |
| EP0617610B1 (en) | 1991-12-18 | 1997-03-19 | Minnesota Mining And Manufacturing Company | Suspension aerosol formulations |
| US5833950A (en) | 1992-07-31 | 1998-11-10 | Glaxo Group Limited | Aerosol formulations containing beclomethasone dipropionate-1, 1, 1, 2-tetrafluoroethane solvate |
| ES2119219T5 (es) | 1993-07-15 | 2011-05-11 | Minnesota Mining And Manufacturing Company | Cierres estancos para uso en un dispositivo para suministrar un aerosol. |
| EP0806940B1 (en) | 1994-12-22 | 2003-04-09 | AstraZeneca AB | Aerosol drug formulations |
| US6013245A (en) | 1995-01-26 | 2000-01-11 | Glaxo Group Limited | Aerosol formulation containing beclomethasone dipropionate and 1,1,1,2,3,3,3-heptafluoro-n-propane as propellant |
| GB9626960D0 (en) | 1996-12-27 | 1997-02-12 | Glaxo Group Ltd | Valve for aerosol container |
| AU718967B2 (en) * | 1997-02-05 | 2000-05-04 | Jagotec Ag | Medical aerosol formulations |
| US5891420A (en) | 1997-04-21 | 1999-04-06 | Aeropharm Technology Limited | Environmentally safe triancinolone acetonide aerosol formulations for oral inhalation |
| US5891419A (en) | 1997-04-21 | 1999-04-06 | Aeropharm Technology Limited | Environmentally safe flunisolide aerosol formulations for oral inhalation |
| US6309623B1 (en) | 1997-09-29 | 2001-10-30 | Inhale Therapeutic Systems, Inc. | Stabilized preparations for use in metered dose inhalers |
| GB9807232D0 (en) | 1998-04-03 | 1998-06-03 | Univ Cardiff | Aerosol composition |
| JP3610426B2 (ja) | 1998-06-04 | 2005-01-12 | 東京エレクトロン株式会社 | 基板姿勢制御装置 |
| JP4570251B2 (ja) * | 1998-07-24 | 2010-10-27 | ヤゴテック アーゲー | 医薬用エーロゾル製剤 |
| US6458338B1 (en) | 1998-09-22 | 2002-10-01 | Aeropharm Technology Incorporated | Amino acid stabilized medicinal aerosol formulations |
| DZ2947A1 (fr) | 1998-11-25 | 2004-03-15 | Chiesi Farma Spa | Inhalateur à compteur de dose sous pression. |
| US6004537A (en) | 1998-12-18 | 1999-12-21 | Baker Norton Pharmaceuticals, Inc. | Pharmaceutical solution aerosol formulations containing fluoroalkanes, budesonide and formoterol |
| AU7026800A (en) | 1999-09-11 | 2001-04-17 | Glaxo Group Limited | Pharmaceutical formulation of fluticasone propionate |
| US6540983B1 (en) | 2000-01-25 | 2003-04-01 | Aeropharm Technology Incorporated | Medical aerosol formulation |
| US6540982B1 (en) | 2000-01-25 | 2003-04-01 | Aeropharm Technology Incorporated | Medical aerosol formulation |
| US6464959B1 (en) | 2000-05-01 | 2002-10-15 | Aeropharm Technology Incorporated | Non-aqueous aerosol suspension comprising troglitazone, a fluid propellant, and an amino acid stabilizer |
| US6548049B1 (en) | 2000-05-01 | 2003-04-15 | Aeropharm Technology Incorporated | Medicinal aerosol formulation |
| US6447750B1 (en) | 2000-05-01 | 2002-09-10 | Aeropharm Technology Incorporated | Medicinal aerosol formulation |
| US6532684B1 (en) * | 2000-10-12 | 2003-03-18 | General Electric Company | System for cleaning pressurized containers |
| SE0200312D0 (sv) * | 2002-02-01 | 2002-02-01 | Astrazeneca Ab | Novel composition |
| EP3384931B1 (en) | 2002-03-01 | 2019-07-24 | Chiesi Farmaceutici S.p.A. | Formoterol superfine formulation |
| SE0203376D0 (sv) * | 2002-11-15 | 2002-11-15 | Astrazeneca Ab | New process |
| EP1452179A1 (en) * | 2003-02-27 | 2004-09-01 | CHIESI FARMACEUTICI S.p.A. | Novel medicament combination of a highly potent long-lasting beta2-agonist and a corticosteroid |
| GB0323685D0 (en) * | 2003-10-09 | 2003-11-12 | Jagotec Ag | Improvements in or relating to organic compounds |
| CN103462894A (zh) * | 2005-03-16 | 2013-12-25 | 霍尼韦尔国际公司 | 药物递送制剂、装置和方法 |
| CN101384248A (zh) * | 2006-02-09 | 2009-03-11 | 贝林格尔英格海姆法玛两合公司 | 用于具有二种或多种活性剂以及至少一种表面活性剂的气雾剂的药物制剂 |
| US20070286814A1 (en) * | 2006-06-12 | 2007-12-13 | Medispray Laboratories Pvt. Ltd. | Stable aerosol pharmaceutical formulations |
| TWI495466B (zh) * | 2010-09-23 | 2015-08-11 | Intech Biopharm Ltd | 用於氣喘之吸入性複方組合物 |
| CN102416179B (zh) * | 2010-09-28 | 2014-05-07 | 益得生物科技股份有限公司 | 用于哮喘的吸入性复方组合物 |
-
2011
- 2011-03-17 TW TW100109223A patent/TWI399202B/zh active
- 2011-08-19 CN CN201110239124.1A patent/CN102670505B/zh active Active
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- 2012-02-14 WO PCT/CN2012/071129 patent/WO2013026269A1/zh not_active Ceased
- 2012-02-14 JP JP2014526363A patent/JP5938476B2/ja not_active Expired - Fee Related
- 2012-02-14 EP EP12825882.9A patent/EP2749275A4/en not_active Withdrawn
- 2012-02-14 CA CA2845258A patent/CA2845258C/en not_active Expired - Fee Related
- 2012-02-14 KR KR1020147004283A patent/KR101586273B1/ko not_active Expired - Fee Related
- 2012-02-14 SG SG2014011597A patent/SG2014011597A/en unknown
- 2012-02-14 AU AU2012300082A patent/AU2012300082B2/en not_active Ceased
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030032632A1 (en) * | 1999-12-24 | 2003-02-13 | Crispps Leslie Alan | Pharmaceutical aerosol formulation of salmeterol and fluticasone propionate |
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| AU2012300082A1 (en) | 2014-03-06 |
| JP2014527056A (ja) | 2014-10-09 |
| WO2013026269A1 (zh) | 2013-02-28 |
| CN102670505B (zh) | 2017-05-24 |
| CA2845258C (en) | 2016-05-10 |
| SG2014011597A (en) | 2014-03-28 |
| KR20140042898A (ko) | 2014-04-07 |
| KR101586273B1 (ko) | 2016-01-18 |
| TW201238591A (en) | 2012-10-01 |
| EP2749275A4 (en) | 2015-08-19 |
| RU2014104996A (ru) | 2015-09-27 |
| EP2749275A1 (en) | 2014-07-02 |
| TWI399202B (zh) | 2013-06-21 |
| CA2845258A1 (en) | 2013-02-28 |
| NZ621362A (en) | 2015-08-28 |
| AU2012300082B2 (en) | 2016-05-19 |
| JP5938476B2 (ja) | 2016-06-22 |
| CN102670505A (zh) | 2012-09-19 |
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