JP2014524920A5 - - Google Patents
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- JP2014524920A5 JP2014524920A5 JP2014520521A JP2014520521A JP2014524920A5 JP 2014524920 A5 JP2014524920 A5 JP 2014524920A5 JP 2014520521 A JP2014520521 A JP 2014520521A JP 2014520521 A JP2014520521 A JP 2014520521A JP 2014524920 A5 JP2014524920 A5 JP 2014524920A5
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- JP
- Japan
- Prior art keywords
- compound
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- formula
- ray powder
- powder diffraction
- Prior art date
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- WPFRVDGFFDXCKM-UHFFFAOYSA-N COC(C(NC(c1cc(Oc2ccccc2)ccc11)=O)=C1O)=O Chemical compound COC(C(NC(c1cc(Oc2ccccc2)ccc11)=O)=C1O)=O WPFRVDGFFDXCKM-UHFFFAOYSA-N 0.000 description 1
- VCOCTEDFDWIIBJ-UHFFFAOYSA-N COC(c1c(-c2cc(Oc3ccccc3)ccc2C(O)=O)[o]cn1)=O Chemical compound COC(c1c(-c2cc(Oc3ccccc3)ccc2C(O)=O)[o]cn1)=O VCOCTEDFDWIIBJ-UHFFFAOYSA-N 0.000 description 1
- UMMWEAOVAUETLR-UHFFFAOYSA-N COC(c1nc(Cl)c(cc(cc2)Oc3ccccc3)c2c1O)=O Chemical compound COC(c1nc(Cl)c(cc(cc2)Oc3ccccc3)c2c1O)=O UMMWEAOVAUETLR-UHFFFAOYSA-N 0.000 description 1
- YOZBGTLTNGAVFU-UHFFFAOYSA-N Cc(nc1C(NCC(O)=O)=O)c(cc(cc2)Oc3ccccc3)c2c1O Chemical compound Cc(nc1C(NCC(O)=O)=O)c(cc(cc2)Oc3ccccc3)c2c1O YOZBGTLTNGAVFU-UHFFFAOYSA-N 0.000 description 1
- QSGJZCCNTOCDRI-UHFFFAOYSA-N Cc(nc1C(NCC(OC)=O)=O)c(cc(cc2)Oc3ccccc3)c2c1O Chemical compound Cc(nc1C(NCC(OC)=O)=O)c(cc(cc2)Oc3ccccc3)c2c1O QSGJZCCNTOCDRI-UHFFFAOYSA-N 0.000 description 1
- RQLQUCXIJNHBDY-UHFFFAOYSA-N Cc(nc1C(O)=O)c(cc(cc2)Oc3ccccc3)c2c1O Chemical compound Cc(nc1C(O)=O)c(cc(cc2)Oc3ccccc3)c2c1O RQLQUCXIJNHBDY-UHFFFAOYSA-N 0.000 description 1
- 0 Cc1cc(Oc2cc3c(C)nc(C(OC)=O)c(*)c3cc2)ccc1 Chemical compound Cc1cc(Oc2cc3c(C)nc(C(OC)=O)c(*)c3cc2)ccc1 0.000 description 1
- CRZSSXUMRNESCC-UHFFFAOYSA-N N#Cc(c(C#N)c1)ccc1Oc1ccccc1 Chemical compound N#Cc(c(C#N)c1)ccc1Oc1ccccc1 CRZSSXUMRNESCC-UHFFFAOYSA-N 0.000 description 1
- NTZMSBAAHBICLE-UHFFFAOYSA-N N#Cc(c(C#N)c1)ccc1[N+]([O-])=O Chemical compound N#Cc(c(C#N)c1)ccc1[N+]([O-])=O NTZMSBAAHBICLE-UHFFFAOYSA-N 0.000 description 1
- HDQBHDKNRKRCNH-UHFFFAOYSA-N O=C(c(c1c2)ccc2Oc2ccccc2)OC1=O Chemical compound O=C(c(c1c2)ccc2Oc2ccccc2)OC1=O HDQBHDKNRKRCNH-UHFFFAOYSA-N 0.000 description 1
- FKDITAXSGNKBOZ-UHFFFAOYSA-N OC(c(c(C(O)=O)c1)ccc1Oc1ccccc1)=O Chemical compound OC(c(c(C(O)=O)c1)ccc1Oc1ccccc1)=O FKDITAXSGNKBOZ-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110207175.6 | 2011-07-22 | ||
| CN201110207175 | 2011-07-22 | ||
| CN201110209657.5 | 2011-07-25 | ||
| CN201110209657 | 2011-07-25 | ||
| CN201110211297 | 2011-07-26 | ||
| CN201110211297.2 | 2011-07-26 | ||
| PCT/CN2012/079058 WO2013013609A1 (en) | 2011-07-22 | 2012-07-23 | Polymorphic forms of compounds as prolyl hydroxylase inhibitor, and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014524920A JP2014524920A (ja) | 2014-09-25 |
| JP2014524920A5 true JP2014524920A5 (https=) | 2015-09-10 |
| JP6099644B2 JP6099644B2 (ja) | 2017-03-22 |
Family
ID=47600518
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014520521A Expired - Fee Related JP6099644B2 (ja) | 2011-07-22 | 2012-07-23 | プロリルヒドロキシラーゼ阻害剤としての化合物の多形体、およびその使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9206134B2 (https=) |
| EP (1) | EP2734504B1 (https=) |
| JP (1) | JP6099644B2 (https=) |
| KR (1) | KR102029951B1 (https=) |
| CN (1) | CN104024227B8 (https=) |
| AU (1) | AU2012289429B2 (https=) |
| CA (1) | CA2842730C (https=) |
| ES (1) | ES2606631T3 (https=) |
| IL (1) | IL230580B (https=) |
| WO (1) | WO2013013609A1 (https=) |
| ZA (1) | ZA201401310B (https=) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2528232C (en) | 2003-06-06 | 2010-05-25 | Fibrogen, Inc. | Novel nitrogen-containing heteroaryl compounds and their use in increasing endogenous erythropoietin |
| NO2686520T3 (https=) | 2011-06-06 | 2018-03-17 | ||
| EP2872487B1 (en) * | 2012-07-16 | 2017-04-26 | Fibrogen, Inc. | Process for making isoquinoline compounds |
| KR20210130849A (ko) * | 2012-07-16 | 2021-11-01 | 피브로겐, 인크. | 프롤릴 하이드록실라제 억제제 [(4-하이드록시-1-메틸-7-페녹시-아이소퀴놀린-3-카보닐)-아미노]-아세트산의 결정형 |
| US8883823B2 (en) | 2012-07-16 | 2014-11-11 | Fibrogen, Inc. | Crystalline forms of a prolyl hydroxylase inhibitor |
| KR20210104173A (ko) | 2013-06-06 | 2021-08-24 | 피브로겐, 인크. | Hif 하이드록실라제 억제자의 약학적 제형 |
| SG10201910773VA (en) | 2013-06-13 | 2020-01-30 | Akebia Therapeutics Inc | Compositions and methods for treating anemia |
| AR099354A1 (es) * | 2013-11-15 | 2016-07-20 | Akebia Therapeutics Inc | Formas sólidas de ácido {[5-(3-clorofenil)-3-hidroxipiridin-2-carbonil]amino}acético, composiciones, y sus usos |
| CN103694172A (zh) * | 2013-12-26 | 2014-04-02 | 辽宁亿灵科创生物医药科技有限公司 | 含氮杂芳基化合物的衍生物 |
| AU2016209126A1 (en) | 2015-01-23 | 2017-08-10 | Akebia Therapeutics, Inc. | Solid forms of 2-(5-(3-fluorophenyl)-3-hydroxypicolinamido)acetic acid, compositions, and uses thereof |
| CN106146490B (zh) * | 2015-03-27 | 2018-10-23 | 沈阳三生制药有限责任公司 | 被芳氧基或杂芳氧基取代的5-羟基-1,7-萘啶化合物、其制备方法及其制药用途 |
| US11324734B2 (en) | 2015-04-01 | 2022-05-10 | Akebia Therapeutics, Inc. | Compositions and methods for treating anemia |
| CN104910113B (zh) * | 2015-05-21 | 2017-05-10 | 中国科学院宁波材料技术与工程研究所 | 一种羟基苯酐的制备方法 |
| CN104892509B (zh) * | 2015-06-04 | 2018-03-09 | 苏州明锐医药科技有限公司 | 诺得司他的制备方法 |
| US10450569B2 (en) | 2015-08-13 | 2019-10-22 | Somagenics, Inc. | Methods and compositions of short small hairpin RNAS and microRNAS for wound healing |
| CN105130888A (zh) | 2015-10-09 | 2015-12-09 | 中国药科大学 | 炔基吡啶类脯氨酰羟化酶抑制剂、其制备方法和医药用途 |
| CN106916105A (zh) * | 2015-12-28 | 2017-07-04 | 徐州万邦金桥制药有限公司 | 一种纯化可博美的方法 |
| CN106187888A (zh) * | 2016-07-18 | 2016-12-07 | 江苏德源药业股份有限公司 | Fg‑4592单晶及其制备方法 |
| CZ2016627A3 (cs) | 2016-10-07 | 2018-04-18 | Zentiva, K.S. | Způsob přípravy (7-fenoxy-4-hydroxy-1-methylisochinolin-3-karbonyl)glycinu (roxadustatu) a jeho intermediátů založený na souběžném otevírání oxazolového kruhu, štěpení etheru a tvorbě iminu |
| CN107954931B (zh) * | 2016-10-17 | 2021-06-22 | 上海医药集团青岛国风药业股份有限公司 | 一种诺得司他的制备方法 |
| CN108017583B (zh) * | 2016-11-01 | 2021-04-06 | 徐州万邦金桥制药有限公司 | 一种可博美的制备方法 |
| WO2019030711A1 (en) * | 2017-08-11 | 2019-02-14 | Dr. Reddy’S Laboratories Limited | POLYMORPHS AND CO-CRYSTALS OF ROXADUSTAT |
| US11192860B2 (en) * | 2017-09-04 | 2021-12-07 | Sandoz Ag | Co-crystal of an orally available HIF prolyl hydroxylase inhibitor |
| CA3083672A1 (en) * | 2017-12-01 | 2019-06-06 | Dr. Reddy's Laboratories Limited | Process for the preparation of roxadustat and its intermediates |
| CN109956870A (zh) * | 2017-12-14 | 2019-07-02 | 南京卡文迪许生物工程技术有限公司 | 一种罗沙司他的合成方法及其中间体化合物 |
| CN108059679B (zh) * | 2017-12-27 | 2020-03-24 | 吉林大学 | 一种人源单链抗体及其应用 |
| CN110218184B (zh) * | 2018-03-01 | 2022-09-27 | 广东东阳光药业有限公司 | 诺德司他共晶及其制备方法 |
| CN115246789B (zh) * | 2018-03-16 | 2023-10-17 | 上海医药集团青岛国风药业股份有限公司 | 一种诺得司他的制备方法 |
| CN108424388B (zh) * | 2018-04-19 | 2020-08-21 | 杭州科巢生物科技有限公司 | 一种慢性贫血药物的制备方法 |
| EP3790863A1 (en) | 2018-05-09 | 2021-03-17 | Akebia Therapeutics Inc. | Process for preparing 2-[[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino]acetic acid |
| CN110903242B (zh) * | 2018-09-14 | 2023-05-12 | 四川科伦药物研究院有限公司 | 罗沙司他中间体的制备方法 |
| CN109369525A (zh) * | 2018-12-29 | 2019-02-22 | 安礼特(上海)医药科技有限公司 | 罗沙司它的新晶型及其制备方法 |
| WO2020178847A1 (en) | 2019-03-01 | 2020-09-10 | Mylan Laboratories Limited | Cocrystal of roxadustat and d-proline |
| CN109776415B (zh) * | 2019-03-07 | 2020-11-17 | 福建南方制药股份有限公司 | 一种Roxadustat中间体的制备方法 |
| IL287258B2 (en) | 2019-04-18 | 2026-01-01 | Nikang Therapeutics Inc | Inhibitors as tetrahydro-1h-cyclopenta[cd] indene derivatives as hypoxia inducible factor -2alpha |
| CN109956901B (zh) * | 2019-04-25 | 2022-09-06 | 南京正大天晴制药有限公司 | 异喹啉酮类化合物的制备方法 |
| US20220340532A1 (en) | 2019-08-07 | 2022-10-27 | Teva Pharmaceuticals International Gmbh | Processes for the preparation of roxadustat and intermediates thereof |
| CN112679428A (zh) * | 2019-10-17 | 2021-04-20 | 罗欣药业(上海)有限公司 | 罗沙司他新晶型及其制备方法 |
| CN112679430B (zh) * | 2019-10-18 | 2023-05-05 | 上海迪赛诺化学制药有限公司 | 一种制备异喹啉酮类化合物的方法 |
| CN112679431B (zh) * | 2019-10-18 | 2023-05-05 | 上海迪赛诺化学制药有限公司 | 一种制备异喹啉酮类化合物的方法 |
| CN112679429B (zh) * | 2019-10-18 | 2023-05-05 | 上海迪赛诺化学制药有限公司 | 一种制备异喹啉酮类化合物的方法 |
| WO2021073623A1 (zh) * | 2019-10-18 | 2021-04-22 | 上海迪赛诺化学制药有限公司 | 一种制备异喹啉酮类化合物的方法 |
| JP2022553706A (ja) | 2019-10-22 | 2022-12-26 | ▲蘇▼州科睿思制▲葯▼有限公司 | 低酸素誘導因子-プロリルヒドロキシラーゼ阻害剤の結晶形 |
| US11524939B2 (en) | 2019-11-13 | 2022-12-13 | Akebia Therapeutics, Inc. | Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino} acetic acid |
| CN111205224B (zh) * | 2020-04-22 | 2020-08-25 | 南京佰麦生物技术有限公司 | 一种罗沙司他水合物的晶型及其制备方法和应用 |
| CN113801060B (zh) * | 2020-06-13 | 2025-06-27 | 苏州鹏旭医药科技有限公司 | 一种多取代异喹啉化合物的制备方法 |
| EP4169906B1 (en) | 2020-06-19 | 2024-09-04 | Jumpcan (Shanghai) Medical Technology Co., Ltd | Method for synthesis of roxadustat and intermediate thereof, and intermediate thereof |
| CN112500344B (zh) * | 2020-11-18 | 2022-07-01 | 江苏豪森药业集团有限公司 | 罗沙司他晶型及其制备方法 |
| CN112194624A (zh) * | 2020-11-18 | 2021-01-08 | 江苏豪森药业集团有限公司 | 一种异喹啉类化合物的晶型及其制备方法 |
| CN115144480B (zh) * | 2021-03-31 | 2023-11-28 | 成都倍特药业股份有限公司 | 一种从罗沙司他中间体中检测吗啉和/或四甲基甲烷二胺的方法 |
| CN115724796A (zh) * | 2021-08-26 | 2023-03-03 | 成都苑东生物制药股份有限公司 | 一种罗沙司他新晶型及其制备方法 |
| WO2023095162A1 (en) | 2021-11-26 | 2023-06-01 | Mylan Laboratories Limited | Cocrystal of roxadustat and nicotinamide |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5470285A (en) * | 1977-11-14 | 1979-06-05 | Tanabe Seiyaku Co Ltd | Production of 4-hydroxyisocarbostyryl-3-carboxylic analog |
| DE19746287A1 (de) * | 1997-10-20 | 1999-04-22 | Hoechst Marion Roussel De Gmbh | Substituierte Isochinolin-2-Carbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel |
| US7893071B2 (en) * | 2001-04-23 | 2011-02-22 | University Of Virginia Patent Foundation | Synthesis and evaluation of novel phthalimide mimics as anti-angiogenic |
| CA2528232C (en) * | 2003-06-06 | 2010-05-25 | Fibrogen, Inc. | Novel nitrogen-containing heteroaryl compounds and their use in increasing endogenous erythropoietin |
| US7189697B2 (en) | 2004-04-13 | 2007-03-13 | Trustees Of Tufts College | Compositions and uses of a galectin for treatment of dry eye syndrome |
| US20060276477A1 (en) | 2005-06-06 | 2006-12-07 | Fibrogen, Inc. | Treatment method for anemia |
| JP5202327B2 (ja) | 2005-12-09 | 2013-06-05 | アムジエン・インコーポレーテツド | プロリルヒドロキシラーゼ阻害活性を示すキノロンベースの化合物、およびこの組成物、およびこの使用 |
| EP2476669A1 (en) * | 2006-01-27 | 2012-07-18 | Fibrogen, Inc. | Cyanoisoquinoline compounds and methods of use thereof |
| US20070293575A1 (en) * | 2006-06-15 | 2007-12-20 | Fibrogen, Inc. | Compounds and methods for treatment of cancer-related anemia |
| JP4311416B2 (ja) | 2006-06-30 | 2009-08-12 | 株式会社日立製作所 | 渦電流探傷法による表面欠陥長さ評価方法 |
| AU2010273101B2 (en) | 2009-07-15 | 2016-02-25 | Beijing Betta Pharmaceuticals Co., Ltd. | Compounds as hypoxia mimetics, and compositions, and uses thereof |
-
2012
- 2012-07-23 US US14/233,902 patent/US9206134B2/en active Active
- 2012-07-23 CN CN201280036322.0A patent/CN104024227B8/zh active Active
- 2012-07-23 EP EP12817360.6A patent/EP2734504B1/en not_active Not-in-force
- 2012-07-23 JP JP2014520521A patent/JP6099644B2/ja not_active Expired - Fee Related
- 2012-07-23 AU AU2012289429A patent/AU2012289429B2/en active Active
- 2012-07-23 WO PCT/CN2012/079058 patent/WO2013013609A1/en not_active Ceased
- 2012-07-23 KR KR1020147004452A patent/KR102029951B1/ko not_active Expired - Fee Related
- 2012-07-23 ES ES12817360.6T patent/ES2606631T3/es active Active
- 2012-07-23 CA CA2842730A patent/CA2842730C/en active Active
-
2014
- 2014-01-22 IL IL230580A patent/IL230580B/en active IP Right Grant
- 2014-02-20 ZA ZA2014/01310A patent/ZA201401310B/en unknown
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