JP2014524748A5 - - Google Patents

Info

Publication number

JP2014524748A5

JP2014524748A5 JP2014520658A JP2014520658A JP2014524748A5 JP 2014524748 A5 JP2014524748 A5 JP 2014524748A5 JP 2014520658 A JP2014520658 A JP 2014520658A JP 2014520658 A JP2014520658 A JP 2014520658A JP 2014524748 A5 JP2014524748 A5 JP 2014524748A5

Authority

JP

Japan

Prior art keywords

binding protein

antigen

antigen binding

seq

substitution

Prior art date

2012-07-19

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
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• 102000025171 antigen binding proteins Human genes 0.000 claims 41
• 108091000831 antigen binding proteins Proteins 0.000 claims 41
• 238000006467 substitution reaction Methods 0.000 claims 16
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 4
• 125000003275 alpha amino acid group Chemical group 0.000 claims 4
• 102100026120 IgG receptor FcRn large subunit p51 Human genes 0.000 claims 3
• 101710177940 IgG receptor FcRn large subunit p51 Proteins 0.000 claims 3
• 201000010099 disease Diseases 0.000 claims 3
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
• 239000008194 pharmaceutical composition Substances 0.000 claims 3
• 206010002556 Ankylosing Spondylitis Diseases 0.000 claims 2
• 208000011231 Crohn disease Diseases 0.000 claims 2
• 201000004681 Psoriasis Diseases 0.000 claims 2
• 201000001263 Psoriatic Arthritis Diseases 0.000 claims 2
• 208000036824 Psoriatic arthropathy Diseases 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 102000039446 nucleic acids Human genes 0.000 claims 2
• 108020004707 nucleic acids Proteins 0.000 claims 2
• 150000007523 nucleic acids Chemical class 0.000 claims 2
• 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
• MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 1
• NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 1
• 102000009109 Fc receptors Human genes 0.000 claims 1
• 108010087819 Fc receptors Proteins 0.000 claims 1
• 208000003456 Juvenile Arthritis Diseases 0.000 claims 1
• 206010059176 Juvenile idiopathic arthritis Diseases 0.000 claims 1
• FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims 1
• 241000269435 Rana <genus> Species 0.000 claims 1
• 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 1
• 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 1
• 125000000539 amino acid group Chemical group 0.000 claims 1
• 238000012217 deletion Methods 0.000 claims 1
• 230000037430 deletion Effects 0.000 claims 1
• 230000001605 fetal effect Effects 0.000 claims 1
• 238000003780 insertion Methods 0.000 claims 1
• 230000037431 insertion Effects 0.000 claims 1
• 201000002215 juvenile rheumatoid arthritis Diseases 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 229960000485 methotrexate Drugs 0.000 claims 1
• 238000012986 modification Methods 0.000 claims 1
• 230000004048 modification Effects 0.000 claims 1
• 239000002773 nucleotide Substances 0.000 claims 1
• 125000003729 nucleotide group Chemical group 0.000 claims 1
• 208000019764 polyarticular juvenile idiopathic arthritis Diseases 0.000 claims 1
• 230000006916 protein interaction Effects 0.000 claims 1
• 238000007920 subcutaneous administration Methods 0.000 claims 1
• 230000007306 turnover Effects 0.000 claims 1