JP2014524746A5 - - Google Patents
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- JP2014524746A5 JP2014524746A5 JP2014520383A JP2014520383A JP2014524746A5 JP 2014524746 A5 JP2014524746 A5 JP 2014524746A5 JP 2014520383 A JP2014520383 A JP 2014520383A JP 2014520383 A JP2014520383 A JP 2014520383A JP 2014524746 A5 JP2014524746 A5 JP 2014524746A5
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- cancer
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- 206010028980 Neoplasm Diseases 0.000 claims description 98
- 101000825949 Homo sapiens R-spondin-2 Proteins 0.000 claims description 28
- 201000011510 cancer Diseases 0.000 claims description 28
- 102100022763 R-spondin-2 Human genes 0.000 claims description 26
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims description 20
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 16
- 108060000903 Beta-catenin Proteins 0.000 claims description 15
- 102000040430 polynucleotide Human genes 0.000 claims description 15
- 108091033319 polynucleotide Proteins 0.000 claims description 15
- 239000002157 polynucleotide Substances 0.000 claims description 15
- 206010009944 Colon cancer Diseases 0.000 claims description 13
- 210000004027 cell Anatomy 0.000 claims description 13
- 239000003814 drug Substances 0.000 claims description 13
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 12
- 229920001184 polypeptide Polymers 0.000 claims description 12
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 12
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 12
- 102000015735 Beta-catenin Human genes 0.000 claims description 11
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 11
- 201000002528 pancreatic cancer Diseases 0.000 claims description 11
- 229940124597 therapeutic agent Drugs 0.000 claims description 10
- 206010006187 Breast cancer Diseases 0.000 claims description 9
- 208000026310 Breast neoplasm Diseases 0.000 claims description 9
- 208000020816 lung neoplasm Diseases 0.000 claims description 9
- 230000011664 signaling Effects 0.000 claims description 9
- 230000002401 inhibitory effect Effects 0.000 claims description 8
- 230000004614 tumor growth Effects 0.000 claims description 8
- 210000004408 hybridoma Anatomy 0.000 claims description 7
- 201000001441 melanoma Diseases 0.000 claims description 7
- 239000002773 nucleotide Substances 0.000 claims description 7
- 125000003729 nucleotide group Chemical group 0.000 claims description 7
- 210000004881 tumor cell Anatomy 0.000 claims description 7
- 208000008839 Kidney Neoplasms Diseases 0.000 claims description 6
- 102100031036 Leucine-rich repeat-containing G-protein coupled receptor 5 Human genes 0.000 claims description 6
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims description 6
- 230000027455 binding Effects 0.000 claims description 6
- 208000005017 glioblastoma Diseases 0.000 claims description 6
- 208000014829 head and neck neoplasm Diseases 0.000 claims description 6
- 208000014018 liver neoplasm Diseases 0.000 claims description 6
- 208000037841 lung tumor Diseases 0.000 claims description 6
- 101001063456 Homo sapiens Leucine-rich repeat-containing G-protein coupled receptor 5 Proteins 0.000 claims description 5
- 230000004913 activation Effects 0.000 claims description 5
- 230000004069 differentiation Effects 0.000 claims description 5
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 5
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 5
- 210000000130 stem cell Anatomy 0.000 claims description 5
- 206010033128 Ovarian cancer Diseases 0.000 claims description 4
- 206010005003 Bladder cancer Diseases 0.000 claims description 3
- 206010008342 Cervix carcinoma Diseases 0.000 claims description 3
- 208000002699 Digestive System Neoplasms Diseases 0.000 claims description 3
- 206010017993 Gastrointestinal neoplasms Diseases 0.000 claims description 3
- 206010019695 Hepatic neoplasm Diseases 0.000 claims description 3
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims description 3
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims description 3
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 3
- 206010060862 Prostate cancer Diseases 0.000 claims description 3
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 3
- 206010038389 Renal cancer Diseases 0.000 claims description 3
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims description 3
- 239000000427 antigen Substances 0.000 claims description 3
- 108091007433 antigens Proteins 0.000 claims description 3
- 102000036639 antigens Human genes 0.000 claims description 3
- 239000002246 antineoplastic agent Substances 0.000 claims description 3
- 230000024245 cell differentiation Effects 0.000 claims description 3
- 201000010881 cervical cancer Diseases 0.000 claims description 3
- 229940127089 cytotoxic agent Drugs 0.000 claims description 3
- 239000003937 drug carrier Substances 0.000 claims description 3
- 201000010536 head and neck cancer Diseases 0.000 claims description 3
- 201000010982 kidney cancer Diseases 0.000 claims description 3
- 201000007270 liver cancer Diseases 0.000 claims description 3
- 201000005202 lung cancer Diseases 0.000 claims description 3
- 239000008194 pharmaceutical composition Substances 0.000 claims description 3
- 208000023958 prostate neoplasm Diseases 0.000 claims description 3
- 230000009870 specific binding Effects 0.000 claims description 3
- 201000005112 urinary bladder cancer Diseases 0.000 claims description 3
- 208000024719 uterine cervix neoplasm Diseases 0.000 claims description 3
- 102000047209 human Rspo2 Human genes 0.000 claims description 2
- 229940121396 wnt pathway inhibitor Drugs 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims 3
- 101710174256 Leucine-rich repeat-containing G-protein coupled receptor 5 Proteins 0.000 claims 1
- 238000000034 method Methods 0.000 description 91
- 101000825954 Homo sapiens R-spondin-1 Proteins 0.000 description 22
- 102100022762 R-spondin-1 Human genes 0.000 description 19
- 230000035772 mutation Effects 0.000 description 16
- 108700001666 APC Genes Proteins 0.000 description 12
- 230000000415 inactivating effect Effects 0.000 description 12
- 102000037126 Leucine-rich repeat-containing G-protein-coupled receptors Human genes 0.000 description 8
- 108091006332 Leucine-rich repeat-containing G-protein-coupled receptors Proteins 0.000 description 8
- 238000003556 assay Methods 0.000 description 8
- 101000825960 Homo sapiens R-spondin-3 Proteins 0.000 description 6
- 102100022766 R-spondin-3 Human genes 0.000 description 6
- 238000010208 microarray analysis Methods 0.000 description 6
- 238000012163 sequencing technique Methods 0.000 description 6
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 4
- 101000825962 Homo sapiens R-spondin-4 Proteins 0.000 description 4
- 102100022759 R-spondin-4 Human genes 0.000 description 4
- 230000003213 activating effect Effects 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 102000050526 human RSPO1 Human genes 0.000 description 3
- 101001063463 Homo sapiens Leucine-rich repeat-containing G-protein coupled receptor 4 Proteins 0.000 description 2
- 101000981765 Homo sapiens Leucine-rich repeat-containing G-protein coupled receptor 6 Proteins 0.000 description 2
- 101100531974 Homo sapiens RSPO2 gene Proteins 0.000 description 2
- 102100031035 Leucine-rich repeat-containing G-protein coupled receptor 4 Human genes 0.000 description 2
- 102100024140 Leucine-rich repeat-containing G-protein coupled receptor 6 Human genes 0.000 description 2
- 238000009396 hybridization Methods 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 239000003550 marker Substances 0.000 description 2
- 239000012188 paraffin wax Substances 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- VEEGZPWAAPPXRB-BJMVGYQFSA-N (3e)-3-(1h-imidazol-5-ylmethylidene)-1h-indol-2-one Chemical group O=C1NC2=CC=CC=C2\C1=C/C1=CN=CN1 VEEGZPWAAPPXRB-BJMVGYQFSA-N 0.000 description 1
- 239000004037 angiogenesis inhibitor Substances 0.000 description 1
- 229940121369 angiogenesis inhibitor Drugs 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161508403P | 2011-07-15 | 2011-07-15 | |
| US61/508,403 | 2011-07-15 | ||
| US201161521547P | 2011-08-09 | 2011-08-09 | |
| US61/521,547 | 2011-08-09 | ||
| US201161570629P | 2011-12-14 | 2011-12-14 | |
| US61/570,629 | 2011-12-14 | ||
| PCT/US2012/046746 WO2013012747A1 (en) | 2011-07-15 | 2012-07-13 | Rspo binding agents and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017094648A Division JP2017169578A (ja) | 2011-07-15 | 2017-05-11 | Ｒｓｐｏ結合剤およびその使用法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014524746A JP2014524746A (ja) | 2014-09-25 |
| JP2014524746A5 true JP2014524746A5 (https=) | 2015-09-03 |
| JP6185463B2 JP6185463B2 (ja) | 2017-08-23 |
Family
ID=47558408
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014520383A Expired - Fee Related JP6185463B2 (ja) | 2011-07-15 | 2012-07-13 | Ｒｓｐｏ結合剤およびその使用法 |
| JP2017094648A Ceased JP2017169578A (ja) | 2011-07-15 | 2017-05-11 | Ｒｓｐｏ結合剤およびその使用法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017094648A Ceased JP2017169578A (ja) | 2011-07-15 | 2017-05-11 | Ｒｓｐｏ結合剤およびその使用法 |
Country Status (14)
| Country | Link |
|---|---|
| US (5) | US8802097B2 (https=) |
| EP (2) | EP2731625B1 (https=) |
| JP (2) | JP6185463B2 (https=) |
| KR (1) | KR20140048276A (https=) |
| CN (2) | CN106167526A (https=) |
| AU (1) | AU2012284254B2 (https=) |
| BR (1) | BR112014000765A2 (https=) |
| CA (1) | CA2841745A1 (https=) |
| CL (1) | CL2014000114A1 (https=) |
| IL (1) | IL230429A0 (https=) |
| MX (1) | MX349198B (https=) |
| RU (1) | RU2014101669A (https=) |
| WO (1) | WO2013012747A1 (https=) |
| ZA (1) | ZA201400525B (https=) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2157192T3 (pl) | 2003-10-10 | 2014-01-31 | Deutsches Krebsforsch | Kompozycje do diagnozowania i terapii chorób związanych z nieprawidłową ekspresją futrin (R-spondin) |
| EA018260B1 (ru) | 2006-09-29 | 2013-06-28 | Онкомед Фармасьютикалз, Инк. | Антитела к дельта-подобному лиганду 4 человека и их применение |
| EP2997975A1 (en) | 2006-10-20 | 2016-03-23 | Deutsches Krebsforschungszentrum Stiftung des Öffentlichen Rechts | Rspondins as modulators of angiogenesis and vasculogenesis |
| DK2173379T3 (en) | 2007-07-02 | 2015-12-07 | Oncomed Pharm Inc | Compositions and methods for treatment and diagnosis of cancer |
| CN102686720B (zh) * | 2009-11-17 | 2013-12-04 | 国立大学法人冈山大学 | 由牙髓细胞向成牙本质细胞的分化诱导方法 |
| US8551479B2 (en) | 2010-09-10 | 2013-10-08 | Oncomed Pharmaceuticals, Inc. | Methods for treating melanoma |
| BR112014000765A2 (pt) | 2011-07-15 | 2017-06-13 | Oncomed Pharm Inc | agentes de ligação a rspo e seus usos |
| IN2015KN00350A (https=) | 2012-07-13 | 2015-07-10 | Oncomed Pharm Inc | |
| AU2014244444A1 (en) * | 2013-03-14 | 2015-09-24 | Amgen Inc. | CHRDL-1 antigen binding proteins and methods of treatment |
| CN105744954B (zh) * | 2013-10-18 | 2021-03-05 | 豪夫迈·罗氏有限公司 | 抗rspo2和/或抗rspo3抗体及其用途 |
| CN103724415B (zh) * | 2013-12-31 | 2015-05-27 | 中山大学 | 斜带石斑鱼性别调控基因Rspo1及其制备方法和应用 |
| CA2952315A1 (en) | 2014-07-11 | 2016-01-14 | Genentech, Inc. | Notch pathway inhibition |
| CA2958144A1 (en) * | 2014-08-15 | 2016-02-18 | Oncomed Pharmaceuticals, Inc. | Rspo1 binding agents and uses thereof |
| JP2017528523A (ja) * | 2014-09-16 | 2017-09-28 | オンコメッド ファーマシューティカルズ インコーポレイテッド | 線維性疾患の治療 |
| MA41123A (fr) * | 2014-12-02 | 2017-10-10 | Oncomed Pharm Inc | Polythérapie pour le traitement du cancer |
| WO2017040660A1 (en) * | 2015-08-31 | 2017-03-09 | Oncomed Pharmaceuticals, Inc. | Combination therapy for treatment of disease |
| WO2017070567A1 (en) * | 2015-10-21 | 2017-04-27 | The Research Foundation For The State University Of New York | Klebsiella pneumoniae antibodies and methods to treat klebsiella pneumoniae infections |
| CA3002957A1 (en) * | 2015-10-23 | 2017-04-27 | Koninklijke Nederlandse Akademie Van Wetenschappen | Binding molecules that inhibit cancer growth |
| CN106913880B (zh) * | 2015-12-24 | 2021-02-12 | 上海交通大学 | 一种含有rspo1的靶向给药系统及其制备与应用 |
| MX2018010445A (es) | 2016-03-01 | 2019-10-17 | Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd | Anticuerpos especificos del receptor de poliovirus humano (rvp). |
| CN105925576B (zh) * | 2016-03-24 | 2018-04-20 | 嘉兴市第一医院 | 针对哺乳动物R‑Spondin3基因靶点的小干扰RNA、短发卡RNA及载体和应用 |
| EP3443004A1 (en) | 2016-04-14 | 2019-02-20 | H. Hoffnabb-La Roche Ag | Anti-rspo3 antibodies and methods of use |
| EP3448875A4 (en) * | 2016-04-29 | 2020-04-08 | Voyager Therapeutics, Inc. | COMPOSITIONS FOR TREATING A DISEASE |
| CN118580366A (zh) | 2017-08-09 | 2024-09-03 | 美勒斯公司 | 结合EGFR和cMET的抗体 |
| CN118909118A (zh) * | 2017-09-07 | 2024-11-08 | 奥古斯塔大学研究所公司 | 程序性细胞死亡蛋白1抗体 |
| CN109529040B (zh) * | 2017-09-21 | 2020-11-13 | 华东师范大学 | LGR4和R-spondin结合抑制剂及其在肿瘤治疗中的用途 |
| AU2018378668B2 (en) * | 2017-12-07 | 2025-04-10 | National Health Research Institutes | Anti-RSPO3 antibodies |
| CN110339364B (zh) * | 2018-04-02 | 2021-02-12 | 上海邦耀生物科技有限公司 | Lgr4/rspo阻断剂与抗免疫检查点抑制剂联合用于肿瘤的免疫治疗 |
| KR20210007959A (ko) | 2018-04-06 | 2021-01-20 | 다나-파버 캔서 인스티튜트 인크. | Hhla2 수용체로서의 kir3dl3, 항-hhla2 항체, 및 이들의 용도 |
| US12497464B1 (en) | 2018-08-03 | 2025-12-16 | Berkeley Therapeutics, Inc. | Antibody, antibody fragments or peptide for treating cancer and methods of formation and administration |
| GB201901710D0 (en) * | 2019-02-07 | 2019-03-27 | Nordic Bioscience As | Collagen type 23 assay |
| CN110467663B (zh) * | 2019-06-18 | 2022-05-10 | 华南农业大学 | Rspo3基因在母猪卵巢颗粒细胞中的应用 |
| US20220267735A1 (en) * | 2019-08-05 | 2022-08-25 | Genex Health Co., Ltd | Method for culturing primary cells from solid tumor of lung cancer and primary tumor cells from pleural effusion of lung cancer and auxiliary reagents |
| WO2021070181A1 (en) | 2019-10-08 | 2021-04-15 | Nectin Therapeutics Ltd. | Antibodies against the poliovirus receptor (pvr) and uses thereof |
| US20230338466A1 (en) * | 2020-06-03 | 2023-10-26 | Children's Hospital Medical Center | Compositions and methods comprising r-spondins for treatment of tumors |
| CN112457400B (zh) * | 2020-12-09 | 2022-03-08 | 福州迈新生物技术开发有限公司 | 抗β-catenin蛋白单克隆抗体、细胞系及其制备方法和应用 |
| JP2025504020A (ja) | 2022-01-28 | 2025-02-06 | ジョージアミューン・インコーポレイテッド | Ｐｄ－１アゴニストであるプログラム細胞死タンパク質１に対する抗体 |
| CN116239680B (zh) * | 2023-02-09 | 2024-02-06 | 义翘神州(泰州)科技有限公司 | 猴痘病毒a29小鼠单克隆包被抗体及检测抗体 |
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| KR102551095B1 (ko) * | 2023-03-21 | 2023-07-04 | 순천향대학교 산학협력단 | 신규한 항-인간 알스폰딘2 항체 및 이의 용도 |
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-
2012
- 2012-07-13 BR BR112014000765A patent/BR112014000765A2/pt unknown
- 2012-07-13 CN CN201610353524.8A patent/CN106167526A/zh active Pending
- 2012-07-13 EP EP12814264.3A patent/EP2731625B1/en active Active
- 2012-07-13 JP JP2014520383A patent/JP6185463B2/ja not_active Expired - Fee Related
- 2012-07-13 CA CA2841745A patent/CA2841745A1/en not_active Abandoned
- 2012-07-13 CN CN201280045135.9A patent/CN104023746B/zh not_active Expired - Fee Related
- 2012-07-13 US US13/549,050 patent/US8802097B2/en not_active Expired - Fee Related
- 2012-07-13 RU RU2014101669/10A patent/RU2014101669A/ru not_active Application Discontinuation
- 2012-07-13 EP EP18162940.3A patent/EP3401329A1/en not_active Withdrawn
- 2012-07-13 KR KR1020147003901A patent/KR20140048276A/ko not_active Ceased
- 2012-07-13 AU AU2012284254A patent/AU2012284254B2/en not_active Ceased
- 2012-07-13 MX MX2014000555A patent/MX349198B/es active IP Right Grant
- 2012-07-13 WO PCT/US2012/046746 patent/WO2013012747A1/en not_active Ceased
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2014
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2015
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