JP2013512278A5 - - Google Patents

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Publication number
JP2013512278A5
JP2013512278A5 JP2012542150A JP2012542150A JP2013512278A5 JP 2013512278 A5 JP2013512278 A5 JP 2013512278A5 JP 2012542150 A JP2012542150 A JP 2012542150A JP 2012542150 A JP2012542150 A JP 2012542150A JP 2013512278 A5 JP2013512278 A5 JP 2013512278A5
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JP
Japan
Prior art keywords
seq
antibody
pharmaceutical composition
tumor
composition according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2012542150A
Other languages
English (en)
Japanese (ja)
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JP2013512278A (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/US2010/058511 external-priority patent/WO2011068840A1/en
Publication of JP2013512278A publication Critical patent/JP2013512278A/ja
Publication of JP2013512278A5 publication Critical patent/JP2013512278A5/ja
Pending legal-status Critical Current

Links

JP2012542150A 2009-12-01 2010-12-01 Ｋ−ｒａｓ変異を含んだ癌を処置するための方法 Pending JP2013512278A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US26555909P 2009-12-01 2009-12-01
US61/265,559 2009-12-01
PCT/US2010/058511 WO2011068840A1 (en) 2009-12-01 2010-12-01 Methods for treating cancers comprising k-ras mutations

Publications (2)

Publication Number Publication Date
JP2013512278A JP2013512278A (ja) 2013-04-11
JP2013512278A5 true JP2013512278A5 (https=) 2014-01-23

Family

ID=44115253

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012542150A Pending JP2013512278A (ja) 2009-12-01 2010-12-01 Ｋ−ｒａｓ変異を含んだ癌を処置するための方法

Country Status (5)

Country Link
US (2) US20110165162A1 (https=)
EP (1) EP2506875A4 (https=)
JP (1) JP2013512278A (https=)
CA (1) CA2782299A1 (https=)
WO (1) WO2011068840A1 (https=)

Families Citing this family (13)

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DK2066694T3 (en) * 2006-09-29 2016-02-08 Oncomed Pharm Inc Compositions and Methods for Diagnosing and Treating Cancer
HUE029661T2 (en) 2009-10-16 2017-03-28 Oncomed Pharm Inc A therapeutic combination and use of DLL4 antagonist antibodies and antihypertensive agents
US8551479B2 (en) 2010-09-10 2013-10-08 Oncomed Pharmaceuticals, Inc. Methods for treating melanoma
LT3485903T (lt) 2011-09-23 2023-02-27 Mereo Biopharma 5, Inc. Vegf/ dll4 surišantys agentai ir jų panaudojimas
US9352039B2 (en) 2012-02-09 2016-05-31 The Regents Of The University Of Michigan Method of reducing the number of EMT and MET type breast cancer stem cells
US9599620B2 (en) 2012-10-31 2017-03-21 Oncomed Pharmaceuticals, Inc. Methods and monitoring of treatment with a DLL4 antagonist
JP2015030720A (ja) * 2013-08-07 2015-02-16 一丸ファルコス株式会社 キネシン抑制剤
ES2808153T3 (es) 2014-10-31 2021-02-25 Mereo Biopharma 5 Inc Terapia de combinación para tratamiento de enfermedad
US11339213B2 (en) 2015-09-23 2022-05-24 Mereo Biopharma 5, Inc. Methods and compositions for treatment of cancer
KR20190095355A (ko) * 2016-12-15 2019-08-14 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 암의 치료를 위한 조성물 및 방법
MX2020014243A (es) 2018-06-19 2021-05-12 Biontech Us Inc Neoantigenos y usos de los mismos.
CA3119458A1 (en) 2018-11-15 2020-05-22 Oncomed Pharmaceuticals, Inc. Methods and monitoring of treatment with vegf/dll4 binding agent
CN112394168B (zh) * 2019-08-15 2023-02-14 中山大学附属第六医院 IgA2检测试剂在制备KRAS突变型结直肠癌诊断剂方面的应用

Family Cites Families (26)

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US20050112121A1 (en) * 1992-04-30 2005-05-26 Yale University Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids
DE69638023D1 (de) * 1995-06-28 2009-10-22 Univ Yale Nukleotid- und proteinsequenzen von delta-genen von vertebraten und darauf basierende methoden
US20020137890A1 (en) * 1997-03-31 2002-09-26 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US6121045A (en) * 1997-04-04 2000-09-19 Millennium Biotherapeutics, Inc. Human Delta3 nucleic acid molecules
US20060122373A1 (en) * 1997-04-04 2006-06-08 Millennium Pharmaceuticals, Inc. Delta3, FTHMA-070, Tango85, Tango77, SPOIL,NEOKINE, Tango129 and integrin alpha subunit protein and nucleic acid molecules and uses thereof
US20030180784A1 (en) * 1997-04-04 2003-09-25 Millennium Pharmaceuticals, Inc. Novel human Delta3 compositions and therapeutic and diagnostic uses therefor
US6664098B1 (en) * 1997-05-14 2003-12-16 Asahi Kasei Kabushiki Kaisha Differentiation inhibitory agent
US6004528A (en) * 1997-09-18 1999-12-21 Bergstein; Ivan Methods of cancer diagnosis and therapy targeted against the cancer stemline
US6984522B2 (en) * 2000-08-03 2006-01-10 Regents Of The University Of Michigan Isolation and use of solid tumor stem cells
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EP1410018A1 (en) * 2001-07-25 2004-04-21 Lorantis Limited Method for detecting modultators of notch signalling
WO2003042246A2 (en) * 2001-11-14 2003-05-22 Lorantis Limited Inhibitors of the notch signalling pathway for use in the treatment of cancer
US20050137130A1 (en) * 2001-11-14 2005-06-23 Bodmer Mark W. Medical treatment
AU2002364537A1 (en) * 2001-12-07 2003-06-23 Regents Of The University Of Michigan Prospective identification and characterization of breast cancer stem cells
GB0218879D0 (en) * 2002-08-14 2002-09-25 Lorantis Ltd Medical treatment
AU2003267563A1 (en) * 2002-09-10 2004-04-30 Lorantis Limited Pharmaceutical composition and medical treatments comprising notch ligand proteins
US20060134121A1 (en) * 2004-10-29 2006-06-22 Gavin Thurston DII4 antagonists, assays, and therapeutic methods thereof
US8048418B2 (en) * 2004-10-29 2011-11-01 Regeneron Pharmaceuticals, Inc. Therapeutic methods for inhibiting tumor growth with combination of Dll4 antagonists and VEGF antagonists
JP2009507796A (ja) * 2005-09-01 2009-02-26 バスジーン セラピューティクス， インコーポレイテッド デルタ様リガンド４のモジュレーターの利用及び同定方法
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DK2066694T3 (en) * 2006-09-29 2016-02-08 Oncomed Pharm Inc Compositions and Methods for Diagnosing and Treating Cancer
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WO2009100349A1 (en) * 2008-02-09 2009-08-13 The Trustees Of Columbia University In The City Of New York Analogues of (-)-picropodophyllin, synthesis and uses thereof

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