JP2014524477A5 - - Google Patents
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- Publication number
- JP2014524477A5 JP2014524477A5 JP2014527288A JP2014527288A JP2014524477A5 JP 2014524477 A5 JP2014524477 A5 JP 2014524477A5 JP 2014527288 A JP2014527288 A JP 2014527288A JP 2014527288 A JP2014527288 A JP 2014527288A JP 2014524477 A5 JP2014524477 A5 JP 2014524477A5
- Authority
- JP
- Japan
- Prior art keywords
- trp
- leu
- peptide
- amphiphilic
- acetylated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 73
- 239000002245 particle Substances 0.000 claims description 40
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims description 30
- 125000001151 peptidyl group Chemical group 0.000 claims description 26
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 15
- 125000003277 amino group Chemical group 0.000 claims description 14
- 239000000203 mixture Substances 0.000 claims description 13
- 125000003301 D-leucyl group Chemical group N[C@@H](C(=O)*)CC(C)C 0.000 claims description 12
- 125000003941 D-tryptophan group Chemical group [H]C1=C([H])C([H])=C2C(C([C@@](N([H])[H])(C(=O)[*])[H])([H])[H])=C([H])N([H])C2=C1[H] 0.000 claims description 12
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims description 12
- 230000002209 hydrophobic effect Effects 0.000 claims description 12
- 239000013543 active substance Substances 0.000 claims description 10
- 101800002011 Amphipathic peptide Proteins 0.000 claims description 9
- 239000003446 ligand Substances 0.000 claims description 9
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims description 8
- 108020004707 nucleic acids Proteins 0.000 claims description 8
- 102000039446 nucleic acids Human genes 0.000 claims description 8
- 150000007523 nucleic acids Chemical class 0.000 claims description 8
- BQVUABVGYYSDCJ-ZFWWWQNUSA-N Leu-Trp Chemical compound C1=CC=C2C(C[C@H](NC(=O)[C@@H](N)CC(C)C)C(O)=O)=CNC2=C1 BQVUABVGYYSDCJ-ZFWWWQNUSA-N 0.000 claims description 6
- BQVUABVGYYSDCJ-UHFFFAOYSA-N Nalpha-L-Leucyl-L-tryptophan Natural products C1=CC=C2C(CC(NC(=O)C(N)CC(C)C)C(O)=O)=CNC2=C1 BQVUABVGYYSDCJ-UHFFFAOYSA-N 0.000 claims description 6
- 210000004027 cell Anatomy 0.000 claims description 6
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 108010001857 Cell Surface Receptors Proteins 0.000 claims description 2
- 108020004414 DNA Proteins 0.000 claims description 2
- 108091027967 Small hairpin RNA Proteins 0.000 claims description 2
- 108020004459 Small interfering RNA Proteins 0.000 claims description 2
- 102000006240 membrane receptors Human genes 0.000 claims description 2
- 108091070501 miRNA Proteins 0.000 claims description 2
- 239000002679 microRNA Substances 0.000 claims description 2
- 239000002924 silencing RNA Substances 0.000 claims description 2
- 239000004055 small Interfering RNA Substances 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- 230000000149 penetrating effect Effects 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 239000008176 lyophilized powder Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000001890 transfection Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161526526P | 2011-08-23 | 2011-08-23 | |
| US61/526,526 | 2011-08-23 | ||
| PCT/US2012/052027 WO2013028843A1 (en) | 2011-08-23 | 2012-08-23 | Peptide nanoparticles and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014524477A JP2014524477A (ja) | 2014-09-22 |
| JP2014524477A5 true JP2014524477A5 (cg-RX-API-DMAC7.html) | 2014-10-30 |
Family
ID=46826904
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014527288A Ceased JP2014524477A (ja) | 2011-08-23 | 2012-08-23 | ペプチドナノ粒子およびその使用 |
Country Status (19)
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8153435B1 (en) | 2005-03-30 | 2012-04-10 | Tracer Detection Technology Corp. | Methods and articles for identifying objects using encapsulated perfluorocarbon tracers |
| WO2017139746A1 (en) * | 2016-02-11 | 2017-08-17 | Mark Daniels | Posh inhibitor complex biomolecules and amphiphile micelles |
| CA3018561A1 (en) | 2016-03-21 | 2017-09-28 | Rhode Island Council On Postsecondary Education | Ph-sensitive peptides |
| DE202017007363U1 (de) * | 2016-12-16 | 2021-02-16 | The Brigham And Women's Hospital, Inc. | Zusammensetzung von Partikeln mit Eisenoxidkernen |
| CN106832003B (zh) * | 2017-02-15 | 2021-01-05 | 中国药科大学 | 一种酸敏性多肽及其应用 |
| EP3773483A4 (en) | 2018-04-06 | 2022-01-26 | Amma Therapeutics, Inc. | Composition for controlled release of therapeutic agents |
| US12319711B2 (en) | 2019-09-20 | 2025-06-03 | Northwestern University | Spherical nucleic acids with tailored and active protein coronae |
| US12378560B2 (en) | 2019-10-29 | 2025-08-05 | Northwestern University | Sequence multiplicity within spherical nucleic acids |
| CN114516819B (zh) * | 2022-02-25 | 2024-02-27 | 顺毅宜昌化工有限公司 | 一种n,n’-二乙酰基肼的制备方法 |
| WO2023244536A2 (en) * | 2022-06-13 | 2023-12-21 | Neubase Therapeutics, Inc. | Oligonucleotide analogue formulations |
| CN116004221B (zh) * | 2022-12-15 | 2023-12-19 | 湖南卓润生物科技有限公司 | 环肽的新应用、吖啶标记复合物与制备方法、检测试剂盒 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3270960A (en) | 1964-09-11 | 1966-09-06 | Sperry Rand Corp | Fluid sensor |
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US3872925A (en) | 1973-04-24 | 1975-03-25 | Gearhart Owen Industries | Through-tubing bridge plug |
| US3842067A (en) | 1973-07-27 | 1974-10-15 | American Home Prod | Synthesis of(des-asn5)-srif and intermediates |
| JPS5726506B2 (cg-RX-API-DMAC7.html) | 1974-03-08 | 1982-06-04 | ||
| US4105603A (en) | 1977-03-28 | 1978-08-08 | The Salk Institute For Biological Studies | Peptides which effect release of hormones |
| US4511390A (en) | 1983-06-10 | 1985-04-16 | E. I. Du Pont De Nemours And Company | Aralkylcarbamoyl peptide alcohols |
| US5643873A (en) | 1992-05-06 | 1997-07-01 | Affymax Technologies N.V. | Peptides and compounds that bind selectins including endothelial leukocyte adhesion molecule 1 |
| US5625048A (en) | 1994-11-10 | 1997-04-29 | The Regents Of The University Of California | Modified green fluorescent proteins |
| US5654276A (en) | 1995-06-07 | 1997-08-05 | Affymax Technologies N.V. | Peptides and compounds that bind to the IL-5 receptor |
| FR2736642B1 (fr) | 1995-07-10 | 1997-09-12 | Pasteur Institut | Immunovecteurs, notamment anticorps et fragments d'anticorps utilisables pour le transport intracellulaire et intranucleaire de principes biologiquement actifs notamment d'haptenes, de proteines et d'acides nucleiques |
| US6124128A (en) | 1996-08-16 | 2000-09-26 | The Regents Of The University Of California | Long wavelength engineered fluorescent proteins |
| WO2001009191A1 (en) | 1999-08-02 | 2001-02-08 | Synt:Em S.A. | Computational design methods for making molecular mimetics |
| CA2439400A1 (en) | 2001-02-26 | 2002-09-06 | The Regents Of The University Of California | Non-oligomerizing tandem fluorescent proteins |
| CA2572964C (en) | 2004-07-06 | 2018-03-06 | 3D Matrix, Inc. | Purified amphiphilic peptide compositions and uses thereof |
| JP6088123B2 (ja) * | 2008-02-01 | 2017-03-01 | アルファ−オー・ペプチドズ・アーゲーＡｌｐｈａ−Ｏ Ｐｅｐｔｉｄｅｓ Ａｇ | ワクチンとして有用な自己会合ペプチドナノ粒子 |
| US20110112040A1 (en) * | 2008-04-28 | 2011-05-12 | President And Fellows Of Harvard College | Supercharged proteins for cell penetration |
-
2012
- 2012-08-23 EP EP12756593.5A patent/EP2748182B1/en not_active Not-in-force
- 2012-08-23 WO PCT/US2012/052027 patent/WO2013028843A1/en not_active Ceased
- 2012-08-23 JP JP2014527288A patent/JP2014524477A/ja not_active Ceased
- 2012-08-23 PT PT127565935T patent/PT2748182T/pt unknown
- 2012-08-23 CN CN201280052123.9A patent/CN104011065B/zh not_active Expired - Fee Related
- 2012-08-23 SG SG11201400073SA patent/SG11201400073SA/en unknown
- 2012-08-23 HU HUE12756593A patent/HUE031511T2/en unknown
- 2012-08-23 KR KR1020147007599A patent/KR20140068087A/ko not_active Withdrawn
- 2012-08-23 MX MX2014002062A patent/MX2014002062A/es unknown
- 2012-08-23 BR BR112014004014-1A patent/BR112014004014A2/pt not_active IP Right Cessation
- 2012-08-23 DK DK12756593.5T patent/DK2748182T3/en active
- 2012-08-23 US US13/592,733 patent/US8828928B2/en not_active Expired - Fee Related
- 2012-08-23 RU RU2014110901/10A patent/RU2014110901A/ru not_active Application Discontinuation
- 2012-08-23 CA CA2845886A patent/CA2845886A1/en not_active Abandoned
- 2012-08-23 AU AU2012298824A patent/AU2012298824B2/en not_active Expired - Fee Related
- 2012-08-23 ES ES12756593.5T patent/ES2610779T3/es active Active
-
2014
- 2014-02-17 IL IL231005A patent/IL231005A0/en unknown
- 2014-02-18 ZA ZA2014/01210A patent/ZA201401210B/en unknown
- 2014-02-20 CL CL2014000418A patent/CL2014000418A1/es unknown
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