JP2014523408A5 - - Google Patents
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- JP2014523408A5 JP2014523408A5 JP2014514023A JP2014514023A JP2014523408A5 JP 2014523408 A5 JP2014523408 A5 JP 2014523408A5 JP 2014514023 A JP2014514023 A JP 2014514023A JP 2014514023 A JP2014514023 A JP 2014514023A JP 2014523408 A5 JP2014523408 A5 JP 2014523408A5
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- Prior art keywords
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- sequence
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- 102100035360 Cerebellar degeneration-related antigen 1 Human genes 0.000 claims 24
- 125000003275 alpha amino acid group Chemical group 0.000 claims 9
- 238000006467 substitution reaction Methods 0.000 claims 9
- 230000037430 deletion Effects 0.000 claims 8
- 238000012217 deletion Methods 0.000 claims 8
- 230000037431 insertion Effects 0.000 claims 8
- 238000003780 insertion Methods 0.000 claims 8
- 208000026278 immune system disease Diseases 0.000 claims 4
- 238000013508 migration Methods 0.000 claims 3
- 230000005012 migration Effects 0.000 claims 3
- 210000000440 neutrophil Anatomy 0.000 claims 3
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 230000035772 mutation Effects 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 2
- 101710098483 C5a anaphylatoxin chemotactic receptor 1 Proteins 0.000 claims 1
- 102100032957 C5a anaphylatoxin chemotactic receptor 1 Human genes 0.000 claims 1
- 101000867983 Homo sapiens C5a anaphylatoxin chemotactic receptor 1 Proteins 0.000 claims 1
- 102000009490 IgG Receptors Human genes 0.000 claims 1
- 108010073807 IgG Receptors Proteins 0.000 claims 1
- 208000005777 Lupus Nephritis Diseases 0.000 claims 1
- 206010057249 Phagocytosis Diseases 0.000 claims 1
- 201000001263 Psoriatic Arthritis Diseases 0.000 claims 1
- 208000036824 Psoriatic arthropathy Diseases 0.000 claims 1
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 230000002860 competitive effect Effects 0.000 claims 1
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 1
- 238000000670 ligand binding assay Methods 0.000 claims 1
- 230000008782 phagocytosis Effects 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11168787.7 | 2011-06-06 | ||
| EP11168787 | 2011-06-06 | ||
| US201161505137P | 2011-07-07 | 2011-07-07 | |
| US61/505,137 | 2011-07-07 | ||
| EP12159172.1 | 2012-03-13 | ||
| EP12159172 | 2012-03-13 | ||
| PCT/EP2012/060524 WO2012168199A1 (en) | 2011-06-06 | 2012-06-04 | Therapeutic antibodies |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016237458A Division JP6416177B2 (ja) | 2011-06-06 | 2016-12-07 | 治療抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014523408A JP2014523408A (ja) | 2014-09-11 |
| JP2014523408A5 true JP2014523408A5 (enExample) | 2015-07-23 |
| JP6141834B2 JP6141834B2 (ja) | 2017-06-07 |
Family
ID=47295509
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014514023A Active JP6141834B2 (ja) | 2011-06-06 | 2012-06-04 | 治療抗体 |
| JP2016237458A Active JP6416177B2 (ja) | 2011-06-06 | 2016-12-07 | 治療抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016237458A Active JP6416177B2 (ja) | 2011-06-06 | 2016-12-07 | 治療抗体 |
Country Status (16)
| Country | Link |
|---|---|
| US (7) | US8613926B2 (enExample) |
| EP (3) | EP2718322B1 (enExample) |
| JP (2) | JP6141834B2 (enExample) |
| KR (1) | KR101978757B1 (enExample) |
| CN (1) | CN103596982B (enExample) |
| AU (1) | AU2012266487B2 (enExample) |
| BR (1) | BR112013031198B1 (enExample) |
| CA (1) | CA2838497C (enExample) |
| DK (3) | DK2718322T3 (enExample) |
| ES (2) | ES2693647T3 (enExample) |
| IL (1) | IL229254A (enExample) |
| PL (2) | PL3424953T3 (enExample) |
| PT (1) | PT3424953T (enExample) |
| RU (1) | RU2616881C2 (enExample) |
| TW (1) | TWI564305B (enExample) |
| WO (1) | WO2012168199A1 (enExample) |
Families Citing this family (53)
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| EP2718322B1 (en) * | 2011-06-06 | 2018-08-08 | Novo Nordisk A/S | Therapeutic antibodies |
| US9657105B2 (en) | 2013-03-15 | 2017-05-23 | City Of Hope | CD123-specific chimeric antigen receptor redirected T cells and methods of their use |
| HRP20221262T1 (hr) * | 2013-09-13 | 2022-12-09 | Beigene Switzerland Gmbh | Protutijela anti-pd1 i njihova uporaba kao terapeutskih i dijagnostičkih sredstava |
| CN113307880B (zh) * | 2014-01-13 | 2025-07-04 | 希望之城公司 | 在Fc间隔物区中具有突变的嵌合抗原受体(CAR)及其使用方法 |
| WO2015140591A1 (en) * | 2014-03-21 | 2015-09-24 | Nordlandssykehuset Hf | Anti-cd14 antibodies and uses thereof |
| CN110156892B (zh) | 2014-07-03 | 2023-05-16 | 百济神州有限公司 | 抗pd-l1抗体及其作为治疗剂及诊断剂的用途 |
| KR102524920B1 (ko) | 2014-07-22 | 2023-04-25 | 아폴로믹스 인코포레이티드 | 항-pd-1 항체 |
| ES2987034T3 (es) | 2014-08-05 | 2024-11-13 | Apollomics Inc | Anticuerpos anti-PD-L1 |
| EP3213075B1 (en) * | 2014-10-31 | 2020-04-29 | CellTrend GmbH | Diagnosis of an autoimmune disease using detection of antibodies directed against c5a-receptor |
| CA3004306A1 (en) * | 2015-11-04 | 2017-05-11 | Stephen J. Forman | Chimeric antigen receptors targeting her2 |
| CA3005986A1 (en) * | 2015-11-23 | 2017-06-01 | Innate Pharma | Cd39 vascular isoform targeting agents |
| ES2970864T3 (es) * | 2015-11-25 | 2024-05-31 | Visterra Inc | Moléculas de anticuerpos contra APRIL y usos de las mismas |
| CN106957366B (zh) * | 2016-01-12 | 2022-02-01 | 上海昀怡健康科技发展有限公司 | 一种C5aR抗体及其制备方法和应用 |
| CN108884169B (zh) | 2016-01-22 | 2022-03-22 | 默沙东公司 | 抗凝血因子xi抗体 |
| CA3172367A1 (en) | 2016-06-14 | 2017-12-21 | Merck Sharp & Dohme Corp. | Anti-coagulation factor xi antibodies |
| NZ749997A (en) | 2016-07-05 | 2022-11-25 | Beigene Ltd | Combination of a pd-l antagonist and a raf inhibitor for treating cancer |
| TWI739887B (zh) | 2016-08-19 | 2021-09-21 | 英屬開曼群島商百濟神州有限公司 | 使用包含btk抑制劑的組合產品治療癌症 |
| EP3573989A4 (en) | 2017-01-25 | 2020-11-18 | Beigene, Ltd. | CRYSTALLINE FORMS OF (S) -7- (1- (BUT-2-YNOYL) PIPERIDIN-4-YL) -2- (4-PHENOXYPHENYL) -4, 5, 6, 7-TETRAHY DROPYRAZOLO [1, 5-A ] PYRIMIDINE-3-CARBOXAMIDE, PREPARATION AND ASSOCIATED USES |
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| US10376595B2 (en) | 2017-04-03 | 2019-08-13 | Inflarx Gmbh | Treatment of inflammatory diseases with inhibitors of C5a activity |
| IL270596B1 (en) * | 2017-05-25 | 2025-09-01 | Bristol Myers Squibb Co | Antibodies comprising modified heavy constant region for use in treating cancer |
| TWI877099B (zh) | 2017-06-26 | 2025-03-21 | 英屬開曼群島商百濟神州有限公司 | 抗ｐｄ－１抗體或其抗原結合片段在製備治療用於患有肝細胞癌（ｈｃｃ）之藥物的用途 |
| WO2019034580A1 (en) * | 2017-08-14 | 2019-02-21 | Morphosys Ag | HUMANIZED ANTIBODIES FOR CD3 |
| WO2019092148A1 (en) * | 2017-11-10 | 2019-05-16 | Innate Pharma | Antibodies with functionalized glutamine residues |
| US11786529B2 (en) | 2017-11-29 | 2023-10-17 | Beigene Switzerland Gmbh | Treatment of indolent or aggressive B-cell lymphomas using a combination comprising BTK inhibitors |
| US20190300610A1 (en) | 2018-03-29 | 2019-10-03 | Hummingbird Bioscience Pte. Ltd. | Vista antigen-binding molecules |
| DK3807316T3 (da) | 2018-06-18 | 2024-07-29 | Innate Pharma | Sammensætninger og fremgangsmåder til behandling af cancer |
| US12365735B2 (en) | 2018-09-17 | 2025-07-22 | The Brigham And Women's Hospital, Inc. | Anti-KLRG1 antibodies |
| CA3121699A1 (en) * | 2018-12-05 | 2020-06-11 | Morphosys Ag | Multispecific antigen-binding molecules |
| NZ778810A (en) * | 2019-03-14 | 2025-10-31 | Morphosys Ag | Antibodies targeting c5ar |
| WO2021110110A1 (zh) * | 2019-12-03 | 2021-06-10 | 上海交通大学医学院 | FcγRIIB亲和力增强的抗体Fc区 |
| TWI869528B (zh) | 2020-01-13 | 2025-01-11 | 美商威特拉公司 | C5ar1抗體分子及其用途 |
| GB2595299B (en) * | 2020-05-21 | 2022-08-03 | Mabsolve Ltd | Modified immunoglobulin FC regions |
| US20230340140A1 (en) | 2020-08-12 | 2023-10-26 | Innate Pharma | Subcutaneous anti-c5ar antagonist treatment regimen with avdoralimab |
| WO2022090556A1 (en) | 2020-11-02 | 2022-05-05 | Hummingbird Bioscience Pte. Ltd. | Bcma/taci antigen-binding molecules |
| CA3173944A1 (en) | 2021-01-13 | 2022-07-21 | Visterra, Inc. | Humanized complement 5a receptor 1 antibodies and methods of use thereof |
| BR112023017887A2 (pt) | 2021-03-12 | 2023-10-10 | Genmab As | Proteína compreendendo um primeiro polipeptídeo e um segundo polipeptídeo, anticorpo biespecífico, ácido nucleico de codificação do dito primeiro ou segundo polipeptídeo, célula hospedeira, composição farmacêutica, proteína, anticorpo biespecífico ou composição farmacêutica para uso, e, métodos de tratamento e de preparo de um anticorpo biespecífico |
| JP2024535053A (ja) | 2021-09-16 | 2024-09-26 | ハミングバード・バイオサイエンス・プライベート・リミテッド | Ｖｉｓｔａ抗原結合性分子を使用する、がんの処置および防止 |
| WO2023046979A1 (en) | 2021-09-27 | 2023-03-30 | Hummingbird Bioscience Pte. Ltd. | Treatment and prevention of cancer using vista antigen-binding molecules |
| CA3234153A1 (en) | 2021-10-08 | 2023-04-13 | David Satijn | Antibodies binding to cd30 and cd3 |
| KR20240123827A (ko) * | 2021-12-16 | 2024-08-14 | 상하이 바오 파마슈티컬스 컴퍼니 리미티드 | 항면역글로불린 분해 효소에 의해 효소 절단된 Fc 변이체 |
| EP4551610A1 (en) | 2022-07-08 | 2025-05-14 | Agency for Science, Technology and Research | Cnx antigen-binding molecules |
| CA3265385A1 (en) | 2022-08-22 | 2024-02-29 | Abdera Therapeutics Inc | DLL3 BINDING MOLECULES AND THEIR USES |
| EP4590706A1 (en) | 2022-09-22 | 2025-07-30 | Hummingbird Bioscience Pte. Ltd. | Treatment and prevention of cancer using vista antigen-binding molecules |
| GB202218388D0 (en) | 2022-12-07 | 2023-01-18 | Vvb Bio Pte Ltd | GP130 antigen-binding molecules |
| US20240238439A1 (en) | 2023-01-03 | 2024-07-18 | Hummingbird Bioscience Pte. Ltd. | Her3-binding antibody-drug conjugate |
| CN120813605A (zh) | 2023-01-06 | 2025-10-17 | 泰温治疗私人有限公司 | 抗原结合分子 |
| WO2024146955A1 (en) | 2023-01-06 | 2024-07-11 | Twain Therapeutics Pte. Ltd. | Antigen-binding molecules |
| US12180274B2 (en) | 2023-05-26 | 2024-12-31 | Inflarx Gmbh | Treatment of pneumonia and ARDS with inhibitors of C5a and IL-6 activity |
| GB202311050D0 (en) | 2023-07-19 | 2023-08-30 | Vvb Bio Pte Ltd | GP130 antigen-binding molecules |
| WO2025125495A1 (en) | 2023-12-13 | 2025-06-19 | Hummingbird Bioscience Pte. Ltd. | Treatment and prevention of cancer using vista antigen-binding molecules |
| WO2025133322A1 (en) | 2023-12-22 | 2025-06-26 | Agency For Science, Technology And Research | Cnx antigen-binding molecules |
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-
2012
- 2012-06-04 EP EP12725447.2A patent/EP2718322B1/en active Active
- 2012-06-04 PT PT181750852T patent/PT3424953T/pt unknown
- 2012-06-04 AU AU2012266487A patent/AU2012266487B2/en active Active
- 2012-06-04 ES ES12725447.2T patent/ES2693647T3/es active Active
- 2012-06-04 PL PL18175085T patent/PL3424953T3/pl unknown
- 2012-06-04 CA CA2838497A patent/CA2838497C/en active Active
- 2012-06-04 DK DK12725447.2T patent/DK2718322T3/en active
- 2012-06-04 CN CN201280028064.1A patent/CN103596982B/zh active Active
- 2012-06-04 DK DK18175085.2T patent/DK3424953T3/da active
- 2012-06-04 PL PL12725447T patent/PL2718322T3/pl unknown
- 2012-06-04 BR BR112013031198-3A patent/BR112013031198B1/pt active IP Right Grant
- 2012-06-04 EP EP20187662.0A patent/EP3798230B1/en active Active
- 2012-06-04 DK DK20187662.0T patent/DK3798230T3/da active
- 2012-06-04 KR KR1020137034239A patent/KR101978757B1/ko active Active
- 2012-06-04 EP EP18175085.2A patent/EP3424953B1/en active Active
- 2012-06-04 WO PCT/EP2012/060524 patent/WO2012168199A1/en not_active Ceased
- 2012-06-04 RU RU2013155029A patent/RU2616881C2/ru active
- 2012-06-04 JP JP2014514023A patent/JP6141834B2/ja active Active
- 2012-06-04 ES ES20187662T patent/ES2929575T3/es active Active
- 2012-06-06 TW TW101120198A patent/TWI564305B/zh active
- 2012-06-06 US US13/490,093 patent/US8613926B2/en active Active
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2013
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- 2013-11-05 IL IL229254A patent/IL229254A/en active IP Right Grant
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2014
- 2014-08-25 US US14/467,393 patent/US20150044231A1/en not_active Abandoned
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2016
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- 2016-12-07 JP JP2016237458A patent/JP6416177B2/ja active Active
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2019
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2020
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2023
- 2023-12-11 US US18/536,032 patent/US20240218076A1/en active Pending
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