JP2019535306A5 - - Google Patents
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- JP2019535306A5 JP2019535306A5 JP2019542804A JP2019542804A JP2019535306A5 JP 2019535306 A5 JP2019535306 A5 JP 2019535306A5 JP 2019542804 A JP2019542804 A JP 2019542804A JP 2019542804 A JP2019542804 A JP 2019542804A JP 2019535306 A5 JP2019535306 A5 JP 2019535306A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- antigen
- monoclonal antibody
- binding fragment
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000012634 fragment Substances 0.000 claims 23
- 239000000427 antigen Substances 0.000 claims 18
- 102000036639 antigens Human genes 0.000 claims 18
- 108091007433 antigens Proteins 0.000 claims 18
- 206010028980 Neoplasm Diseases 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- 125000000539 amino acid group Chemical group 0.000 claims 4
- 102000001708 Protein Isoforms Human genes 0.000 claims 3
- 108010029485 Protein Isoforms Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 206010025323 Lymphomas Diseases 0.000 claims 2
- 206010057249 Phagocytosis Diseases 0.000 claims 2
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 claims 2
- 230000001419 dependent effect Effects 0.000 claims 2
- 208000032839 leukemia Diseases 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 230000008782 phagocytosis Effects 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 208000000733 Paroxysmal Hemoglobinuria Diseases 0.000 claims 1
- 102100036050 Phosphatidylinositol N-acetylglucosaminyltransferase subunit A Human genes 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 208000037979 autoimmune inflammatory disease Diseases 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 230000009827 complement-dependent cellular cytotoxicity Effects 0.000 claims 1
- 230000004540 complement-dependent cytotoxicity Effects 0.000 claims 1
- 231100000433 cytotoxic Toxicity 0.000 claims 1
- 230000001472 cytotoxic effect Effects 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 230000036210 malignancy Effects 0.000 claims 1
- 210000000822 natural killer cell Anatomy 0.000 claims 1
- 201000003045 paroxysmal nocturnal hemoglobinuria Diseases 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16306392 | 2016-10-25 | ||
| EP16306392.8 | 2016-10-25 | ||
| PCT/EP2017/077261 WO2018077926A1 (en) | 2016-10-25 | 2017-10-25 | Monoclonal antibodies binding to the cd160 transmembrane isoform |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019535306A JP2019535306A (ja) | 2019-12-12 |
| JP2019535306A5 true JP2019535306A5 (enExample) | 2020-12-03 |
Family
ID=57570549
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019542804A Pending JP2019535306A (ja) | 2016-10-25 | 2017-10-25 | Ｃｄ１６０膜貫通型アイソフォームと結合するモノクローナル抗体 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US11186635B2 (enExample) |
| EP (1) | EP3532502A1 (enExample) |
| JP (1) | JP2019535306A (enExample) |
| KR (1) | KR20190084264A (enExample) |
| CN (1) | CN110121508A (enExample) |
| AU (1) | AU2017351764A1 (enExample) |
| BR (1) | BR112019008345A8 (enExample) |
| CA (1) | CA3080270A1 (enExample) |
| WO (1) | WO2018077926A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20230071889A1 (en) | 2018-12-21 | 2023-03-09 | Ose Immunotherapeutics | Bifunctional anti-pd-1/il-7 molecule |
| WO2020165374A1 (en) | 2019-02-14 | 2020-08-20 | Ose Immunotherapeutics | Bifunctional molecule comprising il-15ra |
| EP3812008A1 (en) * | 2019-10-23 | 2021-04-28 | Gamamabs Pharma | Amh-competitive antagonist antibody |
| WO2021122866A1 (en) | 2019-12-17 | 2021-06-24 | Ose Immunotherapeutics | Bifunctional molecules comprising an il-7 variant |
| GB202103706D0 (en) * | 2021-03-17 | 2021-04-28 | Ucl Business Ltd | CD160 binding domain |
| US20240182571A1 (en) | 2021-04-09 | 2024-06-06 | Ose Immunotherapeutics | New scaffold for bifunctional molecules with improved properties |
| WO2022214652A1 (en) | 2021-04-09 | 2022-10-13 | Ose Immunotherapeutics | Scaffold for bifunctioanl molecules comprising pd-1 or cd28 and sirp binding domains |
| JP2025508086A (ja) * | 2022-03-09 | 2025-03-21 | オルデラン バイオテクノロジー | 抗ｃｄ１６０膜貫通型アイソフォーム抗体 |
| CN119907811A (zh) | 2022-08-02 | 2025-04-29 | Ose免疫疗法公司 | 针对cd28的多功能分子 |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4861719A (en) | 1986-04-25 | 1989-08-29 | Fred Hutchinson Cancer Research Center | DNA constructs for retrovirus packaging cell lines |
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| US5094941A (en) * | 1987-12-31 | 1992-03-10 | Zymogenetics, Inc. | Monoclonal antibodies to PDGF |
| US5278056A (en) | 1988-02-05 | 1994-01-11 | The Trustees Of Columbia University In The City Of New York | Retroviral packaging cell lines and process of using same |
| WO1989012624A2 (en) | 1988-06-14 | 1989-12-28 | Cetus Corporation | Coupling agents and sterically hindered disulfide linked conjugates prepared therefrom |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| US5670488A (en) | 1992-12-03 | 1997-09-23 | Genzyme Corporation | Adenovirus vector for gene therapy |
| CA2103059C (en) | 1991-06-14 | 2005-03-22 | Paul J. Carter | Method for making humanized antibodies |
| AU3178993A (en) | 1991-11-25 | 1993-06-28 | Enzon, Inc. | Multivalent antigen-binding proteins |
| US5714350A (en) | 1992-03-09 | 1998-02-03 | Protein Design Labs, Inc. | Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region |
| US5635483A (en) | 1992-12-03 | 1997-06-03 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Tumor inhibiting tetrapeptide bearing modified phenethyl amides |
| US5780588A (en) | 1993-01-26 | 1998-07-14 | Arizona Board Of Regents | Elucidation and synthesis of selected pentapeptides |
| ATE341638T1 (de) | 1993-02-22 | 2006-10-15 | Univ Rockefeller | Herstellung von helfer-freien retroviren mit hohem titer mittels transienter transfektion |
| US6214345B1 (en) | 1993-05-14 | 2001-04-10 | Bristol-Myers Squibb Co. | Lysosomal enzyme-cleavable antitumor drug conjugates |
| FR2712812B1 (fr) | 1993-11-23 | 1996-02-09 | Centre Nat Rech Scient | Composition pour la production de produits thérapeutiques in vivo. |
| US5663149A (en) | 1994-12-13 | 1997-09-02 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Human cancer inhibitory pentapeptide heterocyclic and halophenyl amides |
| IL116816A (en) | 1995-01-20 | 2003-05-29 | Rhone Poulenc Rorer Sa | Cell for the production of a defective recombinant adenovirus or an adeno-associated virus and the various uses thereof |
| US6013516A (en) | 1995-10-06 | 2000-01-11 | The Salk Institute For Biological Studies | Vector and method of use for nucleic acid delivery to non-dividing cells |
| AU736549B2 (en) | 1997-05-21 | 2001-08-02 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Method for the production of non-immunogenic proteins |
| CA2293632C (en) | 1997-06-12 | 2011-11-29 | Research Corporation Technologies, Inc. | Artificial antibody polypeptides |
| US6194551B1 (en) | 1998-04-02 | 2001-02-27 | Genentech, Inc. | Polypeptide variants |
| PT2180007E (pt) | 1998-04-20 | 2013-11-25 | Roche Glycart Ag | Engenharia de glicosilação de anticorpos para melhorar a citotoxicidade celular dependente de anticorpos |
| DK2270147T4 (da) | 1999-04-09 | 2020-08-31 | Kyowa Kirin Co Ltd | Fremgangsmåde til at kontrollere aktiviteten af immunologisk funktionelt molekyle |
| ATE309385T1 (de) | 2000-06-28 | 2005-11-15 | Glycofi Inc | Verfahren für die herstellung modifizierter glykoproteine |
| US6884869B2 (en) | 2001-04-30 | 2005-04-26 | Seattle Genetics, Inc. | Pentapeptide compounds and uses related thereto |
| WO2003026577A2 (en) | 2001-09-24 | 2003-04-03 | Seattle Genetics, Inc. | P-amidobenzylethers in drug delivery agents |
| WO2003035835A2 (en) | 2001-10-25 | 2003-05-01 | Genentech, Inc. | Glycoprotein compositions |
| AU2002357060A1 (en) | 2001-12-03 | 2003-06-17 | Abgenix, Inc. | Antibody categorization based on binding characteristics |
| ES2369542T3 (es) | 2002-07-31 | 2011-12-01 | Seattle Genetics, Inc. | Conjugados de auristatina y su uso para tratar cáncer, una enfermedad autoinmune o una enfermedad infecciosa. |
| ES2456325T3 (es) | 2003-11-06 | 2014-04-22 | Seattle Genetics, Inc. | Compuestos de monometilvalina capaces de conjugación con ligandos |
| CA2556752C (en) | 2004-02-23 | 2016-02-02 | Genentech, Inc. | Heterocyclic self-immolative linkers and conjugates |
| ES2533695T3 (es) | 2004-03-02 | 2015-04-14 | Seattle Genetics, Inc. | Anticuerpos cargados parcialmente y métodos para su conjugación |
| EP1626059A1 (en) | 2004-08-09 | 2006-02-15 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Angiogenic and immunologic applications of anti-CD160 specific compounds obtainable from mAb CL1-R2 |
| US8288352B2 (en) | 2004-11-12 | 2012-10-16 | Seattle Genetics, Inc. | Auristatins having an aminobenzoic acid unit at the N terminus |
| JP4658125B2 (ja) | 2005-06-28 | 2011-03-23 | パイオニア株式会社 | 放送受信装置、妨害検出装置および妨害検出方法 |
| DK1912671T3 (da) | 2005-07-18 | 2017-11-27 | Seattle Genetics Inc | Beta-glucuronid-linker-lægemiddelkonjugater |
| EP1880729A1 (en) | 2006-07-20 | 2008-01-23 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of soluble CD160 to suppress immunity |
| JP2010509920A (ja) * | 2006-11-15 | 2010-04-02 | メダレックス インコーポレーティッド | Ｂｔｌａに対するヒトモノクローナル抗体および使用方法 |
| EP2006299A1 (en) | 2007-06-18 | 2008-12-24 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Identification of new isoforms of the MHC-class I specific receptor CD160 and uses thereof |
| EP2210903A1 (en) * | 2009-01-21 | 2010-07-28 | Monoclonal Antibodies Therapeutics | Anti-CD160 monoclonal antibodies and uses thereof |
| EP2548030B1 (en) * | 2010-03-18 | 2015-05-27 | Cornell University | Engineering correctly folded antibodies using inner membrane display of twin-arginine translocation intermediates |
| PL2575881T3 (pl) * | 2010-05-28 | 2018-06-29 | Inserm - Institut National De La Santé Et De La Recherche Médicale | Przeciwciała swoiste wobec CD160 do leczenia zaburzeń oczu związanych z angiogenezą |
| WO2012059882A2 (en) | 2010-11-05 | 2012-05-10 | Rinat Neuroscience Corporation | Engineered polypeptide conjugates and methods for making thereof using transglutaminase |
| WO2013072714A1 (en) * | 2011-11-15 | 2013-05-23 | Centre National De La Recherche Scientifique (Cnrs) | Antibodies for molecular imaging of vulnerable plaques in atherosclerosis |
| EP3245228A1 (en) * | 2015-01-16 | 2017-11-22 | INSERM - Institut National de la Santé et de la Recherche Médicale | Human monoclonal antibodies against orexin receptor type 1 |
-
2017
- 2017-10-25 CA CA3080270A patent/CA3080270A1/en not_active Abandoned
- 2017-10-25 BR BR112019008345A patent/BR112019008345A8/pt not_active Application Discontinuation
- 2017-10-25 AU AU2017351764A patent/AU2017351764A1/en not_active Abandoned
- 2017-10-25 WO PCT/EP2017/077261 patent/WO2018077926A1/en not_active Ceased
- 2017-10-25 JP JP2019542804A patent/JP2019535306A/ja active Pending
- 2017-10-25 EP EP17797084.5A patent/EP3532502A1/en active Pending
- 2017-10-25 CN CN201780080063.4A patent/CN110121508A/zh active Pending
- 2017-10-25 US US16/343,889 patent/US11186635B2/en active Active
- 2017-10-25 KR KR1020197014634A patent/KR20190084264A/ko not_active Ceased
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