JP2014520849A5 - - Google Patents

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JP2014520849A5
JP2014520849A5 JP2014520238A JP2014520238A JP2014520849A5 JP 2014520849 A5 JP2014520849 A5 JP 2014520849A5 JP 2014520238 A JP2014520238 A JP 2014520238A JP 2014520238 A JP2014520238 A JP 2014520238A JP 2014520849 A5 JP2014520849 A5 JP 2014520849A5
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metal
group
bisphosphonate
nanoparticles according
alkyl group
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JP2014520238A
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JP2014520849A (ja
JP6049712B2 (ja
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Priority claimed from PCT/US2012/045954 external-priority patent/WO2013009701A2/en
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JP2014520238A 2011-07-08 2012-07-09 抗癌治療及び画像化並びに骨障害治療のための金属ビスホスホネートナノ粒子 Active JP6049712B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161505806P 2011-07-08 2011-07-08
US61/505,806 2011-07-08
PCT/US2012/045954 WO2013009701A2 (en) 2011-07-08 2012-07-09 Metal bisphosphonate nanoparticles for anti-cancer therapy and imaging and for treating bone disorders

Publications (3)

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JP2014520849A JP2014520849A (ja) 2014-08-25
JP2014520849A5 true JP2014520849A5 (https=) 2015-08-27
JP6049712B2 JP6049712B2 (ja) 2016-12-21

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JP2014520238A Active JP6049712B2 (ja) 2011-07-08 2012-07-09 抗癌治療及び画像化並びに骨障害治療のための金属ビスホスホネートナノ粒子

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US (3) US9693957B2 (https=)
EP (2) EP2729180B1 (https=)
JP (1) JP6049712B2 (https=)
WO (1) WO2013009701A2 (https=)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2011207563B2 (en) 2010-01-19 2016-03-10 Northwestern University Synthetic nanostructures including nucleic acids and/or other entities
WO2013009701A2 (en) 2011-07-08 2013-01-17 The University Of North Carolina At Chapel Hill Metal bisphosphonate nanoparticles for anti-cancer therapy and imaging and for treating bone disorders
HK1166436A2 (en) * 2011-09-08 2012-10-26 Ybs Graphene Company Limited A method of forming a negative ion emitting product and a product formed by such method
EP3024936B1 (en) 2013-07-25 2019-09-04 Exicure, Inc. Spherical nucleic acid-based constructs as immunostimulatory agents for prophylactic and therapeutic use
US10517822B2 (en) 2013-11-06 2019-12-31 The University Of Chicago Nanoscale carriers for the delivery or co-delivery of chemotherapeutics, nucleic acids and photosensitizers
US10182988B2 (en) 2013-12-03 2019-01-22 Northwestern University Liposomal particles, methods of making same and uses thereof
WO2015149072A1 (en) 2014-03-28 2015-10-01 The University Of Chicago Metal-organic frameworks containing nitrogen-donor ligands for efficient catalytic organic transformations
WO2015149068A1 (en) 2014-03-28 2015-10-01 The University Of Chicago Chiral ligand-based metal-organic frameworks for broad-scope asymmetric catalysis
US10413565B2 (en) 2014-04-30 2019-09-17 Northwestern University Nanostructures for modulating intercellular communication and uses thereof
TR201908550T4 (tr) * 2014-06-04 2019-07-22 Exicure Inc Profilaktik veya terapötik uygulamalar için lipozomal sferik nükleik asitler tarafından immün modülatörlerin çok değerlikli teslimi.
MA40428A (fr) * 2014-08-14 2016-02-18 L E A F Holdings Group Llc Médicament à affinité encapsulé dans un liposome
US10588564B2 (en) 2014-09-30 2020-03-17 Moein Health, LLC Method and kit for diagnosing and treating neoplastic tissue
CR20170181A (es) 2014-10-06 2017-05-31 Exicure Inc Compuestos anti-tnf
CN110731961A (zh) 2014-10-14 2020-01-31 芝加哥大学 金属有机框架、药物制剂及其在制备药物中的用途
US10806694B2 (en) 2014-10-14 2020-10-20 The University Of Chicago Nanoparticles for photodynamic therapy, X-ray induced photodynamic therapy, radiotherapy, radiodynamic therapy, chemotherapy, immunotherapy, and any combination thereof
US10517924B2 (en) 2014-11-24 2019-12-31 Northwestern University High density lipoprotein nanoparticles for inflammation
AU2016252864B2 (en) 2015-04-24 2021-10-14 Duke University Metal complexes with bisphosphonate or pyrophosphate useful as imaging agents
WO2017059092A1 (en) 2015-09-30 2017-04-06 Duke University Ascorbate formulations and methods of use as contrast agents
RU2657833C2 (ru) * 2015-12-01 2018-06-15 Общество С Ограниченной Ответственностью "Остерос Биомедика" Стабилизированная лекарственная форма конъюгата этидроната с цитарабином и её применение
WO2017120504A1 (en) * 2016-01-08 2017-07-13 Durfee Paul N Osteotropic nanoparticles for prevention or treatment of bone metastases
WO2017174969A1 (en) * 2016-04-08 2017-10-12 The University Of Birmingham Novel nanonization
AU2016403775B2 (en) * 2016-04-22 2021-10-14 Duke University Manganese complexes with substituted bisphosphonates useful as imaging and therapeutic agents
EP3439666A4 (en) 2016-05-20 2019-12-11 The University of Chicago NANOPARTICLES FOR CHEMOTHERAPY, TARGETED THERAPY, PHOTODYNAMIC THERAPY, IMMUNOTHERAPY AND ALL COMBINATIONS THEREOF
EA030671B1 (ru) 2016-07-20 2018-09-28 Общество С Ограниченной Ответственностью "Остерос Биомедика" Препарат для лечения костных поражений, вызванных злокачественными новообразованиями
US11020425B2 (en) * 2016-12-19 2021-06-01 The Chinese University Of Hong Kong Injectable hydrogels that promote mineralization and afford sustained release of bioactive ions
US11696954B2 (en) 2017-04-28 2023-07-11 Exicure Operating Company Synthesis of spherical nucleic acids using lipophilic moieties
MX2020000387A (es) 2017-07-13 2020-08-17 Univ Northwestern Método general y directo para preparar nanopartículas de estructura organometálica funcionalizadas con oligonucleotidos.
EP3638367A4 (en) 2017-08-02 2021-07-21 The University of Chicago NANOMETRIC ORGANOMETALLIC AND NANOPLAQUE ORGANOMETALLIC LAYERS FOR X-RAY INDUCED PHOTODYNAMIC THERAPY, RADIOTHERAPY, RADIODYNAMIC THERAPY, CHEMOTHERAPY, IMMUNOTHERAPY, AND ANY COMBINATION OF THESE
US20190314324A1 (en) 2018-04-13 2019-10-17 The University Of Chicago Combination of micheliolide derivatives or nanoparticles with ionizing radiation and checkpoint inhibitors for cancer therapy
WO2020068798A1 (en) 2018-09-24 2020-04-02 Guo Jimin Living mammalian cells modified with functional modular nanoparticles
US12582727B2 (en) * 2018-10-16 2026-03-24 The Regents Of The University Of Colorado, A Body Corporate Chemiluminescent and fluorescent nanoparticle for optical imaging of cancer
US12208164B2 (en) 2019-02-28 2025-01-28 Unm Rainforest Innovations Modular metal-organic polyhedra superassembly compositions
US12319711B2 (en) 2019-09-20 2025-06-03 Northwestern University Spherical nucleic acids with tailored and active protein coronae
WO2021062204A1 (en) * 2019-09-27 2021-04-01 Greenmark Biomedical Inc. Bisphosphonate loaded starch nanoparticle
US12378560B2 (en) 2019-10-29 2025-08-05 Northwestern University Sequence multiplicity within spherical nucleic acids
WO2021097194A1 (en) * 2019-11-14 2021-05-20 Board Of Regents, The University Of Texas System Compositions and methods for controlled delivery and protection of therapeutic agents
CN111420071A (zh) * 2020-03-27 2020-07-17 苏州欣影生物医药技术有限公司 一种纳米颗粒磁共振造影剂、制备方法及应用
DE102020116859A1 (de) 2020-06-26 2021-12-30 Pharma Development Holding Gmbh Liposomen
IT202000021292A1 (it) * 2020-09-09 2022-03-09 Consiglio Nazionale Ricerche Composizione in forma di polvere a base di microparticelle incorporanti nanoparticelle per la veicolazione di composti terapeutici/diagnostici
KR102514126B1 (ko) * 2020-12-24 2023-03-24 가톨릭대학교 산학협력단 히알루론산 나노입자를 유효성분으로 함유하는 전이성 골종양 광역학 치료용 조성물
CN114230610B (zh) * 2021-11-26 2023-05-23 西南医科大学附属医院 放射性标记物、其前体化合物、及制法和应用
WO2023107920A1 (en) * 2021-12-07 2023-06-15 The Trustees Of The University Of Pennsylvania Anisamide-containing lipids and compositions and methods of use thereof
CN115501202B (zh) * 2022-10-12 2023-05-19 北京大学 一种递送过渡态唾液酸转移酶抑制剂的核壳纳米粒子及其制备方法和应用
WO2024236527A1 (en) * 2023-05-16 2024-11-21 Magvitae Innovations Inc A novel non-stoichiometric multi-element adjuvant (nsma) and composition thereof
IT202300015396A1 (it) * 2023-07-21 2025-01-21 Torino Politecnico Nanoparticelle rivestite e loro uso per il trasporto di agenti terapeutici e diagnostici
WO2025077898A1 (en) * 2023-10-13 2025-04-17 The Chinese University Of Hong Kong A therapeutic nucleic acid-encased nanoworm for gene delivery and endosomal escape

Family Cites Families (118)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL61351A (en) 1980-10-27 1983-12-30 Yeda Res & Dev Organometallic polymers,their preparation and compositions of co-ordination compounds containing them
US5147806A (en) 1988-04-29 1992-09-15 Igen, Inc. Method and apparatus for conducting electrochemiluminescence measurements
US5213788A (en) 1988-09-29 1993-05-25 Ranney David F Physically and chemically stabilized polyatomic clusters for magnetic resonance image and spectral enhancement
WO1992001477A1 (en) 1990-07-26 1992-02-06 G.D. Searle & Co. Polymeric drug delivery system
US6013638A (en) 1991-10-02 2000-01-11 The United States Of America As Represented By The Department Of Health And Human Services Adenovirus comprising deletions on the E1A, E1B and E3 regions for transfer of genes to the lung
US5858784A (en) 1991-12-17 1999-01-12 The Regents Of The University Of California Expression of cloned genes in the lung by aerosol- and liposome-based delivery
US5871710A (en) 1992-09-04 1999-02-16 The General Hospital Corporation Graft co-polymer adducts of platinum (II) compounds
US5591730A (en) * 1993-10-12 1997-01-07 The Regents Of The University Of California Inhibition of urinary calculi growth
US20010003647A1 (en) 1995-06-07 2001-06-14 Ji Sun Coreatant-including electrochemiluminescent compounds, methods, systems and kits utilizing same
US5641623A (en) 1995-01-04 1997-06-24 Martin; Mark T. Electrochemiluminescence assay
US6022737A (en) 1995-11-02 2000-02-08 Amgen Inc. Formulations for non-viral in vivo transfection in the lungs
US5648508A (en) 1995-11-22 1997-07-15 Nalco Chemical Company Crystalline metal-organic microporous materials
US5874064A (en) 1996-05-24 1999-02-23 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
CA2278056C (en) 1997-01-24 2006-12-12 Norsk Hydro Asa Gemcitabine derivatives
US6180082B1 (en) 1997-11-24 2001-01-30 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Method to enhance tissue accumulation of radiolabeled compounds
US6984400B2 (en) 1998-07-14 2006-01-10 Yissum Research Development Company Of The Hebrew University Of Jerusalem Method of treating restenosis using bisphosphonate nanoparticles
US6818227B1 (en) 1999-02-08 2004-11-16 Alza Corporation Liposome composition and method for administration of a radiosensitizer
DE60011053T2 (de) 1999-02-18 2005-05-25 SuperGen, Inc., Dublin An phosphocholin gebundene prodrug-derivate
US20020064520A1 (en) 1999-08-19 2002-05-30 Yanina Rozenberg Targeted artificial gene delivery
NZ517929A (en) 1999-09-25 2004-02-27 Univ Iowa Res Found Immunostimulatory nucleic acids
US6602932B2 (en) 1999-12-15 2003-08-05 North Carolina State University Nanoparticle composites and nanocapsules for guest encapsulation and methods for synthesizing same
MXPA02009924A (es) * 2000-04-07 2004-08-19 Univ Texas Composiones unicas de fosfolipidos de ion anfoterico y bisfosfonatos y uso de las composiciones como sistemas de suministro de bisfosfato con toxicidad gi reducida.
US6471968B1 (en) 2000-05-12 2002-10-29 Regents Of The University Of Michigan Multifunctional nanodevice platform
US6548264B1 (en) 2000-05-17 2003-04-15 University Of Florida Coated nanoparticles
US6565873B1 (en) 2000-10-25 2003-05-20 Salvona Llc Biodegradable bioadhesive controlled release system of nano-particles for oral care products
JP2004517619A (ja) 2000-12-21 2004-06-17 ノバルティス アクチエンゲゼルシャフト インターロイキン−１関連遺伝子およびタンパク質
US20020127224A1 (en) 2001-03-02 2002-09-12 James Chen Use of photoluminescent nanoparticles for photodynamic therapy
ATE334992T1 (de) 2001-04-30 2006-08-15 Univ Michigan Isoretikuläre organometallische grundstrukturen, verfahren zu deren bildung und systematische entwicklung von deren porengrösse und funktionalität, mit anwendung für die gasspeicherung
AU2003226082A1 (en) 2002-03-25 2003-11-11 The General Hospital Corporation Methods of adjuvant photodynamic therapy to enhance radiation sensitization
KR100995486B1 (ko) 2002-09-28 2010-11-22 맥네일-피피씨, 인코포레이티드 개구가 있는 쉘을 포함하는 속방성 투여형
AU2003220472A1 (en) * 2002-09-28 2004-04-19 Mcneil-Ppc, Inc. Modified release dosage form with two cores
WO2004041203A2 (en) 2002-11-04 2004-05-21 Xenoport, Inc. Gemcitabine prodrugs, pharmaceutical compositions and uses thereof
KR100401335B1 (en) 2003-03-08 2003-10-10 Mijitech Co Ltd Metal nanoparticle surface-coated with silicon oxides and preparation thereof
US6878838B2 (en) * 2003-03-24 2005-04-12 The University Of North Carolina At Chapel Hill Chiral porous metal phosphonates for heterogeneous asymmetric catalysis
WO2004084871A1 (en) 2003-03-26 2004-10-07 Ltt Bio-Pharma Co., Ltd. Intravenous nanoparticles for targenting drug delivery and sustained drug release
EP1620079A1 (en) * 2003-04-03 2006-02-01 Semafore Pharmaceuticals, Inc. Bone targeting of biodegradable drug-containing nanoparticles
EP1633760B1 (en) 2003-05-09 2010-05-05 The Regents of The University of Michigan MOFs with a high surface area and methods for producing them
WO2005000858A2 (en) * 2003-06-27 2005-01-06 Akira Odani Bisphosphonate complexes
US20080039533A1 (en) 2003-07-31 2008-02-14 3M Innovative Properties Company Bioactive Compositions Comprising Triazines
KR20060092254A (ko) 2003-09-23 2006-08-22 라이트 사이언시즈 코포레이션 표적화된 ｐｄｔ 제제의 선택성을 증진시키는 표적 결합에의해 활성화된 일중항 산소 감광제
WO2005048942A2 (en) 2003-11-13 2005-06-02 Pharmacia Corporation Combination therapy comprising a cox-2 inhibitor and an antineoplastic agent
US20050147963A1 (en) 2003-12-29 2005-07-07 Intel Corporation Composite organic-inorganic nanoparticles and methods for use thereof
WO2005092195A1 (ja) 2004-03-29 2005-10-06 National Institute Of Radiological Sciences ヒール効果補正フィルタ、ｘ線照射装置、ｘ線ｃｔ装置及びｘ線ｃｔ撮像方法
US20070259966A1 (en) 2004-04-22 2007-11-08 Allos Therapeutics, Inc. Coadministration of Radiation, Efaproxiral Sodium, and Supplemental Oxygen for the Treatment of Cancer
FR2869803B1 (fr) 2004-05-10 2006-07-28 Nanobiotix Sarl Particules activables, preparation et utilisations
FR2874016B1 (fr) 2004-06-30 2006-11-24 Centre Nat Rech Scient Cnrse Nanoparticules de derives de la gemcitabine
US7964571B2 (en) 2004-12-09 2011-06-21 Egen, Inc. Combination of immuno gene therapy and chemotherapy for treatment of cancer and hyperproliferative diseases
US20070218049A1 (en) 2006-02-02 2007-09-20 Wei Chen Nanoparticle based photodynamic therapy and methods of making and using same
WO2006087722A1 (en) 2005-02-17 2006-08-24 Hadasit Medical Research Services And Development Ltd. Bisphosphonates for treating endometriosis
CN1305937C (zh) 2005-02-25 2007-03-21 复旦大学 一种金属配位聚合物纳米结构材料的制备方法
BRPI0606280A2 (pt) * 2005-03-17 2009-06-09 Elan Pharma Int Ltd composições de bisfosfonato nanoparticulado
NO322682B1 (no) 2005-03-18 2006-11-27 Clavis Pharma Asa Anvendelse av gemcitabinderivater for fremstilling av orale doseringsformer ved kreftbehandling, samt slike orale doseringsformer
PE20070360A1 (es) 2005-09-01 2007-04-19 Novartis Ag Composiciones de liposomas
US20080095699A1 (en) 2006-10-20 2008-04-24 Shiying Zheng Imaging contrast agents using nanoparticles
US7263170B2 (en) 2005-09-30 2007-08-28 Pellegrino Anthony J Radiation therapy system featuring rotatable filter assembly
US20070088161A1 (en) 2005-10-19 2007-04-19 Stockel Richard F Novel chelated bisphosphonates for use as pharmaceutical agents
WO2007090295A1 (en) 2006-02-09 2007-08-16 Simon Fraser University Birefringent metal-containing coordination polymers
US20100189222A1 (en) 2006-02-16 2010-07-29 Steller Micro Devices Panoramic irradiation system using flat panel x-ray sources
KR100943923B1 (ko) 2006-03-17 2010-02-24 홍순해 킬레이팅 유기 고분자와 생물학적 금속으로 이루어진 나노입자, 그리고 ｅｐｒ 효과를 이용한 새로운 광범위 무독성항암제 및 그 제조 방법
US20090317335A1 (en) 2006-04-20 2009-12-24 Wenbin Lin Hybrid Nanomaterials as Multimodal Imaging Contrast Agents
GB0613362D0 (en) 2006-07-05 2006-08-16 Hemocorm Ltd Therapeutic delivery of carbon monoxide
WO2008010263A1 (fr) 2006-07-18 2008-01-24 Mitsubishi Electric Corporation Procédé de production d'une électrode pour le traitement de surface par décharge et procédé de traitement de surface par décharge
US7699099B2 (en) * 2006-08-02 2010-04-20 B.J. Services Company, U.S.A. Modified Christmas tree components and associated methods for using coiled tubing in a well
WO2008016172A1 (fr) 2006-08-04 2008-02-07 Kurume University Inhibiteur de métastase
US7985868B1 (en) 2006-11-01 2011-07-26 Sandia Corporation Hybrid metal organic scintillator materials system and particle detector
US20080124281A1 (en) 2006-11-29 2008-05-29 Board Of Regents, The University Of Texas System Nanotubular probes as ultrasensitive mr contrast agent
FR2910009B1 (fr) 2006-12-19 2009-03-06 Commissariat Energie Atomique Procede de preparation d'un film organique a la surface d'un support solide dans des conditions non-electrochimiques, su pport solide ainsi obtenu et kit de preparation
JPWO2008102632A1 (ja) 2007-02-21 2010-05-27 コニカミノルタエムジー株式会社 Ｘ線バンドパスフィルタ、ｘ線照射システム及びｘ線撮影システム
JP2010523595A (ja) 2007-04-04 2010-07-15 マサチューセッツ インスティテュート オブ テクノロジー ポリ（アミノ酸）ターゲッティング部分
KR20090001013A (ko) 2007-06-29 2009-01-08 주식회사 웰스킨 인돌-3-알킬카복실산을 함유하는 여드름 치료제 및 피지분비 억제제, 및 이를 포함하는 광역학적 치료용 키트
US20110034714A1 (en) * 2007-07-06 2011-02-10 Hisao Ekimoto Metal complex compound, cancer therapeutic agent composition containing the metal complex compound as an active ingredient, and intermediate for the metal complex compound
US8486452B2 (en) 2007-07-20 2013-07-16 Mylan Pharmaceuticals Inc. Stabilized tolterodine tartrate formulations
JP5730574B2 (ja) 2007-09-25 2015-06-10 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 食用に適した生体適合性金属有機構造体
FR2921838A1 (fr) * 2007-10-05 2009-04-10 Guerbet Sa Nouveau procede de preparation de nanoparticules recouvertes d'une couche stabilisatrice gem-bisphosphonate couplee a des ligands de biodistribution hydrophile
WO2009139939A2 (en) 2008-02-22 2009-11-19 The University Of North Carolina At Chapel Hill Hybrid nanoparticles as anti-cancer therapeutic agents and dual therapeutic/imaging contrast agents
US20110053862A1 (en) 2008-03-12 2011-03-03 Intradigm Corporation Compositions comprising survivin sirna and methods of use thereof
GB0807862D0 (en) 2008-04-29 2008-06-04 Uni I Oslo Compounds
US8968705B2 (en) 2008-08-22 2015-03-03 Colorado School Of Mines Gold/lanthanide nanoparticle conjugates and uses thereof
US20100221329A1 (en) 2008-12-03 2010-09-02 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase c agonists and methods of use
EP2198885B1 (en) 2008-12-19 2012-02-08 Biolitec AG Calcium phosphate nanoparticles as dye carrier for photodynamic therapy
EP2445532A1 (en) 2009-04-24 2012-05-02 Socpra - Sciences Santé Et Humaines Compositions comprising a radiosensitizer and an anti-cancer agent and methods of uses thereof
CN102448497A (zh) 2009-05-25 2012-05-09 默克专利有限公司 在癌症治疗中的西仑吉肽的持续给药
EP2438076B1 (en) * 2009-06-05 2018-12-19 Nanyang Technological University Targeted drug delivery to the bone
GB0914287D0 (en) 2009-08-14 2009-09-30 Pci Biotech As Compositions
WO2011049743A1 (en) 2009-10-06 2011-04-28 Stellarray, Inc. Self contained irradiation system using flat panel x-ray sources
CN102573914B (zh) 2009-10-16 2016-06-29 大学健康网络 卟啉纳米囊泡
KR20120086729A (ko) 2009-11-20 2012-08-03 클라비스 파마 에이에스에이 젬시타빈 유도체의 비경구적 제제
GB201013307D0 (en) 2010-08-09 2010-09-22 Univ St Andrews Anti-microbial metal organic framework
IT1401882B1 (it) * 2010-10-01 2013-08-28 Rosa De Nanoparticelle autoassemblanti per il rilascio di bifosfonati nel trattamento di tumori.
WO2012138419A1 (en) 2011-04-04 2012-10-11 Georgia Tech Research Corporation Mof nanocrystals
NO2694640T3 (https=) 2011-04-15 2018-03-17
US20120301537A1 (en) 2011-05-23 2012-11-29 Delta-Fly Pharma, Inc. LIPOSOME CONTAINING shRNA MOLECULE TARGETING A THYMIDYLATE SYNTHASE AND USE THEREOF
JP6076968B2 (ja) 2011-06-06 2017-02-08 ユニバーシティ・ヘルス・ネットワーク ポルフィリン−リン脂質コンジュゲートを合成する方法
WO2012174379A2 (en) 2011-06-16 2012-12-20 University Of South Florida Polyhedral cage-containing metalloporphyrin frameworks, methods of making, and methods of using
WO2013009701A2 (en) 2011-07-08 2013-01-17 The University Of North Carolina At Chapel Hill Metal bisphosphonate nanoparticles for anti-cancer therapy and imaging and for treating bone disorders
WO2013012628A2 (en) 2011-07-15 2013-01-24 The University Of Georgia Research Foundation, Inc. Immune-stimulating photoactive hybrid nanoparticles
IN2014CN02153A (https=) 2011-08-23 2015-05-29 Yeda Res & Dev
CN102432654A (zh) 2011-09-26 2012-05-02 宋云龙 吉西他滨酰胺衍生物及其制备方法和用途
WO2013068965A2 (en) 2011-11-11 2013-05-16 Koninklijke Philips Electronics N.V. Lighting apparatus and manufacturing method for manufacturing the lighting apparatus
EA029635B1 (ru) 2011-12-16 2018-04-30 Нанобиотикс Применение наночастицы, включающей металлический материал, покрытый материалом оксида гафния, в онкологии и композиция, ее содержащая
US20130209755A1 (en) 2012-02-15 2013-08-15 Phillip Dene Hustad Self-assembled structures, method of manufacture thereof and articles comprising the same
EP2861256B1 (en) 2012-06-15 2019-10-23 The Brigham and Women's Hospital, Inc. Compositions for treating cancer and methods for making the same
US20150344577A1 (en) 2013-01-11 2015-12-03 Dingfu Biotarget Co., Ltd Agents for treating tumors, use and method thereof
US10350275B2 (en) 2013-09-21 2019-07-16 Advantagene, Inc. Methods of cytotoxic gene therapy to treat tumors
US10517822B2 (en) 2013-11-06 2019-12-31 The University Of Chicago Nanoscale carriers for the delivery or co-delivery of chemotherapeutics, nucleic acids and photosensitizers
WO2015149068A1 (en) 2014-03-28 2015-10-01 The University Of Chicago Chiral ligand-based metal-organic frameworks for broad-scope asymmetric catalysis
WO2015149072A1 (en) 2014-03-28 2015-10-01 The University Of Chicago Metal-organic frameworks containing nitrogen-donor ligands for efficient catalytic organic transformations
US10806694B2 (en) 2014-10-14 2020-10-20 The University Of Chicago Nanoparticles for photodynamic therapy, X-ray induced photodynamic therapy, radiotherapy, radiodynamic therapy, chemotherapy, immunotherapy, and any combination thereof
CN110731961A (zh) 2014-10-14 2020-01-31 芝加哥大学 金属有机框架、药物制剂及其在制备药物中的用途
US20180214563A1 (en) 2015-07-31 2018-08-02 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Immunostimulatory nanocarrier
WO2017066328A1 (en) 2015-10-12 2017-04-20 The University Of Chicago Stabilization of active metal catalysts at metal-organic framework nodes for highly efficient organic transformations
CN105457038A (zh) 2015-11-09 2016-04-06 东南大学 一种速释型药物磷脂化合物及其药物组合物
EP3439666A4 (en) 2016-05-20 2019-12-11 The University of Chicago NANOPARTICLES FOR CHEMOTHERAPY, TARGETED THERAPY, PHOTODYNAMIC THERAPY, IMMUNOTHERAPY AND ALL COMBINATIONS THEREOF
US11673125B2 (en) 2016-08-18 2023-06-13 The University Of Chicago Metal oxide-supported earth-abundant metal catalysts for highly efficient organic transformations
EP3638367A4 (en) 2017-08-02 2021-07-21 The University of Chicago NANOMETRIC ORGANOMETALLIC AND NANOPLAQUE ORGANOMETALLIC LAYERS FOR X-RAY INDUCED PHOTODYNAMIC THERAPY, RADIOTHERAPY, RADIODYNAMIC THERAPY, CHEMOTHERAPY, IMMUNOTHERAPY, AND ANY COMBINATION OF THESE
US20190314324A1 (en) 2018-04-13 2019-10-17 The University Of Chicago Combination of micheliolide derivatives or nanoparticles with ionizing radiation and checkpoint inhibitors for cancer therapy
US12042788B2 (en) 2019-08-21 2024-07-23 The University Of Chicago Strongly Lewis acidic metal-organic frameworks for continuous flow catalysis
JP2023526501A (ja) 2020-05-22 2023-06-21 ザ・ユニバーシティ・オブ・シカゴ 金属有機構造体が癌免疫療法の為の低分子及びバイオ高分子を送達する

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