JP2016536318A5 - - Google Patents
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- JP2016536318A5 JP2016536318A5 JP2016528894A JP2016528894A JP2016536318A5 JP 2016536318 A5 JP2016536318 A5 JP 2016536318A5 JP 2016528894 A JP2016528894 A JP 2016528894A JP 2016528894 A JP2016528894 A JP 2016528894A JP 2016536318 A5 JP2016536318 A5 JP 2016536318A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- metal
- nanoscale particles
- lipid
- nanoscale
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000002105 nanoparticle Substances 0.000 claims 22
- 108020004707 nucleic acids Proteins 0.000 claims 17
- 150000007523 nucleic acids Chemical class 0.000 claims 17
- 102000039446 nucleic acids Human genes 0.000 claims 17
- 150000002632 lipids Chemical class 0.000 claims 7
- 239000011159 matrix material Substances 0.000 claims 7
- 229940122361 Bisphosphonate Drugs 0.000 claims 6
- 108020004459 Small interfering RNA Proteins 0.000 claims 6
- 239000002246 antineoplastic agent Substances 0.000 claims 6
- 150000004663 bisphosphonates Chemical class 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 6
- 229940124597 therapeutic agent Drugs 0.000 claims 6
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 239000011248 coating agent Substances 0.000 claims 4
- 239000011247 coating layer Substances 0.000 claims 4
- 229940127089 cytotoxic agent Drugs 0.000 claims 4
- 239000002184 metal Substances 0.000 claims 4
- 229910021645 metal ion Inorganic materials 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 102100033350 ATP-dependent translocase ABCB1 Human genes 0.000 claims 2
- 239000000232 Lipid Bilayer Substances 0.000 claims 2
- 206010033128 Ovarian cancer Diseases 0.000 claims 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
- 230000003796 beauty Effects 0.000 claims 2
- 125000002091 cationic group Chemical group 0.000 claims 2
- -1 cationic lipid Chemical class 0.000 claims 2
- 229940044683 chemotherapy drug Drugs 0.000 claims 2
- 239000013256 coordination polymer Substances 0.000 claims 2
- 229920001795 coordination polymer Polymers 0.000 claims 2
- 239000004530 micro-emulsion Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 2
- 229940002612 prodrug Drugs 0.000 claims 2
- 239000000651 prodrug Substances 0.000 claims 2
- 102100021569 Apoptosis regulator Bcl-2 Human genes 0.000 claims 1
- 102100021663 Baculoviral IAP repeat-containing protein 5 Human genes 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 101000971171 Homo sapiens Apoptosis regulator Bcl-2 Proteins 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 108010047230 Member 1 Subfamily B ATP Binding Cassette Transporter Proteins 0.000 claims 1
- 101100226013 Mus musculus Ercc1 gene Proteins 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 108010002687 Survivin Proteins 0.000 claims 1
- 238000002512 chemotherapy Methods 0.000 claims 1
- 229960004316 cisplatin Drugs 0.000 claims 1
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims 1
- 238000000576 coating method Methods 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 230000009881 electrostatic interaction Effects 0.000 claims 1
- 239000012216 imaging agent Substances 0.000 claims 1
- 239000013554 lipid monolayer Substances 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229910044991 metal oxide Inorganic materials 0.000 claims 1
- 150000004706 metal oxides Chemical class 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 108091070501 miRNA Proteins 0.000 claims 1
- 239000002679 microRNA Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- DWAFYCQODLXJNR-BNTLRKBRSA-L oxaliplatin Chemical compound O1C(=O)C(=O)O[Pt]11N[C@@H]2CCCC[C@H]2N1 DWAFYCQODLXJNR-BNTLRKBRSA-L 0.000 claims 1
- 229960001756 oxaliplatin Drugs 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 claims 1
- 239000003504 photosensitizing agent Substances 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 229940126585 therapeutic drug Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361900698P | 2013-11-06 | 2013-11-06 | |
| US61/900,698 | 2013-11-06 | ||
| PCT/US2014/064388 WO2015069926A1 (en) | 2013-11-06 | 2014-11-06 | Nanoscale carriers for the delivery or co-delivery of chemotherapeutics, nucleic acids and photosensitizers |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019167976A Division JP2020011974A (ja) | 2013-11-06 | 2019-09-17 | 化学療法用薬剤、核酸及び光増感剤の送達又は共送達のためのナノスケール輸送体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016536318A JP2016536318A (ja) | 2016-11-24 |
| JP2016536318A5 true JP2016536318A5 (https=) | 2017-12-14 |
| JP6590802B2 JP6590802B2 (ja) | 2019-10-16 |
Family
ID=53042088
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016528894A Active JP6590802B2 (ja) | 2013-11-06 | 2014-11-06 | 化学療法用薬剤、核酸及び光増感剤の送達又は共送達のためのナノスケール輸送体 |
| JP2019167976A Pending JP2020011974A (ja) | 2013-11-06 | 2019-09-17 | 化学療法用薬剤、核酸及び光増感剤の送達又は共送達のためのナノスケール輸送体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019167976A Pending JP2020011974A (ja) | 2013-11-06 | 2019-09-17 | 化学療法用薬剤、核酸及び光増感剤の送達又は共送達のためのナノスケール輸送体 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US10517822B2 (https=) |
| EP (1) | EP3065713B1 (https=) |
| JP (2) | JP6590802B2 (https=) |
| CN (1) | CN105873569B (https=) |
| WO (1) | WO2015069926A1 (https=) |
Families Citing this family (40)
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|---|---|---|---|---|
| WO2013009701A2 (en) | 2011-07-08 | 2013-01-17 | The University Of North Carolina At Chapel Hill | Metal bisphosphonate nanoparticles for anti-cancer therapy and imaging and for treating bone disorders |
| CA2889182A1 (en) * | 2012-10-26 | 2014-05-01 | The University Of Chicago | Synergistic combination of immunologic inhibitors for the treatment of cancer |
| WO2015149072A1 (en) | 2014-03-28 | 2015-10-01 | The University Of Chicago | Metal-organic frameworks containing nitrogen-donor ligands for efficient catalytic organic transformations |
| WO2015149068A1 (en) | 2014-03-28 | 2015-10-01 | The University Of Chicago | Chiral ligand-based metal-organic frameworks for broad-scope asymmetric catalysis |
| EP3206987B2 (en) | 2014-10-14 | 2024-07-24 | The University of Chicago | Nanoparticles for photodynamic therapy, x-ray induced photodynamic therapy, radiotherapy, chemotherapy, immunotherapy, and any combination thereof |
| US10806694B2 (en) | 2014-10-14 | 2020-10-20 | The University Of Chicago | Nanoparticles for photodynamic therapy, X-ray induced photodynamic therapy, radiotherapy, radiodynamic therapy, chemotherapy, immunotherapy, and any combination thereof |
| AU2015230812A1 (en) * | 2015-09-25 | 2017-04-13 | The University Of Sydney | Treatment and prevention of adrenocortical carcinoma |
| US10953393B2 (en) | 2015-10-12 | 2021-03-23 | The University Of Chicago | Stabilization of active metal catalysts at metal-organic framework nodes for highly efficient organic transformations |
| US20170362609A1 (en) | 2016-05-02 | 2017-12-21 | Massachusetts Institute Of Technology | AMPHIPHILIC NANOPARTICLES FOR CODELIVERY OF WATER-INSOLUBLE SMALL MOLECULES AND RNAi |
| EP3439666A4 (en) * | 2016-05-20 | 2019-12-11 | The University of Chicago | NANOPARTICLES FOR CHEMOTHERAPY, TARGETED THERAPY, PHOTODYNAMIC THERAPY, IMMUNOTHERAPY AND ALL COMBINATIONS THEREOF |
| US11673125B2 (en) | 2016-08-18 | 2023-06-13 | The University Of Chicago | Metal oxide-supported earth-abundant metal catalysts for highly efficient organic transformations |
| WO2018067431A1 (en) * | 2016-10-03 | 2018-04-12 | Purdue Research Foundation | Re-sensitizing drug-resistant cancer cells by combinational therapy |
| CN108318311B (zh) * | 2017-01-15 | 2022-01-18 | 复旦大学 | 一种硬骨特异性钙质荧光染色方法及其应用 |
| CN106947010B (zh) * | 2017-04-06 | 2018-12-11 | 哈尔滨工业大学 | 一种利用光引发raft聚合原位诱导自组装制备蛋白质基纳米粒子的方法 |
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| EP3638367A4 (en) | 2017-08-02 | 2021-07-21 | The University of Chicago | NANOMETRIC ORGANOMETALLIC AND NANOPLAQUE ORGANOMETALLIC LAYERS FOR X-RAY INDUCED PHOTODYNAMIC THERAPY, RADIOTHERAPY, RADIODYNAMIC THERAPY, CHEMOTHERAPY, IMMUNOTHERAPY, AND ANY COMBINATION OF THESE |
| CN109554397A (zh) * | 2017-09-26 | 2019-04-02 | 广州宏柯源生物科技有限公司 | 纳米颗粒及其制备方法 |
| CN107753946B (zh) * | 2017-10-23 | 2020-11-27 | 福州大学 | 一种适配体修饰的靶向载药纳米粒及其制备方法与应用 |
| GB201717975D0 (en) * | 2017-10-31 | 2017-12-13 | Cambridge Entpr Ltd | Metal organic framework-based compositions and uses thereof |
| KR102212226B1 (ko) * | 2017-12-21 | 2021-02-05 | (주) 에이치엔에이파마켐 | 금속-유기 골격체 및 나노셀룰로오스를 이용한 경피전달용 복합체 |
| US20190314324A1 (en) | 2018-04-13 | 2019-10-17 | The University Of Chicago | Combination of micheliolide derivatives or nanoparticles with ionizing radiation and checkpoint inhibitors for cancer therapy |
| CN108619511B (zh) * | 2018-04-20 | 2020-12-15 | 山东大学 | 一种基于阿糖胞苷小分子前药的金属有机框架载药系统的制备方法和应用 |
| CN108794532A (zh) * | 2018-05-18 | 2018-11-13 | 东北林业大学 | 脑磷脂类似物、制备方法及用途 |
| CN111110846B (zh) * | 2018-10-30 | 2021-07-23 | 国家纳米科学中心 | 一种金属-核酸纳米颗粒及其制备方法和用途 |
| CN111139234B (zh) * | 2018-11-06 | 2022-02-01 | 举康(上海)生物科技有限公司 | 一种游离dna提取试剂盒 |
| MX2021005462A (es) | 2018-11-09 | 2021-08-24 | Arbutus Biopharma Corp | Lipidos cationicos que contienen silicio. |
| US20220177494A1 (en) * | 2019-04-08 | 2022-06-09 | Wisconsin Alumni Research Foundation | pH-RESPONSIVE SILICA METAL ORGANIC FRAMEWORK NANOPARTICLES FOR DELIVERY OF BIOACTIVE MOLECULES |
| CN110201160B (zh) * | 2019-05-20 | 2021-12-03 | 广东医科大学 | 锆金属有机骨架化合物的制备方法 |
| CN110862546B (zh) * | 2019-10-12 | 2021-07-09 | 厦门大学 | 一种甲氨蝶呤金属配位聚合物及其制备方法和应用 |
| EP4058190A4 (en) * | 2019-11-14 | 2023-12-13 | Board of Regents, The University of Texas System | COMPOSITIONS AND METHODS FOR THE CONTROLLED DELIVERY AND PROTECTION OF THERAPEUTICS |
| WO2021237209A1 (en) * | 2020-05-22 | 2021-11-25 | The University Of Chicago | Metal-organic frameworks deliver small molecules and biomacromolecules for cancer immunotherapy |
| JP2023538231A (ja) | 2020-07-23 | 2023-09-07 | エンゾー バイオケム，インコーポレイテッド | 蛍光クエンチャーポリマーコンジュゲート及びその使用 |
| CN115998862B (zh) * | 2021-10-21 | 2025-07-11 | 北京化工大学 | 肿瘤特异性酶响应的光动力治疗纳米材料及其制备与应用 |
| CN114099706B (zh) * | 2021-11-30 | 2024-10-01 | 江南大学 | 一种用于乳腺癌治疗的mof药物载体及其制备方法 |
| CN114748644B (zh) * | 2022-05-20 | 2023-08-18 | 齐齐哈尔大学 | 一种以zif-8为基质的藻蓝蛋白分子印迹药物载体的制备方法 |
| CN115501202B (zh) * | 2022-10-12 | 2023-05-19 | 北京大学 | 一种递送过渡态唾液酸转移酶抑制剂的核壳纳米粒子及其制备方法和应用 |
| CN115449088B (zh) * | 2022-10-28 | 2023-06-16 | 中国人民解放军陆军特色医学中心 | 一种高孔隙cof纳米颗粒及其制备方法和作为药物载体的应用 |
| CN116212050B (zh) * | 2023-03-20 | 2025-08-08 | 浙江大学 | 一种小分子化疗药/生物大分子/金属有机框架复合材料的制备方法及其产品和应用 |
| CN117138055B (zh) * | 2023-06-02 | 2024-04-16 | 中山大学附属第一医院 | 一种双载体的阿霉素载药纳米材料及其制备方法 |
| CN116808235A (zh) * | 2023-06-27 | 2023-09-29 | 安徽瑞拜药业有限公司 | 一种核酸载体及其制备方法 |
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| WO2013009701A2 (en) | 2011-07-08 | 2013-01-17 | The University Of North Carolina At Chapel Hill | Metal bisphosphonate nanoparticles for anti-cancer therapy and imaging and for treating bone disorders |
| CN102432654A (zh) | 2011-09-26 | 2012-05-02 | 宋云龙 | 吉西他滨酰胺衍生物及其制备方法和用途 |
| WO2013068965A2 (en) | 2011-11-11 | 2013-05-16 | Koninklijke Philips Electronics N.V. | Lighting apparatus and manufacturing method for manufacturing the lighting apparatus |
| WO2015149068A1 (en) | 2014-03-28 | 2015-10-01 | The University Of Chicago | Chiral ligand-based metal-organic frameworks for broad-scope asymmetric catalysis |
| WO2015149072A1 (en) | 2014-03-28 | 2015-10-01 | The University Of Chicago | Metal-organic frameworks containing nitrogen-donor ligands for efficient catalytic organic transformations |
-
2014
- 2014-11-06 US US15/034,799 patent/US10517822B2/en active Active
- 2014-11-06 JP JP2016528894A patent/JP6590802B2/ja active Active
- 2014-11-06 EP EP14860910.0A patent/EP3065713B1/en active Active
- 2014-11-06 CN CN201480072258.0A patent/CN105873569B/zh active Active
- 2014-11-06 WO PCT/US2014/064388 patent/WO2015069926A1/en not_active Ceased
-
2019
- 2019-09-17 JP JP2019167976A patent/JP2020011974A/ja active Pending
- 2019-09-20 US US16/577,818 patent/US20200085742A1/en not_active Abandoned
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