JP2014518064A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2014518064A5 JP2014518064A5 JP2014513760A JP2014513760A JP2014518064A5 JP 2014518064 A5 JP2014518064 A5 JP 2014518064A5 JP 2014513760 A JP2014513760 A JP 2014513760A JP 2014513760 A JP2014513760 A JP 2014513760A JP 2014518064 A5 JP2014518064 A5 JP 2014518064A5
- Authority
- JP
- Japan
- Prior art keywords
- fibrosis
- seq
- amino acid
- antibody
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 70
- 206010016654 Fibrosis Diseases 0.000 claims description 46
- 230000004761 fibrosis Effects 0.000 claims description 44
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 28
- 238000000034 method Methods 0.000 claims description 20
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims description 18
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims description 18
- 208000035475 disorder Diseases 0.000 claims description 18
- 239000008194 pharmaceutical composition Substances 0.000 claims description 18
- 150000001413 amino acids Chemical class 0.000 claims description 17
- 206010028980 Neoplasm Diseases 0.000 claims description 16
- 102000039446 nucleic acids Human genes 0.000 claims description 14
- 108020004707 nucleic acids Proteins 0.000 claims description 14
- 150000007523 nucleic acids Chemical class 0.000 claims description 14
- 210000004027 cell Anatomy 0.000 claims description 12
- 238000001356 surgical procedure Methods 0.000 claims description 12
- 206010018364 Glomerulonephritis Diseases 0.000 claims description 10
- 201000010099 disease Diseases 0.000 claims description 10
- 231100000241 scar Toxicity 0.000 claims description 8
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims description 7
- 208000010412 Glaucoma Diseases 0.000 claims description 6
- 206010023421 Kidney fibrosis Diseases 0.000 claims description 6
- 206010064930 age-related macular degeneration Diseases 0.000 claims description 6
- 201000011510 cancer Diseases 0.000 claims description 6
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims description 6
- 210000004443 dendritic cell Anatomy 0.000 claims description 6
- 230000006870 function Effects 0.000 claims description 6
- 208000014674 injury Diseases 0.000 claims description 6
- 230000002207 retinal effect Effects 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 5
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims description 4
- 208000007342 Diabetic Nephropathies Diseases 0.000 claims description 4
- 206010019280 Heart failures Diseases 0.000 claims description 4
- 208000034189 Sclerosis Diseases 0.000 claims description 4
- 208000002847 Surgical Wound Diseases 0.000 claims description 4
- 206010069351 acute lung injury Diseases 0.000 claims description 4
- 208000019425 cirrhosis of liver Diseases 0.000 claims description 4
- 210000004087 cornea Anatomy 0.000 claims description 4
- 208000033679 diabetic kidney disease Diseases 0.000 claims description 4
- 230000000893 fibroproliferative effect Effects 0.000 claims description 4
- 208000019423 liver disease Diseases 0.000 claims description 4
- 229920001184 polypeptide Polymers 0.000 claims description 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 4
- 230000000750 progressive effect Effects 0.000 claims description 4
- 230000006785 proliferative vitreoretinopathy Effects 0.000 claims description 4
- 208000005069 pulmonary fibrosis Diseases 0.000 claims description 4
- 210000003289 regulatory T cell Anatomy 0.000 claims description 4
- 201000002793 renal fibrosis Diseases 0.000 claims description 4
- 208000037803 restenosis Diseases 0.000 claims description 4
- 230000004283 retinal dysfunction Effects 0.000 claims description 4
- 230000037390 scarring Effects 0.000 claims description 4
- 230000009885 systemic effect Effects 0.000 claims description 4
- 230000008733 trauma Effects 0.000 claims description 4
- 239000012634 fragment Substances 0.000 claims description 3
- 208000007122 AIDS-Associated Nephropathy Diseases 0.000 claims description 2
- 208000025494 Aortic disease Diseases 0.000 claims description 2
- 201000001320 Atherosclerosis Diseases 0.000 claims description 2
- 208000017283 Bile Duct disease Diseases 0.000 claims description 2
- 206010006448 Bronchiolitis Diseases 0.000 claims description 2
- 208000009903 Camurati-Engelmann Syndrome Diseases 0.000 claims description 2
- 206010007559 Cardiac failure congestive Diseases 0.000 claims description 2
- 206010007572 Cardiac hypertrophy Diseases 0.000 claims description 2
- 208000006029 Cardiomegaly Diseases 0.000 claims description 2
- 208000024172 Cardiovascular disease Diseases 0.000 claims description 2
- 206010007764 Cataract subcapsular Diseases 0.000 claims description 2
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims description 2
- 208000032544 Cicatrix Diseases 0.000 claims description 2
- 206010056370 Congestive cardiomyopathy Diseases 0.000 claims description 2
- 208000006069 Corneal Opacity Diseases 0.000 claims description 2
- 208000011231 Crohn disease Diseases 0.000 claims description 2
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims description 2
- 108010036949 Cyclosporine Proteins 0.000 claims description 2
- 206010012689 Diabetic retinopathy Diseases 0.000 claims description 2
- 201000010046 Dilated cardiomyopathy Diseases 0.000 claims description 2
- 206010014561 Emphysema Diseases 0.000 claims description 2
- 208000000571 Fibrocystic breast disease Diseases 0.000 claims description 2
- 208000008069 Geographic Atrophy Diseases 0.000 claims description 2
- 206010020772 Hypertension Diseases 0.000 claims description 2
- 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 claims description 2
- 208000014919 IgG4-related retroperitoneal fibrosis Diseases 0.000 claims description 2
- 206010061216 Infarction Diseases 0.000 claims description 2
- 208000029523 Interstitial Lung disease Diseases 0.000 claims description 2
- 208000007177 Left Ventricular Hypertrophy Diseases 0.000 claims description 2
- 208000001826 Marfan syndrome Diseases 0.000 claims description 2
- 208000009525 Myocarditis Diseases 0.000 claims description 2
- 208000022873 Ocular disease Diseases 0.000 claims description 2
- 208000001132 Osteoporosis Diseases 0.000 claims description 2
- 208000018737 Parkinson disease Diseases 0.000 claims description 2
- 208000004362 Penile Induration Diseases 0.000 claims description 2
- 208000020758 Peyronie disease Diseases 0.000 claims description 2
- 206010036346 Posterior capsule opacification Diseases 0.000 claims description 2
- 208000002158 Proliferative Vitreoretinopathy Diseases 0.000 claims description 2
- 208000003782 Raynaud disease Diseases 0.000 claims description 2
- 208000012322 Raynaud phenomenon Diseases 0.000 claims description 2
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 claims description 2
- 201000007737 Retinal degeneration Diseases 0.000 claims description 2
- 206010038848 Retinal detachment Diseases 0.000 claims description 2
- 206010038934 Retinopathy proliferative Diseases 0.000 claims description 2
- 206010038979 Retroperitoneal fibrosis Diseases 0.000 claims description 2
- 206010039710 Scleroderma Diseases 0.000 claims description 2
- 208000004350 Strabismus Diseases 0.000 claims description 2
- 208000036038 Subretinal fibrosis Diseases 0.000 claims description 2
- 201000009594 Systemic Scleroderma Diseases 0.000 claims description 2
- 206010042953 Systemic sclerosis Diseases 0.000 claims description 2
- 206010060872 Transplant failure Diseases 0.000 claims description 2
- 206010057469 Vascular stenosis Diseases 0.000 claims description 2
- 206010058990 Venous occlusion Diseases 0.000 claims description 2
- 208000036866 Vitreoretinopathy Diseases 0.000 claims description 2
- 208000000208 Wet Macular Degeneration Diseases 0.000 claims description 2
- 208000027418 Wounds and injury Diseases 0.000 claims description 2
- 208000011341 adult acute respiratory distress syndrome Diseases 0.000 claims description 2
- 201000000028 adult respiratory distress syndrome Diseases 0.000 claims description 2
- 238000002399 angioplasty Methods 0.000 claims description 2
- 210000004204 blood vessel Anatomy 0.000 claims description 2
- 210000001185 bone marrow Anatomy 0.000 claims description 2
- 208000011803 breast fibrocystic disease Diseases 0.000 claims description 2
- 239000002775 capsule Substances 0.000 claims description 2
- 230000009787 cardiac fibrosis Effects 0.000 claims description 2
- 230000003915 cell function Effects 0.000 claims description 2
- 229960001265 ciclosporin Drugs 0.000 claims description 2
- 230000007882 cirrhosis Effects 0.000 claims description 2
- 210000000795 conjunctiva Anatomy 0.000 claims description 2
- 230000008602 contraction Effects 0.000 claims description 2
- 231100000269 corneal opacity Toxicity 0.000 claims description 2
- 238000012258 culturing Methods 0.000 claims description 2
- 229930182912 cyclosporin Natural products 0.000 claims description 2
- 230000001461 cytolytic effect Effects 0.000 claims description 2
- 230000006378 damage Effects 0.000 claims description 2
- 201000001981 dermatomyositis Diseases 0.000 claims description 2
- 210000004207 dermis Anatomy 0.000 claims description 2
- 206010012601 diabetes mellitus Diseases 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 claims description 2
- 210000000871 endothelium corneal Anatomy 0.000 claims description 2
- 239000013604 expression vector Substances 0.000 claims description 2
- 208000030533 eye disease Diseases 0.000 claims description 2
- 230000001497 fibrovascular Effects 0.000 claims description 2
- 206010061989 glomerulosclerosis Diseases 0.000 claims description 2
- 208000015210 hypertensive heart disease Diseases 0.000 claims description 2
- 206010020871 hypertrophic cardiomyopathy Diseases 0.000 claims description 2
- 230000001969 hypertrophic effect Effects 0.000 claims description 2
- 208000015181 infectious disease Diseases 0.000 claims description 2
- 208000036971 interstitial lung disease 2 Diseases 0.000 claims description 2
- 208000011379 keloid formation Diseases 0.000 claims description 2
- 230000005976 liver dysfunction Effects 0.000 claims description 2
- 208000002780 macular degeneration Diseases 0.000 claims description 2
- 239000012528 membrane Substances 0.000 claims description 2
- 230000009245 menopause Effects 0.000 claims description 2
- 210000003205 muscle Anatomy 0.000 claims description 2
- 208000010125 myocardial infarction Diseases 0.000 claims description 2
- 210000000822 natural killer cell Anatomy 0.000 claims description 2
- 208000021971 neovascular inflammatory vitreoretinopathy Diseases 0.000 claims description 2
- 239000002773 nucleotide Substances 0.000 claims description 2
- 125000003729 nucleotide group Chemical group 0.000 claims description 2
- 230000000414 obstructive effect Effects 0.000 claims description 2
- 244000052769 pathogen Species 0.000 claims description 2
- 230000002093 peripheral effect Effects 0.000 claims description 2
- 208000005987 polymyositis Diseases 0.000 claims description 2
- 230000002062 proliferating effect Effects 0.000 claims description 2
- 208000023504 respiratory system disease Diseases 0.000 claims description 2
- 230000004264 retinal detachment Effects 0.000 claims description 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims description 2
- 230000037387 scars Effects 0.000 claims description 2
- 208000020431 spinal cord injury Diseases 0.000 claims description 2
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims description 2
- 210000001519 tissue Anatomy 0.000 claims description 2
- 230000003614 tolerogenic effect Effects 0.000 claims description 2
- 231100000167 toxic agent Toxicity 0.000 claims description 2
- 239000003440 toxic substance Substances 0.000 claims description 2
- 210000001585 trabecular meshwork Anatomy 0.000 claims description 2
- 239000013598 vector Substances 0.000 claims description 2
- 230000029663 wound healing Effects 0.000 claims description 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 102000009618 Transforming Growth Factors Human genes 0.000 claims 1
- 108010009583 Transforming Growth Factors Proteins 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 description 1
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- 206010009944 Colon cancer Diseases 0.000 description 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 description 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 description 1
- 208000032612 Glial tumor Diseases 0.000 description 1
- 206010018338 Glioma Diseases 0.000 description 1
- 208000008839 Kidney Neoplasms Diseases 0.000 description 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 description 1
- 206010033128 Ovarian cancer Diseases 0.000 description 1
- 206010061535 Ovarian neoplasm Diseases 0.000 description 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 description 1
- 206010060862 Prostate cancer Diseases 0.000 description 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 1
- 206010038389 Renal cancer Diseases 0.000 description 1
- 208000005718 Stomach Neoplasms Diseases 0.000 description 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 description 1
- 201000004101 esophageal cancer Diseases 0.000 description 1
- 230000003176 fibrotic effect Effects 0.000 description 1
- 206010017758 gastric cancer Diseases 0.000 description 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 description 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 description 1
- 201000010982 kidney cancer Diseases 0.000 description 1
- 201000005202 lung cancer Diseases 0.000 description 1
- 208000020816 lung neoplasm Diseases 0.000 description 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 description 1
- 201000001441 melanoma Diseases 0.000 description 1
- 201000002528 pancreatic cancer Diseases 0.000 description 1
- 208000008443 pancreatic carcinoma Diseases 0.000 description 1
- 201000011549 stomach cancer Diseases 0.000 description 1
- 201000005112 urinary bladder cancer Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161493230P | 2011-06-03 | 2011-06-03 | |
| US61/493,230 | 2011-06-03 | ||
| PCT/US2012/040545 WO2012167143A1 (en) | 2011-06-03 | 2012-06-01 | Antibodies specific for tgf-beta |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018123833A Division JP6571843B2 (ja) | 2011-06-03 | 2018-06-29 | ＴＧＦ−βに特異的な抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014518064A JP2014518064A (ja) | 2014-07-28 |
| JP2014518064A5 true JP2014518064A5 (cg-RX-API-DMAC7.html) | 2015-07-23 |
| JP6363948B2 JP6363948B2 (ja) | 2018-07-25 |
Family
ID=47259913
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014513760A Active JP6363948B2 (ja) | 2011-06-03 | 2012-06-01 | ＴＧＦ−βに特異的な抗体 |
| JP2018123833A Active JP6571843B2 (ja) | 2011-06-03 | 2018-06-29 | ＴＧＦ−βに特異的な抗体 |
| JP2019146320A Active JP6877500B2 (ja) | 2011-06-03 | 2019-08-08 | ＴＧＦ−βに特異的な抗体 |
| JP2021074575A Active JP7179903B2 (ja) | 2011-06-03 | 2021-04-27 | ＴＧＦ－βに特異的な抗体 |
| JP2022183014A Pending JP2023015300A (ja) | 2011-06-03 | 2022-11-16 | ＴＧＦ－βに特異的な抗体 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018123833A Active JP6571843B2 (ja) | 2011-06-03 | 2018-06-29 | ＴＧＦ−βに特異的な抗体 |
| JP2019146320A Active JP6877500B2 (ja) | 2011-06-03 | 2019-08-08 | ＴＧＦ−βに特異的な抗体 |
| JP2021074575A Active JP7179903B2 (ja) | 2011-06-03 | 2021-04-27 | ＴＧＦ－βに特異的な抗体 |
| JP2022183014A Pending JP2023015300A (ja) | 2011-06-03 | 2022-11-16 | ＴＧＦ－βに特異的な抗体 |
Country Status (26)
Families Citing this family (107)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9589417B2 (en) | 2005-07-14 | 2017-03-07 | Ag 18, Llc | Interactive gaming among a plurality of players systems and methods |
| US20110229471A1 (en) | 2008-11-26 | 2011-09-22 | Cedars-Sinai Medical Center | Methods of determining responsiveness to anti-tnf alpha therapy in inflammatory bowel disease |
| US8956859B1 (en) | 2010-08-13 | 2015-02-17 | Aviex Technologies Llc | Compositions and methods for determining successful immunization by one or more vaccines |
| MX351600B (es) | 2011-06-03 | 2017-10-20 | Xoma Technology Ltd | Anticuerpo especificos para tgf-beta. |
| WO2014028862A1 (en) | 2012-08-17 | 2014-02-20 | Cornell University | Use of dna in circulating exosomes as a diagnostic marker for metastasic disease |
| CA2908553A1 (en) | 2013-03-27 | 2014-10-02 | Cedars-Sinai Medical Center | Mitigation and reversal of fibrosis and inflammation by inhibition of tl1a function and related signaling pathways |
| EP2981822B1 (en) | 2013-05-06 | 2020-09-02 | Scholar Rock, Inc. | Compositions and methods for growth factor modulation |
| EP4105236A1 (en) | 2013-07-19 | 2022-12-21 | Cedars-Sinai Medical Center | Anti-tl1a (tnfsf15) antibody for treatment of inflammatory bowel disease |
| CA2928626C (en) | 2013-11-14 | 2023-03-14 | The Doshisha | Drug for treating corneal endothelium by promoting cell proliferation or inhibiting cell damage |
| EP4005585B1 (en) | 2013-11-21 | 2024-03-27 | The Brigham & Women's Hospital, Inc. | Compositions and methods for treating right ventricular hypertrophy |
| WO2015153732A2 (en) | 2014-04-01 | 2015-10-08 | Cornell University | Use of double-stranded dna in exosomes: a novel biomarker in cancer detection |
| EP3174550B1 (en) * | 2014-08-01 | 2020-01-29 | The Brigham and Women's Hospital, Inc. | Methods and compositions relating to treatment of pulmonary arterial hypertension |
| WO2016024628A1 (ja) * | 2014-08-14 | 2016-02-18 | 学校法人東京医科大学 | 樹状細胞の抗癌免疫賦活能の促進方法およびその用途 |
| US11397182B2 (en) | 2014-10-07 | 2022-07-26 | Cornell University | Methods for prognosing and preventing metastatic liver disease |
| MA41044A (fr) | 2014-10-08 | 2017-08-15 | Novartis Ag | Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer |
| EA201790834A1 (ru) | 2014-10-14 | 2018-01-31 | Новартис Аг | Молекулы антител к pd-l1 и их применение |
| TWI733661B (zh) | 2015-03-04 | 2021-07-21 | 美商健臻公司 | 以高親合性、結合性及特異性結合轉化生長因子－β１的經修飾ＩｇＧ抗體 |
| TWI726870B (zh) | 2015-03-04 | 2021-05-11 | 美商健臻公司 | 具有高親和性、結合性及專一性之結合轉形生長因子-β１的ｓｃＦｖ-Ｆｃ二聚體 |
| CN116327915A (zh) | 2015-04-03 | 2023-06-27 | 佐马技术有限公司 | 使用TGF-β抑制剂和PD-1抑制剂治疗癌症 |
| US11971402B2 (en) | 2015-04-24 | 2024-04-30 | Cornell University | Methods and reagents for determination and treatment of organotropic metastasis |
| EP4335418A3 (en) | 2015-06-06 | 2024-05-22 | Cloudbreak Therapeutics, LLC | Compositions and methods for treating pterygium |
| WO2016201282A2 (en) | 2015-06-12 | 2016-12-15 | Ludwig Institute For Cancer Research Ltd | TGF-β3 SPECIFIC ANTIBODIES AND METHODS AND USES THEREOF |
| HUE055469T2 (hu) | 2015-07-29 | 2021-11-29 | Novartis Ag | A LAG-3 elleni antitest molekulákat tartalmazó kombinált terápiák |
| KR102716215B1 (ko) | 2015-10-06 | 2024-10-10 | 리젠츠 오브 더 유니버시티 오브 미네소타 | 치료 화합물 및 방법 |
| MX2018006269A (es) * | 2015-11-23 | 2018-09-05 | Merck Patent Gmbh | Anticuerpo anti-alfa-v-integrina para el tratamiento de fibrosis y/o trastornos fibroticos. |
| JP2019503349A (ja) | 2015-12-17 | 2019-02-07 | ノバルティス アーゲー | Ｐｄ−１に対する抗体分子およびその使用 |
| EP3381472A4 (en) | 2015-12-24 | 2019-07-31 | The Doshisha | MEDICINAL PRODUCTS FOR THE TREATMENT OR PREVENTION OF DISTURBANCES CAUSED BY TGF SIGNALS AND USE THEREOF |
| AU2017219254B2 (en) * | 2016-02-17 | 2019-12-12 | Novartis Ag | TGFbeta 2 antibodies |
| DK3365368T3 (da) | 2016-03-11 | 2023-06-26 | Scholar Rock Inc | Tgfbeta1-bindende immunoglobuliner og anvendelse deraf |
| JP7082945B2 (ja) | 2016-03-17 | 2022-06-09 | シーダーズ―シナイ メディカル センター | Ｒｎａｓｅｔ２により炎症性腸疾患を診断する方法 |
| US10233255B2 (en) | 2016-04-25 | 2019-03-19 | Sorrento Therapeutics, Inc. | Antibody therapeutics that bind STAT3 |
| GB201608052D0 (en) * | 2016-05-09 | 2016-06-22 | Univ Oslo Hf | T-cell receptors which recognise frameshift mutants of TGF-beta RII |
| EP3458608B1 (en) | 2016-05-17 | 2025-07-23 | F. Hoffmann-La Roche AG | Stromal gene signatures for diagnosis and use in immunotherapy |
| CN109476698B (zh) | 2016-05-20 | 2023-10-17 | 西达-赛奈医疗中心 | 基于基因的炎性肠病诊断 |
| KR20240052865A (ko) | 2016-06-02 | 2024-04-23 | 에이디에스 테라퓨틱스 엘엘씨 | 녹내장 수술 성공을 개선하기 위해 닌테다닙을 사용하는 조성물 및 방법 |
| GB201610044D0 (en) | 2016-06-08 | 2016-07-20 | Ucb Biopharma Sprl | Antibodies |
| EP3490600A1 (en) | 2016-08-01 | 2019-06-05 | Xoma (Us) Llc | Parathyroid hormone receptor 1 (pth1r) antibodies and uses thereof |
| BR112019005944A2 (pt) | 2016-09-28 | 2019-06-11 | Musc Foudation For Res Development | anticorpos que se ligam à interleucina 2 e usos dos mesmos |
| WO2018064515A1 (en) * | 2016-09-30 | 2018-04-05 | Academia Sinica | Microrna let-7 and transforming growth factor beta receptor iii axis as target for cardiac injuries |
| US11752315B1 (en) | 2016-10-07 | 2023-09-12 | Carlos A. Hakim | Method of treating normal pressure hydrocephalus |
| MY191324A (en) | 2016-10-26 | 2022-06-15 | Cedars Sinai Medical Center | Neutralizing anti-tl1a monoclonal antibodies |
| CN117398457A (zh) * | 2017-01-06 | 2024-01-16 | 供石公司 | 亚型特异性、背景许可性TGFβ1抑制剂及其用途 |
| TW202506185A (zh) | 2017-01-20 | 2025-02-16 | 法商賽諾菲公司 | 抗TGF-β抗體及其用途 |
| AR110755A1 (es) | 2017-01-20 | 2019-05-02 | Genzyme Corp | Anticuerpos dirigidos a hueso |
| EP3576773B1 (en) * | 2017-02-01 | 2023-10-18 | Acceleron Pharma Inc. | Tgf beta and actrii antagonists for use in treating leukemia |
| CN106800598B (zh) * | 2017-02-09 | 2020-08-07 | 广州桂雨生物科技有限公司 | 一种抗体保存液及其制备方法 |
| CA3054839C (en) | 2017-03-01 | 2023-08-29 | Chengdu Huitai Biomedicine Co., Ltd. | Polypeptides and uses thereof for treatment of a fibrosis disease |
| CN106860855B (zh) * | 2017-03-01 | 2021-06-11 | 成都惠泰生物医药有限公司 | 多肽及多肽衍生物在预防和治疗纤维化疾病中的应用 |
| JP2020186172A (ja) * | 2017-06-19 | 2020-11-19 | 株式会社ボナック | 抗ＴＧＦ−β１抗体 |
| WO2018237173A1 (en) | 2017-06-22 | 2018-12-27 | Novartis Ag | Antibody molecules to cd73 and uses thereof |
| MX2019015885A (es) | 2017-06-22 | 2020-09-10 | Novartis Ag | Moleculas de anticuerpo que se unen a cd73 y usos de las mismas. |
| US11576914B2 (en) | 2017-07-26 | 2023-02-14 | The Doshisha | Drug for treating or preventing disorder caused by TGF-β signaling, and application thereof |
| WO2019045086A1 (ja) * | 2017-08-29 | 2019-03-07 | 林化成株式会社 | 活性型もしくは潜在型ＴＧＦ−β１特異的抗体の用途 |
| JP7544597B2 (ja) | 2017-11-06 | 2024-09-03 | ジェネンテック， インコーポレイテッド | がんの診断及び療法 |
| US20200277378A1 (en) | 2017-11-16 | 2020-09-03 | Novartis Ag | Combination therapies |
| US20200371091A1 (en) | 2017-11-30 | 2020-11-26 | Novartis Ag | Bcma-targeting chimeric antigen receptor, and uses thereof |
| WO2019125981A1 (en) | 2017-12-19 | 2019-06-27 | Musc Foundation Of Research Development | T regulatory (trey) cell translantation in osteogenesis imperfecta (oi) |
| WO2019133950A1 (en) * | 2017-12-30 | 2019-07-04 | The Regents Of The University Of Colorado, A Body Corporate | Smad7 for treatment and prevention of posterior capsule opacification |
| US20210147547A1 (en) | 2018-04-13 | 2021-05-20 | Novartis Ag | Dosage Regimens For Anti-Pd-L1 Antibodies And Uses Thereof |
| CA3098374A1 (en) | 2018-04-25 | 2019-10-31 | Prometheus Biosciences, Inc. | Optimized anti-tl1a antibodies |
| US20210214459A1 (en) | 2018-05-31 | 2021-07-15 | Novartis Ag | Antibody molecules to cd73 and uses thereof |
| CN112384531B (zh) | 2018-06-01 | 2024-05-14 | 诺华股份有限公司 | 针对bcma的结合分子及其用途 |
| AR116109A1 (es) | 2018-07-10 | 2021-03-31 | Novartis Ag | Derivados de 3-(5-amino-1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos |
| EP3820575A1 (en) | 2018-07-10 | 2021-05-19 | Sanofi | Combination therapies against cancer targeting cd38 and tgf-beta |
| WO2020021465A1 (en) | 2018-07-25 | 2020-01-30 | Advanced Accelerator Applications (Italy) S.R.L. | Method of treatment of neuroendocrine tumors |
| JP7407822B2 (ja) | 2018-08-30 | 2024-01-04 | エイチシーダブリュー バイオロジックス インコーポレイテッド | 単鎖キメラポリペプチドおよびその使用 |
| EP4659757A2 (en) | 2018-08-30 | 2025-12-10 | ImmunityBio, Inc. | Multi-chain chimeric polypeptides and uses thereof |
| CA3114707A1 (en) | 2018-10-19 | 2020-04-23 | Regents Of The University Of Minnesota | Nk engager molecules and methods of use thereof |
| DE102018126842B4 (de) * | 2018-10-26 | 2020-10-15 | Carl Zeiss Meditec Ag | Ophthalmologisches Implantat, Verfahren zum Herstellen eines ophthalmologischen Implantats und Verwendung eines Liganden zur Herstellung eines ophthalmologischen Implantats |
| WO2020128972A1 (en) | 2018-12-20 | 2020-06-25 | Novartis Ag | Dosing regimen and pharmaceutical combination comprising 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives |
| WO2020128613A1 (en) | 2018-12-21 | 2020-06-25 | Novartis Ag | Use of il-1beta binding antibodies |
| WO2020128637A1 (en) | 2018-12-21 | 2020-06-25 | Novartis Ag | Use of il-1 binding antibodies in the treatment of a msi-h cancer |
| EA202192130A1 (ru) | 2019-01-30 | 2021-12-28 | Сколар Рок, Инк. | Специфичные к ltbp-комплексу ингибиторы tgf и их применение |
| JP7483732B2 (ja) | 2019-02-15 | 2024-05-15 | ノバルティス アーゲー | ３－（１－オキソ－５－（ピペリジン－４－イル）イソインドリン－２－イル）ピペリジン－２，６－ジオン誘導体及びその使用 |
| ES2982474T3 (es) | 2019-02-15 | 2024-10-16 | Novartis Ag | Derivados de 3-(1-oxoisoindolin-2-il)piperidin-1,6-diona sustituidos y usos de estos |
| BR102019007045A8 (pt) * | 2019-04-05 | 2023-05-09 | Univ Federal De Uberlandia | Peptídeos sintéticos com afinidade ao receptor de tgf-beta, composição farmacêutica e uso dos mesmos como imunomuduladores no tratamento de doenças autoimunes, inflamatórias ou alérgicas |
| CN114269903B (zh) | 2019-06-21 | 2025-11-25 | 免疫生物公司 | 多链嵌合多肽和其用途 |
| AU2020322474A1 (en) | 2019-08-01 | 2022-03-10 | Vaccinex,Inc. | Combined inhibition of semaphorin-4D and TGFβ and compositions therefor |
| TW202124446A (zh) | 2019-09-18 | 2021-07-01 | 瑞士商諾華公司 | 與ｅｎｔｐｄ２抗體之組合療法 |
| CA3158638A1 (en) | 2019-10-24 | 2021-04-29 | Prometheus Biosciences, Inc. | Humanized antibodies to tnf-like ligand 1a (tl1a) and uses thereof |
| JP2023507190A (ja) | 2019-12-20 | 2023-02-21 | ノバルティス アーゲー | 増殖性疾患を治療するための抗ＴＧＦβ抗体及びチェックポイント阻害薬の使用 |
| AU2021219720B2 (en) | 2020-02-11 | 2025-10-02 | Immunitybio, Inc. | Chromatography resin and uses thereof |
| US12398189B2 (en) | 2020-02-11 | 2025-08-26 | HCW Biologics, Inc. | Methods of activating regulatory T cells |
| US12115191B2 (en) | 2020-02-11 | 2024-10-15 | Immunitybio, Inc. | Methods of treating age-related and inflammatory diseases |
| US11801304B2 (en) | 2020-02-19 | 2023-10-31 | Nammi Therapeutics, Inc. | Formulated and/or co-formulated liposome compositions containing TFGB antagonist prodrugs useful in the treatment of cancer and methods thereof |
| CN111440238B (zh) * | 2020-03-27 | 2022-09-20 | 国典(北京)医药科技有限公司 | 抗人转化生长因子β1的纳米抗体及其制备方法和应用 |
| CN111440239B (zh) * | 2020-03-27 | 2022-07-15 | 中国医学科学院基础医学研究所 | 抗人转化生长因子β1的纳米抗体B3及其制备方法和应用 |
| JP7734693B2 (ja) | 2020-04-29 | 2025-09-05 | イミュニティーバイオ インコーポレイテッド | 抗ｃｄ２６タンパク質及びそれらの使用法 |
| US12024545B2 (en) | 2020-06-01 | 2024-07-02 | HCW Biologics, Inc. | Methods of treating aging-related disorders |
| US20230321067A1 (en) | 2020-06-23 | 2023-10-12 | Novartis Ag | Dosing regimen comprising 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives |
| US20230338587A1 (en) | 2020-08-31 | 2023-10-26 | Advanced Accelerator Applications International Sa | Method of treating psma-expressing cancers |
| WO2022043557A1 (en) | 2020-08-31 | 2022-03-03 | Advanced Accelerator Applications International Sa | Method of treating psma-expressing cancers |
| JP2023546759A (ja) * | 2020-10-23 | 2023-11-07 | ハン，ハック | 腫瘍壊死因子－アルファおよびトランスフォーミング増殖因子－ベータの二機能性アンタゴニストならびにその使用 |
| AU2021373366A1 (en) | 2020-11-06 | 2023-06-01 | Novartis Ag | Cd19 binding molecules and uses thereof |
| WO2022115611A1 (en) | 2020-11-25 | 2022-06-02 | Catamaran Bio, Inc. | Cellular therapeutics engineered with signal modulators and methods of use thereof |
| US20240141060A1 (en) | 2021-01-29 | 2024-05-02 | Novartis Ag | Dosage regimes for anti-cd73 and anti-entpd2 antibodies and uses thereof |
| TW202304979A (zh) | 2021-04-07 | 2023-02-01 | 瑞士商諾華公司 | 抗ＴＧＦβ抗體及其他治療劑用於治療增殖性疾病之用途 |
| CN112940119B (zh) * | 2021-04-26 | 2022-05-20 | 北京芳渟阳生生物科技有限公司 | 一种单克隆抗体及其与间充质干细胞外泌体的联合应用 |
| AR125874A1 (es) | 2021-05-18 | 2023-08-23 | Novartis Ag | Terapias de combinación |
| AU2022325953B2 (en) | 2021-08-11 | 2025-12-18 | Immunitybio, Inc. | Multi-chain chimeric polypeptides and use thereof in the treatment of liver diseases |
| WO2023080900A1 (en) | 2021-11-05 | 2023-05-11 | Genentech, Inc. | Methods and compositions for classifying and treating kidney cancer |
| WO2023201310A1 (en) | 2022-04-13 | 2023-10-19 | HCW Biologics, Inc. | Multi-chain chimeric polypeptide for use in the treatment of circardian clock gene disorder |
| US20230372444A1 (en) | 2022-04-13 | 2023-11-23 | HCW Biologics, Inc. | Methods of reducing neuroinflammation |
| EP4599089A1 (en) | 2022-10-05 | 2025-08-13 | Genentech, Inc. | Methods and compositions for classifying and treating bladder cancer |
| WO2024077166A1 (en) | 2022-10-05 | 2024-04-11 | Genentech, Inc. | Methods and compositions for classifying and treating lung cancer |
| WO2024097918A1 (en) | 2022-11-04 | 2024-05-10 | Novartis Ag | Nkg2d fusion protein cancer therapy |
| CN116874598B (zh) * | 2023-07-11 | 2024-10-01 | 广西大学 | 一种大片吸虫bmp单克隆抗体及其制备方法与应用 |
Family Cites Families (132)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US30985A (en) | 1860-12-18 | Thomas l | ||
| US1000836A (en) | 1909-10-15 | 1911-08-15 | Singer Mfg Co | Looper mechanism for sewing-machines. |
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| JPS6023084B2 (ja) | 1979-07-11 | 1985-06-05 | 味の素株式会社 | 代用血液 |
| WO1981001145A1 (en) | 1979-10-18 | 1981-04-30 | Univ Illinois | Hydrolytic enzyme-activatible pro-drugs |
| US4391904A (en) | 1979-12-26 | 1983-07-05 | Syva Company | Test strip kits in immunoassays and compositions therein |
| US4419446A (en) | 1980-12-31 | 1983-12-06 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant DNA process utilizing a papilloma virus DNA as a vector |
| NZ201705A (en) | 1981-08-31 | 1986-03-14 | Genentech Inc | Recombinant dna method for production of hepatitis b surface antigen in yeast |
| JPS5896026A (ja) | 1981-10-30 | 1983-06-07 | Nippon Chemiphar Co Ltd | 新規ウロキナ−ゼ誘導体およびその製造法ならびにそれを含有する血栓溶解剤 |
| US4640835A (en) | 1981-10-30 | 1987-02-03 | Nippon Chemiphar Company, Ltd. | Plasminogen activator derivatives |
| EP0098110B1 (en) | 1982-06-24 | 1989-10-18 | NIHON CHEMICAL RESEARCH KABUSHIKI KAISHA also known as JAPAN CHEMICAL RESEARCH CO., LTD | Long-acting composition |
| US4601978A (en) | 1982-11-24 | 1986-07-22 | The Regents Of The University Of California | Mammalian metallothionein promoter system |
| US4560655A (en) | 1982-12-16 | 1985-12-24 | Immunex Corporation | Serum-free cell culture medium and process for making same |
| US4657866A (en) | 1982-12-21 | 1987-04-14 | Sudhir Kumar | Serum-free, synthetic, completely chemically defined tissue culture media |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| DD266710A3 (de) | 1983-06-06 | 1989-04-12 | Ve Forschungszentrum Biotechnologie | Verfahren zur biotechnischen Herstellung van alkalischer Phosphatase |
| US4767704A (en) | 1983-10-07 | 1988-08-30 | Columbia University In The City Of New York | Protein-free culture medium |
| US4496689A (en) | 1983-12-27 | 1985-01-29 | Miles Laboratories, Inc. | Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer |
| US4965199A (en) | 1984-04-20 | 1990-10-23 | Genentech, Inc. | Preparation of functional human factor VIII in mammalian cells using methotrexate based selection |
| US4879231A (en) | 1984-10-30 | 1989-11-07 | Phillips Petroleum Company | Transformation of yeasts of the genus pichia |
| US5262319A (en) * | 1985-04-19 | 1993-11-16 | Oncogene Science, Inc. | Method for obtaining bone marrow free of tumor cells using transforming growth factor β3 |
| EP0206448B1 (en) | 1985-06-19 | 1990-11-14 | Ajinomoto Co., Inc. | Hemoglobin combined with a poly(alkylene oxide) |
| US4766106A (en) | 1985-06-26 | 1988-08-23 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using polymer conjugation |
| GB8516415D0 (en) | 1985-06-28 | 1985-07-31 | Celltech Ltd | Culture of animal cells |
| US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
| US5057313A (en) | 1986-02-25 | 1991-10-15 | The Center For Molecular Medicine And Immunology | Diagnostic and therapeutic antibody conjugates |
| EP0272253A4 (en) | 1986-03-07 | 1990-02-05 | Massachusetts Inst Technology | METHOD FOR IMPROVING GLYCOPROTE INSTABILITY. |
| US4927762A (en) | 1986-04-01 | 1990-05-22 | Cell Enterprises, Inc. | Cell culture medium with antioxidant |
| GB8610600D0 (en) | 1986-04-30 | 1986-06-04 | Novo Industri As | Transformation of trichoderma |
| US4791192A (en) | 1986-06-26 | 1988-12-13 | Takeda Chemical Industries, Ltd. | Chemically modified protein with polyethyleneglycol |
| US5567610A (en) | 1986-09-04 | 1996-10-22 | Bioinvent International Ab | Method of producing human monoclonal antibodies and kit therefor |
| GB8705477D0 (en) | 1987-03-09 | 1987-04-15 | Carlton Med Prod | Drug delivery systems |
| DE3883899T3 (de) | 1987-03-18 | 1999-04-22 | Sb2, Inc., Danville, Calif. | Geänderte antikörper. |
| US4975278A (en) | 1988-02-26 | 1990-12-04 | Bristol-Myers Company | Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells |
| EP0315456B1 (en) | 1987-11-05 | 1994-06-01 | Hybritech Incorporated | Polysaccharide-modified immunoglobulins having reduced immunogenic potential or improved pharmacokinetics |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| DE68925971T2 (de) | 1988-09-23 | 1996-09-05 | Cetus Oncology Corp | Zellenzuchtmedium für erhöhtes zellenwachstum, zur erhöhung der langlebigkeit und expression der produkte |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5750373A (en) | 1990-12-03 | 1998-05-12 | Genentech, Inc. | Enrichment method for variant proteins having altered binding properties, M13 phagemids, and growth hormone variants |
| US5175384A (en) | 1988-12-05 | 1992-12-29 | Genpharm International | Transgenic mice depleted in mature t-cells and methods for making transgenic mice |
| US5571714A (en) | 1988-12-22 | 1996-11-05 | Celtrix Pharmaceuticals, Inc. | Monoclonal antibodies which bind both transforming growth factors β1 and β2 and methods of use |
| FR2646437B1 (fr) | 1989-04-28 | 1991-08-30 | Transgene Sa | Nouvelles sequences d'adn, leur application en tant que sequence codant pour un peptide signal pour la secretion de proteines matures par des levures recombinantes, cassettes d'expression, levures transformees et procede de preparation de proteines correspondant |
| EP0402226A1 (en) | 1989-06-06 | 1990-12-12 | Institut National De La Recherche Agronomique | Transformation vectors for yeast yarrowia |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| WO1991000906A1 (en) | 1989-07-12 | 1991-01-24 | Genetics Institute, Inc. | Chimeric and transgenic animals capable of producing human antibodies |
| EP0494264B1 (en) | 1989-09-29 | 1997-06-18 | La Jolla Cancer Research Foundation | Inhibiting transforming growth factor to prevent accumulation of extracellular matrix |
| KR0185192B1 (ko) | 1989-10-05 | 1999-04-01 | 제임스 더블유. 데이비 | 신규의 유전자 및 폴리펩티드의 무세포 합성 및 분리 |
| ATE139258T1 (de) | 1990-01-12 | 1996-06-15 | Cell Genesys Inc | Erzeugung xenogener antikörper |
| US6657103B1 (en) | 1990-01-12 | 2003-12-02 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US5229275A (en) | 1990-04-26 | 1993-07-20 | Akzo N.V. | In-vitro method for producing antigen-specific human monoclonal antibodies |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| GB9014932D0 (en) | 1990-07-05 | 1990-08-22 | Celltech Ltd | Recombinant dna product and method |
| EP0585287B1 (en) | 1990-07-10 | 1999-10-13 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| US5770429A (en) | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5122469A (en) | 1990-10-03 | 1992-06-16 | Genentech, Inc. | Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins |
| AU1545692A (en) | 1991-03-01 | 1992-10-06 | Protein Engineering Corporation | Process for the development of binding mini-proteins |
| US5658727A (en) | 1991-04-10 | 1997-08-19 | The Scripps Research Institute | Heterodimeric receptor libraries using phagemids |
| DE4122599C2 (de) | 1991-07-08 | 1993-11-11 | Deutsches Krebsforsch | Phagemid zum Screenen von Antikörpern |
| US5565332A (en) | 1991-09-23 | 1996-10-15 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
| US5348867A (en) | 1991-11-15 | 1994-09-20 | George Georgiou | Expression of proteins on bacterial surface |
| AU3178993A (en) | 1991-11-25 | 1993-06-28 | Enzon, Inc. | Multivalent antigen-binding proteins |
| EP0616536B1 (en) | 1991-12-04 | 1999-03-17 | La Jolla Cancer Research Foundation | Use of decorin or biglycan for the manufacture of a medicament in the treatment of diabetes-associated pathology |
| CA2103887C (en) | 1991-12-13 | 2005-08-30 | Gary M. Studnicka | Methods and materials for preparation of modified antibody variable domains and therapeutic uses thereof |
| FI92507C (fi) | 1991-12-19 | 1994-11-25 | Valto Ilomaeki | Menetelmä ja laite maaperään pakotettavien putkien ohjaamiseksi |
| EP0626012B1 (en) | 1992-02-11 | 2003-07-09 | Cell Genesys, Inc. | Homogenotization of gene-targeting events |
| CA2131151A1 (en) | 1992-03-24 | 1994-09-30 | Kevin S. Johnson | Methods for producing members of specific binding pairs |
| US5573905A (en) | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
| ATE381614T1 (de) | 1992-07-24 | 2008-01-15 | Amgen Fremont Inc | Bildung von xenogenen antikörpern |
| US6664114B1 (en) | 1992-08-03 | 2003-12-16 | Sapidyne Instruments, Inc. | Solid phase assay for detection of ligands |
| EP0670905B1 (en) | 1992-09-22 | 2003-07-23 | Biofocus Discovery Limited | Recombinant viruses displaying a nonviral polypeptide on their external surface |
| DK0752248T3 (da) | 1992-11-13 | 2000-11-13 | Idec Pharma Corp | Terapeutisk anvendelse af kimæriske og radioaktivt mærkede antistoffer mod humant B-lymfocytbegrænset differentieringsantig |
| AU690171B2 (en) | 1993-12-03 | 1998-04-23 | Medical Research Council | Recombinant binding proteins and peptides |
| US6054287A (en) | 1994-05-27 | 2000-04-25 | Methodist Hospital Of Indiana, Inc. | Cell-type-specific methods and devices for the low temperature preservation of the cells of an animal species |
| US5824784A (en) | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| US6130364A (en) | 1995-03-29 | 2000-10-10 | Abgenix, Inc. | Production of antibodies using Cre-mediated site-specific recombination |
| US6091001A (en) | 1995-03-29 | 2000-07-18 | Abgenix, Inc. | Production of antibodies using Cre-mediated site-specific recombination |
| US6096871A (en) | 1995-04-14 | 2000-08-01 | Genentech, Inc. | Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life |
| AU5632296A (en) | 1995-04-27 | 1996-11-18 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| WO1996034096A1 (en) | 1995-04-28 | 1996-10-31 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US6489145B1 (en) | 1996-07-09 | 2002-12-03 | Diversa Corporation | Method of DNA shuffling |
| US6537776B1 (en) | 1999-06-14 | 2003-03-25 | Diversa Corporation | Synthetic ligation reassembly in directed evolution |
| JP4046354B2 (ja) | 1996-03-18 | 2008-02-13 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | 増大した半減期を有する免疫グロブリン様ドメイン |
| JPH1080273A (ja) * | 1996-05-13 | 1998-03-31 | Hoechst Yakuhin Kogyo Kk | Ｍｐ５２に対するモノクローナル抗体 |
| US6699658B1 (en) | 1996-05-31 | 2004-03-02 | Board Of Trustees Of The University Of Illinois | Yeast cell surface display of proteins and uses thereof |
| GB9712818D0 (en) | 1996-07-08 | 1997-08-20 | Cambridge Antibody Tech | Labelling and selection of specific binding molecules |
| EP2305027B1 (en) | 1996-12-03 | 2014-07-02 | Amgen Fremont Inc. | Transgenic mammals having human Ig loci including plural VH and Vkappa regions and antibodies produced therefrom |
| US6306393B1 (en) | 1997-03-24 | 2001-10-23 | Immunomedics, Inc. | Immunotherapy of B-cell malignancies using anti-CD22 antibodies |
| US20020032315A1 (en) | 1997-08-06 | 2002-03-14 | Manuel Baca | Anti-vegf antibodies |
| CA2293693A1 (en) * | 1997-06-06 | 1998-12-10 | Asat Ag Applied Science & Technology | Anti-gpiib/iiia recombinant antibodies |
| US20030044772A1 (en) | 1997-08-04 | 2003-03-06 | Applied Molecular Evolution [Formerly Ixsys] | Methods for identifying ligand specific binding molecules |
| US6342220B1 (en) | 1997-08-25 | 2002-01-29 | Genentech, Inc. | Agonist antibodies |
| US6194551B1 (en) | 1998-04-02 | 2001-02-27 | Genentech, Inc. | Polypeptide variants |
| US20020029391A1 (en) | 1998-04-15 | 2002-03-07 | Claude Geoffrey Davis | Epitope-driven human antibody production and gene expression profiling |
| GB9809951D0 (en) | 1998-05-08 | 1998-07-08 | Univ Cambridge Tech | Binding molecules |
| WO2000040227A2 (en) | 1999-01-05 | 2000-07-13 | University Of Utah | Methods for treating conditions associated with the accumulation of excess extracellular matrix |
| US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| US6492497B1 (en) | 1999-04-30 | 2002-12-10 | Cambridge Antibody Technology Limited | Specific binding members for TGFbeta1 |
| US6833268B1 (en) | 1999-06-10 | 2004-12-21 | Abgenix, Inc. | Transgenic animals for producing specific isotypes of human antibodies via non-cognate switch regions |
| WO2001024812A1 (en) | 1999-10-06 | 2001-04-12 | N.V. Nutricia | USE OF TRANSFORMING GROWTH FACTOR β AND GROWTH FACTORS IN THE TREATMENT AND PREVENTION OF DISEASES OF THE INTESTINAL MUCOSA |
| US6475220B1 (en) | 1999-10-15 | 2002-11-05 | Whiteside Biomechanics, Inc. | Spinal cable system |
| JP2001206899A (ja) | 1999-11-18 | 2001-07-31 | Japan Tobacco Inc | ＴＧＦ−βＩＩ型受容体に対するヒトモノクローナル抗体及びその医薬用途 |
| US7560534B2 (en) | 2000-05-08 | 2009-07-14 | Celldex Research Corporation | Molecular conjugates comprising human monoclonal antibodies to dendritic cells |
| MXPA03004793A (es) | 2000-11-30 | 2004-12-03 | Medarex Inc | Roedores transgenicos transcromosomales para elaborar anticuerpos humnanos. |
| US7829084B2 (en) | 2001-01-17 | 2010-11-09 | Trubion Pharmaceuticals, Inc. | Binding constructs and methods for use thereof |
| US20030133939A1 (en) | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
| US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
| EP1421203A4 (en) | 2001-05-17 | 2005-06-01 | Diversa Corp | NEW ANTIGEN-BINDING MOLECULES FOR THERAPEUTIC, DIAGNOSTIC, PROPHYLACTIC, ENZYMATIC, INDUSTRIAL AND AGRICULTURAL APPLICATIONS AND METHOD FOR THE PRODUCTION AND SCREENING THEREOF |
| US7074175B2 (en) | 2001-07-25 | 2006-07-11 | Erik Schroeder Handy | Thermotherapy via targeted delivery of nanoscale magnetic particles |
| US6997863B2 (en) | 2001-07-25 | 2006-02-14 | Triton Biosystems, Inc. | Thermotherapy via targeted delivery of nanoscale magnetic particles |
| US7371849B2 (en) | 2001-09-13 | 2008-05-13 | Institute For Antibodies Co., Ltd. | Methods of constructing camel antibody libraries |
| US20040132101A1 (en) | 2002-09-27 | 2004-07-08 | Xencor | Optimized Fc variants and methods for their generation |
| DK1527100T3 (da) | 2002-03-29 | 2009-09-07 | Schering Corp | Humane monoklonale antistoffer mod interleukin-5 og fremgangsm der og sammens tninger omfattende samme |
| CA2490280A1 (en) * | 2002-07-01 | 2004-01-08 | Human Genome Sciences, Inc. | Antibodies that specifically bind to reg iv |
| EP1391213A1 (en) | 2002-08-21 | 2004-02-25 | Boehringer Ingelheim International GmbH | Compositions and methods for treating cancer using maytansinoid CD44 antibody immunoconjugates and chemotherapeutic agents |
| US7369111B2 (en) | 2003-04-29 | 2008-05-06 | Samsung Electronics Co., Ltd. | Gate driving circuit and display apparatus having the same |
| WO2005097832A2 (en) * | 2004-03-31 | 2005-10-20 | Genentech, Inc. | Humanized anti-tgf-beta antibodies |
| EP1796715A2 (en) | 2004-09-22 | 2007-06-20 | Genzyme Corporation | USE OF TGF-ß ANTAGONISTS TO LIMIT NEPHROTOXICITY OF IMMUNOSUPPRESSIVE AGENTS |
| TR201901929T4 (tr) * | 2005-02-08 | 2019-03-21 | Genzyme Corp | TGFBeta'ya antikorlar. |
| PL1874818T3 (pl) * | 2005-04-22 | 2011-09-30 | Lilly Co Eli | Przeciwciała swoiste wobec TGF-beta 1 |
| AU2006330542B2 (en) | 2005-12-23 | 2012-05-24 | Eli Lilly And Company | TGF-beta binding compositions |
| WO2008105886A2 (en) * | 2006-05-26 | 2008-09-04 | Macrogenics, Inc. | HUMANIZED FCγRIIB-SPECIFIC ANTIBODIES AND METHODS OF USE THEREOF |
| JP5732182B2 (ja) * | 2006-10-27 | 2015-06-10 | エルパス・インコーポレイテッドＬｐａｔｈ， Ｉｎｃ． | 眼疾患と症状を処置するための組成物および方法 |
| NO347649B1 (no) * | 2006-12-14 | 2024-02-12 | Regeneron Pharma | Humant antistoff eller antistoff fragment som spesifikt binder human deltaliknende ligand 4 (hDII4), nukleinsyremolekyl som koder for slike og vektor og vert-vektorsystemer, samt fremgangsmåte for fremstilling, sammensetning og anvendelse. |
| GB0702888D0 (en) | 2007-02-14 | 2007-03-28 | Glaxo Group Ltd | Novel Antibodies |
| US20090258005A1 (en) * | 2007-05-29 | 2009-10-15 | Trubion Pharmaceuticals Inc. | Therapeutic compositions and methods |
| KR100883430B1 (ko) | 2007-06-13 | 2009-02-12 | 한국생명공학연구원 | 혈관내피성장인자 수용체를 중화하는 인간 단클론항체 및그 용도 |
| WO2009043173A1 (en) * | 2007-10-05 | 2009-04-09 | Centre For Addiction And Mental Health | Cc2d2a gene mutations associated with joubert syndrome and diagnostic methods for identifying the same |
| AU2008347218B2 (en) | 2007-12-31 | 2015-02-05 | Xoma Technology Ltd. | Methods and materials for targeted mutagenesis |
| JP2011526794A (ja) * | 2008-07-02 | 2011-10-20 | エマージェント プロダクト デベロップメント シアトル， エルエルシー | ＴＧＦ−βアンタゴニスト多重標的結合性分子 |
| MX351600B (es) | 2011-06-03 | 2017-10-20 | Xoma Technology Ltd | Anticuerpo especificos para tgf-beta. |
-
2012
- 2012-06-01 MX MX2013014210A patent/MX351600B/es active IP Right Grant
- 2012-06-01 SG SG10201902706VA patent/SG10201902706VA/en unknown
- 2012-06-01 KR KR1020227015009A patent/KR102577578B1/ko active Active
- 2012-06-01 AU AU2012261933A patent/AU2012261933B2/en not_active Ceased
- 2012-06-01 EA EA201990698A patent/EA201990698A1/ru unknown
- 2012-06-01 CN CN201710825973.2A patent/CN108424451B/zh active Active
- 2012-06-01 EP EP21186327.9A patent/EP3954704A1/en not_active Withdrawn
- 2012-06-01 KR KR1020207024212A patent/KR102395736B1/ko active Active
- 2012-06-01 EA EA201391777A patent/EA032790B1/ru unknown
- 2012-06-01 SG SG2013088992A patent/SG195253A1/en unknown
- 2012-06-01 ES ES12792320T patent/ES2894398T3/es active Active
- 2012-06-01 CN CN201280037239.5A patent/CN103732623B/zh active Active
- 2012-06-01 CN CN202211008736.4A patent/CN116333113A/zh active Pending
- 2012-06-01 PL PL12792320T patent/PL2714735T3/pl unknown
- 2012-06-01 KR KR1020197034936A patent/KR102148982B1/ko active Active
- 2012-06-01 HR HRP20211582TT patent/HRP20211582T1/hr unknown
- 2012-06-01 LT LTEPPCT/US2012/040545T patent/LT2714735T/lt unknown
- 2012-06-01 WO PCT/US2012/040545 patent/WO2012167143A1/en not_active Ceased
- 2012-06-01 EP EP12792320.9A patent/EP2714735B1/en active Active
- 2012-06-01 KR KR1020147000014A patent/KR102051014B1/ko active Active
- 2012-06-01 BR BR112013030958-0A patent/BR112013030958B1/pt active IP Right Grant
- 2012-06-01 US US13/486,983 patent/US8569462B2/en not_active Expired - Fee Related
- 2012-06-01 MY MYPI2013004341A patent/MY171135A/en unknown
- 2012-06-01 PT PT12792320T patent/PT2714735T/pt unknown
- 2012-06-01 HU HUE12792320A patent/HUE056808T2/hu unknown
- 2012-06-01 CA CA2837556A patent/CA2837556C/en active Active
- 2012-06-01 JP JP2014513760A patent/JP6363948B2/ja active Active
- 2012-06-01 MY MYPI2017001581A patent/MY192843A/en unknown
- 2012-06-01 PH PH1/2013/502489A patent/PH12013502489B1/en unknown
- 2012-06-01 SI SI201231959T patent/SI2714735T1/sl unknown
- 2012-06-01 DK DK12792320.9T patent/DK2714735T3/da active
- 2012-06-01 RS RS20211295A patent/RS62457B1/sr unknown
-
2013
- 2013-09-26 US US14/038,436 patent/US9145458B2/en active Active
- 2013-11-26 IL IL229638A patent/IL229638B/en unknown
- 2013-12-02 ZA ZA2013/09050A patent/ZA201309050B/en unknown
-
2015
- 2015-07-24 US US14/808,666 patent/US9714285B2/en not_active Expired - Fee Related
-
2017
- 2017-05-24 AU AU2017203482A patent/AU2017203482B2/en not_active Ceased
- 2017-06-14 US US15/622,955 patent/US10358486B2/en active Active
-
2018
- 2018-02-22 PH PH12018500401A patent/PH12018500401B1/en unknown
- 2018-06-29 JP JP2018123833A patent/JP6571843B2/ja active Active
-
2019
- 2019-06-07 US US16/435,022 patent/US11098111B2/en not_active Expired - Fee Related
- 2019-07-03 AU AU2019204781A patent/AU2019204781B2/en not_active Ceased
- 2019-08-08 JP JP2019146320A patent/JP6877500B2/ja active Active
-
2020
- 2020-05-12 IL IL274595A patent/IL274595B2/en unknown
-
2021
- 2021-04-27 JP JP2021074575A patent/JP7179903B2/ja active Active
- 2021-07-15 US US17/376,933 patent/US12071475B2/en active Active
- 2021-08-12 AU AU2021215206A patent/AU2021215206A1/en not_active Abandoned
- 2021-10-19 CY CY20211100907T patent/CY1124610T1/el unknown
-
2022
- 2022-11-16 JP JP2022183014A patent/JP2023015300A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2014518064A5 (cg-RX-API-DMAC7.html) | ||
| AU2011201340B2 (en) | Novel anti-PIGF antibody | |
| JP2025011323A (ja) | ＶＥ－ＰＴＰ（ＨＰＴＰ－β）を標的化するヒト化モノクローナル抗体 | |
| JP2013515486A5 (cg-RX-API-DMAC7.html) | ||
| JP7512272B2 (ja) | Ａｌｋ２抗体及びその使用方法 | |
| EA033359B1 (ru) | Комбинация леналидомида и полипептидной конструкции и ее применение | |
| RU2011142974A (ru) | НОВЫЕ АНТИТЕЛА ПРОТИВ α5β1 И ИХ ПРИМЕНЕНИЕ | |
| JP2018511609A5 (cg-RX-API-DMAC7.html) | ||
| JP2019513726A5 (cg-RX-API-DMAC7.html) | ||
| JP6944958B2 (ja) | 持続性浮腫を伴う滲出性加齢黄斑変性の処置のためのシロリムスの使用 | |
| CN105007939B (zh) | 人抗vegfr-2/kdr抗体 | |
| RU2018119014A (ru) | АНТИТЕЛА ПРОТИВ Нtr1 И СПОСОБЫ ИХ ПРИМЕНЕНИЯ | |
| EP2600896B1 (en) | Treating breast cancer with anti-il-19 antibody | |
| JP2018530574A5 (cg-RX-API-DMAC7.html) | ||
| US20250304672A1 (en) | Methods for treating spinal cord injury and pain | |
| US20130004486A1 (en) | Treatment of vascularized pigment epithelial detachment with anti-vegf therapy | |
| JP2024088730A (ja) | インテグリンアルファ９の遮断はリンパ弁形成を抑制し、移植片の生存を促進する | |
| CN119367532A (zh) | 用于靶向和杀死α-vβ-3（αvβ3）阳性癌症干细胞（CSC）以及治疗耐药性和转移性癌症的组合物和方法 | |
| US20240279324A1 (en) | Multispecific antagonists | |
| JP2020531480A5 (cg-RX-API-DMAC7.html) | ||
| WO2022201084A1 (en) | Methods for treating ocular diseases | |
| JPWO2021041373A5 (cg-RX-API-DMAC7.html) | ||
| TW202544038A (zh) | 用於治療甲狀腺眼病的方法 | |
| NZ746655A (en) | Treatment of ocular diseases with fully-human post-translationally modified anti-vegf fab | |
| WO2025217230A1 (en) | Vectorized anti-complement antibodies and complement agents and administration thereof |