JP2014514022A5 - - Google Patents
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- Publication number
- JP2014514022A5 JP2014514022A5 JP2013557802A JP2013557802A JP2014514022A5 JP 2014514022 A5 JP2014514022 A5 JP 2014514022A5 JP 2013557802 A JP2013557802 A JP 2013557802A JP 2013557802 A JP2013557802 A JP 2013557802A JP 2014514022 A5 JP2014514022 A5 JP 2014514022A5
- Authority
- JP
- Japan
- Prior art keywords
- local anesthetic
- microneedles
- combinations
- group
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003589 local anesthetic agent Substances 0.000 claims description 39
- 239000011248 coating agent Substances 0.000 claims description 25
- 238000000576 coating method Methods 0.000 claims description 25
- 238000000034 method Methods 0.000 claims description 17
- 239000007787 solid Substances 0.000 claims description 11
- ZKMNUMMKYBVTFN-HNNXBMFYSA-N (S)-ropivacaine Chemical compound CCCN1CCCC[C@H]1C(=O)NC1=C(C)C=CC=C1C ZKMNUMMKYBVTFN-HNNXBMFYSA-N 0.000 claims description 8
- LEBVLXFERQHONN-UHFFFAOYSA-N 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide Chemical compound CCCCN1CCCCC1C(=O)NC1=C(C)C=CC=C1C LEBVLXFERQHONN-UHFFFAOYSA-N 0.000 claims description 8
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 claims description 8
- 229960003150 bupivacaine Drugs 0.000 claims description 8
- 230000005496 eutectics Effects 0.000 claims description 8
- 229960004194 lidocaine Drugs 0.000 claims description 8
- 229960001807 prilocaine Drugs 0.000 claims description 8
- MVFGUOIZUNYYSO-UHFFFAOYSA-N prilocaine Chemical compound CCCNC(C)C(=O)NC1=CC=CC=C1C MVFGUOIZUNYYSO-UHFFFAOYSA-N 0.000 claims description 8
- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 claims description 8
- 229960004919 procaine Drugs 0.000 claims description 8
- 229960001549 ropivacaine Drugs 0.000 claims description 8
- GKCBAIGFKIBETG-UHFFFAOYSA-N tetracaine Chemical compound CCCCNC1=CC=C(C(=O)OCCN(C)C)C=C1 GKCBAIGFKIBETG-UHFFFAOYSA-N 0.000 claims description 8
- 229960002372 tetracaine Drugs 0.000 claims description 8
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 239000011159 matrix material Substances 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 4
- 229920002307 Dextran Polymers 0.000 description 2
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 2
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- 150000001720 carbohydrates Chemical group 0.000 description 2
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 102000008100 Human Serum Albumin Human genes 0.000 description 1
- 108091006905 Human Serum Albumin Proteins 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229950008882 polysorbate Drugs 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 229940049703 saccharin sodium dihydrate Drugs 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161449988P | 2011-03-07 | 2011-03-07 | |
| US61/449,988 | 2011-03-07 | ||
| PCT/US2012/027858 WO2012122163A1 (en) | 2011-03-07 | 2012-03-06 | Microneedle devices and methods |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014514022A JP2014514022A (ja) | 2014-06-19 |
| JP2014514022A5 true JP2014514022A5 (cg-RX-API-DMAC7.html) | 2015-04-23 |
| JP5941072B2 JP5941072B2 (ja) | 2016-06-29 |
Family
ID=45841654
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013557802A Active JP5941072B2 (ja) | 2011-03-07 | 2012-03-06 | マイクロニードルデバイス及び方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20140066843A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2683359B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5941072B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR102058978B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN103429222B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2012225609B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112013022955A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2829354C (cg-RX-API-DMAC7.html) |
| DK (1) | DK2683359T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2542012T3 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2012122163A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2008241470B2 (en) | 2007-04-16 | 2013-11-07 | Corium Pharma Solutions, Inc. | Solvent-cast microneedle arrays containing active |
| WO2009048607A1 (en) | 2007-10-10 | 2009-04-16 | Corium International, Inc. | Vaccine delivery via microneedle arrays |
| US8834423B2 (en) | 2009-10-23 | 2014-09-16 | University of Pittsburgh—of the Commonwealth System of Higher Education | Dissolvable microneedle arrays for transdermal delivery to human skin |
| WO2011140274A2 (en) | 2010-05-04 | 2011-11-10 | Corium International, Inc. | Method and device for transdermal delivery of parathyroid hormone using a microprojection array |
| EP3881781B1 (en) | 2011-10-12 | 2023-03-29 | Vaxxas Pty Limited | Delivery device |
| BR112014027242A2 (pt) * | 2012-05-01 | 2017-06-27 | Univ Carnegie Mellon | arranjos de microagulha carregada na ponta para inserção transdérmica |
| CN104755128B (zh) * | 2012-11-02 | 2018-05-11 | 考司美德制药株式会社 | 视黄酸微针 |
| KR102265808B1 (ko) | 2012-12-21 | 2021-06-16 | 코리움, 인크. | 치료제의 전달을 위한 마이크로어레이 및 그것의 사용방법 |
| EP2968887B1 (en) | 2013-03-12 | 2022-05-04 | Corium, Inc. | Microprojection applicators |
| JP2016512754A (ja) | 2013-03-15 | 2016-05-09 | コリウム インターナショナル， インコーポレイテッド | 治療剤の送達のためのマイクロアレイ、使用方法および製造方法 |
| CN105246458B (zh) | 2013-03-15 | 2020-09-15 | 考里安公司 | 用于治疗剂递送的微阵列及其使用方法 |
| EP2968116A1 (en) | 2013-03-15 | 2016-01-20 | Corium International, Inc. | Microarray with polymer-free microstructures, methods of making, and methods of use |
| MX2015012433A (es) * | 2013-03-15 | 2016-02-03 | Corium Int Inc | Matriz de microestructura para suministro de agentes activos. |
| EP4194028A1 (en) | 2013-03-15 | 2023-06-14 | Corium Pharma Solutions, Inc. | Multiple impact microprojection applicators |
| WO2015010599A1 (en) * | 2013-07-22 | 2015-01-29 | Tuo Jin | Fabrication process of phase-transition microneedle patch |
| DK3052181T3 (da) * | 2013-09-30 | 2022-10-24 | Georgia Tech Res Inst | Mikronåleplastre og systemer |
| US20160279401A1 (en) | 2015-03-27 | 2016-09-29 | Allergan, Inc. | Dissolvable microneedles for skin treatment |
| KR101703050B1 (ko) * | 2014-07-10 | 2017-02-07 | 주식회사 주빅 | 경피전달용 미세돌기 구조체 |
| EP3193828B8 (en) * | 2014-08-29 | 2023-04-05 | Corium Pharma Solutions, Inc. | Microstructure array for delivery of active agents |
| EP3188714A1 (en) | 2014-09-04 | 2017-07-12 | Corium International, Inc. | Microstructure array, methods of making, and methods of use |
| CN106687172B (zh) * | 2014-09-11 | 2020-06-23 | 久光制药株式会社 | 微针装置 |
| JP6621754B2 (ja) | 2014-10-27 | 2019-12-18 | 久光製薬株式会社 | 遺伝子組換型卵胞刺激ホルモンを含有するマイクロニードルデバイス |
| EP3225276A4 (en) * | 2014-11-28 | 2018-06-27 | Terumo Kabushiki Kaisha | Microneedle device |
| WO2016149673A1 (en) | 2015-03-18 | 2016-09-22 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Bioactive components conjugated to substrates of microneedle arrays |
| WO2017004067A1 (en) | 2015-06-29 | 2017-01-05 | Corium International, Inc. | Microarray for delivery of therapeutic agent, methods of use, and methods of making |
| AU2016288176A1 (en) | 2015-06-30 | 2017-12-07 | The Gillette Company Llc | Polymeric cutting edge structures and method of manufacturing thereof |
| EP3355981B1 (en) | 2015-09-28 | 2025-11-19 | Vaxxas Pty Limited | Microprojection arrays with enhanced skin penetrating properties and methods thereof |
| US11684763B2 (en) | 2015-10-16 | 2023-06-27 | University of Pittsburgh—of the Commonwealth System of Higher Education | Multi-component bio-active drug delivery and controlled release to the skin by microneedle array devices |
| WO2017120322A1 (en) | 2016-01-05 | 2017-07-13 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Skin microenvironment targeted delivery for promoting immune and other responses |
| KR101876176B1 (ko) * | 2016-02-17 | 2018-07-09 | 가톨릭관동대학교산학협력단 | 봉독 추출물 함유 경피투과 패치 |
| KR101876177B1 (ko) * | 2016-02-17 | 2018-07-09 | 가톨릭관동대학교산학협력단 | 경피투과 보툴리눔 독소 패치 |
| KR102139337B1 (ko) * | 2016-03-17 | 2020-07-29 | 주식회사 엘지생활건강 | 미세바늘패치를 이용한 히알루론산 필러 |
| US10562200B2 (en) | 2016-06-28 | 2020-02-18 | The Gillette Company Llc | Polymeric cutting edge structures and method of manufacturing polymeric cutting edge structures |
| KR101779393B1 (ko) * | 2016-07-22 | 2017-09-19 | 주식회사 파마리서치프로덕트 | 핵산을 포함하는 마이크로니들 어레이 및 이의 제조방법 |
| EP3582752A1 (en) | 2017-02-17 | 2019-12-25 | Allergan, Inc. | Microneedle array with active ingredient |
| WO2018176102A1 (en) | 2017-03-31 | 2018-10-04 | Vaxxas Pty Limited | Device and method for coating surfaces |
| TWI633901B (zh) * | 2017-05-16 | 2018-09-01 | 怡定興科技股份有限公司 | 醫美微針貼片之製作方法 |
| JP2018196401A (ja) * | 2017-05-19 | 2018-12-13 | ロレアル | マイクロニードルシート |
| DE102017117784A1 (de) * | 2017-08-04 | 2019-02-07 | Lts Lohmann Therapie-Systeme Ag | Applikatorsystem enthaltend ein Mikronadelarray aufweisend einen Wirkstoff für die Wundheilung |
| KR102006071B1 (ko) | 2017-08-18 | 2019-07-31 | 가천대학교 산학협력단 | 마이크로 니들 및 이의 제조방법 |
| JP7345792B2 (ja) | 2017-09-19 | 2023-09-19 | エルジー ハウスホールド アンド ヘルスケア リミテッド | マイクロニードルパッチを用いたヒアルロン酸フィラー |
| ES2908820T3 (es) * | 2017-12-14 | 2022-05-04 | Lts Lohmann Therapie Systeme Ag | Matriz de microagujas con un principio activo en forma de sales |
| WO2019226599A1 (en) * | 2018-05-22 | 2019-11-28 | Alkalidx, Inc. | Diagnostics and treatments of anesthetic insensitive subjects |
| JP2021528155A (ja) * | 2018-06-18 | 2021-10-21 | キンデーバ ドラッグ デリバリー リミティド パートナーシップ | マイクロニードルアレイを検査するための方法及び装置 |
| CN113874067A (zh) * | 2019-03-29 | 2021-12-31 | 瓦克萨斯私人有限公司 | 用于疫苗的高密度微突出物阵列贴片 |
| WO2020232394A1 (en) | 2019-05-16 | 2020-11-19 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Microneedle arrays with undercut features for cutaneous and non-cutaneous drug delivery |
| GB2586475A (en) * | 2019-08-20 | 2021-02-24 | Innoture Ip Ltd | Methods |
| CN115734798A (zh) | 2020-04-28 | 2023-03-03 | 提克纳有限责任公司 | 微针组件 |
| CN111991344B (zh) * | 2020-09-28 | 2023-01-13 | 四川大学 | 一种适用于局部麻醉的微针贴片及其制备方法 |
| CN116723879A (zh) * | 2020-12-30 | 2023-09-08 | 佐治亚科技研究公司 | 用于诱导汗液以进行医学诊断的方法和装置 |
| US12178979B2 (en) | 2021-10-13 | 2024-12-31 | Satio, Inc. | Dermal patch for delivering a pharmaceutical |
| US12053284B2 (en) | 2021-11-08 | 2024-08-06 | Satio, Inc. | Dermal patch for collecting a physiological sample |
| US12023156B2 (en) | 2021-10-13 | 2024-07-02 | Satio, Inc. | Dermal patch for collecting a physiological sample |
| US11877848B2 (en) | 2021-11-08 | 2024-01-23 | Satio, Inc. | Dermal patch for collecting a physiological sample |
| US11964121B2 (en) | 2021-10-13 | 2024-04-23 | Satio, Inc. | Mono dose dermal patch for pharmaceutical delivery |
| US12214346B2 (en) | 2021-10-13 | 2025-02-04 | Satio, Inc. | Dermal patch with a diagnostic test strip |
| US12029562B2 (en) | 2021-04-14 | 2024-07-09 | Satio, Inc. | Dermal patch system |
| US12048543B2 (en) | 2021-11-08 | 2024-07-30 | Satio, Inc. | Dermal patch for collecting a physiological sample with removable vial |
| EP4403202A4 (en) * | 2021-09-15 | 2025-10-01 | Cosmed Pharmaceutical Co Ltd | DRUG-COATED MICRONEEDLE ARRAY |
| CN114699510B (zh) * | 2021-12-29 | 2024-07-16 | 浙江湃肽生物有限公司 | 一种司美格鲁肽微针阵列及其制备方法 |
| CN121127287A (zh) * | 2023-03-16 | 2025-12-12 | 联邦高等教育系统匹兹堡大学 | 用于有效皮肤免疫的生物可溶解微针阵列-金属-有机框架-疫苗生物复合物及其制备 |
| JPWO2024202258A1 (cg-RX-API-DMAC7.html) * | 2023-03-30 | 2024-10-03 | ||
| CN119462417A (zh) * | 2023-08-10 | 2025-02-18 | 中科中山药物创新研究院 | 药物包合物共晶、组合物、其制备方法和应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5585398A (en) * | 1994-07-15 | 1996-12-17 | Ernst; Amy A. | Topical anesthetic comprising lidocaine, adrenaline, and tetracaine, and its method of use |
| AU750809B2 (en) * | 1997-09-26 | 2002-07-25 | Noven Pharmaceuticals, Inc. | Bioadhesive compositions and methods for topical administration of active agents |
| JP2003525895A (ja) * | 2000-03-09 | 2003-09-02 | アストラゼネカ・アクチエボラーグ | 固形分散剤の製造方法 |
| US6455066B1 (en) * | 2000-03-10 | 2002-09-24 | Epicept Corporation | Intradermal-penetration agents for topical local anesthetic administration |
| US6881203B2 (en) | 2001-09-05 | 2005-04-19 | 3M Innovative Properties Company | Microneedle arrays and methods of manufacturing the same |
| CA2492867C (en) | 2002-07-19 | 2011-07-05 | 3M Innovative Properties Company | Microneedle devices and microneedle delivery apparatus |
| ES2223277B1 (es) * | 2003-06-19 | 2006-03-01 | Fernando Bouffard Fita | Composicion anestesica para administracion topica. |
| WO2005123173A1 (en) | 2004-06-10 | 2005-12-29 | 3M Innovative Properties Company | Patch application device and kit |
| US20060253078A1 (en) * | 2005-04-25 | 2006-11-09 | Wu Jeffrey M | Method of treating skin disorders with stratum corneum piercing device |
| WO2006138719A2 (en) * | 2005-06-17 | 2006-12-28 | Georgia Tech Research Corporation | Coated microstructures and method of manufacture thereof |
| JP2007089792A (ja) | 2005-09-28 | 2007-04-12 | Nano Device & System Research Inc | 経皮投与装置 |
| KR20080066712A (ko) * | 2005-09-30 | 2008-07-16 | 티티아이 엘뷰 가부시키가이샤 | 관능화된 미세바늘 경피 약물 전달 시스템, 장치 및 방법 |
| EP2153863B1 (en) * | 2007-05-15 | 2022-03-16 | Hisamitsu Pharmaceutical Co., Inc. | Method of coating microneedle |
| CN101336895B (zh) * | 2008-08-21 | 2010-08-25 | 董萍 | 一种碱化固液双态表皮快速麻醉纳米乳及其制备方法 |
| US8834423B2 (en) * | 2009-10-23 | 2014-09-16 | University of Pittsburgh—of the Commonwealth System of Higher Education | Dissolvable microneedle arrays for transdermal delivery to human skin |
| US10800040B1 (en) | 2017-12-14 | 2020-10-13 | Amazon Technologies, Inc. | Simulation-real world feedback loop for learning robotic control policies |
-
2012
- 2012-03-06 DK DK12709232.8T patent/DK2683359T3/en active
- 2012-03-06 WO PCT/US2012/027858 patent/WO2012122163A1/en not_active Ceased
- 2012-03-06 AU AU2012225609A patent/AU2012225609B2/en active Active
- 2012-03-06 KR KR1020137026210A patent/KR102058978B1/ko active Active
- 2012-03-06 CN CN201280012104.3A patent/CN103429222B/zh active Active
- 2012-03-06 JP JP2013557802A patent/JP5941072B2/ja active Active
- 2012-03-06 ES ES12709232.8T patent/ES2542012T3/es active Active
- 2012-03-06 US US14/003,693 patent/US20140066843A1/en not_active Abandoned
- 2012-03-06 EP EP20120709232 patent/EP2683359B1/en active Active
- 2012-03-06 BR BR112013022955A patent/BR112013022955A2/pt not_active Application Discontinuation
- 2012-03-06 CA CA2829354A patent/CA2829354C/en active Active
-
2018
- 2018-08-09 US US16/059,522 patent/US20180344631A1/en not_active Abandoned
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