JP2014507473A5 - - Google Patents
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- JP2014507473A5 JP2014507473A5 JP2013557801A JP2013557801A JP2014507473A5 JP 2014507473 A5 JP2014507473 A5 JP 2014507473A5 JP 2013557801 A JP2013557801 A JP 2013557801A JP 2013557801 A JP2013557801 A JP 2013557801A JP 2014507473 A5 JP2014507473 A5 JP 2014507473A5
- Authority
- JP
- Japan
- Prior art keywords
- local anesthetic
- microneedles
- coating
- combinations
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000003589 local anesthetic agent Substances 0.000 claims description 44
- 239000011248 coating agent Substances 0.000 claims description 29
- 238000000576 coating method Methods 0.000 claims description 29
- 238000000034 method Methods 0.000 claims description 21
- 239000007787 solid Substances 0.000 claims description 11
- 239000000384 adrenergic alpha-2 receptor agonist Substances 0.000 claims description 9
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 claims description 8
- 239000000533 adrenergic alpha-1 receptor agonist Substances 0.000 claims description 8
- 229960004194 lidocaine Drugs 0.000 claims description 8
- 229960001807 prilocaine Drugs 0.000 claims description 8
- MVFGUOIZUNYYSO-UHFFFAOYSA-N prilocaine Chemical compound CCCNC(C)C(=O)NC1=CC=CC=C1C MVFGUOIZUNYYSO-UHFFFAOYSA-N 0.000 claims description 8
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 239000011159 matrix material Substances 0.000 claims description 2
- WYWIFABBXFUGLM-UHFFFAOYSA-N oxymetazoline Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C)=C1CC1=NCCN1 WYWIFABBXFUGLM-UHFFFAOYSA-N 0.000 description 4
- 239000000546 pharmaceutical excipient Substances 0.000 description 4
- BYJAVTDNIXVSPW-UHFFFAOYSA-N tetryzoline Chemical compound N1CCN=C1C1C2=CC=CC=C2CCC1 BYJAVTDNIXVSPW-UHFFFAOYSA-N 0.000 description 4
- GJSURZIOUXUGAL-UHFFFAOYSA-N Clonidine Chemical compound ClC1=CC=CC(Cl)=C1NC1=NCCN1 GJSURZIOUXUGAL-UHFFFAOYSA-N 0.000 description 3
- INJOMKTZOLKMBF-UHFFFAOYSA-N Guanfacine Chemical compound NC(=N)NC(=O)CC1=C(Cl)C=CC=C1Cl INJOMKTZOLKMBF-UHFFFAOYSA-N 0.000 description 3
- 229960002610 apraclonidine Drugs 0.000 description 3
- IEJXVRYNEISIKR-UHFFFAOYSA-N apraclonidine Chemical compound ClC1=CC(N)=CC(Cl)=C1NC1=NCCN1 IEJXVRYNEISIKR-UHFFFAOYSA-N 0.000 description 3
- 229960002896 clonidine Drugs 0.000 description 3
- 229960002048 guanfacine Drugs 0.000 description 3
- -1 methylnorepinephrine Chemical compound 0.000 description 3
- XFYDIVBRZNQMJC-UHFFFAOYSA-N tizanidine Chemical compound ClC=1C=CC2=NSN=C2C=1NC1=NCCN1 XFYDIVBRZNQMJC-UHFFFAOYSA-N 0.000 description 3
- 229960000488 tizanidine Drugs 0.000 description 3
- YKFCISHFRZHKHY-NGQGLHOPSA-N (2s)-2-amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoic acid;trihydrate Chemical compound O.O.O.OC(=O)[C@](N)(C)CC1=CC=C(O)C(O)=C1.OC(=O)[C@](N)(C)CC1=CC=C(O)C(O)=C1 YKFCISHFRZHKHY-NGQGLHOPSA-N 0.000 description 2
- UCTWMZQNUQWSLP-VIFPVBQESA-N (R)-adrenaline Chemical compound CNC[C@H](O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-VIFPVBQESA-N 0.000 description 2
- 229930182837 (R)-adrenaline Natural products 0.000 description 2
- CNIIGCLFLJGOGP-UHFFFAOYSA-N 2-(1-naphthalenylmethyl)-4,5-dihydro-1H-imidazole Chemical compound C=1C=CC2=CC=CC=C2C=1CC1=NCCN1 CNIIGCLFLJGOGP-UHFFFAOYSA-N 0.000 description 2
- WTQYWNWRJNXDEG-UHFFFAOYSA-N 6-Hydroxy-hyoscyamin Natural products CN1C(C2)CC(O)C1CC2OC(=O)C(CO)C1=CC=CC=C1 WTQYWNWRJNXDEG-UHFFFAOYSA-N 0.000 description 2
- XYLJNLCSTIOKRM-UHFFFAOYSA-N Alphagan Chemical compound C1=CC2=NC=CN=C2C(Br)=C1NC1=NCCN1 XYLJNLCSTIOKRM-UHFFFAOYSA-N 0.000 description 2
- 229920002307 Dextran Polymers 0.000 description 2
- WDZVGELJXXEGPV-YIXHJXPBSA-N Guanabenz Chemical compound NC(N)=N\N=C\C1=C(Cl)C=CC=C1Cl WDZVGELJXXEGPV-YIXHJXPBSA-N 0.000 description 2
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 2
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 2
- WJAJPNHVVFWKKL-UHFFFAOYSA-N Methoxamine Chemical compound COC1=CC=C(OC)C(C(O)C(C)N)=C1 WJAJPNHVVFWKKL-UHFFFAOYSA-N 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- HUCJFAOMUPXHDK-UHFFFAOYSA-N Xylometazoline Chemical compound CC1=CC(C(C)(C)C)=CC(C)=C1CC1=NCCN1 HUCJFAOMUPXHDK-UHFFFAOYSA-N 0.000 description 2
- ZHOWHMXTJFZXRB-UHFFFAOYSA-N amidefrine Chemical compound CNCC(O)C1=CC=CC(NS(C)(=O)=O)=C1 ZHOWHMXTJFZXRB-UHFFFAOYSA-N 0.000 description 2
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- QXAITBQSYVNQDR-ZIOPAAQOSA-N amitraz Chemical compound C=1C=C(C)C=C(C)C=1/N=C/N(C)\C=N\C1=CC=C(C)C=C1C QXAITBQSYVNQDR-ZIOPAAQOSA-N 0.000 description 2
- WTQYWNWRJNXDEG-LEOABGAYSA-N anisodamine Chemical compound C1([C@@H](CO)C(=O)O[C@@H]2C[C@H]3[C@@H](O)C[C@@H](C2)N3C)=CC=CC=C1 WTQYWNWRJNXDEG-LEOABGAYSA-N 0.000 description 2
- 229960003679 brimonidine Drugs 0.000 description 2
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- 229940083181 centrally acting adntiadrenergic agent methyldopa Drugs 0.000 description 2
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- JXMXDKHEZLKQPB-UHFFFAOYSA-N detomidine Chemical compound CC1=CC=CC(CC=2[N]C=NC=2)=C1C JXMXDKHEZLKQPB-UHFFFAOYSA-N 0.000 description 2
- 229960004253 dexmedetomidine Drugs 0.000 description 2
- HRLIOXLXPOHXTA-NSHDSACASA-N dexmedetomidine Chemical compound C1([C@@H](C)C=2C(=C(C)C=CC=2)C)=CN=C[N]1 HRLIOXLXPOHXTA-NSHDSACASA-N 0.000 description 2
- 229960005139 epinephrine Drugs 0.000 description 2
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- OFKDAAIKGIBASY-VFGNJEKYSA-N ergotamine Chemical compound C([C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@@](C(N21)=O)(C)NC(=O)[C@H]1CN([C@H]2C(C3=CC=CC4=NC=C([C]34)C2)=C1)C)C1=CC=CC=C1 OFKDAAIKGIBASY-VFGNJEKYSA-N 0.000 description 2
- XCGSFFUVFURLIX-UHFFFAOYSA-N ergotaminine Natural products C1=C(C=2C=CC=C3NC=C(C=23)C2)C2N(C)CC1C(=O)NC(C(N12)=O)(C)OC1(O)C1CCCN1C(=O)C2CC1=CC=CC=C1 XCGSFFUVFURLIX-UHFFFAOYSA-N 0.000 description 2
- 229960004553 guanabenz Drugs 0.000 description 2
- ACGDKVXYNVEAGU-UHFFFAOYSA-N guanethidine Chemical compound NC(N)=NCCN1CCCCCCC1 ACGDKVXYNVEAGU-UHFFFAOYSA-N 0.000 description 2
- 229960003602 guanethidine Drugs 0.000 description 2
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 2
- 229960005209 lofexidine Drugs 0.000 description 2
- KSMAGQUYOIHWFS-UHFFFAOYSA-N lofexidine Chemical compound N=1CCNC=1C(C)OC1=C(Cl)C=CC=C1Cl KSMAGQUYOIHWFS-UHFFFAOYSA-N 0.000 description 2
- 229960005192 methoxamine Drugs 0.000 description 2
- 229960001528 oxymetazoline Drugs 0.000 description 2
- 229960001802 phenylephrine Drugs 0.000 description 2
- SONNWYBIRXJNDC-VIFPVBQESA-N phenylephrine Chemical compound CNC[C@H](O)C1=CC=CC(O)=C1 SONNWYBIRXJNDC-VIFPVBQESA-N 0.000 description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- 229960000337 tetryzoline Drugs 0.000 description 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 1
- SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 description 1
- QHGUCRYDKWKLMG-QMMMGPOBSA-N (R)-octopamine Chemical compound NC[C@H](O)C1=CC=C(O)C=C1 QHGUCRYDKWKLMG-QMMMGPOBSA-N 0.000 description 1
- YFGHCGITMMYXAQ-UHFFFAOYSA-N 2-[(diphenylmethyl)sulfinyl]acetamide Chemical compound C=1C=CC=CC=1C(S(=O)CC(=O)N)C1=CC=CC=C1 YFGHCGITMMYXAQ-UHFFFAOYSA-N 0.000 description 1
- PTKSEFOSCHHMPD-SNVBAGLBSA-N 2-amino-n-[(2s)-2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]acetamide Chemical compound COC1=CC=C(OC)C([C@H](O)CNC(=O)CN)=C1 PTKSEFOSCHHMPD-SNVBAGLBSA-N 0.000 description 1
- VTZPAJGVRWKMAG-UHFFFAOYSA-N 3-(1h-imidazol-5-ylmethyl)-2,3-dihydro-1h-inden-5-ol Chemical compound C12=CC(O)=CC=C2CCC1CC1=CN=CN1 VTZPAJGVRWKMAG-UHFFFAOYSA-N 0.000 description 1
- DHSSDEDRBUKTQY-UHFFFAOYSA-N 6-prop-2-enyl-4,5,7,8-tetrahydrothiazolo[4,5-d]azepin-2-amine Chemical compound C1CN(CC=C)CCC2=C1N=C(N)S2 DHSSDEDRBUKTQY-UHFFFAOYSA-N 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- 102000008100 Human Serum Albumin Human genes 0.000 description 1
- 108091006905 Human Serum Albumin Proteins 0.000 description 1
- QHGUCRYDKWKLMG-MRVPVSSYSA-N Octopamine Natural products NC[C@@H](O)C1=CC=C(O)C=C1 QHGUCRYDKWKLMG-MRVPVSSYSA-N 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- CQXADFVORZEARL-UHFFFAOYSA-N Rilmenidine Chemical compound C1CC1C(C1CC1)NC1=NCCO1 CQXADFVORZEARL-UHFFFAOYSA-N 0.000 description 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 229950006455 fadolmidine Drugs 0.000 description 1
- QKIQJNNDIWGVEH-UUILKARUSA-N guanoxabenz Chemical compound ONC(/N)=N/N=C/C1=C(Cl)C=CC=C1Cl QKIQJNNDIWGVEH-UUILKARUSA-N 0.000 description 1
- 229960001016 guanoxabenz Drugs 0.000 description 1
- PNHJTLDBYZVCGW-UHFFFAOYSA-N indanidine Chemical compound C=1C=CC2=NN(C)C=C2C=1NC1=NCCN1 PNHJTLDBYZVCGW-UHFFFAOYSA-N 0.000 description 1
- 229950003924 indanidine Drugs 0.000 description 1
- FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 description 1
- HRLIOXLXPOHXTA-UHFFFAOYSA-N medetomidine Chemical compound C=1C=CC(C)=C(C)C=1C(C)C1=CN=C[N]1 HRLIOXLXPOHXTA-UHFFFAOYSA-N 0.000 description 1
- 229960002140 medetomidine Drugs 0.000 description 1
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- 238000012986 modification Methods 0.000 description 1
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- 229960001576 octopamine Drugs 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229950008882 polysorbate Drugs 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 229960000764 rilmenidine Drugs 0.000 description 1
- KDPNLRQZHDJRFU-UHFFFAOYSA-N romifidine Chemical compound FC1=CC=CC(Br)=C1NC1=NCCN1 KDPNLRQZHDJRFU-UHFFFAOYSA-N 0.000 description 1
- 229960005089 romifidine Drugs 0.000 description 1
- 229940049703 saccharin sodium dihydrate Drugs 0.000 description 1
- 229950008418 talipexole Drugs 0.000 description 1
- 229960000833 xylometazoline Drugs 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161449993P | 2011-03-07 | 2011-03-07 | |
| US61/449,993 | 2011-03-07 | ||
| PCT/US2012/027857 WO2012122162A1 (en) | 2011-03-07 | 2012-03-06 | Microneedle devices and methods |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017000354A Division JP2017105784A (ja) | 2011-03-07 | 2017-01-05 | マイクロニードルデバイス及び方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014507473A JP2014507473A (ja) | 2014-03-27 |
| JP2014507473A5 true JP2014507473A5 (cg-RX-API-DMAC7.html) | 2015-04-23 |
| JP6423152B2 JP6423152B2 (ja) | 2018-11-14 |
Family
ID=45841653
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013557801A Active JP6423152B2 (ja) | 2011-03-07 | 2012-03-06 | マイクロニードルデバイス及び方法 |
| JP2017000354A Pending JP2017105784A (ja) | 2011-03-07 | 2017-01-05 | マイクロニードルデバイス及び方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017000354A Pending JP2017105784A (ja) | 2011-03-07 | 2017-01-05 | マイクロニードルデバイス及び方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20140066842A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2683358B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP6423152B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR102058979B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN103402496B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2012225608B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112013022949A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2829352A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2012122162A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (81)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0402131D0 (en) | 2004-01-30 | 2004-03-03 | Isis Innovation | Delivery method |
| WO2012122162A1 (en) * | 2011-03-07 | 2012-09-13 | 3M Innovative Properties Company | Microneedle devices and methods |
| EP3881781B1 (en) | 2011-10-12 | 2023-03-29 | Vaxxas Pty Limited | Delivery device |
| WO2013096026A1 (en) | 2011-12-21 | 2013-06-27 | 3M Innovative Properties Company | Transdermal adhesive patch assembly with removable microneedle array and method of using same |
| US12161831B2 (en) | 2012-09-13 | 2024-12-10 | Avraham Amir | Microneedles and compositions for skin augmentation |
| WO2014041531A1 (en) * | 2012-09-13 | 2014-03-20 | Amir Avraham | Delivery devices and methods for skin augmentation |
| JP5472771B1 (ja) * | 2012-09-28 | 2014-04-16 | コスメディ製薬株式会社 | 段差に薬物を保持したマイクロニードル |
| EP2906284B8 (en) | 2012-10-10 | 2021-01-20 | Kindeva Drug Delivery L.P. | Force-controlled applicator for applying a microneedle device to skin |
| EP2906285B1 (en) | 2012-10-10 | 2019-06-12 | 3M Innovative Properties Company | Applicator for applying a microneedle device to skin |
| US9789299B2 (en) | 2012-11-16 | 2017-10-17 | 3M Innovative Properties Company | Force-controlled applicator for applying a microneedle device to skin |
| EP2938390A1 (en) | 2012-12-27 | 2015-11-04 | 3M Innovative Properties Company | Article with hollow microneedles and method of making |
| ES2873202T3 (es) | 2013-01-08 | 2021-11-03 | Kindeva Drug Delivery Lp | Aplicador para aplicar un dispositivo de microagujas a la piel |
| RU2679107C2 (ru) * | 2013-01-21 | 2019-02-05 | Пхэан Эстетикс Инк. | Микроигла, форма для ее изготовления и способ изготовления микроиглы |
| JP6081215B2 (ja) * | 2013-02-13 | 2017-02-15 | 久光製薬株式会社 | コーティング及びマイクロニードルデバイス |
| WO2014153447A2 (en) | 2013-03-22 | 2014-09-25 | 3M Innovative Properties Company | Microneedle applicator comprising a counter assembly |
| EP3003458B1 (en) | 2013-05-31 | 2019-12-04 | 3M Innovative Properties Company | Microneedle injection apparatus comprising a dual cover |
| US9872975B2 (en) | 2013-05-31 | 2018-01-23 | 3M Innovative Properties Company | Microneedle injection and infusion apparatus and method of using same |
| EP3381500B1 (en) | 2013-05-31 | 2020-11-04 | 3M Innovative Properties Co. | Microneedle injection apparatus comprising an inverted actuator |
| US10099043B2 (en) | 2013-07-16 | 2018-10-16 | 3M Innovative Properties Company | Hollow microneedle array article |
| EP3021930B1 (en) | 2013-07-16 | 2020-10-07 | 3M Innovative Properties Company | Hollow microneedle with beveled tip |
| JP6602757B2 (ja) | 2013-07-16 | 2019-11-06 | スリーエム イノベイティブ プロパティズ カンパニー | マイクロニードルを備える物品 |
| CN105407956B (zh) | 2013-07-16 | 2018-12-11 | 3M创新有限公司 | 具有斜面开口的空心微针 |
| GB201317641D0 (en) * | 2013-10-05 | 2013-11-20 | Chowdhury Dewan F H | Novel solid dosage form |
| US9833405B2 (en) | 2014-03-19 | 2017-12-05 | Nano And Advanced Materials Institute Limited | Biodegradable microdepot delivery system for topical delivery |
| CN104922093B (zh) * | 2014-03-19 | 2019-06-18 | 纳米及先进材料研发院有限公司 | 用于局部递送的可生物降解的微贮库型递送系统 |
| US20160279401A1 (en) | 2015-03-27 | 2016-09-29 | Allergan, Inc. | Dissolvable microneedles for skin treatment |
| WO2016028122A1 (ko) * | 2014-08-21 | 2016-02-25 | 연세대학교 산학협력단 | 음압을 이용한 마이크로구조체의 제조방법 및 그로부터 제조된 마이크로구조체 |
| EP3341070B1 (en) * | 2014-08-27 | 2019-12-11 | Neuronano AB | Apparatus for implantation of a medical device into neural tissue |
| CN106687172B (zh) * | 2014-09-11 | 2020-06-23 | 久光制药株式会社 | 微针装置 |
| JP6621754B2 (ja) | 2014-10-27 | 2019-12-18 | 久光製薬株式会社 | 遺伝子組換型卵胞刺激ホルモンを含有するマイクロニードルデバイス |
| AU2016209496B2 (en) | 2015-01-21 | 2018-06-28 | Kindeva Drug Delivery L.P. | Microneedle array and method of use |
| SG11201706081SA (en) | 2015-01-27 | 2017-08-30 | 3M Innovative Properties Co | Alum-containing coating formulations for microneedle vaccine patches |
| CA2975275C (en) | 2015-02-02 | 2023-08-29 | Vaxxas Pty Limited | Microprojection array applicator and method |
| JP5852280B1 (ja) | 2015-03-23 | 2016-02-03 | コスメディ製薬株式会社 | マイクロニードルおよびその製造 |
| KR102203635B1 (ko) * | 2015-06-10 | 2021-01-15 | 주식회사 엘지생활건강 | 속용해성 미세바늘 패치 |
| WO2017045031A1 (en) | 2015-09-18 | 2017-03-23 | Vaxxas Pty Limited | Microprojection arrays with microprojections having large surface area profiles |
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| EP3355981B1 (en) | 2015-09-28 | 2025-11-19 | Vaxxas Pty Limited | Microprojection arrays with enhanced skin penetrating properties and methods thereof |
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- 2012-03-06 US US14/003,663 patent/US20140066842A1/en not_active Abandoned
- 2012-03-06 CA CA2829352A patent/CA2829352A1/en not_active Abandoned
- 2012-03-06 KR KR1020137026209A patent/KR102058979B1/ko active Active
- 2012-03-06 BR BR112013022949A patent/BR112013022949A2/pt not_active Application Discontinuation
- 2012-03-06 EP EP12709231.0A patent/EP2683358B1/en active Active
- 2012-03-06 CN CN201280012043.0A patent/CN103402496B/zh active Active
- 2012-03-06 AU AU2012225608A patent/AU2012225608B2/en active Active
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