JP2014503482A5 - - Google Patents
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- JP2014503482A5 JP2014503482A5 JP2013537154A JP2013537154A JP2014503482A5 JP 2014503482 A5 JP2014503482 A5 JP 2014503482A5 JP 2013537154 A JP2013537154 A JP 2013537154A JP 2013537154 A JP2013537154 A JP 2013537154A JP 2014503482 A5 JP2014503482 A5 JP 2014503482A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- antibody
- domain
- immunoglobulin
- hypervariable regions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102000013691 Interleukin-17 Human genes 0.000 claims 22
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 10
- 108010074051 C-Reactive Protein Proteins 0.000 claims 8
- 102100032752 C-reactive protein Human genes 0.000 claims 7
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 7
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 7
- 101001090860 Homo sapiens Myeloblastin Proteins 0.000 claims 4
- 102100034681 Myeloblastin Human genes 0.000 claims 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- GLGAUBPACOBAMV-DOFZRALJSA-N arachidonylcyclopropylamide Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)NC1CC1 GLGAUBPACOBAMV-DOFZRALJSA-N 0.000 claims 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 210000003743 erythrocyte Anatomy 0.000 claims 2
- 239000000710 homodimer Substances 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 238000004062 sedimentation Methods 0.000 claims 2
- 102000006395 Globulins Human genes 0.000 claims 1
- 108010044091 Globulins Proteins 0.000 claims 1
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims 1
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims 1
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 claims 1
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 claims 1
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 230000036039 immunity Effects 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 229960000485 methotrexate Drugs 0.000 claims 1
- 229960004540 secukinumab Drugs 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 230000003442 weekly effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41053310P | 2010-11-05 | 2010-11-05 | |
| US61/410,533 | 2010-11-05 | ||
| PCT/EP2011/069476 WO2012059598A2 (en) | 2010-11-05 | 2011-11-04 | Methods of treating rheumatoid arthritis using il-17 antagonists |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015232562A Division JP6049843B2 (ja) | 2010-11-05 | 2015-11-30 | Ｉｌ−１７アンタゴニストを用いて関節リウマチを治療する方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014503482A JP2014503482A (ja) | 2014-02-13 |
| JP2014503482A5 true JP2014503482A5 (enExample) | 2014-12-18 |
Family
ID=44906168
Family Applications (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013537154A Pending JP2014503482A (ja) | 2010-11-05 | 2011-11-04 | Ｉｌ−１７アンタゴニストを用いて関節リウマチを治療する方法 |
| JP2015232562A Active JP6049843B2 (ja) | 2010-11-05 | 2015-11-30 | Ｉｌ−１７アンタゴニストを用いて関節リウマチを治療する方法 |
| JP2016139469A Active JP6250109B2 (ja) | 2010-11-05 | 2016-07-14 | Ｉｌ−１７アンタゴニストを用いて関節リウマチを治療する方法 |
| JP2017223669A Active JP6515168B2 (ja) | 2010-11-05 | 2017-11-21 | Ｉｌ−１７アンタゴニストを用いて関節リウマチを治療する方法 |
| JP2019076324A Pending JP2019142912A (ja) | 2010-11-05 | 2019-04-12 | Ｉｌ−１７アンタゴニストを用いて関節リウマチを治療する方法 |
| JP2021031383A Pending JP2021104995A (ja) | 2010-11-05 | 2021-03-01 | Ｉｌ−１７アンタゴニストを用いて関節リウマチを治療する方法 |
| JP2023084472A Pending JP2023109910A (ja) | 2010-11-05 | 2023-05-23 | Ｉｌ－１７アンタゴニストを用いて関節リウマチを治療する方法 |
| JP2025034128A Pending JP2025102772A (ja) | 2010-11-05 | 2025-03-04 | Ｉｌ－１７アンタゴニストを用いて関節リウマチを治療する方法 |
Family Applications After (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015232562A Active JP6049843B2 (ja) | 2010-11-05 | 2015-11-30 | Ｉｌ−１７アンタゴニストを用いて関節リウマチを治療する方法 |
| JP2016139469A Active JP6250109B2 (ja) | 2010-11-05 | 2016-07-14 | Ｉｌ−１７アンタゴニストを用いて関節リウマチを治療する方法 |
| JP2017223669A Active JP6515168B2 (ja) | 2010-11-05 | 2017-11-21 | Ｉｌ−１７アンタゴニストを用いて関節リウマチを治療する方法 |
| JP2019076324A Pending JP2019142912A (ja) | 2010-11-05 | 2019-04-12 | Ｉｌ−１７アンタゴニストを用いて関節リウマチを治療する方法 |
| JP2021031383A Pending JP2021104995A (ja) | 2010-11-05 | 2021-03-01 | Ｉｌ−１７アンタゴニストを用いて関節リウマチを治療する方法 |
| JP2023084472A Pending JP2023109910A (ja) | 2010-11-05 | 2023-05-23 | Ｉｌ－１７アンタゴニストを用いて関節リウマチを治療する方法 |
| JP2025034128A Pending JP2025102772A (ja) | 2010-11-05 | 2025-03-04 | Ｉｌ－１７アンタゴニストを用いて関節リウマチを治療する方法 |
Country Status (31)
| Country | Link |
|---|---|
| US (10) | US9744234B2 (enExample) |
| EP (6) | EP2635303A2 (enExample) |
| JP (8) | JP2014503482A (enExample) |
| KR (5) | KR20160067984A (enExample) |
| CN (2) | CN104800844A (enExample) |
| AU (1) | AU2011325134B2 (enExample) |
| BR (1) | BR112013011176A2 (enExample) |
| CA (2) | CA3116725C (enExample) |
| CL (1) | CL2013001213A1 (enExample) |
| CY (1) | CY1121802T1 (enExample) |
| DE (1) | DE20187001T1 (enExample) |
| DK (2) | DK3757126T3 (enExample) |
| ES (3) | ES2733712T3 (enExample) |
| FI (1) | FI3757126T3 (enExample) |
| HR (2) | HRP20251174T1 (enExample) |
| HU (1) | HUE044038T2 (enExample) |
| IL (4) | IL311014A (enExample) |
| LT (2) | LT3757126T (enExample) |
| MA (1) | MA34647B1 (enExample) |
| MX (1) | MX362591B (enExample) |
| PH (1) | PH12013500890A1 (enExample) |
| PL (1) | PL3111954T3 (enExample) |
| PT (2) | PT3757126T (enExample) |
| RS (1) | RS67377B1 (enExample) |
| RU (1) | RU2582937C2 (enExample) |
| SG (2) | SG189138A1 (enExample) |
| SI (2) | SI3111954T1 (enExample) |
| SM (1) | SMT202500423T1 (enExample) |
| TR (1) | TR201909531T4 (enExample) |
| TW (3) | TWI616204B (enExample) |
| WO (1) | WO2012059598A2 (enExample) |
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| US9284283B2 (en) | 2012-02-02 | 2016-03-15 | Ensemble Therapeutics Corporation | Macrocyclic compounds for modulating IL-17 |
| US20140004131A1 (en) * | 2012-05-04 | 2014-01-02 | Novartis Ag | Antibody formulation |
| WO2014155278A2 (en) | 2013-03-26 | 2014-10-02 | Novartis Ag | Methods of treating autoimmune diseases using il-17 antagonists |
| JP2016539925A (ja) | 2013-10-22 | 2016-12-22 | ノビミューン エスアー | Ｔｌｒ４リガンドまたは他のバイオマーカーのレベルが上昇した患者における障害の診断および処置を行うための方法および組成物 |
| CN105916883B (zh) * | 2014-01-28 | 2019-12-03 | 北京韩美药品有限公司 | 双功能融合蛋白及其制备方法和用途 |
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| FR3021976B1 (fr) * | 2014-06-06 | 2018-11-02 | Hospices Civils De Lyon | Marqueur biologique permettant d'evaluer le niveau pro-inflammatoire dependant de la contribution fonctionnelle de l'il-17 chez un individu |
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| KR20210110287A (ko) * | 2018-09-26 | 2021-09-07 | 비엘라 바이오, 인크. | Cd40l 길항제 및 이의 용도 |
| EP3914250A1 (en) * | 2019-01-22 | 2021-12-01 | F. Hoffmann-La Roche AG | Methods of treating rheumatoid arthritis, chronic spontaneous urticaria, and systemic lupus erythematosis using an inhibitor of bruton's tyrosine kinase |
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| KR102169901B1 (ko) * | 2019-05-17 | 2020-10-26 | 연세대학교 산학협력단 | Dna 메틸화를 이용한 면역 항암 요법의 치료 반응에 관한 정보 제공 방법 및 이를 이용한 키트 |
| EP4010077A1 (en) * | 2019-08-05 | 2022-06-15 | Evelo Biosciences, Inc. | Compositions and methods of treating psoriasis and atopic dermatitis using prevotella histicola |
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