JP2014503482A - Il−17アンタゴニストを用いて関節リウマチを治療する方法 - Google Patents

Il−17アンタゴニストを用いて関節リウマチを治療する方法 Download PDF

Info

Publication number
JP2014503482A
JP2014503482A JP2013537154A JP2013537154A JP2014503482A JP 2014503482 A JP2014503482 A JP 2014503482A JP 2013537154 A JP2013537154 A JP 2013537154A JP 2013537154 A JP2013537154 A JP 2013537154A JP 2014503482 A JP2014503482 A JP 2014503482A
Authority
JP
Japan
Prior art keywords
antagonist
patient
crp
dose
acpa
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2013537154A
Other languages
English (en)
Japanese (ja)
Other versions
JP2014503482A5 (enExample
Inventor
ムポフ,シェファード
リチャード,ハノ
サンガベル,カーシナサン
マカチェク,マティアス
Original Assignee
ノバルティス アーゲー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44906168&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP2014503482(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by ノバルティス アーゲー filed Critical ノバルティス アーゲー
Publication of JP2014503482A publication Critical patent/JP2014503482A/ja
Publication of JP2014503482A5 publication Critical patent/JP2014503482A5/ja
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591Stabilisation, fragmentation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244Interleukins [IL]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/55Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicinal Preparation (AREA)
JP2013537154A 2010-11-05 2011-11-04 Il−17アンタゴニストを用いて関節リウマチを治療する方法 Pending JP2014503482A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41053310P 2010-11-05 2010-11-05
US61/410,533 2010-11-05
PCT/EP2011/069476 WO2012059598A2 (en) 2010-11-05 2011-11-04 Methods of treating rheumatoid arthritis using il-17 antagonists

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015232562A Division JP6049843B2 (ja) 2010-11-05 2015-11-30 Il−17アンタゴニストを用いて関節リウマチを治療する方法

Publications (2)

Publication Number Publication Date
JP2014503482A true JP2014503482A (ja) 2014-02-13
JP2014503482A5 JP2014503482A5 (enExample) 2014-12-18

Family

ID=44906168

Family Applications (8)

Application Number Title Priority Date Filing Date
JP2013537154A Pending JP2014503482A (ja) 2010-11-05 2011-11-04 Il−17アンタゴニストを用いて関節リウマチを治療する方法
JP2015232562A Active JP6049843B2 (ja) 2010-11-05 2015-11-30 Il−17アンタゴニストを用いて関節リウマチを治療する方法
JP2016139469A Active JP6250109B2 (ja) 2010-11-05 2016-07-14 Il−17アンタゴニストを用いて関節リウマチを治療する方法
JP2017223669A Active JP6515168B2 (ja) 2010-11-05 2017-11-21 Il−17アンタゴニストを用いて関節リウマチを治療する方法
JP2019076324A Pending JP2019142912A (ja) 2010-11-05 2019-04-12 Il−17アンタゴニストを用いて関節リウマチを治療する方法
JP2021031383A Pending JP2021104995A (ja) 2010-11-05 2021-03-01 Il−17アンタゴニストを用いて関節リウマチを治療する方法
JP2023084472A Pending JP2023109910A (ja) 2010-11-05 2023-05-23 Il-17アンタゴニストを用いて関節リウマチを治療する方法
JP2025034128A Pending JP2025102772A (ja) 2010-11-05 2025-03-04 Il-17アンタゴニストを用いて関節リウマチを治療する方法

Family Applications After (7)

Application Number Title Priority Date Filing Date
JP2015232562A Active JP6049843B2 (ja) 2010-11-05 2015-11-30 Il−17アンタゴニストを用いて関節リウマチを治療する方法
JP2016139469A Active JP6250109B2 (ja) 2010-11-05 2016-07-14 Il−17アンタゴニストを用いて関節リウマチを治療する方法
JP2017223669A Active JP6515168B2 (ja) 2010-11-05 2017-11-21 Il−17アンタゴニストを用いて関節リウマチを治療する方法
JP2019076324A Pending JP2019142912A (ja) 2010-11-05 2019-04-12 Il−17アンタゴニストを用いて関節リウマチを治療する方法
JP2021031383A Pending JP2021104995A (ja) 2010-11-05 2021-03-01 Il−17アンタゴニストを用いて関節リウマチを治療する方法
JP2023084472A Pending JP2023109910A (ja) 2010-11-05 2023-05-23 Il-17アンタゴニストを用いて関節リウマチを治療する方法
JP2025034128A Pending JP2025102772A (ja) 2010-11-05 2025-03-04 Il-17アンタゴニストを用いて関節リウマチを治療する方法

Country Status (30)

Country Link
US (10) US9744234B2 (enExample)
EP (6) EP4116325A1 (enExample)
JP (8) JP2014503482A (enExample)
KR (5) KR20140008305A (enExample)
CN (2) CN104800844A (enExample)
AU (1) AU2011325134B2 (enExample)
BR (1) BR112013011176A2 (enExample)
CA (2) CA3116725C (enExample)
CL (1) CL2013001213A1 (enExample)
CY (1) CY1121802T1 (enExample)
DE (1) DE20187001T1 (enExample)
DK (2) DK3111954T3 (enExample)
ES (3) ES3030036T3 (enExample)
FI (1) FI3757126T3 (enExample)
HR (2) HRP20251174T1 (enExample)
HU (1) HUE044038T2 (enExample)
IL (4) IL311014A (enExample)
LT (2) LT3111954T (enExample)
MA (1) MA34647B1 (enExample)
MX (1) MX362591B (enExample)
PH (1) PH12013500890A1 (enExample)
PL (1) PL3111954T3 (enExample)
PT (2) PT3757126T (enExample)
RS (1) RS67377B1 (enExample)
RU (1) RU2582937C2 (enExample)
SG (2) SG189138A1 (enExample)
SI (1) SI3111954T1 (enExample)
TR (1) TR201909531T4 (enExample)
TW (3) TWI604851B (enExample)
WO (1) WO2012059598A2 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018502910A (ja) * 2014-12-22 2018-02-01 ノバルティス アーゲー Il−17抗体の医薬製品および安定した液体組成物
JP2022549200A (ja) * 2019-09-20 2022-11-24 ノバルティス アーゲー インターロイキン-17(il-17)アンタゴニストを使用して自己免疫疾患を治療する方法
JP2025011274A (ja) * 2014-12-22 2025-01-23 ノバルティス アーゲー Il-17抗体中のシステイン残基の選択的還元

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG185354A1 (en) 2010-05-20 2012-12-28 Ablynx Nv Biological materials related to her3
HRP20251174T1 (hr) 2010-11-05 2025-11-21 Novartis Ag Postupci za liječenje psorijatičnog artritisa uporabom il-17 antagonista
UA117218C2 (uk) 2011-05-05 2018-07-10 Мерк Патент Гмбх Поліпептид, спрямований проти il-17a, il-17f та/або il17-a/f
SG10201707813YA (en) 2011-10-11 2017-11-29 Medimmune Llc Cd40l-specific tn3-derived scaffolds and methods of use thereof
EP2809660B1 (en) 2012-02-02 2016-01-20 Ensemble Therapeutics Corporation Macrocyclic compounds for modulating il-17
US20140004131A1 (en) * 2012-05-04 2014-01-02 Novartis Ag Antibody formulation
WO2014155278A2 (en) 2013-03-26 2014-10-02 Novartis Ag Methods of treating autoimmune diseases using il-17 antagonists
AU2014338991B2 (en) 2013-10-22 2020-06-11 Novimmune S.A. Methods and compositions for diagnosis and treatment of disorders in patients with elevated levels of TLR4 ligands and other biomarkers
KR20160113268A (ko) * 2014-01-28 2016-09-28 베이징 한미 파마슈티컬 컴퍼니 리미티드 이기능 융합단백질,이의 제조방법 및 용도
EP3603748A1 (en) 2014-05-13 2020-02-05 MedImmune Limited Anti-b7-h1 and anti-ctla-4 antibodies for treating non-small cell lung cancer
US11548940B2 (en) 2014-05-15 2023-01-10 Rani Therapeutics, Llc Anti-interleukin antibody preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
EP3142645A4 (en) 2014-05-15 2017-12-27 Rani Therapeutics, LLC Pharmaceutical compositions and methods for fabrication of solid masses comprising polypeptides and/or proteins
FR3021976B1 (fr) * 2014-06-06 2018-11-02 Hospices Civils De Lyon Marqueur biologique permettant d'evaluer le niveau pro-inflammatoire dependant de la contribution fonctionnelle de l'il-17 chez un individu
US20160002326A1 (en) * 2014-06-10 2016-01-07 Abbvie Inc. Compositions and methods for treating rheumatoid arthritis
NL2013007B1 (en) * 2014-06-16 2016-07-05 Ablynx Nv Methods of treating TTP with immunoglobulin single variable domains and uses thereof.
CA2960754A1 (en) 2014-09-10 2016-03-17 Novartis Ag Use of il-17 antagonists to inhibit the progression of structural damage in psoriatic arthritis patients
CN107106655A (zh) * 2014-10-22 2017-08-29 阿尔莫生物科技股份有限公司 使用白细胞介素‑10治疗疾病和病症的方法
CA2978449A1 (en) 2015-03-02 2016-09-09 180 Therapeutics Lp Method of treating a localized fibrotic disorder using an il-33 antagonist
EP3167892A1 (en) 2015-11-10 2017-05-17 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for preventing or treating imflammatory bowel diseases
EP3365011A1 (en) * 2015-10-19 2018-08-29 Novartis AG Methods of treating non-radiographic axial spondyloarthritis using interleukin-17 (il-17) antagonists
EP3504648A1 (en) * 2016-08-23 2019-07-03 CSL Behring GmbH Method of preventing acute attacks of hereditary angioedema associated with c1 esterase inhibitor deficiency
CN111344043A (zh) * 2017-11-02 2020-06-26 诺华股份有限公司 使用白细胞介素-17(il-17)拮抗剂治疗肌腱病的方法
GB201719447D0 (en) * 2017-11-23 2018-01-10 Ucb Biopharma Sprl Pharmaceutical composition
CN119746057A (zh) * 2018-05-09 2025-04-04 诺华股份有限公司 卡那吉努单抗的用途
AU2019346457B2 (en) * 2018-09-26 2025-05-08 Viela Bio, Inc. CD40l antagonist and uses thereof
AU2020213265B2 (en) * 2019-01-22 2025-01-16 F. Hoffmann-La Roche Ag Methods of treating rheumatoid arthritis, chronic spontaneous urticaria, and systemic lupus erythematosis using an inhibitor of Bruton's tyrosine kinase
MX2021009851A (es) 2019-02-18 2021-09-10 Lilly Co Eli Formulacion de anticuerpos terapeuticos.
KR102169901B1 (ko) * 2019-05-17 2020-10-26 연세대학교 산학협력단 Dna 메틸화를 이용한 면역 항암 요법의 치료 반응에 관한 정보 제공 방법 및 이를 이용한 키트
CN110179746A (zh) * 2019-05-17 2019-08-30 通化东宝生物科技有限公司 一种稳定的苏金单抗注射剂及其制备方法
MX2022001607A (es) * 2019-08-05 2022-03-11 Evelo Biosciences Inc Composiciones y metodos para tratar la psoriasis y la dermatitis atopica usando prevotella histicola.
AU2020386669A1 (en) 2019-11-19 2022-06-02 Novartis Ag Methods of treating Lupus Nephritis using interleukin-17 (IL-17) antagonists
CN112915201B (zh) * 2019-12-06 2023-06-27 珠海市丽珠单抗生物技术有限公司 包含抗il-17抗体的液体制剂
WO2021146850A1 (en) * 2020-01-20 2021-07-29 Tsinghua University A critical role of febrile temperature in regulating interleukin (il) -17 producing cells via smad4
WO2022113105A1 (en) * 2020-11-25 2022-06-02 Dr. Reddy's Laboratories Limited Stable therapeutic protein formulation and methods of making the same
TW202241505A (zh) * 2021-01-04 2022-11-01 大陸商江蘇恆瑞醫藥股份有限公司 抗il-17抗體治療自體免疫性疾病和炎症的方法
TW202246329A (zh) * 2021-03-03 2022-12-01 大陸商蘇州盛迪亞生物醫藥有限公司 抗il-17抗體治療自體免疫性疾病和炎症的方法
KR102339377B1 (ko) * 2021-03-29 2021-12-13 김지혜 사용자 맞춤형 문화 예술 컨텐츠 제공 방법 및 장치
CN117500834A (zh) * 2021-06-21 2024-02-02 百时美施贵宝公司 使用蔗糖、甘露糖醇和甘氨酸来减少高浓度冻干生物制剂药物产品的重构时间
CN114306594A (zh) * 2021-12-21 2022-04-12 华中科技大学同济医学院附属协和医院 地舒单抗在制备治疗膝关节骨性关节炎的药物中的应用
EP4406553A1 (en) 2023-01-27 2024-07-31 Fresenius Kabi Deutschland GmbH Stable secukinumab biopharmaceutical composition
WO2024156841A1 (en) 2023-01-27 2024-08-02 Fresenius Kabi Deutschland Gmbh Biopharmaceutical composition
WO2025071335A1 (ko) * 2023-09-27 2025-04-03 삼성바이오에피스 주식회사 항-il-17 항체의 안정한 액상 제형

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008507988A (ja) * 2004-08-05 2008-03-21 ノバルティス アクチエンゲゼルシャフト Il−17拮抗性抗体
JP2010530972A (ja) * 2007-06-20 2010-09-16 シェーリング コーポレイション 炎症性関節疾患に対する抗il−17a治療のための関節破壊のバイオマーカー

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0565233A (ja) 1991-03-08 1993-03-19 Mitsui Toatsu Chem Inc モノクローナル抗体含有凍結乾燥製剤
US5250442A (en) * 1993-04-08 1993-10-05 Orestes Cabezas Method of treating rheumatoid arthritis using tetracycline
US6309636B1 (en) * 1995-09-14 2001-10-30 Cancer Research Institute Of Contra Costa Recombinant peptides derived from the Mc3 anti-BA46 antibody, methods of use thereof, and methods of humanizing antibody peptides
EP0852951A1 (de) 1996-11-19 1998-07-15 Roche Diagnostics GmbH Stabile lyophilisierte pharmazeutische Zubereitungen von mono- oder polyklonalen Antikörpern
US20050147609A1 (en) 1998-05-15 2005-07-07 Genentech, Inc. Use of anti-IL-17 antibody for the treatment of cartilage damaged by osteoarthritis
JP2000186046A (ja) 1998-10-14 2000-07-04 Snow Brand Milk Prod Co Ltd 慢性関節リウマチ治療剤及び診断方法
US6395511B1 (en) 1998-11-27 2002-05-28 Darwin Discovery, Ltd. Nucleic acids encoding a novel family of TGF-β binding proteins from humans
US20040009535A1 (en) 1998-11-27 2004-01-15 Celltech R&D, Inc. Compositions and methods for increasing bone mineralization
JP4159682B2 (ja) 1998-12-22 2008-10-01 株式会社クラレ 止血材
ATE454137T1 (de) 2001-07-25 2010-01-15 Facet Biotech Corp Stabile lyophilisierte pharmazeutische formulierung des igg-antikörpers daclizumab
CA2466641A1 (en) 2001-11-09 2003-05-22 Centocor, Inc. Lyophilized monoclonal antibody compositions
AU2003223214B2 (en) 2002-03-01 2008-09-18 Celltech R & D, Inc. Methods to increase or decrease bone density
AU2003276430A1 (en) 2002-06-14 2003-12-31 Stowers Institute For Medical Research Wise/sost nucleic acid sequences and amino acid sequences
US6974701B2 (en) 2003-03-21 2005-12-13 Hemovations, Llc Erythrocyte sedimentation rate (ESR) test measurement instrument of unitary design and method of using the same
NZ544618A (en) 2003-06-16 2009-02-28 Celltech R & D Inc Antibodies specific for sclerostin and methods for increasing bone mineralization
US8461155B2 (en) 2003-09-22 2013-06-11 University Of Connecticut Sclerostin and the inhibition of WNT signaling and bone formation
US8039642B2 (en) 2003-12-09 2011-10-18 Life Technologies Corporation Pyrenyloxysulfonic acid fluorescent agents
JP3936365B2 (ja) 2004-09-14 2007-06-27 ソニーケミカル&インフォメーションデバイス株式会社 機能素子実装モジュール及びその製造方法
DK1865986T3 (en) 2005-03-08 2016-04-11 Pfizer Prod Inc The anti-CTLA-4 antibody compositions
US7592429B2 (en) 2005-05-03 2009-09-22 Ucb Sa Sclerostin-binding antibody
US8003108B2 (en) 2005-05-03 2011-08-23 Amgen Inc. Sclerostin epitopes
EP1957474A4 (en) 2005-11-04 2011-08-24 Harvard College SYNTHESIS OF FTSZ HEMMERN
MY149159A (en) 2005-11-15 2013-07-31 Hoffmann La Roche Method for treating joint damage
WO2007074880A1 (ja) 2005-12-28 2007-07-05 Chugai Seiyaku Kabushiki Kaisha 抗体含有安定化製剤
JP5068270B2 (ja) * 2006-01-31 2012-11-07 ノバルティス アーゲー 癌を処置するためのil−17アンタゴニスト抗体
TW200815469A (en) 2006-06-23 2008-04-01 Astrazeneca Ab Compounds
WO2008030611A2 (en) 2006-09-05 2008-03-13 Medarex, Inc. Antibodies to bone morphogenic proteins and receptors therefor and methods for their use
WO2008029908A1 (fr) 2006-09-07 2008-03-13 Kyowa Hakko Kirin Co., Ltd. Préparation pharmaceutique lyophilisée stable comprenant un anticorps
US7833527B2 (en) 2006-10-02 2010-11-16 Amgen Inc. Methods of treating psoriasis using IL-17 Receptor A antibodies
UA99716C2 (ru) * 2006-10-02 2012-09-25 Кирин-Амген Инк. Антитело, которое специфично связывает человеческий il-17 рецептор а (il-17ra)
EP2460828A3 (en) 2006-11-10 2012-08-08 UCB Pharma, S.A. Antibodies and diagnostics
US20100036091A1 (en) 2006-11-10 2010-02-11 Amgen Inc. Antibody-based diagnostics and therapeutics
MX2009008096A (es) 2007-02-02 2009-08-07 Novartis Ag Moduladores de los componentes de enlace de esclerostatina para el tratamiento de trastornos relacionados con los huesos.
MY149129A (en) 2007-03-20 2013-07-15 Lilly Co Eli Anti-sclerostin antibodies
UA96473C2 (ru) 2007-03-22 2011-11-10 Имклоун Ллк Жидкая стойкая композиция, которая содержит антитело imc-а12
AU2008232903B9 (en) * 2007-03-30 2013-09-05 Medimmune Llc Antibodies with decreased deamidation profiles
US7720605B2 (en) 2007-06-22 2010-05-18 Weyerhaeuser Nr Company Identifying vegetation attributes from LiDAR data
CL2008002775A1 (es) 2007-09-17 2008-11-07 Amgen Inc Uso de un agente de unión a esclerostina para inhibir la resorción ósea.
TWI489993B (zh) 2007-10-12 2015-07-01 Novartis Ag 骨硬化素(sclerostin)抗體組合物及使用方法
BRPI0819688A2 (pt) 2007-12-14 2015-06-16 Amgen Inc Processo para tratamento de fratura óssea com anticorpos anti-esclerostina.
SG191639A1 (en) 2008-06-03 2013-07-31 Abbott Lab Dual variable domain immunoglobulins and uses thereof
US20090301682A1 (en) 2008-06-05 2009-12-10 Baker Hughes Incorporated Casting furnace method and apparatus
AU2009268585C1 (en) 2008-07-08 2014-10-02 Abbvie Inc. Prostaglandin E2 dual variable domain immunoglobulins and uses thereof
WO2010034443A1 (en) 2008-09-29 2010-04-01 F. Hoffmann-La Roche Ag Antibodies against human il 17 and uses thereof
EP2358392B1 (en) 2008-11-12 2019-01-09 MedImmune, LLC Antibody formulation
FR2938547B1 (fr) 2008-11-14 2012-11-16 Total Raffinage Marketing Liant synthetique clair
US20110256130A1 (en) 2008-12-01 2011-10-20 Joshua Robert Schultz Methods of treating inflammatory disorders
PE20160653A1 (es) 2009-03-05 2016-07-24 Abbvie Inc Proteinas de union a il-17
EP2625199B1 (en) 2010-10-08 2017-11-22 Novartis AG Methods of treating psoriasis using il-17 antagonists
HRP20251174T1 (hr) 2010-11-05 2025-11-21 Novartis Ag Postupci za liječenje psorijatičnog artritisa uporabom il-17 antagonista
WO2012082573A1 (en) 2010-12-13 2012-06-21 Novartis Ag Predictive methods and methods of treating arthritis using il-17 antagonists
EP2783014A1 (en) 2011-11-21 2014-10-01 Novartis AG Methods of treating psoriatic arthritis (psa) using il-17 antagonists and psa response or non- response alleles
KR20150010709A (ko) 2012-04-20 2015-01-28 노파르티스 아게 Il-17 길항제를 사용하는 강직성 척추염의 치료 방법
WO2014155278A2 (en) 2013-03-26 2014-10-02 Novartis Ag Methods of treating autoimmune diseases using il-17 antagonists
EP3365011A1 (en) 2015-10-19 2018-08-29 Novartis AG Methods of treating non-radiographic axial spondyloarthritis using interleukin-17 (il-17) antagonists
US11280479B2 (en) 2017-10-18 2022-03-22 The Sloan Company Sign box light module

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008507988A (ja) * 2004-08-05 2008-03-21 ノバルティス アクチエンゲゼルシャフト Il−17拮抗性抗体
JP2010530972A (ja) * 2007-06-20 2010-09-16 シェーリング コーポレイション 炎症性関節疾患に対する抗il−17a治療のための関節破壊のバイオマーカー

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
JPN5014001240; HUEBER WOLFGANG: 'EFFECTS OF AIN457, A FULLY HUMAN ANTIBODY TO INTERLEUKIN-17A, ON PSORIASIS, 以下備考' SCIENCE TRANSLATIONAL MEDICINE V2 N52/ ARTICLE NO.: 52RA72, 20101001, P1-9, AMERICAN ASSO. FOR THE ADVANCEMENT OF SCIENCE *
JPN5014001242; MACHOLD K P: 'VERY RECENT ONSET RHEUMATOID ARTHRITIS : CLINICAL AND SEROLOGICAL PATIENT 以下備考' RHEUMATOLOGY V46 N2, 200702, P342-349 *
JPN6015034568; Pharmaceutics: the Science of Dosage Form Design second edition, 2002, p275-288 *
JPN6015034569; 抗ヒトTNFalphaモノクローナル抗体製剤 レミケード点滴静注用100 インフリキシマブ(遺伝子組換え)製 , 201001, 田辺三菱製薬株式会社 *
JPN6015034570; 14th International Conference on Behcet's Disease ABSTRACT BOOK Book No. O-012, 201007, p19-20 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018502910A (ja) * 2014-12-22 2018-02-01 ノバルティス アーゲー Il−17抗体の医薬製品および安定した液体組成物
JP2020011963A (ja) * 2014-12-22 2020-01-23 ノバルティス アーゲー Il−17抗体の医薬製品および安定した液体組成物
JP2023113906A (ja) * 2014-12-22 2023-08-16 ノバルティス アーゲー Il-17抗体の医薬製品および安定した液体組成物
JP2025011274A (ja) * 2014-12-22 2025-01-23 ノバルティス アーゲー Il-17抗体中のシステイン残基の選択的還元
JP2022549200A (ja) * 2019-09-20 2022-11-24 ノバルティス アーゲー インターロイキン-17(il-17)アンタゴニストを使用して自己免疫疾患を治療する方法

Also Published As

Publication number Publication date
EP3757126A1 (en) 2020-12-30
CA2813849A1 (en) 2012-05-10
MX2013005060A (es) 2013-06-28
PH12013500890A1 (en) 2013-07-01
IL225309A0 (en) 2013-06-27
EP3111954B1 (en) 2019-04-03
TW201306864A (zh) 2013-02-16
EP2635303A2 (en) 2013-09-11
DK3111954T3 (da) 2019-07-15
PL3111954T3 (pl) 2019-10-31
IL225309B (en) 2021-05-31
US20250205332A1 (en) 2025-06-26
TW201517917A (zh) 2015-05-16
US20200276305A1 (en) 2020-09-03
KR20140008305A (ko) 2014-01-21
IL262559A (en) 2018-12-31
JP2016065094A (ja) 2016-04-28
US20220193234A1 (en) 2022-06-23
US20190307880A1 (en) 2019-10-10
CY1121802T1 (el) 2020-07-31
US20210128726A1 (en) 2021-05-06
RU2013125775A (ru) 2014-12-10
CA2813849C (en) 2021-06-15
KR20150020734A (ko) 2015-02-26
JP2023109910A (ja) 2023-08-08
JP2025102772A (ja) 2025-07-08
JP2019142912A (ja) 2019-08-29
KR20180129991A (ko) 2018-12-05
US20230293683A1 (en) 2023-09-21
HRP20251174T1 (hr) 2025-11-21
TWI618543B (zh) 2018-03-21
CA3116725A1 (en) 2012-05-10
AU2011325134A1 (en) 2013-04-04
CL2013001213A1 (es) 2014-03-28
DE20187001T1 (de) 2021-04-01
US9744234B2 (en) 2017-08-29
EP4116325A1 (en) 2023-01-11
WO2012059598A3 (en) 2012-09-27
TWI616204B (zh) 2018-03-01
SG10201505624VA (en) 2015-09-29
PT3111954T (pt) 2019-07-10
MX362591B (es) 2019-01-25
ES3030036T3 (en) 2025-06-26
SI3111954T1 (sl) 2019-08-30
LT3757126T (lt) 2025-12-10
US20180008706A1 (en) 2018-01-11
EP3542820A1 (en) 2019-09-25
MA34647B1 (fr) 2013-11-02
IL262559B (en) 2022-06-01
IL311014A (en) 2024-04-01
EP3111954A1 (en) 2017-01-04
CN103189074A (zh) 2013-07-03
TW201726170A (zh) 2017-08-01
EP3912640B1 (en) 2025-03-05
ES2804624T1 (es) 2021-02-08
CA3116725C (en) 2023-10-24
JP2018065826A (ja) 2018-04-26
EP3757126B1 (en) 2025-09-03
LT3111954T (lt) 2019-07-10
DK3757126T3 (da) 2025-09-29
JP6049843B2 (ja) 2016-12-21
CN104800844A (zh) 2015-07-29
RS67377B1 (sr) 2025-11-28
WO2012059598A2 (en) 2012-05-10
FI3757126T3 (fi) 2025-10-12
US20210177966A1 (en) 2021-06-17
SG189138A1 (en) 2013-05-31
JP2021104995A (ja) 2021-07-26
HRP20191162T1 (hr) 2019-10-04
RU2582937C2 (ru) 2016-04-27
HUE044038T2 (hu) 2019-09-30
IL282625A (en) 2021-06-30
JP6515168B2 (ja) 2019-05-15
US10363307B2 (en) 2019-07-30
TWI604851B (zh) 2017-11-11
PT3757126T (pt) 2025-11-13
US20230346926A1 (en) 2023-11-02
ES2733712T3 (es) 2019-12-02
AU2011325134B2 (en) 2014-10-23
US11534491B2 (en) 2022-12-27
JP6250109B2 (ja) 2017-12-20
KR20180019247A (ko) 2018-02-23
US12465635B2 (en) 2025-11-11
EP3912640A1 (en) 2021-11-24
TR201909531T4 (tr) 2019-07-22
KR20160067984A (ko) 2016-06-14
US20130209480A1 (en) 2013-08-15
JP2017002064A (ja) 2017-01-05
BR112013011176A2 (pt) 2020-09-01

Similar Documents

Publication Publication Date Title
US12465635B2 (en) Methods of treating inflammatory arthritis using secukinumab
HK40010039A (en) Methods of treating psoriatic arthritis using il-17 antagonists
HK40040628A (en) Methods of treating psoriatic arthritis using il-17 antagonists
HK40035240A (en) Methods of treating psoriatic arthritis using il-17 antagonists
HK40083901A (en) Methods of treating rheumatoid arthritis using il-17 antagonists
HK40061520A (en) Pharmaceutical compositions comprising secukinumab
HK1229257B (en) Methods of treating ankylosing spondylitis using anti-il-17 antibodies
HK1229257A1 (en) Methods of treating ankylosing spondylitis using anti-il-17 antibodies

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20141030

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20141030

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20150901

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20160209