JP2014502971A5 - - Google Patents
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- JP2014502971A5 JP2014502971A5 JP2013548563A JP2013548563A JP2014502971A5 JP 2014502971 A5 JP2014502971 A5 JP 2014502971A5 JP 2013548563 A JP2013548563 A JP 2013548563A JP 2013548563 A JP2013548563 A JP 2013548563A JP 2014502971 A5 JP2014502971 A5 JP 2014502971A5
- Authority
- JP
- Japan
- Prior art keywords
- blood
- poly
- sorbent
- polymer
- acrylate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000008280 blood Substances 0.000 claims description 96
- 210000004369 blood Anatomy 0.000 claims description 96
- 239000002594 sorbent Substances 0.000 claims description 36
- 239000010836 blood and blood product Substances 0.000 claims description 27
- -1 polyethylene propylene Polymers 0.000 claims description 5
- RCRCTBLIHCHWDZ-UHFFFAOYSA-N 2-Arachidonoyl Glycerol Chemical compound CCCCCC=CCC=CCC=CCC=CCCCC(=O)OC(CO)CO RCRCTBLIHCHWDZ-UHFFFAOYSA-N 0.000 claims description 4
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 claims description 4
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 claims description 4
- 239000012528 membrane Substances 0.000 claims description 4
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 claims description 4
- 108090000288 Glycoproteins Proteins 0.000 claims description 3
- 102000003886 Glycoproteins Human genes 0.000 claims description 3
- 102000029797 Prion Human genes 0.000 claims description 3
- 108091000054 Prion Proteins 0.000 claims description 3
- 229940079593 drug Drugs 0.000 claims description 3
- 239000003814 drug Substances 0.000 claims description 3
- 150000002632 lipids Chemical class 0.000 claims description 3
- 239000003053 toxin Substances 0.000 claims description 3
- 231100000765 toxin Toxicity 0.000 claims description 3
- 108700012359 toxins Proteins 0.000 claims description 3
- 101800004538 Bradykinin Proteins 0.000 claims description 2
- 108010029697 CD40 Ligand Proteins 0.000 claims description 2
- 102100032937 CD40 ligand Human genes 0.000 claims description 2
- 108010067225 Cell Adhesion Molecules Proteins 0.000 claims description 2
- 102000016289 Cell Adhesion Molecules Human genes 0.000 claims description 2
- 102000019034 Chemokines Human genes 0.000 claims description 2
- 108010012236 Chemokines Proteins 0.000 claims description 2
- 102000004127 Cytokines Human genes 0.000 claims description 2
- 108090000695 Cytokines Proteins 0.000 claims description 2
- QXZGBUJJYSLZLT-UHFFFAOYSA-N H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH Natural products NC(N)=NCCCC(N)C(=O)N1CCCC1C(=O)N1C(C(=O)NCC(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CO)C(=O)N2C(CCC2)C(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CCCN=C(N)N)C(O)=O)CCC1 QXZGBUJJYSLZLT-UHFFFAOYSA-N 0.000 claims description 2
- 102000001554 Hemoglobins Human genes 0.000 claims description 2
- 108010054147 Hemoglobins Proteins 0.000 claims description 2
- 102000014150 Interferons Human genes 0.000 claims description 2
- 108010050904 Interferons Proteins 0.000 claims description 2
- 102100035792 Kininogen-1 Human genes 0.000 claims description 2
- 108010077861 Kininogens Proteins 0.000 claims description 2
- 102000010631 Kininogens Human genes 0.000 claims description 2
- 108010093008 Kinins Proteins 0.000 claims description 2
- 102000002397 Kinins Human genes 0.000 claims description 2
- 108010050619 Monokines Proteins 0.000 claims description 2
- 102000013967 Monokines Human genes 0.000 claims description 2
- 102000035195 Peptidases Human genes 0.000 claims description 2
- 108091005804 Peptidases Proteins 0.000 claims description 2
- 239000004365 Protease Substances 0.000 claims description 2
- LGEQQWMQCRIYKG-DOFZRALJSA-N anandamide Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)NCCO LGEQQWMQCRIYKG-DOFZRALJSA-N 0.000 claims description 2
- 239000000427 antigen Substances 0.000 claims description 2
- 108091007433 antigens Proteins 0.000 claims description 2
- 102000036639 antigens Human genes 0.000 claims description 2
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical class CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 claims description 2
- LGEQQWMQCRIYKG-UHFFFAOYSA-N arachidonic acid ethanolamide Natural products CCCCCC=CCC=CCC=CCC=CCCCC(=O)NCCO LGEQQWMQCRIYKG-UHFFFAOYSA-N 0.000 claims description 2
- 230000000975 bioactive effect Effects 0.000 claims description 2
- QXZGBUJJYSLZLT-FDISYFBBSA-N bradykinin Chemical compound NC(=N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(=O)NCC(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CO)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)CCC1 QXZGBUJJYSLZLT-FDISYFBBSA-N 0.000 claims description 2
- 210000003850 cellular structure Anatomy 0.000 claims description 2
- 230000000295 complement effect Effects 0.000 claims description 2
- 239000002158 endotoxin Substances 0.000 claims description 2
- 229960001340 histamine Drugs 0.000 claims description 2
- 239000005550 inflammation mediator Substances 0.000 claims description 2
- 229940047124 interferons Drugs 0.000 claims description 2
- 150000002617 leukotrienes Chemical class 0.000 claims description 2
- 230000002107 myocardial effect Effects 0.000 claims description 2
- 229940094443 oxytocics prostaglandins Drugs 0.000 claims description 2
- 150000003815 prostacyclins Chemical class 0.000 claims description 2
- 150000003180 prostaglandins Chemical class 0.000 claims description 2
- FNKQXYHWGSIFBK-RPDRRWSUSA-N sapropterin Chemical compound N1=C(N)NC(=O)C2=C1NC[C@H]([C@@H](O)[C@@H](O)C)N2 FNKQXYHWGSIFBK-RPDRRWSUSA-N 0.000 claims description 2
- 229960004617 sapropterin Drugs 0.000 claims description 2
- 229940076279 serotonin Drugs 0.000 claims description 2
- 231100000617 superantigen Toxicity 0.000 claims description 2
- 150000003595 thromboxanes Chemical class 0.000 claims description 2
- 239000000463 material Substances 0.000 claims 34
- 238000000034 method Methods 0.000 claims 34
- 239000011148 porous material Substances 0.000 claims 34
- 229920000642 polymer Polymers 0.000 claims 32
- 238000000746 purification Methods 0.000 claims 27
- 229940125691 blood product Drugs 0.000 claims 22
- 239000012530 fluid Substances 0.000 claims 19
- 239000000203 mixture Substances 0.000 claims 10
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 8
- SOGAXMICEFXMKE-UHFFFAOYSA-N Butylmethacrylate Chemical compound CCCCOC(=O)C(C)=C SOGAXMICEFXMKE-UHFFFAOYSA-N 0.000 claims 6
- BAPJBEWLBFYGME-UHFFFAOYSA-N Methyl acrylate Chemical compound COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 claims 6
- 239000011324 bead Substances 0.000 claims 6
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 5
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 claims 5
- 229920000669 heparin Polymers 0.000 claims 5
- 229960002897 heparin Drugs 0.000 claims 5
- 239000002245 particle Substances 0.000 claims 5
- JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 claims 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 4
- PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 239000007787 solid Substances 0.000 claims 4
- MHHJQVRGRPHIMR-UHFFFAOYSA-N 1-phenylprop-2-en-1-ol Chemical compound C=CC(O)C1=CC=CC=C1 MHHJQVRGRPHIMR-UHFFFAOYSA-N 0.000 claims 3
- IGGDKDTUCAWDAN-UHFFFAOYSA-N 1-vinylnaphthalene Chemical compound C1=CC=C2C(C=C)=CC=CC2=C1 IGGDKDTUCAWDAN-UHFFFAOYSA-N 0.000 claims 3
- SJIXRGNQPBQWMK-UHFFFAOYSA-N 2-(diethylamino)ethyl 2-methylprop-2-enoate Chemical compound CCN(CC)CCOC(=O)C(C)=C SJIXRGNQPBQWMK-UHFFFAOYSA-N 0.000 claims 3
- QHVBLSNVXDSMEB-UHFFFAOYSA-N 2-(diethylamino)ethyl prop-2-enoate Chemical compound CCN(CC)CCOC(=O)C=C QHVBLSNVXDSMEB-UHFFFAOYSA-N 0.000 claims 3
- DPBJAVGHACCNRL-UHFFFAOYSA-N 2-(dimethylamino)ethyl prop-2-enoate Chemical compound CN(C)CCOC(=O)C=C DPBJAVGHACCNRL-UHFFFAOYSA-N 0.000 claims 3
- GNSFRPWPOGYVLO-UHFFFAOYSA-N 3-hydroxypropyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCCO GNSFRPWPOGYVLO-UHFFFAOYSA-N 0.000 claims 3
- NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical compound C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 claims 3
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims 3
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims 3
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 3
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 claims 3
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 3
- 229920001311 Poly(hydroxyethyl acrylate) Polymers 0.000 claims 3
- 229920002845 Poly(methacrylic acid) Polymers 0.000 claims 3
- 239000002202 Polyethylene glycol Substances 0.000 claims 3
- 229920002125 Sokalan® Polymers 0.000 claims 3
- MPMBRWOOISTHJV-UHFFFAOYSA-N but-1-enylbenzene Chemical compound CCC=CC1=CC=CC=C1 MPMBRWOOISTHJV-UHFFFAOYSA-N 0.000 claims 3
- CQEYYJKEWSMYFG-UHFFFAOYSA-N butyl acrylate Chemical compound CCCCOC(=O)C=C CQEYYJKEWSMYFG-UHFFFAOYSA-N 0.000 claims 3
- 238000006243 chemical reaction Methods 0.000 claims 3
- 229920001577 copolymer Polymers 0.000 claims 3
- 239000003431 cross linking reagent Substances 0.000 claims 3
- ZNAOFAIBVOMLPV-UHFFFAOYSA-N hexadecyl 2-methylprop-2-enoate Chemical compound CCCCCCCCCCCCCCCCOC(=O)C(C)=C ZNAOFAIBVOMLPV-UHFFFAOYSA-N 0.000 claims 3
- PZDUWXKXFAIFOR-UHFFFAOYSA-N hexadecyl prop-2-enoate Chemical compound CCCCCCCCCCCCCCCCOC(=O)C=C PZDUWXKXFAIFOR-UHFFFAOYSA-N 0.000 claims 3
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims 3
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 3
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 3
- ZQXSMRAEXCEDJD-UHFFFAOYSA-N n-ethenylformamide Chemical compound C=CNC=O ZQXSMRAEXCEDJD-UHFFFAOYSA-N 0.000 claims 3
- NZIDBRBFGPQCRY-UHFFFAOYSA-N octyl 2-methylprop-2-enoate Chemical compound CCCCCCCCOC(=O)C(C)=C NZIDBRBFGPQCRY-UHFFFAOYSA-N 0.000 claims 3
- 229940065472 octyl acrylate Drugs 0.000 claims 3
- ANISOHQJBAQUQP-UHFFFAOYSA-N octyl prop-2-enoate Chemical compound CCCCCCCCOC(=O)C=C ANISOHQJBAQUQP-UHFFFAOYSA-N 0.000 claims 3
- 229920001223 polyethylene glycol Polymers 0.000 claims 3
- 229920002338 polyhydroxyethylmethacrylate Polymers 0.000 claims 3
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 3
- 239000000843 powder Substances 0.000 claims 3
- HJWLCRVIBGQPNF-UHFFFAOYSA-N prop-2-enylbenzene Chemical compound C=CCC1=CC=CC=C1 HJWLCRVIBGQPNF-UHFFFAOYSA-N 0.000 claims 3
- JKNCOURZONDCGV-UHFFFAOYSA-N 2-(dimethylamino)ethyl 2-methylprop-2-enoate Chemical compound CN(C)CCOC(=O)C(C)=C JKNCOURZONDCGV-UHFFFAOYSA-N 0.000 claims 2
- QZPSOSOOLFHYRR-UHFFFAOYSA-N 3-hydroxypropyl prop-2-enoate Chemical compound OCCCOC(=O)C=C QZPSOSOOLFHYRR-UHFFFAOYSA-N 0.000 claims 2
- 239000004793 Polystyrene Substances 0.000 claims 2
- 239000012620 biological material Substances 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 239000002131 composite material Substances 0.000 claims 2
- 239000000835 fiber Substances 0.000 claims 2
- RRAMGCGOFNQTLD-UHFFFAOYSA-N hexamethylene diisocyanate Chemical compound O=C=NCCCCCCN=C=O RRAMGCGOFNQTLD-UHFFFAOYSA-N 0.000 claims 2
- 239000000367 immunologic factor Substances 0.000 claims 2
- 230000000968 intestinal effect Effects 0.000 claims 2
- 239000013335 mesoporous material Substances 0.000 claims 2
- 239000002184 metal Substances 0.000 claims 2
- 239000000178 monomer Substances 0.000 claims 2
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 claims 2
- 239000002952 polymeric resin Substances 0.000 claims 2
- 229920000098 polyolefin Polymers 0.000 claims 2
- 229920002223 polystyrene Polymers 0.000 claims 2
- 229920002635 polyurethane Polymers 0.000 claims 2
- 239000004814 polyurethane Substances 0.000 claims 2
- 239000002296 pyrolytic carbon Substances 0.000 claims 2
- 239000000377 silicon dioxide Substances 0.000 claims 2
- 239000002002 slurry Substances 0.000 claims 2
- 238000001179 sorption measurement Methods 0.000 claims 2
- 239000000725 suspension Substances 0.000 claims 2
- 229920003002 synthetic resin Polymers 0.000 claims 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical class OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims 1
- 206010018910 Haemolysis Diseases 0.000 claims 1
- 206010067122 Haemolytic transfusion reaction Diseases 0.000 claims 1
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 claims 1
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical class CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims 1
- 229920001054 Poly(ethylene‐co‐vinyl acetate) Polymers 0.000 claims 1
- 208000003441 Transfusion reaction Diseases 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 239000000853 adhesive Substances 0.000 claims 1
- 230000001070 adhesive effect Effects 0.000 claims 1
- 230000004888 barrier function Effects 0.000 claims 1
- 229920000249 biocompatible polymer Polymers 0.000 claims 1
- 230000015556 catabolic process Effects 0.000 claims 1
- 239000012611 container material Substances 0.000 claims 1
- 238000006731 degradation reaction Methods 0.000 claims 1
- 239000002270 dispersing agent Substances 0.000 claims 1
- 210000003743 erythrocyte Anatomy 0.000 claims 1
- SUPCQIBBMFXVTL-UHFFFAOYSA-N ethyl 2-methylprop-2-enoate Chemical compound CCOC(=O)C(C)=C SUPCQIBBMFXVTL-UHFFFAOYSA-N 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 238000003306 harvesting Methods 0.000 claims 1
- 230000008588 hemolysis Effects 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 125000005641 methacryl group Chemical group 0.000 claims 1
- 239000011859 microparticle Substances 0.000 claims 1
- 239000004014 plasticizer Substances 0.000 claims 1
- 239000004800 polyvinyl chloride Substances 0.000 claims 1
- PNXMTCDJUBJHQJ-UHFFFAOYSA-N propyl prop-2-enoate Chemical compound CCCOC(=O)C=C PNXMTCDJUBJHQJ-UHFFFAOYSA-N 0.000 claims 1
- 150000003254 radicals Chemical class 0.000 claims 1
- 125000003011 styrenyl group Chemical group [H]\C(*)=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- 239000002550 vasoactive agent Substances 0.000 claims 1
- 239000012190 activator Substances 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161430374P | 2011-01-06 | 2011-01-06 | |
| US61/430,374 | 2011-01-06 | ||
| US13/344,166 US10064406B2 (en) | 2011-01-06 | 2012-01-05 | Polymeric sorbent for removal of impurities from whole blood and blood products |
| US13/344,166 | 2012-01-05 | ||
| PCT/US2012/020429 WO2012094565A1 (en) | 2011-01-06 | 2012-01-06 | Polymeric sorbent for removal of impurities from whole blood and blood products |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014502971A JP2014502971A (ja) | 2014-02-06 |
| JP2014502971A5 true JP2014502971A5 (enExample) | 2015-02-19 |
| JP5946469B2 JP5946469B2 (ja) | 2016-07-06 |
Family
ID=46457720
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013548563A Active JP5946469B2 (ja) | 2011-01-06 | 2012-01-06 | 全血および血液製剤からの不純物の除去のためのポリマー性収着剤 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US10064406B2 (enExample) |
| EP (1) | EP2665358B1 (enExample) |
| JP (1) | JP5946469B2 (enExample) |
| CN (2) | CN109847403A (enExample) |
| AU (1) | AU2012204271B2 (enExample) |
| CA (1) | CA2823953C (enExample) |
| ES (1) | ES2690970T3 (enExample) |
| WO (1) | WO2012094565A1 (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2552459B1 (en) | 2010-04-01 | 2018-07-18 | Cytosorbents Corporation | Method of treating inflammation |
| US20130323319A1 (en) | 2010-11-12 | 2013-12-05 | Getts Consulting And Project Management | Modified immune-modulating particles |
| CN103826451B (zh) * | 2011-08-12 | 2016-08-17 | 西托索尔本茨公司 | 用于从全血和血液制品中除去杂质的聚合物吸着剂 |
| EP2731425B1 (en) | 2011-09-19 | 2018-04-11 | Fenwal, Inc. | Red blood cell products and the storage of red blood cells in containers free of phthalate plasticizer |
| KR20210096312A (ko) | 2012-06-21 | 2021-08-04 | 노쓰웨스턴유니버시티 | 펩티드 접합된 입자 |
| ES2996347T3 (en) * | 2012-06-29 | 2025-02-12 | Cytosorbents Corp | Biocompatible sorbent |
| CN105263476A (zh) | 2013-03-13 | 2016-01-20 | 库尔制药开发公司 | 用于治疗炎症的免疫修饰性颗粒 |
| US10398625B2 (en) | 2013-03-13 | 2019-09-03 | Fenwal, Inc. | Medical containers with terephthalate plasticizer for storing red blood cell products |
| EP2981308B1 (en) | 2013-04-01 | 2020-02-05 | Cytosorbents Corporation | Hemocompatibility modifiers for cross-linked polymeric material |
| CN103230781A (zh) * | 2013-05-03 | 2013-08-07 | 重庆大学 | 一种用于血液净化法去除内毒素的肝素-苯丙氨酸吸附材料 |
| IL318076A (en) | 2013-08-13 | 2025-02-01 | Univ Northwestern | Peptide-conjugated particles |
| JP6621414B2 (ja) * | 2014-01-30 | 2019-12-18 | フレゼニウス・ヘモケア・イタリア・ソシエタ・ア・レスポンサビリタ・リミタータＦＲＥＳＥＮＩＵＳ ＨＥＭＯＣＡＲＥ ＩＴＡＬＩＡ Ｓ．ｒ．ｌ． | 濾過装置 |
| KR102554521B1 (ko) | 2014-02-20 | 2023-07-11 | 프레제니우스 카비 도이치란트 게엠베하 | 적혈구 제품, 혈장 및 혈소판의 보관을 위한 비-ｄｅｈｐ 가소제를 갖는 의료용 컨테이너 및 시스템 구성요소 |
| JP2017525489A (ja) | 2014-08-26 | 2017-09-07 | スリーエム イノベイティブ プロパティズ カンパニー | 炎症性メディエーター並びに顆粒球及び単球を血液から除去するためのシステム |
| US9931357B2 (en) * | 2014-10-02 | 2018-04-03 | Cytosorbents Corporation | Use of gastrointestinally administered porous enteron sorbent polymers to prevent or treat radiation induced mucositis, esophagitis, enteritis, colitis, and gastrointestinal acute radiation syndrome |
| US9522971B2 (en) * | 2014-12-31 | 2016-12-20 | Chung Yuan Christian University | Amine modifying material and application thereof |
| RU2619864C2 (ru) * | 2015-06-30 | 2017-05-18 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Псковский государственный университет" | Способ получения полимерного гемосорбента |
| WO2017070415A1 (en) | 2015-10-22 | 2017-04-27 | Cytosorbents Corporation | Multi-functional hemocompatible porous polymer bead sorbent for removing protein based toxins an potassium from biological fluids |
| CN105749886A (zh) * | 2016-04-08 | 2016-07-13 | 华南理工大学 | 血液灌流器医用高分子微球吸附剂及其制备方法 |
| CN105959752A (zh) * | 2016-04-29 | 2016-09-21 | 镇江惠通电子有限公司 | 终端与遥控终端的适配方法、装置及遥控终端 |
| US11065600B2 (en) * | 2016-05-26 | 2021-07-20 | Cytosorbents Corporation | Use of a hemocompatible porous polymer bead sorbent for removal of endotoxemia-inducing molecules |
| JP7011833B2 (ja) * | 2016-05-26 | 2022-02-10 | ドレクセル ユニバーシティ | 血液からサイトカインを吸着するための開曲面グラファイト材料 |
| CN106334540B (zh) * | 2016-10-09 | 2018-07-31 | 南开大学 | 一种用于血液或血浆灌流去除内毒素的吸附剂及其制备方法 |
| CN107126936B (zh) * | 2017-04-17 | 2020-07-17 | 天津大学 | 一种带有包埋材料的血液净化吸附剂及制备方法 |
| KR20200010418A (ko) * | 2017-05-23 | 2020-01-30 | 사이토솔벤츠 코포레이션 | 외상성 뇌 손상을 치료하는 방법 |
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