JP5946469B2 - 全血および血液製剤からの不純物の除去のためのポリマー性収着剤 - Google Patents

全血および血液製剤からの不純物の除去のためのポリマー性収着剤 Download PDF

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JP5946469B2
JP5946469B2 JP2013548563A JP2013548563A JP5946469B2 JP 5946469 B2 JP5946469 B2 JP 5946469B2 JP 2013548563 A JP2013548563 A JP 2013548563A JP 2013548563 A JP2013548563 A JP 2013548563A JP 5946469 B2 JP5946469 B2 JP 5946469B2
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methacrylate
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JP2014502971A5 (enExample
JP2014502971A (ja
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チャン，フィリップ・ピー
カポニ，ヴィンセント・ジェイ
ゴロビシュ，トーマス・ディー
アリ，フマイラ・ベガム
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サイトソーベンツ・コーポレーション
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/14—Mechanical aspects of preservation; Apparatus or containers therefor
    • A01N1/146—Non-refrigerated containers specially adapted for transporting or storing living parts whilst preserving
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/16—Physical preservation processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/26—Synthetic macromolecular compounds
    • B01J20/265—Synthetic macromolecular compounds modified or post-treated polymers
    • B01J20/267—Cross-linked polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28002—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their physical properties
    • B01J20/28004—Sorbent size or size distribution, e.g. particle size
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28054—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their surface properties or porosity
    • B01J20/28069—Pore volume, e.g. total pore volume, mesopore volume, micropore volume
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28054—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their surface properties or porosity
    • B01J20/28078—Pore diameter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3206—Organic carriers, supports or substrates
    • B01J20/3208—Polymeric carriers, supports or substrates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3268—Macromolecular compounds
    • B01J20/327—Polymers obtained by reactions involving only carbon to carbon unsaturated bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3268—Macromolecular compounds
    • B01J20/3272—Polymers obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3268—Macromolecular compounds
    • B01J20/328—Polymers on the carrier being further modified
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T29/00—Metal working
    • Y10T29/49—Method of mechanical manufacture
    • Y10T29/49826—Assembling or joining
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Environmental Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Dentistry (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • External Artificial Organs (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
JP2013548563A 2011-01-06 2012-01-06 全血および血液製剤からの不純物の除去のためのポリマー性収着剤 Active JP5946469B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161430374P 2011-01-06 2011-01-06
US61/430,374 2011-01-06
US13/344,166 2012-01-05
US13/344,166 US10064406B2 (en) 2011-01-06 2012-01-05 Polymeric sorbent for removal of impurities from whole blood and blood products
PCT/US2012/020429 WO2012094565A1 (en) 2011-01-06 2012-01-06 Polymeric sorbent for removal of impurities from whole blood and blood products

Publications (3)

Publication Number Publication Date
JP2014502971A JP2014502971A (ja) 2014-02-06
JP2014502971A5 JP2014502971A5 (enExample) 2015-02-19
JP5946469B2 true JP5946469B2 (ja) 2016-07-06

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JP2013548563A Active JP5946469B2 (ja) 2011-01-06 2012-01-06 全血および血液製剤からの不純物の除去のためのポリマー性収着剤

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US (1) US10064406B2 (enExample)
EP (1) EP2665358B1 (enExample)
JP (1) JP5946469B2 (enExample)
CN (2) CN109847403A (enExample)
AU (1) AU2012204271B2 (enExample)
CA (1) CA2823953C (enExample)
ES (1) ES2690970T3 (enExample)
WO (1) WO2012094565A1 (enExample)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3384916A1 (en) 2010-04-01 2018-10-10 Cytosorbents Corporation Sorbent for treating inflammation
MX358598B (es) 2010-11-12 2018-08-27 Cour Pharmaceuticals Dev Company Partículas inmuno-moduladoras modificadas.
ES2806075T3 (es) * 2011-08-12 2021-02-16 Cytosorbents Corp Sorbente polimérico para la eliminación de impurezas de sangre completa y productos sanguíneos
US9993389B2 (en) 2011-09-19 2018-06-12 Fenwal, Inc. Red blood cell products and the storage of red blood cells in containers free of phthalate plasticizer
US10201596B2 (en) 2012-06-21 2019-02-12 Northwestern University Peptide conjugated particles for the treatment of allergy
EP2866854B1 (en) 2012-06-29 2020-08-05 Cytosorbents Corporation Polymers for use in methods
CN105263476A (zh) 2013-03-13 2016-01-20 库尔制药开发公司 用于治疗炎症的免疫修饰性颗粒
US10398625B2 (en) 2013-03-13 2019-09-03 Fenwal, Inc. Medical containers with terephthalate plasticizer for storing red blood cell products
CA2908202A1 (en) * 2013-04-01 2014-10-09 Cytosorbents Corporation Hemocompatibility modifiers for cross-linked polymeric material
CN103230781A (zh) * 2013-05-03 2013-08-07 重庆大学 一种用于血液净化法去除内毒素的肝素-苯丙氨酸吸附材料
ME03590B (me) 2013-08-13 2020-07-20 Univ Northwestern Čestice konjugovane peptidom
WO2015113699A1 (en) * 2014-01-30 2015-08-06 Fresenius Hemocare Italia Srl Filtering device
US11160728B2 (en) 2014-02-20 2021-11-02 Fresenius Kabi Deutschland Gmbh Medical containers and system components with non-DEHP plasticizers for storing red blood cell products, plasma and platelets
CN106659834B (zh) 2014-08-26 2019-06-18 3M创新有限公司 用于去除血液中的促炎介质以及粒细胞和单核细胞的系统
JP6865679B2 (ja) * 2014-10-02 2021-04-28 サイトソーベンツ・コーポレーション 放射線で誘発された粘膜炎、食道炎、小腸炎、大腸炎、及び胃腸管急性放射線症候群を予防又は治療するための胃腸管投与多孔質消化管吸着剤ポリマーの使用
US9522971B2 (en) * 2014-12-31 2016-12-20 Chung Yuan Christian University Amine modifying material and application thereof
RU2619864C2 (ru) * 2015-06-30 2017-05-18 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Псковский государственный университет" Способ получения полимерного гемосорбента
CA3001698C (en) 2015-10-22 2025-01-07 Cytosorbents Corporation Sorbant in the form of porous, blood-compatible polymer beads, multifunctional for the elimination of protein-based toxins and potassium from biological fluids
CN105749886A (zh) * 2016-04-08 2016-07-13 华南理工大学 血液灌流器医用高分子微球吸附剂及其制备方法
CN105959752A (zh) * 2016-04-29 2016-09-21 镇江惠通电子有限公司 终端与遥控终端的适配方法、装置及遥控终端
JP7011833B2 (ja) * 2016-05-26 2022-02-10 ドレクセル ユニバーシティ 血液からサイトカインを吸着するための開曲面グラファイト材料
JP7033083B2 (ja) 2016-05-26 2022-03-09 サイトソーベンツ・コーポレーション 内毒素血症誘発分子を除去するための血液適合性多孔質ポリマービーズ収着材の使用
CN106334540B (zh) * 2016-10-09 2018-07-31 南开大学 一种用于血液或血浆灌流去除内毒素的吸附剂及其制备方法
CN107126936B (zh) * 2017-04-17 2020-07-17 天津大学 一种带有包埋材料的血液净化吸附剂及制备方法
RU2653125C1 (ru) * 2017-05-23 2018-05-07 Акционерное общество "ПЕРСПЕКТИВНЫЕ МЕДИЦИНСКИЕ ТЕХНОЛОГИИ" Полимерный сорбент, способ его получения и использования
KR20200010418A (ko) * 2017-05-23 2020-01-30 사이토솔벤츠 코포레이션 외상성 뇌 손상을 치료하는 방법
CN108608088B (zh) * 2018-07-13 2024-06-21 广西广协智能科技有限公司 一种冷藏回温锡膏柜
CN110237569A (zh) * 2019-07-10 2019-09-17 嘉兴市北加州电子科技有限责任公司 一种液相分离装置及应用
CA3179746A1 (en) * 2020-04-07 2021-10-14 Cytosorbents Corporation Blood and toxin filter device and use of same
CN111811996B (zh) * 2020-05-29 2022-10-04 深圳市帝迈生物技术有限公司 白细胞分类试剂盒及其制备方法、染料废液处理方法
CN113926010B (zh) * 2021-10-11 2023-08-29 山东威高血液净化制品股份有限公司 一种用于中空纤维血液净化装置体外测试的全血模拟液
CN114073865B (zh) * 2022-01-17 2022-11-25 深圳市达科为生物工程有限公司 去除血清中外泌体的方法及过滤装置
CN114950383B (zh) * 2022-04-08 2024-02-06 淄博康贝医疗器械有限公司 血液净化用细胞因子吸附剂及制备方法
CN117696017B (zh) * 2024-02-05 2024-05-07 四川大学华西医院 一种血液净化吸附改性材料及其制备方法

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4064042A (en) * 1975-02-18 1977-12-20 Rohm And Haas Company Purification of blood using partially pyrolyzed polymer particles
US4272894A (en) * 1979-03-21 1981-06-16 Salviati Impianti S.P.A. Drying step in a method of producing ceramic articles
DE2929959A1 (de) * 1979-07-24 1981-02-19 Hoechst Ag Thermoplastische kunststoffmasse
JPS58170717A (ja) * 1982-03-31 1983-10-07 Teiji Tsuruta Ｂ細胞の分離材および分離器ならびに分離方法
NL8301035A (nl) * 1983-03-23 1984-10-16 Organon Teknika Bv Macromoleculair materiaal met carbonylgroepen geschikt als sorbent voor stikstofverbindingen.
JPS6361007A (ja) * 1986-08-30 1988-03-17 Res Dev Corp Of Japan 金属錯体尿素分解樹脂及び尿素分解剤
JP2732252B2 (ja) * 1987-12-07 1998-03-25 株式会社ジェイ・エム・エス ヘモグロビン選択吸着剤
JPH01189346A (ja) 1988-01-22 1989-07-28 Tokyo Organ Chem Ind Ltd β↓２−ミクログロブリン吸着体
JPH01200918A (ja) * 1988-02-06 1989-08-14 Nagaharu Kawamoto 発泡樹脂による断熱層形成用型枠並びに断熱層形成方法
JP3208132B2 (ja) * 1990-11-30 2001-09-10 テルモ株式会社 血液成分分離方法
JP2726170B2 (ja) * 1991-05-09 1998-03-11 帝人株式会社 変性セルロース系ポリマー、血液処理器及びその製造方法
US5211850A (en) * 1991-07-26 1993-05-18 Research Medical, Inc. Plasma filter sorbent system for removal of components from blood
JPH0558707A (ja) 1991-09-06 1993-03-09 Art Ceramic Kk 廃棄物を利用した人工石又はタイルの製造法
JP2822718B2 (ja) 1991-09-26 1998-11-11 松下電器産業株式会社 データ処理装置及びデータ処理方法
US5217743A (en) * 1992-02-07 1993-06-08 Paradigm Biotechnologies Partnership Biomaterials of enhanced biocompatibility
JP3246681B2 (ja) 1992-10-16 2002-01-15 旭メディカル株式会社 トランスサイレチン吸着剤
KR100220927B1 (ko) 1995-12-26 1999-09-15 마모루 우메가에 백혈구 제거 필터재
JP3313572B2 (ja) 1996-04-03 2002-08-12 ヘモネティクス・コーポレーション 血液処理用遠心分離器ボウル
US20010018179A1 (en) 1998-01-06 2001-08-30 Derek J. Hei Batch devices for the reduction of compounds from biological compositions containing cells and methods of use
US6416487B1 (en) 1997-07-30 2002-07-09 Renal Tech International Llc Method of removing beta-2 microglobulin from blood
EP1044066A1 (en) * 1998-01-06 2000-10-18 Cerus Corporation Batch devices for the reduction of compounds from biological compositions containing cells and methods of use
JPH11290662A (ja) 1998-04-14 1999-10-26 Nof Corp 中空糸膜及びその製造方法
ATE464947T1 (de) * 1999-01-22 2010-05-15 Dow Global Technologies Inc Oberflächenverändertes divinylbenzenharz mit hämokompatibler beschichtung
EP1148063A1 (de) * 2000-04-18 2001-10-24 Octapharma AG Haemostatisch aktives vWF enthaltendes Präparat und Verfahren zu seiner Herstellung
EP1345666A1 (en) * 2000-12-29 2003-09-24 Upfront Chromatography A/S Extracorporeal capturing of specific bio-macromolecular entities from extracellular body fluids
ATE494053T1 (de) * 2001-01-29 2011-01-15 Asahi Kasei Medical Co Ltd Filter zur behandlung von blut und verfahren zur herstellung desselben
US20020197252A1 (en) 2001-04-10 2002-12-26 Renal Tech International Selective adsorption devices and systems
AU2003213758A1 (en) 2002-03-14 2003-09-29 Fenwal, Inc. Compound removal device
DE50310322D1 (de) 2002-05-09 2008-09-25 Hemoteq Ag Hemokompatibel beschichtete medizinprodukte, deren herstellung und verwendung
US7255895B2 (en) * 2003-01-21 2007-08-14 Bioarray Solutions, Ltd. Method for controlling solute loading of polymer microparticles
JP5391520B2 (ja) 2006-02-21 2014-01-15 東レ株式会社 改質基材の製造方法
JP5027591B2 (ja) 2006-08-18 2012-09-19 株式会社カネカ 架橋ポリマー粒子およびその製法
US8211310B2 (en) * 2006-11-20 2012-07-03 Cytosorbents, Inc. Size-selective polymer system
US7875182B2 (en) 2006-11-20 2011-01-25 Cytosorbents, Inc. Size-selective hemoperfusion polymeric adsorbents
JP2010512939A (ja) * 2006-12-21 2010-04-30 ネーデルランド オルガニサティ フォール トウゲパストナチュールウェテンスカッペリューク オンデルツォイック ティーエヌオー 血液から毒性物質を除去するための装置
CN100469692C (zh) * 2006-12-29 2009-03-18 上海师范大学 含氮有序介孔碳及其合成方法
CN101910268B (zh) 2007-11-09 2014-07-30 3M创新有限公司 多孔聚合物树脂
JP2009125265A (ja) 2007-11-22 2009-06-11 Kaneka Corp サイトカイン吸着材
JP2009165667A (ja) 2008-01-16 2009-07-30 Asahi Kasei Medical Co Ltd プリオン除去機能を有するフィルター
JP2009178523A (ja) * 2008-02-01 2009-08-13 Kaneka Corp 可溶性腫瘍壊死因子受容体の吸着材、吸着方法および吸着装置
CN101279242A (zh) 2008-05-20 2008-10-08 大连理工大学 用于抗体清除的血液净化吸附剂
CA2729340C (en) 2008-06-26 2017-07-11 Cytosorbents, Inc. Removal of myoglobin from blood and/or physiological fluids
JP5349873B2 (ja) 2008-09-04 2013-11-20 大阪有機化学工業株式会社 医療用材料
US20100210989A1 (en) * 2008-12-23 2010-08-19 Janet Lesley Macpherson Processing blood
JP5341559B2 (ja) 2009-03-03 2013-11-13 和雄 寺本 多孔性吸着材
EA201171195A8 (ru) * 2009-03-30 2014-08-29 Серулин Фарма Инк. Конъюгаты, частицы, композиции "полимер-агент" и способы их применения
JP6126167B2 (ja) 2015-07-02 2017-05-10 日立マクセル株式会社 デジタルコンテンツ受信装置、および、デジタルコンテンツ受信方法

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US20130011824A1 (en) 2013-01-10
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US10064406B2 (en) 2018-09-04
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