JP2014502971A5 - - Google Patents
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- JP2014502971A5 JP2014502971A5 JP2013548563A JP2013548563A JP2014502971A5 JP 2014502971 A5 JP2014502971 A5 JP 2014502971A5 JP 2013548563 A JP2013548563 A JP 2013548563A JP 2013548563 A JP2013548563 A JP 2013548563A JP 2014502971 A5 JP2014502971 A5 JP 2014502971A5
- Authority
- JP
- Japan
- Prior art keywords
- blood
- poly
- sorbent
- polymer
- acrylate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000008280 blood Substances 0.000 claims description 96
- 210000004369 blood Anatomy 0.000 claims description 96
- 239000002594 sorbent Substances 0.000 claims description 36
- 239000010836 blood and blood product Substances 0.000 claims description 27
- -1 polyethylene propylene Polymers 0.000 claims description 5
- RCRCTBLIHCHWDZ-UHFFFAOYSA-N 2-Arachidonoyl Glycerol Chemical compound CCCCCC=CCC=CCC=CCC=CCCCC(=O)OC(CO)CO RCRCTBLIHCHWDZ-UHFFFAOYSA-N 0.000 claims description 4
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 claims description 4
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 claims description 4
- 239000012528 membrane Substances 0.000 claims description 4
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 claims description 4
- 108090000288 Glycoproteins Proteins 0.000 claims description 3
- 102000003886 Glycoproteins Human genes 0.000 claims description 3
- 102000029797 Prion Human genes 0.000 claims description 3
- 108091000054 Prion Proteins 0.000 claims description 3
- 229940079593 drug Drugs 0.000 claims description 3
- 239000003814 drug Substances 0.000 claims description 3
- 150000002632 lipids Chemical class 0.000 claims description 3
- 239000003053 toxin Substances 0.000 claims description 3
- 231100000765 toxin Toxicity 0.000 claims description 3
- 108700012359 toxins Proteins 0.000 claims description 3
- 101800004538 Bradykinin Proteins 0.000 claims description 2
- 108010029697 CD40 Ligand Proteins 0.000 claims description 2
- 102100032937 CD40 ligand Human genes 0.000 claims description 2
- 108010067225 Cell Adhesion Molecules Proteins 0.000 claims description 2
- 102000016289 Cell Adhesion Molecules Human genes 0.000 claims description 2
- 102000019034 Chemokines Human genes 0.000 claims description 2
- 108010012236 Chemokines Proteins 0.000 claims description 2
- 102000004127 Cytokines Human genes 0.000 claims description 2
- 108090000695 Cytokines Proteins 0.000 claims description 2
- QXZGBUJJYSLZLT-UHFFFAOYSA-N H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH Natural products NC(N)=NCCCC(N)C(=O)N1CCCC1C(=O)N1C(C(=O)NCC(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CO)C(=O)N2C(CCC2)C(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CCCN=C(N)N)C(O)=O)CCC1 QXZGBUJJYSLZLT-UHFFFAOYSA-N 0.000 claims description 2
- 102000001554 Hemoglobins Human genes 0.000 claims description 2
- 108010054147 Hemoglobins Proteins 0.000 claims description 2
- 102000014150 Interferons Human genes 0.000 claims description 2
- 108010050904 Interferons Proteins 0.000 claims description 2
- 102100035792 Kininogen-1 Human genes 0.000 claims description 2
- 108010077861 Kininogens Proteins 0.000 claims description 2
- 102000010631 Kininogens Human genes 0.000 claims description 2
- 108010093008 Kinins Proteins 0.000 claims description 2
- 102000002397 Kinins Human genes 0.000 claims description 2
- 108010050619 Monokines Proteins 0.000 claims description 2
- 102000013967 Monokines Human genes 0.000 claims description 2
- 102000035195 Peptidases Human genes 0.000 claims description 2
- 108091005804 Peptidases Proteins 0.000 claims description 2
- 239000004365 Protease Substances 0.000 claims description 2
- LGEQQWMQCRIYKG-DOFZRALJSA-N anandamide Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)NCCO LGEQQWMQCRIYKG-DOFZRALJSA-N 0.000 claims description 2
- 239000000427 antigen Substances 0.000 claims description 2
- 108091007433 antigens Proteins 0.000 claims description 2
- 102000036639 antigens Human genes 0.000 claims description 2
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical class CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 claims description 2
- LGEQQWMQCRIYKG-UHFFFAOYSA-N arachidonic acid ethanolamide Natural products CCCCCC=CCC=CCC=CCC=CCCCC(=O)NCCO LGEQQWMQCRIYKG-UHFFFAOYSA-N 0.000 claims description 2
- 230000000975 bioactive effect Effects 0.000 claims description 2
- QXZGBUJJYSLZLT-FDISYFBBSA-N bradykinin Chemical compound NC(=N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(=O)NCC(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CO)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)CCC1 QXZGBUJJYSLZLT-FDISYFBBSA-N 0.000 claims description 2
- 210000003850 cellular structure Anatomy 0.000 claims description 2
- 230000000295 complement effect Effects 0.000 claims description 2
- 239000002158 endotoxin Substances 0.000 claims description 2
- 229960001340 histamine Drugs 0.000 claims description 2
- 239000005550 inflammation mediator Substances 0.000 claims description 2
- 229940047124 interferons Drugs 0.000 claims description 2
- 150000002617 leukotrienes Chemical class 0.000 claims description 2
- 230000002107 myocardial effect Effects 0.000 claims description 2
- 229940094443 oxytocics prostaglandins Drugs 0.000 claims description 2
- 150000003815 prostacyclins Chemical class 0.000 claims description 2
- 150000003180 prostaglandins Chemical class 0.000 claims description 2
- FNKQXYHWGSIFBK-RPDRRWSUSA-N sapropterin Chemical compound N1=C(N)NC(=O)C2=C1NC[C@H]([C@@H](O)[C@@H](O)C)N2 FNKQXYHWGSIFBK-RPDRRWSUSA-N 0.000 claims description 2
- 229960004617 sapropterin Drugs 0.000 claims description 2
- 229940076279 serotonin Drugs 0.000 claims description 2
- 231100000617 superantigen Toxicity 0.000 claims description 2
- 150000003595 thromboxanes Chemical class 0.000 claims description 2
- 239000000463 material Substances 0.000 claims 34
- 238000000034 method Methods 0.000 claims 34
- 239000011148 porous material Substances 0.000 claims 34
- 229920000642 polymer Polymers 0.000 claims 32
- 238000000746 purification Methods 0.000 claims 27
- 229940125691 blood product Drugs 0.000 claims 22
- 239000012530 fluid Substances 0.000 claims 19
- 239000000203 mixture Substances 0.000 claims 10
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 8
- SOGAXMICEFXMKE-UHFFFAOYSA-N Butylmethacrylate Chemical compound CCCCOC(=O)C(C)=C SOGAXMICEFXMKE-UHFFFAOYSA-N 0.000 claims 6
- BAPJBEWLBFYGME-UHFFFAOYSA-N Methyl acrylate Chemical compound COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 claims 6
- 239000011324 bead Substances 0.000 claims 6
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 5
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 claims 5
- 229920000669 heparin Polymers 0.000 claims 5
- 229960002897 heparin Drugs 0.000 claims 5
- 239000002245 particle Substances 0.000 claims 5
- JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 claims 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 4
- PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 239000007787 solid Substances 0.000 claims 4
- MHHJQVRGRPHIMR-UHFFFAOYSA-N 1-phenylprop-2-en-1-ol Chemical compound C=CC(O)C1=CC=CC=C1 MHHJQVRGRPHIMR-UHFFFAOYSA-N 0.000 claims 3
- IGGDKDTUCAWDAN-UHFFFAOYSA-N 1-vinylnaphthalene Chemical compound C1=CC=C2C(C=C)=CC=CC2=C1 IGGDKDTUCAWDAN-UHFFFAOYSA-N 0.000 claims 3
- SJIXRGNQPBQWMK-UHFFFAOYSA-N 2-(diethylamino)ethyl 2-methylprop-2-enoate Chemical compound CCN(CC)CCOC(=O)C(C)=C SJIXRGNQPBQWMK-UHFFFAOYSA-N 0.000 claims 3
- QHVBLSNVXDSMEB-UHFFFAOYSA-N 2-(diethylamino)ethyl prop-2-enoate Chemical compound CCN(CC)CCOC(=O)C=C QHVBLSNVXDSMEB-UHFFFAOYSA-N 0.000 claims 3
- DPBJAVGHACCNRL-UHFFFAOYSA-N 2-(dimethylamino)ethyl prop-2-enoate Chemical compound CN(C)CCOC(=O)C=C DPBJAVGHACCNRL-UHFFFAOYSA-N 0.000 claims 3
- GNSFRPWPOGYVLO-UHFFFAOYSA-N 3-hydroxypropyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCCO GNSFRPWPOGYVLO-UHFFFAOYSA-N 0.000 claims 3
- NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical compound C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 claims 3
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims 3
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims 3
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 3
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 claims 3
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 3
- 229920001311 Poly(hydroxyethyl acrylate) Polymers 0.000 claims 3
- 229920002845 Poly(methacrylic acid) Polymers 0.000 claims 3
- 239000002202 Polyethylene glycol Substances 0.000 claims 3
- 229920002125 Sokalan® Polymers 0.000 claims 3
- MPMBRWOOISTHJV-UHFFFAOYSA-N but-1-enylbenzene Chemical compound CCC=CC1=CC=CC=C1 MPMBRWOOISTHJV-UHFFFAOYSA-N 0.000 claims 3
- CQEYYJKEWSMYFG-UHFFFAOYSA-N butyl acrylate Chemical compound CCCCOC(=O)C=C CQEYYJKEWSMYFG-UHFFFAOYSA-N 0.000 claims 3
- 238000006243 chemical reaction Methods 0.000 claims 3
- 229920001577 copolymer Polymers 0.000 claims 3
- 239000003431 cross linking reagent Substances 0.000 claims 3
- ZNAOFAIBVOMLPV-UHFFFAOYSA-N hexadecyl 2-methylprop-2-enoate Chemical compound CCCCCCCCCCCCCCCCOC(=O)C(C)=C ZNAOFAIBVOMLPV-UHFFFAOYSA-N 0.000 claims 3
- PZDUWXKXFAIFOR-UHFFFAOYSA-N hexadecyl prop-2-enoate Chemical compound CCCCCCCCCCCCCCCCOC(=O)C=C PZDUWXKXFAIFOR-UHFFFAOYSA-N 0.000 claims 3
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims 3
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 3
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 3
- ZQXSMRAEXCEDJD-UHFFFAOYSA-N n-ethenylformamide Chemical compound C=CNC=O ZQXSMRAEXCEDJD-UHFFFAOYSA-N 0.000 claims 3
- NZIDBRBFGPQCRY-UHFFFAOYSA-N octyl 2-methylprop-2-enoate Chemical compound CCCCCCCCOC(=O)C(C)=C NZIDBRBFGPQCRY-UHFFFAOYSA-N 0.000 claims 3
- 229940065472 octyl acrylate Drugs 0.000 claims 3
- ANISOHQJBAQUQP-UHFFFAOYSA-N octyl prop-2-enoate Chemical compound CCCCCCCCOC(=O)C=C ANISOHQJBAQUQP-UHFFFAOYSA-N 0.000 claims 3
- 229920001223 polyethylene glycol Polymers 0.000 claims 3
- 229920002338 polyhydroxyethylmethacrylate Polymers 0.000 claims 3
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 3
- 239000000843 powder Substances 0.000 claims 3
- HJWLCRVIBGQPNF-UHFFFAOYSA-N prop-2-enylbenzene Chemical compound C=CCC1=CC=CC=C1 HJWLCRVIBGQPNF-UHFFFAOYSA-N 0.000 claims 3
- JKNCOURZONDCGV-UHFFFAOYSA-N 2-(dimethylamino)ethyl 2-methylprop-2-enoate Chemical compound CN(C)CCOC(=O)C(C)=C JKNCOURZONDCGV-UHFFFAOYSA-N 0.000 claims 2
- QZPSOSOOLFHYRR-UHFFFAOYSA-N 3-hydroxypropyl prop-2-enoate Chemical compound OCCCOC(=O)C=C QZPSOSOOLFHYRR-UHFFFAOYSA-N 0.000 claims 2
- 239000004793 Polystyrene Substances 0.000 claims 2
- 239000012620 biological material Substances 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 239000002131 composite material Substances 0.000 claims 2
- 239000000835 fiber Substances 0.000 claims 2
- RRAMGCGOFNQTLD-UHFFFAOYSA-N hexamethylene diisocyanate Chemical compound O=C=NCCCCCCN=C=O RRAMGCGOFNQTLD-UHFFFAOYSA-N 0.000 claims 2
- 239000000367 immunologic factor Substances 0.000 claims 2
- 230000000968 intestinal effect Effects 0.000 claims 2
- 239000013335 mesoporous material Substances 0.000 claims 2
- 239000002184 metal Substances 0.000 claims 2
- 239000000178 monomer Substances 0.000 claims 2
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 claims 2
- 239000002952 polymeric resin Substances 0.000 claims 2
- 229920000098 polyolefin Polymers 0.000 claims 2
- 229920002223 polystyrene Polymers 0.000 claims 2
- 229920002635 polyurethane Polymers 0.000 claims 2
- 239000004814 polyurethane Substances 0.000 claims 2
- 239000002296 pyrolytic carbon Substances 0.000 claims 2
- 239000000377 silicon dioxide Substances 0.000 claims 2
- 239000002002 slurry Substances 0.000 claims 2
- 238000001179 sorption measurement Methods 0.000 claims 2
- 239000000725 suspension Substances 0.000 claims 2
- 229920003002 synthetic resin Polymers 0.000 claims 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical class OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims 1
- 206010018910 Haemolysis Diseases 0.000 claims 1
- 206010067122 Haemolytic transfusion reaction Diseases 0.000 claims 1
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 claims 1
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical class CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims 1
- 229920001054 Poly(ethylene‐co‐vinyl acetate) Polymers 0.000 claims 1
- 208000003441 Transfusion reaction Diseases 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 239000000853 adhesive Substances 0.000 claims 1
- 230000001070 adhesive effect Effects 0.000 claims 1
- 230000004888 barrier function Effects 0.000 claims 1
- 229920000249 biocompatible polymer Polymers 0.000 claims 1
- 230000015556 catabolic process Effects 0.000 claims 1
- 239000012611 container material Substances 0.000 claims 1
- 238000006731 degradation reaction Methods 0.000 claims 1
- 239000002270 dispersing agent Substances 0.000 claims 1
- 210000003743 erythrocyte Anatomy 0.000 claims 1
- SUPCQIBBMFXVTL-UHFFFAOYSA-N ethyl 2-methylprop-2-enoate Chemical compound CCOC(=O)C(C)=C SUPCQIBBMFXVTL-UHFFFAOYSA-N 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 238000003306 harvesting Methods 0.000 claims 1
- 230000008588 hemolysis Effects 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 125000005641 methacryl group Chemical group 0.000 claims 1
- 239000011859 microparticle Substances 0.000 claims 1
- 239000004014 plasticizer Substances 0.000 claims 1
- 239000004800 polyvinyl chloride Substances 0.000 claims 1
- PNXMTCDJUBJHQJ-UHFFFAOYSA-N propyl prop-2-enoate Chemical compound CCCOC(=O)C=C PNXMTCDJUBJHQJ-UHFFFAOYSA-N 0.000 claims 1
- 150000003254 radicals Chemical class 0.000 claims 1
- 125000003011 styrenyl group Chemical group [H]\C(*)=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- 239000002550 vasoactive agent Substances 0.000 claims 1
- 239000012190 activator Substances 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161430374P | 2011-01-06 | 2011-01-06 | |
| US61/430,374 | 2011-01-06 | ||
| US13/344,166 | 2012-01-05 | ||
| US13/344,166 US10064406B2 (en) | 2011-01-06 | 2012-01-05 | Polymeric sorbent for removal of impurities from whole blood and blood products |
| PCT/US2012/020429 WO2012094565A1 (en) | 2011-01-06 | 2012-01-06 | Polymeric sorbent for removal of impurities from whole blood and blood products |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014502971A JP2014502971A (ja) | 2014-02-06 |
| JP2014502971A5 true JP2014502971A5 (cg-RX-API-DMAC7.html) | 2015-02-19 |
| JP5946469B2 JP5946469B2 (ja) | 2016-07-06 |
Family
ID=46457720
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013548563A Active JP5946469B2 (ja) | 2011-01-06 | 2012-01-06 | 全血および血液製剤からの不純物の除去のためのポリマー性収着剤 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US10064406B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2665358B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5946469B2 (cg-RX-API-DMAC7.html) |
| CN (2) | CN103533830A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2012204271B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2823953C (cg-RX-API-DMAC7.html) |
| ES (1) | ES2690970T3 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2012094565A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2795177C (en) | 2010-04-01 | 2018-07-03 | Cytosorbents Corporation | Method of treating inflammation |
| JP5909745B2 (ja) | 2010-11-12 | 2016-04-27 | クール ファーマシューティカルズ ディベロップメント カンパニー | 炎症性疾患の治療薬、ならびにウイルスまたは細菌感染疾患の治療薬 |
| CA2844688C (en) * | 2011-08-12 | 2021-10-19 | Cytosorbents Corporation | Polymeric sorbent for removal of impurities from whole blood and blood products |
| US9993389B2 (en) | 2011-09-19 | 2018-06-12 | Fenwal, Inc. | Red blood cell products and the storage of red blood cells in containers free of phthalate plasticizer |
| BR112014032207B1 (pt) | 2012-06-21 | 2021-07-27 | Northwestern University | Composição compreendendo um antígeno acoplado a uma partícula transportadora e uso de um antígeno acoplado a uma partícula transportadora |
| ES2823582T3 (es) * | 2012-06-29 | 2021-05-07 | Cytosorbents Corp | Polímeros para su uso en métodos |
| IL303425A (en) | 2013-03-13 | 2023-08-01 | Cour Pharmaceuticals Dev Company | Secondary vaccine particles for the treatment of inflammation |
| US10398625B2 (en) | 2013-03-13 | 2019-09-03 | Fenwal, Inc. | Medical containers with terephthalate plasticizer for storing red blood cell products |
| WO2014165421A1 (en) | 2013-04-01 | 2014-10-09 | Cytosorbents Corporation | Hemocompatibility modifiers for cross-linked polymeric material |
| CN103230781A (zh) * | 2013-05-03 | 2013-08-07 | 重庆大学 | 一种用于血液净化法去除内毒素的肝素-苯丙氨酸吸附材料 |
| EP3033102B2 (en) | 2013-08-13 | 2023-12-20 | Northwestern University | Peptide conjugated particles |
| JP6621414B2 (ja) * | 2014-01-30 | 2019-12-18 | フレゼニウス・ヘモケア・イタリア・ソシエタ・ア・レスポンサビリタ・リミタータＦＲＥＳＥＮＩＵＳ ＨＥＭＯＣＡＲＥ ＩＴＡＬＩＡ Ｓ．ｒ．ｌ． | 濾過装置 |
| KR102554521B1 (ko) | 2014-02-20 | 2023-07-11 | 프레제니우스 카비 도이치란트 게엠베하 | 적혈구 제품, 혈장 및 혈소판의 보관을 위한 비-ｄｅｈｐ 가소제를 갖는 의료용 컨테이너 및 시스템 구성요소 |
| EP3185926B1 (de) | 2014-08-26 | 2018-11-28 | 3M Innovative Properties Company | System zur entfernung von proinflammatorischen mediatoren sowie von granulozyten und monozyten aus blut |
| WO2016054458A1 (en) * | 2014-10-02 | 2016-04-07 | Cytosorbents Corporation | Use of gastroinstestinally administered porous enteron sorbent polymers to prevent or treat radiation induced mucositis, esophagitis, enteritis, colitis, and gastrointestinal acute radiation syndrome |
| US9522971B2 (en) * | 2014-12-31 | 2016-12-20 | Chung Yuan Christian University | Amine modifying material and application thereof |
| RU2619864C2 (ru) * | 2015-06-30 | 2017-05-18 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Псковский государственный университет" | Способ получения полимерного гемосорбента |
| US11040061B2 (en) | 2015-10-22 | 2021-06-22 | Cytosorbents Corporation | Multi-functional hemocompatible porous polymer bead sorbent for removing protein based toxins and potassium from biological fluids |
| CN105749886A (zh) * | 2016-04-08 | 2016-07-13 | 华南理工大学 | 血液灌流器医用高分子微球吸附剂及其制备方法 |
| CN105959752A (zh) * | 2016-04-29 | 2016-09-21 | 镇江惠通电子有限公司 | 终端与遥控终端的适配方法、装置及遥控终端 |
| AU2017272021B2 (en) * | 2016-05-26 | 2021-09-02 | Cytosorbents Corporation | The use of a Hemocompatible porous polymer bead sorbent for removal of Endotoxemia-inducing molecules |
| CN109310810A (zh) * | 2016-05-26 | 2019-02-05 | 德雷塞尔大学 | 用于从血液吸附细胞因子的开放表面石墨材料 |
| CN106334540B (zh) * | 2016-10-09 | 2018-07-31 | 南开大学 | 一种用于血液或血浆灌流去除内毒素的吸附剂及其制备方法 |
| CN107126936B (zh) * | 2017-04-17 | 2020-07-17 | 天津大学 | 一种带有包埋材料的血液净化吸附剂及制备方法 |
| US12076474B2 (en) * | 2017-05-23 | 2024-09-03 | Cytosorbents, Inc. | Method of treating traumatic brain injury |
| RU2653125C1 (ru) * | 2017-05-23 | 2018-05-07 | Акционерное общество "ПЕРСПЕКТИВНЫЕ МЕДИЦИНСКИЕ ТЕХНОЛОГИИ" | Полимерный сорбент, способ его получения и использования |
| CN108608088B (zh) * | 2018-07-13 | 2024-06-21 | 广西广协智能科技有限公司 | 一种冷藏回温锡膏柜 |
| CN110237569A (zh) * | 2019-07-10 | 2019-09-17 | 嘉兴市北加州电子科技有限责任公司 | 一种液相分离装置及应用 |
| WO2021207338A1 (en) * | 2020-04-07 | 2021-10-14 | Cytosorbents Corporation | Blood and toxin filter device and use of same |
| CN111811996B (zh) * | 2020-05-29 | 2022-10-04 | 深圳市帝迈生物技术有限公司 | 白细胞分类试剂盒及其制备方法、染料废液处理方法 |
| CN113926010B (zh) * | 2021-10-11 | 2023-08-29 | 山东威高血液净化制品股份有限公司 | 一种用于中空纤维血液净化装置体外测试的全血模拟液 |
| CN114073865B (zh) * | 2022-01-17 | 2022-11-25 | 深圳市达科为生物工程有限公司 | 去除血清中外泌体的方法及过滤装置 |
| CN114950383B (zh) * | 2022-04-08 | 2024-02-06 | 淄博康贝医疗器械有限公司 | 血液净化用细胞因子吸附剂及制备方法 |
| CN117696017B (zh) * | 2024-02-05 | 2024-05-07 | 四川大学华西医院 | 一种血液净化吸附改性材料及其制备方法 |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4064042A (en) * | 1975-02-18 | 1977-12-20 | Rohm And Haas Company | Purification of blood using partially pyrolyzed polymer particles |
| US4272894A (en) * | 1979-03-21 | 1981-06-16 | Salviati Impianti S.P.A. | Drying step in a method of producing ceramic articles |
| DE2929959A1 (de) * | 1979-07-24 | 1981-02-19 | Hoechst Ag | Thermoplastische kunststoffmasse |
| JPS58170717A (ja) * | 1982-03-31 | 1983-10-07 | Teiji Tsuruta | Ｂ細胞の分離材および分離器ならびに分離方法 |
| NL8301035A (nl) | 1983-03-23 | 1984-10-16 | Organon Teknika Bv | Macromoleculair materiaal met carbonylgroepen geschikt als sorbent voor stikstofverbindingen. |
| JPS6361007A (ja) * | 1986-08-30 | 1988-03-17 | Res Dev Corp Of Japan | 金属錯体尿素分解樹脂及び尿素分解剤 |
| JP2732252B2 (ja) * | 1987-12-07 | 1998-03-25 | 株式会社ジェイ・エム・エス | ヘモグロビン選択吸着剤 |
| JPH01189346A (ja) | 1988-01-22 | 1989-07-28 | Tokyo Organ Chem Ind Ltd | β↓２−ミクログロブリン吸着体 |
| JPH01200918A (ja) * | 1988-02-06 | 1989-08-14 | Nagaharu Kawamoto | 発泡樹脂による断熱層形成用型枠並びに断熱層形成方法 |
| JP3208132B2 (ja) * | 1990-11-30 | 2001-09-10 | テルモ株式会社 | 血液成分分離方法 |
| JP2726170B2 (ja) * | 1991-05-09 | 1998-03-11 | 帝人株式会社 | 変性セルロース系ポリマー、血液処理器及びその製造方法 |
| US5211850A (en) * | 1991-07-26 | 1993-05-18 | Research Medical, Inc. | Plasma filter sorbent system for removal of components from blood |
| JPH0558707A (ja) | 1991-09-06 | 1993-03-09 | Art Ceramic Kk | 廃棄物を利用した人工石又はタイルの製造法 |
| JP2822718B2 (ja) | 1991-09-26 | 1998-11-11 | 松下電器産業株式会社 | データ処理装置及びデータ処理方法 |
| US5217743A (en) * | 1992-02-07 | 1993-06-08 | Paradigm Biotechnologies Partnership | Biomaterials of enhanced biocompatibility |
| JP3246681B2 (ja) | 1992-10-16 | 2002-01-15 | 旭メディカル株式会社 | トランスサイレチン吸着剤 |
| ES2202491T3 (es) | 1995-12-26 | 2004-04-01 | Asahi Medical Co., Ltd. | Material de filtracion para la eliminacion de leucocitos. |
| JP3313572B2 (ja) * | 1996-04-03 | 2002-08-12 | ヘモネティクス・コーポレーション | 血液処理用遠心分離器ボウル |
| US20010018179A1 (en) | 1998-01-06 | 2001-08-30 | Derek J. Hei | Batch devices for the reduction of compounds from biological compositions containing cells and methods of use |
| US6416487B1 (en) * | 1997-07-30 | 2002-07-09 | Renal Tech International Llc | Method of removing beta-2 microglobulin from blood |
| WO1999034914A1 (en) | 1998-01-06 | 1999-07-15 | Cerus Corporation | Batch devices for the reduction of compounds from biological compositions containing cells and methods of use |
| JPH11290662A (ja) | 1998-04-14 | 1999-10-26 | Nof Corp | 中空糸膜及びその製造方法 |
| WO2000043120A1 (en) | 1999-01-22 | 2000-07-27 | The Dow Chemical Company | Surface modified divinylbenzene resin having a hemocompatible coating |
| EP1148063A1 (de) * | 2000-04-18 | 2001-10-24 | Octapharma AG | Haemostatisch aktives vWF enthaltendes Präparat und Verfahren zu seiner Herstellung |
| JP2004516896A (ja) * | 2000-12-29 | 2004-06-10 | アップフロント・クロマトグラフィー・アー／エス | 細胞外体液からの特異的生体高分子物質の体外捕獲 |
| ATE494053T1 (de) * | 2001-01-29 | 2011-01-15 | Asahi Kasei Medical Co Ltd | Filter zur behandlung von blut und verfahren zur herstellung desselben |
| US20020197252A1 (en) * | 2001-04-10 | 2002-12-26 | Renal Tech International | Selective adsorption devices and systems |
| EP1487559A4 (en) | 2002-03-14 | 2008-12-24 | Fenwal Inc | DEVICE FOR EXTRACTING COMPOUNDS |
| MXPA04011111A (es) | 2002-05-09 | 2005-07-14 | Hemoteq Gmbh | Productos medicos que comprenden un revestimiento hemocompatible, produccion y uso de los mismos. |
| US7255895B2 (en) | 2003-01-21 | 2007-08-14 | Bioarray Solutions, Ltd. | Method for controlling solute loading of polymer microparticles |
| JP5391520B2 (ja) | 2006-02-21 | 2014-01-15 | 東レ株式会社 | 改質基材の製造方法 |
| JP5027591B2 (ja) | 2006-08-18 | 2012-09-19 | 株式会社カネカ | 架橋ポリマー粒子およびその製法 |
| US8211310B2 (en) * | 2006-11-20 | 2012-07-03 | Cytosorbents, Inc. | Size-selective polymer system |
| US7875182B2 (en) | 2006-11-20 | 2011-01-25 | Cytosorbents, Inc. | Size-selective hemoperfusion polymeric adsorbents |
| US9033908B2 (en) * | 2006-12-21 | 2015-05-19 | Nederlandse Organisatie Voor Toegepast—Natuurwetenschappelijk Onderzoek Tno | Device for the removal of toxic substances from blood |
| CN100469692C (zh) * | 2006-12-29 | 2009-03-18 | 上海师范大学 | 含氮有序介孔碳及其合成方法 |
| JP5426564B2 (ja) * | 2007-11-09 | 2014-02-26 | スリーエム イノベイティブ プロパティズ カンパニー | 多孔質高分子樹脂 |
| JP2009125265A (ja) | 2007-11-22 | 2009-06-11 | Kaneka Corp | サイトカイン吸着材 |
| JP2009165667A (ja) | 2008-01-16 | 2009-07-30 | Asahi Kasei Medical Co Ltd | プリオン除去機能を有するフィルター |
| JP2009178523A (ja) * | 2008-02-01 | 2009-08-13 | Kaneka Corp | 可溶性腫瘍壊死因子受容体の吸着材、吸着方法および吸着装置 |
| CN101279242A (zh) * | 2008-05-20 | 2008-10-08 | 大连理工大学 | 用于抗体清除的血液净化吸附剂 |
| US20110210074A1 (en) | 2008-06-26 | 2011-09-01 | Winchester James F | Removal of myoglobin from blood and/or physiological fluids |
| JP5349873B2 (ja) | 2008-09-04 | 2013-11-20 | 大阪有機化学工業株式会社 | 医療用材料 |
| US20100210989A1 (en) | 2008-12-23 | 2010-08-19 | Janet Lesley Macpherson | Processing blood |
| JP5341559B2 (ja) | 2009-03-03 | 2013-11-13 | 和雄 寺本 | 多孔性吸着材 |
| EA201171195A8 (ru) * | 2009-03-30 | 2014-08-29 | Серулин Фарма Инк. | Конъюгаты, частицы, композиции "полимер-агент" и способы их применения |
| JP6126167B2 (ja) | 2015-07-02 | 2017-05-10 | 日立マクセル株式会社 | デジタルコンテンツ受信装置、および、デジタルコンテンツ受信方法 |
-
2012
- 2012-01-05 US US13/344,166 patent/US10064406B2/en active Active
- 2012-01-06 CN CN201280004791.4A patent/CN103533830A/zh active Pending
- 2012-01-06 CN CN201811229100.6A patent/CN109847403A/zh active Pending
- 2012-01-06 CA CA2823953A patent/CA2823953C/en active Active
- 2012-01-06 JP JP2013548563A patent/JP5946469B2/ja active Active
- 2012-01-06 EP EP12732231.1A patent/EP2665358B1/en active Active
- 2012-01-06 WO PCT/US2012/020429 patent/WO2012094565A1/en not_active Ceased
- 2012-01-06 AU AU2012204271A patent/AU2012204271B2/en not_active Ceased
- 2012-01-06 ES ES12732231.1T patent/ES2690970T3/es active Active
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