JP2014502264A5 - - Google Patents
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- Publication number
- JP2014502264A5 JP2014502264A5 JP2013539912A JP2013539912A JP2014502264A5 JP 2014502264 A5 JP2014502264 A5 JP 2014502264A5 JP 2013539912 A JP2013539912 A JP 2013539912A JP 2013539912 A JP2013539912 A JP 2013539912A JP 2014502264 A5 JP2014502264 A5 JP 2014502264A5
- Authority
- JP
- Japan
- Prior art keywords
- ischemia
- reperfusion
- failure
- pharmaceutical composition
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 *N(*)*C(CCCC[C@]1SSCC1)=O Chemical compound *N(*)*C(CCCC[C@]1SSCC1)=O 0.000 description 3
- MWNSABYZRPRURL-SECBINFHSA-N OS(CCNC(CCCC[C@H]1SSCC1)=O)(=O)=O Chemical compound OS(CCNC(CCCC[C@H]1SSCC1)=O)(=O)=O MWNSABYZRPRURL-SECBINFHSA-N 0.000 description 3
- RIAHXAKSGTUVMS-YHMJZVADSA-N OC(CCC(C(O)=O)NC(CCCC[C@H]1SSCC1)=O)=O Chemical compound OC(CCC(C(O)=O)NC(CCCC[C@H]1SSCC1)=O)=O RIAHXAKSGTUVMS-YHMJZVADSA-N 0.000 description 1
- FJQBMUUPXJEBJH-OQFOIZHKSA-N OC(CCNC(CCC/C=C1\SSCC1)=O)=O Chemical compound OC(CCNC(CCC/C=C1\SSCC1)=O)=O FJQBMUUPXJEBJH-OQFOIZHKSA-N 0.000 description 1
- JXESCYLVMRTSPW-SECBINFHSA-N OC(CN(CC(O)=O)C(CCCC[C@H]1SSCC1)=O)=O Chemical compound OC(CN(CC(O)=O)C(CCCC[C@H]1SSCC1)=O)=O JXESCYLVMRTSPW-SECBINFHSA-N 0.000 description 1
- NEBJBHGIXSLSNP-CYBMUJFWSA-N OC(c(cc1)ccc1NC(CCCC[C@H]1SSCC1)=O)=O Chemical compound OC(c(cc1)ccc1NC(CCCC[C@H]1SSCC1)=O)=O NEBJBHGIXSLSNP-CYBMUJFWSA-N 0.000 description 1
- JAJCWADBXZGGSD-GFCCVEGCSA-N OS(c(cc1)ccc1NC(CCCC[C@H]1SSCC1)=O)(=O)=O Chemical compound OS(c(cc1)ccc1NC(CCCC[C@H]1SSCC1)=O)(=O)=O JAJCWADBXZGGSD-GFCCVEGCSA-N 0.000 description 1
- XJZPVXSJQIELFX-AAFJCEBUSA-N [O-][NH+](CCCCC[C@H]1SSCC1)C(Cc(cc1)ccc1O)C(O)=O Chemical compound [O-][NH+](CCCCC[C@H]1SSCC1)C(Cc(cc1)ccc1O)C(O)=O XJZPVXSJQIELFX-AAFJCEBUSA-N 0.000 description 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41524110P | 2010-11-18 | 2010-11-18 | |
| US41524010P | 2010-11-18 | 2010-11-18 | |
| US61/415,240 | 2010-11-18 | ||
| US61/415,241 | 2010-11-18 | ||
| US201161478310P | 2011-04-22 | 2011-04-22 | |
| US61/478,310 | 2011-04-22 | ||
| US201161500974P | 2011-06-24 | 2011-06-24 | |
| US61/500,974 | 2011-06-24 | ||
| PCT/US2011/060259 WO2012067947A1 (en) | 2010-11-18 | 2011-11-10 | Lipoyl compounds and their use for treating ischemic injury |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015232258A Division JP6280094B2 (ja) | 2010-11-18 | 2015-11-27 | リポイル化合物および虚血性傷害を治療するためのその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014502264A JP2014502264A (ja) | 2014-01-30 |
| JP2014502264A5 true JP2014502264A5 (https=) | 2014-12-25 |
Family
ID=45217651
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013539912A Pending JP2014502264A (ja) | 2010-11-18 | 2011-11-10 | リポイル化合物および虚血性傷害を治療するためのその使用 |
| JP2015232258A Expired - Fee Related JP6280094B2 (ja) | 2010-11-18 | 2015-11-27 | リポイル化合物および虚血性傷害を治療するためのその使用 |
| JP2017213078A Withdrawn JP2018016652A (ja) | 2010-11-18 | 2017-11-02 | リポイル化合物および虚血性傷害を治療するためのその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015232258A Expired - Fee Related JP6280094B2 (ja) | 2010-11-18 | 2015-11-27 | リポイル化合物および虚血性傷害を治療するためのその使用 |
| JP2017213078A Withdrawn JP2018016652A (ja) | 2010-11-18 | 2017-11-02 | リポイル化合物および虚血性傷害を治療するためのその使用 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US8815937B2 (https=) |
| EP (1) | EP2640423B1 (https=) |
| JP (3) | JP2014502264A (https=) |
| KR (1) | KR20140020840A (https=) |
| CN (1) | CN103561770B (https=) |
| AU (1) | AU2011329215C1 (https=) |
| BR (1) | BR112013012057B1 (https=) |
| CA (1) | CA2817362C (https=) |
| DK (1) | DK2640423T3 (https=) |
| ES (1) | ES2640474T3 (https=) |
| IL (1) | IL226258A (https=) |
| MX (1) | MX344933B (https=) |
| NZ (1) | NZ610378A (https=) |
| SG (1) | SG190794A1 (https=) |
| WO (1) | WO2012067947A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8541396B2 (en) | 2009-04-24 | 2013-09-24 | National University Of Singapore | Morpholin-4-ium 4 methoxyphenyl (morpholino) phosphinodithioate (GYY4137) as a novel vasodilator agent |
| US7928067B2 (en) | 2009-05-14 | 2011-04-19 | Ischemix Llc | Compositions and methods for treating ischemia and ischemia-reperfusion injury |
| DK2640423T3 (en) | 2010-11-18 | 2017-10-02 | Ischemix Llc | LIPOYL COMPOUNDS AND THEIR USE IN TREATMENT OF ISchemic DAMAGE |
| ITFI20120170A1 (it) * | 2012-08-28 | 2014-03-01 | Consorzio Interuniversitario Nazion Ale Per La Sci | Nuovi composti ad azione anti-allodinica ed anti-iperalgesica. |
| EP3110800A1 (en) * | 2014-02-27 | 2017-01-04 | Consorzio Interuniversitario Nazionale Per La Scienza E La Tecnologia Dei Materiali (INSTM) | Novel compounds having anti-allodynic and antihyperalgesic activity |
| WO2015174948A1 (en) | 2014-05-14 | 2015-11-19 | Ischemix, LLC | Formulations comprising lipoyl compounds |
| EP4018997A1 (en) * | 2016-03-14 | 2022-06-29 | NeoStrata Company, Inc. | N-lipoic -amino acid or peptide, derivatives and their uses |
| RU2657820C1 (ru) * | 2017-03-13 | 2018-06-15 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Волгоградский государственный медицинский университет" Министерства здравоохранения Российской Федерации ФГБОУ ВО ВолгГМУ МЗ РФ | 4-(4-Ацетоксибензоиламино)бутаноилглицин, обладающий церебропротекторным действием при ишемии головного мозга |
| AU2018258158A1 (en) | 2017-04-25 | 2019-11-21 | Ischemix Llc | Compositions and methods for treating traumatic brain injury |
| US20240124520A1 (en) * | 2019-10-16 | 2024-04-18 | The Board Of Trustees Of The Leland Stanford Junior University | N-acylated histidine dipeptides as anticancer agents |
| US11306076B2 (en) * | 2020-05-11 | 2022-04-19 | Xi'an Taikomed Pharmaceutical Technology Co., Ltd. | Silibinin lipoic acid ester with hepatoprotective activity and a method of preparing the same |
| CN116199666B (zh) * | 2023-03-07 | 2025-02-28 | 中国药科大学 | 两亲性化合物及其药物组合物 |
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| US3875207A (en) | 1967-01-25 | 1975-04-01 | Ciba Geigy Corp | Process for the temporary protection of amino groups in peptide syntheses |
| US3854480A (en) | 1969-04-01 | 1974-12-17 | Alza Corp | Drug-delivery system |
| CA1219824A (en) | 1981-04-17 | 1987-03-31 | David C. Ward | Modified nucleotides and methods of preparing and using same |
| US4452775A (en) | 1982-12-03 | 1984-06-05 | Syntex (U.S.A.) Inc. | Cholesterol matrix delivery system for sustained release of macromolecules |
| US5288706A (en) | 1987-12-25 | 1994-02-22 | Mitsui Toatsu Chemicals, Incorporated | Medicament for prevention and remedy of diseases of the pancreas and others |
| US5039660A (en) | 1988-03-02 | 1991-08-13 | Endocon, Inc. | Partially fused peptide pellet |
| FR2653334B1 (fr) | 1989-10-19 | 1991-12-20 | Erphar Ste Civile | Preparation cosmetique de bronzage. |
| DE59010810D1 (de) | 1989-11-09 | 1998-04-16 | Asta Medica Ag | Arzneimittel enthaltend als Wirkstoff R-alpha-Liponsäure oder S-alpha-Liponsäure |
| DE4000397A1 (de) | 1990-01-09 | 1991-07-11 | Hoechst Ag | Lipidselektive antioxidantien sowie deren herstellung und verwendung |
| CA2118496C (en) | 1992-04-24 | 2005-01-11 | Roger Randall Charles New | Method of reducing microorganism adhesion |
| WO1997000889A1 (en) | 1995-06-21 | 1997-01-09 | Asahi Kasei Kogyo Kabushiki Kaisha | Peptides binding to low-density lipoproteins |
| JPH0990542A (ja) | 1995-09-28 | 1997-04-04 | Konica Corp | ハロゲン化銀写真感光材料 |
| FR2741075B1 (fr) | 1995-11-15 | 1998-01-30 | Rech De Pathologie Appliquee S | Conjugues peptidiques, leur utilisation a titre de medicament et compositions les contenant |
| CA2264485A1 (en) | 1996-09-06 | 1998-03-12 | St. Elizabeth's Medical Center Of Boston, Inc. | Gata-6 transcription factor: compositions and methods |
| IL123887A0 (en) * | 1997-04-02 | 1998-10-30 | Sankyo Co | Dithiolan derivatives their use and pharmaceutical compositions containing the same |
| JPH11269170A (ja) * | 1997-04-02 | 1999-10-05 | Sankyo Co Ltd | ジチオラン誘導体 |
| JPH117099A (ja) | 1997-06-13 | 1999-01-12 | Fuji Photo Film Co Ltd | ハロゲン化銀写真感光材料 |
| US6090842A (en) | 1998-03-10 | 2000-07-18 | The Regents Of The University Of California | Lipoic acid analogs |
| JP2000169371A (ja) * | 1998-10-02 | 2000-06-20 | Sankyo Co Ltd | ジチオラン誘導体を含有する医薬 |
| EP1133317A1 (de) | 1998-11-26 | 2001-09-19 | Pentapharm AG | Transportsystemkonjugate |
| WO2001009118A2 (en) | 1999-07-29 | 2001-02-08 | Patrick T Prendergast | Dithiolthione compounds for the treatment of neurological disorders and for memory enhancement |
| US6890896B1 (en) | 1999-11-18 | 2005-05-10 | Ceremedix, Inc. | Compositions and methods for counteracting effects of reactive oxygen species and free radicals |
| CA2389429C (en) | 1999-11-18 | 2012-05-29 | Victor E. Shashoua | Compositions and methods for counteracting effects of reactive oxygen species and free radicals |
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| EP1371640B1 (en) | 2001-03-19 | 2009-10-28 | Senju Pharmaceutical Co., Ltd. | Novel a-lipoic acid derivative and use thereof |
| JP2005515156A (ja) | 2001-05-25 | 2005-05-26 | セレメディックス，インク． | 反応性酸素種およびフリーラジカルの効力を中和するための単一アミノ酸に基づく化合物 |
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| JP2012508165A (ja) * | 2008-11-07 | 2012-04-05 | イスティテュート ビオキーミコ ナッツィオナーレ サーヴィオ エスアールエル | α−リポ酸誘導体及び薬物製剤へのそれらの使用 |
| US7928067B2 (en) | 2009-05-14 | 2011-04-19 | Ischemix Llc | Compositions and methods for treating ischemia and ischemia-reperfusion injury |
| EP3069612A3 (en) * | 2009-06-15 | 2016-10-19 | Encore Health, LLC | Dithiol compounds, derivatives, and uses therefor |
| EP2821405B1 (en) * | 2009-06-15 | 2016-04-13 | Encore Health, LLC | Choline esters for treating presbyopia and cataract |
| IT1397154B1 (it) | 2010-01-04 | 2013-01-04 | Ghelardini | Composti ad efficacia sia analgesica che antiperalgesica. |
| DK2640423T3 (en) | 2010-11-18 | 2017-10-02 | Ischemix Llc | LIPOYL COMPOUNDS AND THEIR USE IN TREATMENT OF ISchemic DAMAGE |
| US20150329519A1 (en) | 2014-05-14 | 2015-11-19 | Ischemix, LLC | Formulations Comprising Lipoyl Compounds |
-
2011
- 2011-11-10 DK DK11793558.5T patent/DK2640423T3/en active
- 2011-11-10 KR KR1020137015640A patent/KR20140020840A/ko not_active Ceased
- 2011-11-10 EP EP11793558.5A patent/EP2640423B1/en active Active
- 2011-11-10 NZ NZ610378A patent/NZ610378A/en not_active IP Right Cessation
- 2011-11-10 US US13/885,289 patent/US8815937B2/en active Active
- 2011-11-10 BR BR112013012057-6A patent/BR112013012057B1/pt not_active IP Right Cessation
- 2011-11-10 WO PCT/US2011/060259 patent/WO2012067947A1/en not_active Ceased
- 2011-11-10 ES ES11793558.5T patent/ES2640474T3/es active Active
- 2011-11-10 MX MX2013005508A patent/MX344933B/es active IP Right Grant
- 2011-11-10 SG SG2013036546A patent/SG190794A1/en unknown
- 2011-11-10 CN CN201180065214.1A patent/CN103561770B/zh not_active Expired - Fee Related
- 2011-11-10 CA CA2817362A patent/CA2817362C/en active Active
- 2011-11-10 AU AU2011329215A patent/AU2011329215C1/en not_active Ceased
- 2011-11-10 JP JP2013539912A patent/JP2014502264A/ja active Pending
-
2013
- 2013-05-09 IL IL226258A patent/IL226258A/en active IP Right Grant
-
2014
- 2014-08-11 US US14/456,646 patent/US9359325B2/en active Active
-
2015
- 2015-11-27 JP JP2015232258A patent/JP6280094B2/ja not_active Expired - Fee Related
-
2017
- 2017-11-02 JP JP2017213078A patent/JP2018016652A/ja not_active Withdrawn
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