JP2014500880A5 - - Google Patents
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- JP2014500880A5 JP2014500880A5 JP2013539257A JP2013539257A JP2014500880A5 JP 2014500880 A5 JP2014500880 A5 JP 2014500880A5 JP 2013539257 A JP2013539257 A JP 2013539257A JP 2013539257 A JP2013539257 A JP 2013539257A JP 2014500880 A5 JP2014500880 A5 JP 2014500880A5
- Authority
- JP
- Japan
- Prior art keywords
- variant
- fgf21
- pharmaceutical composition
- diabetes
- type
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41547610P | 2010-11-19 | 2010-11-19 | |
| US61/415,476 | 2010-11-19 | ||
| PCT/EP2011/070344 WO2012066075A1 (en) | 2010-11-19 | 2011-11-17 | Methods of treating fgf21-associated disorders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017000935A Division JP2017110010A (ja) | 2010-11-19 | 2017-01-06 | Ｆｇｆ２１関連障害を処置する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014500880A JP2014500880A (ja) | 2014-01-16 |
| JP2014500880A5 true JP2014500880A5 (https=) | 2015-01-08 |
| JP6110304B2 JP6110304B2 (ja) | 2017-04-05 |
Family
ID=44999776
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013539257A Expired - Fee Related JP6110304B2 (ja) | 2010-11-19 | 2011-11-17 | Ｆｇｆ２１関連障害を処置する方法 |
| JP2017000935A Pending JP2017110010A (ja) | 2010-11-19 | 2017-01-06 | Ｆｇｆ２１関連障害を処置する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017000935A Pending JP2017110010A (ja) | 2010-11-19 | 2017-01-06 | Ｆｇｆ２１関連障害を処置する方法 |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US9023791B2 (https=) |
| EP (2) | EP2640741A1 (https=) |
| JP (2) | JP6110304B2 (https=) |
| KR (1) | KR20130115305A (https=) |
| CN (2) | CN103328502B (https=) |
| AP (1) | AP2013006871A0 (https=) |
| AR (1) | AR083920A1 (https=) |
| AU (1) | AU2011331166A1 (https=) |
| CA (1) | CA2817786A1 (https=) |
| CL (1) | CL2013001410A1 (https=) |
| CO (1) | CO6791605A2 (https=) |
| CR (1) | CR20130234A (https=) |
| CU (1) | CU24115B1 (https=) |
| EA (1) | EA201390739A1 (https=) |
| GT (1) | GT201300131A (https=) |
| IL (1) | IL226401A0 (https=) |
| MA (1) | MA34710B1 (https=) |
| MX (1) | MX2013005639A (https=) |
| NZ (1) | NZ611108A (https=) |
| PE (1) | PE20140574A1 (https=) |
| PH (1) | PH12013501010A1 (https=) |
| SG (1) | SG190324A1 (https=) |
| TW (1) | TW201302782A (https=) |
| UY (1) | UY33739A (https=) |
| WO (1) | WO2012066075A1 (https=) |
| ZA (1) | ZA201303498B (https=) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107501407B (zh) | 2007-03-30 | 2022-03-18 | Ambrx公司 | 经修饰fgf-21多肽和其用途 |
| US8034770B2 (en) | 2008-06-04 | 2011-10-11 | Amgen Inc. | FGF21 polypeptides comprising two or more mutations |
| WO2011130729A2 (en) | 2010-04-16 | 2011-10-20 | Salk Institute For Biological Studies | Methods for treating metabolic disorders using fgf |
| CN105601748B (zh) | 2011-07-01 | 2021-08-27 | 恩格姆生物制药公司 | 用于代谢病症和疾病治疗的组合物、应用和方法 |
| TWI593708B (zh) | 2011-09-26 | 2017-08-01 | 諾華公司 | 治療代謝病症之融合蛋白質 |
| UY34347A (es) | 2011-09-26 | 2013-04-30 | Novartis Ag | Proteínas de función dual para tratar trastornos metabólicos |
| AU2013263349B2 (en) | 2012-05-17 | 2016-09-08 | Extend Biosciences, Inc | Carriers for improved drug delivery |
| US9290557B2 (en) | 2012-11-28 | 2016-03-22 | Ngm Biopharmaceuticals, Inc. | Compositions comprising variants and fusions of FGF19 polypeptides |
| HK1214832A1 (zh) | 2012-11-28 | 2016-08-05 | 恩格姆生物制药公司 | 用於代謝病症和疾病治療的組合物和方法 |
| US9273107B2 (en) | 2012-12-27 | 2016-03-01 | Ngm Biopharmaceuticals, Inc. | Uses and methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases |
| ES2915851T3 (es) | 2012-12-27 | 2022-06-27 | Ngm Biopharmaceuticals Inc | Péptidos quiméricos de FGF19 para usar en el tratamiento de trastornos de ácidos biliares |
| TWI696462B (zh) * | 2013-07-10 | 2020-06-21 | 日商興和股份有限公司 | 非酒精性脂肪性肝疾病治療劑 |
| EP3057605A1 (en) | 2013-10-18 | 2016-08-24 | Novartis AG | Methods of treating diabetes and related disorders |
| AU2014340241B2 (en) | 2013-10-21 | 2018-11-01 | Salk Institute For Biological Studies | Mutated fibroblast growth factor (FGF) 1 and methods of use |
| WO2015061331A1 (en) | 2013-10-21 | 2015-04-30 | Salk Institute For Biological Studies | Chimeric fibroblast growth factor (fgf) 2/fgf1 peptides and methods of use |
| CA2927592C (en) | 2013-10-28 | 2020-08-18 | Ngm Biopharmaceuticals, Inc. | Fgf-19 variants for treating a fgf-19 dependent cancer or tumor |
| PE20170256A1 (es) | 2014-01-24 | 2017-04-22 | Ngm Biopharmaceuticals Inc | Proteinas de union y sus metodos de uso |
| US20170065678A1 (en) | 2014-03-11 | 2017-03-09 | Novartis Ag | Methods of treating metabolic disorders associated with lipodystrophies and defects in insulin production or signaling |
| AU2015236073B2 (en) | 2014-03-25 | 2020-04-30 | Regeneron Pharmaceuticals, Inc. | FGF21 receptor agonists and uses thereof |
| WO2015183890A2 (en) | 2014-05-28 | 2015-12-03 | Ngm Biopharmaceuticals, Inc. | Methods and compositions for the treatment of metabolic disorders and diseases |
| AU2015277438B2 (en) | 2014-06-16 | 2020-02-27 | Ngm Biopharmaceuticals, Inc. | Methods and uses for modulating bile acid homeostasis and treatment of bile acid disorders and diseases |
| US10293026B2 (en) | 2014-09-08 | 2019-05-21 | Osaka University | Agent for preventing or treating demyelinating disease |
| WO2016048999A2 (en) * | 2014-09-23 | 2016-03-31 | Salk Institute For Biological Studies | Fgf21 truncations and mutants and uses thereof |
| US9616109B2 (en) | 2014-10-22 | 2017-04-11 | Extend Biosciences, Inc. | Insulin vitamin D conjugates |
| WO2016065042A1 (en) | 2014-10-22 | 2016-04-28 | Extend Biosciences, Inc. | Therapeutic vitamin d conjugates |
| US9789197B2 (en) | 2014-10-22 | 2017-10-17 | Extend Biosciences, Inc. | RNAi vitamin D conjugates |
| RU2729161C2 (ru) | 2014-10-23 | 2020-08-04 | ЭнДжиЭм БАЙОФАРМАСЬЮТИКАЛЗ, ИНК. | Фармацевтические композиции, содержащие варианты пептидов, и способы их применения |
| CN114805532A (zh) | 2014-10-24 | 2022-07-29 | 百时美施贵宝公司 | 修饰的fgf-21多肽及其用途 |
| US10434144B2 (en) | 2014-11-07 | 2019-10-08 | Ngm Biopharmaceuticals, Inc. | Methods for treatment of bile acid-related disorders and prediction of clinical sensitivity to treatment of bile acid-related disorders |
| CN105802948B (zh) * | 2014-12-29 | 2020-06-09 | 江苏众红生物工程创药研究院有限公司 | 聚乙二醇定点修饰的门冬酰胺酶及其制备方法与应用 |
| KR20160088656A (ko) | 2015-01-16 | 2016-07-26 | 주식회사유한양행 | 지속형 fgf21 융합 단백질 및 이를 포함하는 약학적 조성물 |
| TWI849231B (zh) | 2015-03-03 | 2024-07-21 | 香港商南沙生物科技（香港）有限公司 | 聚乙二醇化介白素-11之組合物及方法 |
| US10800843B2 (en) | 2015-07-29 | 2020-10-13 | Ngm Biopharmaceuticals, Inc. | Beta klotho-binding proteins |
| KR102670157B1 (ko) | 2015-10-28 | 2024-05-29 | 주식회사유한양행 | 이중 작용 단백질 및 이를 포함하는 약학적 조성물 |
| KR102668200B1 (ko) | 2015-10-28 | 2024-05-23 | 주식회사유한양행 | 지속형 fgf21 융합 단백질 및 이를 포함하는 약학적 조성물 |
| EP3368059A4 (en) | 2015-10-30 | 2019-03-27 | Salk Institute for Biological Studies | TREATMENT OF STEROID-INDUCED HYPERGLYCEMIA WITH FIBROBLAST GROWTH FACTOR (FGF) -1 ANALOGUE |
| JP6728352B2 (ja) | 2015-11-09 | 2020-07-22 | エヌジーエム バイオファーマシューティカルス，インコーポレーテッド | 胆汁酸に関係した障害の治療方法 |
| KR101838687B1 (ko) | 2016-01-26 | 2018-03-15 | 한국생명공학연구원 | 나노포어를 이용한 단백질-단백질 상호작용 저해제 스크리닝 방법 |
| MX2018014475A (es) * | 2016-05-25 | 2019-05-23 | Univ Texas | Métodos y composiciones para el tratamiento de trastornos secretorios. |
| US11123438B2 (en) | 2016-08-19 | 2021-09-21 | Ampsource Biopharma Shanghai Inc. | Linker peptide for constructing fusion protein |
| CN106317226B (zh) | 2016-08-19 | 2017-09-05 | 安源医药科技（上海）有限公司 | 用于构建融合蛋白的连接肽 |
| CN106279437B (zh) | 2016-08-19 | 2017-10-31 | 安源医药科技（上海）有限公司 | 高糖基化人凝血因子viii融合蛋白及其制备方法与用途 |
| CA3034399A1 (en) | 2016-08-26 | 2018-03-01 | Ngm Biopharmaceuticals, Inc. | Methods of treating fibroblast growth factor 19-mediated cancers and tumors |
| CN106220724B (zh) * | 2016-09-13 | 2019-10-11 | 河南师范大学 | 人成纤维细胞生长因子21重组蛋白及其制备方法和应用 |
| CN106432509B (zh) * | 2016-09-13 | 2019-05-21 | 河南师范大学 | 一种治疗代谢疾病的重组人成纤维细胞生长因子21融合蛋白及其制备方法和应用 |
| CN106397607A (zh) * | 2016-09-13 | 2017-02-15 | 河南师范大学 | 重组人成纤维细胞生长因子21融合蛋白及其在制备治疗代谢疾病药物中的应用 |
| MX2019005380A (es) | 2016-11-10 | 2019-08-12 | Yuhan Corp | Composicion farmaceutica que comprende proteinas de fusion para prevenir o tratar la hepatitis, la fibrosis hepatica y la cirrosis hepatica. |
| WO2018166461A1 (en) | 2017-03-14 | 2018-09-20 | Sunshine Lake Pharma Co., Ltd. | Dual-target fusion proteins comprising the fc portion of an immunoglobulin |
| CN107050429B (zh) * | 2017-04-01 | 2020-12-15 | 杭州生物医药创新研究中心 | 人成纤维生长因子21在制备用于治疗脑卒中药物中的应用 |
| US11560416B2 (en) | 2017-04-21 | 2023-01-24 | Yuhan Corporation | Method for producing dual function proteins and its derivatives |
| IL270882B2 (en) | 2017-05-24 | 2024-02-01 | Univ Barcelona Autonoma | Viral expression vectors containing the coding sequence for FIBROBLAST GROWTH FACTOR 21 (FGF21 |
| SG11202001379WA (en) * | 2017-09-08 | 2020-03-30 | Bristol Myers Squibb Co | Modified fibroblast growth factor 21 (fgf-21) for use in methods for treating nonalcoholic steatohepatitis (nash) |
| WO2019119673A1 (zh) | 2017-12-19 | 2019-06-27 | 北京吉源生物科技有限公司 | 一种双基因修饰的干细胞及其用途 |
| WO2019123427A1 (en) * | 2017-12-22 | 2019-06-27 | Novartis Ag | Methods of treating metabolic disorders with fgf21 variants |
| KR20210027426A (ko) | 2018-07-03 | 2021-03-10 | 브리스톨-마이어스 스큅 컴퍼니 | Fgf21 제제 |
| US20200390858A1 (en) * | 2019-04-17 | 2020-12-17 | Ngm Biopharmaceuticals, Inc. | Combination Therapy for Modulating Bile Acid Homeostasis and Treatment of Bile Acid Disorders and Diseases |
| US11542309B2 (en) | 2019-07-31 | 2023-01-03 | Salk Institute For Biological Studies | Fibroblast growth factor 1 (FGF1) mutant proteins that selectively activate FGFR1B to reduce blood glucose |
| EP4087612A1 (en) | 2020-01-08 | 2022-11-16 | Bristol-Myers Squibb Company | Fgf-21 conjugate formulations |
| CN113728013B (zh) | 2020-01-11 | 2022-06-14 | 北京质肽生物医药科技有限公司 | Glp-1和fgf21的融合蛋白的缀合物 |
| US11981718B2 (en) | 2020-05-27 | 2024-05-14 | Ampsource Biopharma Shanghai Inc. | Dual-function protein for lipid and blood glucose regulation |
| JP2023538533A (ja) | 2020-08-07 | 2023-09-08 | ブリストル－マイヤーズ スクイブ カンパニー | 線維症の処置のための、ｃｃｒ２／５拮抗剤と組み合わせたｆｇｆ２１ |
| KR20220021207A (ko) | 2020-08-13 | 2022-02-22 | 주식회사 나이벡 | 이소골 형성 부작용 경감으로 치료효과가 증진된 골형성 단백질-9, 10의 변이체 및 이를 포함하는 약학적 조성물 |
| US20240123031A1 (en) | 2020-11-25 | 2024-04-18 | Bristol-Myers Squibb Company | Methods of treating liver diseases |
| WO2023284822A1 (en) | 2021-07-14 | 2023-01-19 | Beijing Ql Biopharmaceutical Co., Ltd. | Fusion polypeptides for metabolic disorders |
| CN113717269B (zh) * | 2021-08-31 | 2022-04-19 | 赣江中药创新中心 | 一种重组的变体fgf21蛋白及其制备方法和应用 |
| CN114699509A (zh) * | 2021-09-23 | 2022-07-05 | 中南大学湘雅三医院 | Fgf21调控糖尿病缺血创面细胞焦亡的机制的应用 |
| KR20250075704A (ko) | 2022-09-30 | 2025-05-28 | 익스텐드 바이오사이언시즈, 인크. | 장기-지속형 부갑상선 호르몬 |
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-
2011
- 2011-11-15 US US13/296,343 patent/US9023791B2/en active Active
- 2011-11-17 MX MX2013005639A patent/MX2013005639A/es not_active Application Discontinuation
- 2011-11-17 PE PE2013001217A patent/PE20140574A1/es not_active Application Discontinuation
- 2011-11-17 JP JP2013539257A patent/JP6110304B2/ja not_active Expired - Fee Related
- 2011-11-17 EA EA201390739A patent/EA201390739A1/ru unknown
- 2011-11-17 CA CA2817786A patent/CA2817786A1/en not_active Abandoned
- 2011-11-17 SG SG2013038195A patent/SG190324A1/en unknown
- 2011-11-17 NZ NZ611108A patent/NZ611108A/en not_active IP Right Cessation
- 2011-11-17 PH PH1/2013/501010A patent/PH12013501010A1/en unknown
- 2011-11-17 AP AP2013006871A patent/AP2013006871A0/xx unknown
- 2011-11-17 WO PCT/EP2011/070344 patent/WO2012066075A1/en not_active Ceased
- 2011-11-17 CN CN201180065381.6A patent/CN103328502B/zh not_active Expired - Fee Related
- 2011-11-17 CU CU20130073A patent/CU24115B1/es active IP Right Grant
- 2011-11-17 EP EP11785007.3A patent/EP2640741A1/en not_active Withdrawn
- 2011-11-17 AU AU2011331166A patent/AU2011331166A1/en not_active Abandoned
- 2011-11-17 CN CN201610319790.9A patent/CN105837680A/zh active Pending
- 2011-11-17 EP EP16151097.9A patent/EP3067364A3/en not_active Withdrawn
- 2011-11-17 UY UY33739A patent/UY33739A/es not_active Application Discontinuation
- 2011-11-17 KR KR20137015741A patent/KR20130115305A/ko not_active Withdrawn
- 2011-11-18 TW TW100142397A patent/TW201302782A/zh unknown
- 2011-11-18 AR ARP110104305 patent/AR083920A1/es unknown
-
2013
- 2013-05-14 ZA ZA2013/03498A patent/ZA201303498B/en unknown
- 2013-05-16 IL IL226401A patent/IL226401A0/en unknown
- 2013-05-17 GT GT201300131A patent/GT201300131A/es unknown
- 2013-05-17 CL CL2013001410A patent/CL2013001410A1/es unknown
- 2013-05-20 CR CR20130234A patent/CR20130234A/es unknown
- 2013-05-24 CO CO13128283A patent/CO6791605A2/es unknown
- 2013-06-05 MA MA35962A patent/MA34710B1/fr unknown
-
2015
- 2015-04-02 US US14/676,863 patent/US20160051628A1/en not_active Abandoned
-
2017
- 2017-01-06 JP JP2017000935A patent/JP2017110010A/ja active Pending
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