JP2014500870A5 - - Google Patents
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- JP2014500870A5 JP2014500870A5 JP2013538923A JP2013538923A JP2014500870A5 JP 2014500870 A5 JP2014500870 A5 JP 2014500870A5 JP 2013538923 A JP2013538923 A JP 2013538923A JP 2013538923 A JP2013538923 A JP 2013538923A JP 2014500870 A5 JP2014500870 A5 JP 2014500870A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- pharmaceutically acceptable
- compound
- acceptable salt
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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- 150000001875 compounds Chemical class 0.000 claims 27
- 150000003839 salts Chemical class 0.000 claims 23
- 229910052739 hydrogen Inorganic materials 0.000 claims 20
- 239000001257 hydrogen Substances 0.000 claims 20
- 238000000034 method Methods 0.000 claims 17
- 150000002431 hydrogen Chemical class 0.000 claims 11
- 125000000217 alkyl group Chemical group 0.000 claims 10
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 7
- 125000001309 chloro group Chemical group Cl* 0.000 claims 7
- 125000001153 fluoro group Chemical group F* 0.000 claims 7
- 206010028980 Neoplasm Diseases 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 6
- 238000006317 isomerization reaction Methods 0.000 claims 6
- 125000003710 aryl alkyl group Chemical group 0.000 claims 4
- 125000003107 substituted aryl group Chemical group 0.000 claims 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 3
- 201000001441 melanoma Diseases 0.000 claims 3
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 208000006332 Choriocarcinoma Diseases 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
- 206010025323 Lymphomas Diseases 0.000 claims 2
- 208000034578 Multiple myelomas Diseases 0.000 claims 2
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 201000000582 Retinoblastoma Diseases 0.000 claims 2
- 206010039491 Sarcoma Diseases 0.000 claims 2
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 2
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 claims 2
- 239000002246 antineoplastic agent Substances 0.000 claims 2
- 208000029742 colonic neoplasm Diseases 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 206010017758 gastric cancer Diseases 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 230000003463 hyperproliferative effect Effects 0.000 claims 2
- 208000032839 leukemia Diseases 0.000 claims 2
- 201000005202 lung cancer Diseases 0.000 claims 2
- 208000020816 lung neoplasm Diseases 0.000 claims 2
- 201000011549 stomach cancer Diseases 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 1
- 125000005350 hydroxycycloalkyl group Chemical group 0.000 claims 1
- 206010024627 liposarcoma Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 125000000547 substituted alkyl group Chemical group 0.000 claims 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- LRJBXXRILYOKRP-RTXPCENHSA-N CC(C)(C)C[C@@H]([C@@](C1Cc2ccccc2)(c(ccc(Cl)c2)c2N2)C2=O)N[C@H]1C(N[C@H](CC1)CC[C@@H]1O)=O Chemical compound CC(C)(C)C[C@@H]([C@@](C1Cc2ccccc2)(c(ccc(Cl)c2)c2N2)C2=O)N[C@H]1C(N[C@H](CC1)CC[C@@H]1O)=O LRJBXXRILYOKRP-RTXPCENHSA-N 0.000 description 1
- NQMLXUVTDJNBIP-OLSAQFFOSA-N CC(C)(C)C[C@@H]([C@@]([C@H]1C(C2)C=CC=C2Cl)(c(c(N2)c3)cc(F)c3Cl)C2=O)N[C@H]1C(N[C@H](CC1)CC[C@@H]1O)=O Chemical compound CC(C)(C)C[C@@H]([C@@]([C@H]1C(C2)C=CC=C2Cl)(c(c(N2)c3)cc(F)c3Cl)C2=O)N[C@H]1C(N[C@H](CC1)CC[C@@H]1O)=O NQMLXUVTDJNBIP-OLSAQFFOSA-N 0.000 description 1
- DYTUNXFWZMTYRO-HNOBZUPDSA-N CC(C)(C)C[C@@H]([C@@]([C@H]1c2cccc(Cl)c2F)(c(c(N2)c3)ccc3Cl)C2=O)N(C)[C@H]1C(NC(C1)CC1(C)O)=O Chemical compound CC(C)(C)C[C@@H]([C@@]([C@H]1c2cccc(Cl)c2F)(c(c(N2)c3)ccc3Cl)C2=O)N(C)[C@H]1C(NC(C1)CC1(C)O)=O DYTUNXFWZMTYRO-HNOBZUPDSA-N 0.000 description 1
- IDKAKZRYYDCJDU-AEPXTFJPSA-N CC(C)(C)C[C@@H]([C@@]([C@H]1c2cccc(Cl)c2F)(c(c(N2)c3)ccc3Cl)C2=O)N[C@H]1C(NC(CC1)CCC1O)=O Chemical compound CC(C)(C)C[C@@H]([C@@]([C@H]1c2cccc(Cl)c2F)(c(c(N2)c3)ccc3Cl)C2=O)N[C@H]1C(NC(CC1)CCC1O)=O IDKAKZRYYDCJDU-AEPXTFJPSA-N 0.000 description 1
- MQWCXKGKQLNYQG-UHFFFAOYSA-N CC(CC1)CCC1O Chemical compound CC(CC1)CCC1O MQWCXKGKQLNYQG-UHFFFAOYSA-N 0.000 description 1
- POOPNLXAGUARSE-SRZAULEESA-N CCN([C@@H](CC(C)(C)C)[C@@]([C@H]1c2cccc(Cl)c2F)(c(c(N2)c3)ccc3Cl)C2=O)[C@H]1C(N[C@H](C1)C[C@@]1(C)O)=O Chemical compound CCN([C@@H](CC(C)(C)C)[C@@]([C@H]1c2cccc(Cl)c2F)(c(c(N2)c3)ccc3Cl)C2=O)[C@H]1C(N[C@H](C1)C[C@@]1(C)O)=O POOPNLXAGUARSE-SRZAULEESA-N 0.000 description 1
- YFFXIRDLSYBFRD-CKZFGEAVSA-N C[C@@H]([C@@]([C@H]1Cc2ccccc2)(c(c(N2)c3)ccc3Cl)/C2=[O]\c2ccccc2)N[C@H]1C(NC1CCCCC1)=O Chemical compound C[C@@H]([C@@]([C@H]1Cc2ccccc2)(c(c(N2)c3)ccc3Cl)/C2=[O]\c2ccccc2)N[C@H]1C(NC1CCCCC1)=O YFFXIRDLSYBFRD-CKZFGEAVSA-N 0.000 description 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41309410P | 2010-11-12 | 2010-11-12 | |
| US61/413,094 | 2010-11-12 | ||
| US201161451958P | 2011-03-11 | 2011-03-11 | |
| US201161451968P | 2011-03-11 | 2011-03-11 | |
| US61/451,968 | 2011-03-11 | ||
| US61/451,958 | 2011-03-11 | ||
| US201161470992P | 2011-04-01 | 2011-04-01 | |
| US61/470,992 | 2011-04-01 | ||
| PCT/US2011/060300 WO2012065022A2 (en) | 2010-11-12 | 2011-11-11 | Spiro-oxindole mdm2 antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014500870A JP2014500870A (ja) | 2014-01-16 |
| JP2014500870A5 true JP2014500870A5 (OSRAM) | 2014-12-25 |
Family
ID=46048358
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013538923A Ceased JP2014500870A (ja) | 2010-11-12 | 2011-11-11 | スピロ−オキシインドールｍｄｍ２アンタゴニスト |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US8680132B2 (OSRAM) |
| EP (1) | EP2638046A4 (OSRAM) |
| JP (1) | JP2014500870A (OSRAM) |
| KR (1) | KR101929188B1 (OSRAM) |
| CN (1) | CN103298818B (OSRAM) |
| AR (1) | AR083849A1 (OSRAM) |
| AU (1) | AU2011326395B2 (OSRAM) |
| CA (1) | CA2817585A1 (OSRAM) |
| CO (1) | CO6721010A2 (OSRAM) |
| CR (1) | CR20130271A (OSRAM) |
| DO (1) | DOP2013000104A (OSRAM) |
| EA (1) | EA201390682A1 (OSRAM) |
| EC (1) | ECSP13012678A (OSRAM) |
| GT (1) | GT201300118A (OSRAM) |
| IL (1) | IL226275A0 (OSRAM) |
| MA (1) | MA34732B1 (OSRAM) |
| MX (1) | MX2013005238A (OSRAM) |
| NI (1) | NI201300041A (OSRAM) |
| NZ (1) | NZ611866A (OSRAM) |
| PE (1) | PE20140408A1 (OSRAM) |
| PH (1) | PH12013500955A1 (OSRAM) |
| SG (1) | SG190230A1 (OSRAM) |
| TW (1) | TWI535723B (OSRAM) |
| UA (1) | UA109464C2 (OSRAM) |
| UY (1) | UY33725A (OSRAM) |
| WO (1) | WO2012065022A2 (OSRAM) |
| ZA (1) | ZA201304042B (OSRAM) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG176463A1 (en) | 2005-02-22 | 2011-12-29 | Univ Michigan | Small molecule inhibitors of mdm2 and uses thereof |
| PL2118123T3 (pl) | 2007-01-31 | 2016-06-30 | Dana Farber Cancer Inst Inc | Stabilizowane peptydy p53 i ich zastosowania |
| KR101525754B1 (ko) | 2007-03-28 | 2015-06-09 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 스티칭된 폴리펩티드 |
| JP2013510860A (ja) | 2009-11-12 | 2013-03-28 | ザ、リージェンツ、オブ、ザ、ユニバーシティ、オブ、ミシガン | スピロ−オキシインドールｍｄｍ２アンタゴニスト |
| US8440693B2 (en) | 2009-12-22 | 2013-05-14 | Novartis Ag | Substituted isoquinolinones and quinazolinones |
| CA2807685C (en) | 2010-08-13 | 2020-10-06 | Aileron Therapeutics, Inc. | P53 derived peptidomimetic macrocycle |
| RU2612534C2 (ru) | 2011-03-10 | 2017-03-09 | Дайити Санкио Компани, Лимитед | Диспиропирролидиновые производные |
| SG194873A1 (en) | 2011-05-11 | 2013-12-30 | Sanofi Sa | Spiro-oxindole mdm2 antagonists |
| TW201806968A (zh) | 2011-10-18 | 2018-03-01 | 艾利倫治療公司 | 擬肽巨環化合物 |
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| CA2945527C (en) | 2014-04-17 | 2022-05-17 | The Regents Of The University Of Michigan | Mdm2 inhibitors and therapeutic methods using the same |
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-
2011
- 2011-11-11 TW TW100141225A patent/TWI535723B/zh not_active IP Right Cessation
- 2011-11-11 WO PCT/US2011/060300 patent/WO2012065022A2/en not_active Ceased
- 2011-11-11 CN CN201180064853.6A patent/CN103298818B/zh not_active Expired - Fee Related
- 2011-11-11 SG SG2013035894A patent/SG190230A1/en unknown
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- 2011-11-11 US US13/294,315 patent/US8680132B2/en not_active Expired - Fee Related
- 2011-11-11 CA CA2817585A patent/CA2817585A1/en not_active Abandoned
- 2011-11-11 KR KR1020137015168A patent/KR101929188B1/ko not_active Expired - Fee Related
- 2011-11-11 EA EA201390682A patent/EA201390682A1/ru unknown
- 2011-11-11 UA UAA201307447A patent/UA109464C2/uk unknown
- 2011-11-11 NZ NZ61186611A patent/NZ611866A/en not_active IP Right Cessation
- 2011-11-11 EP EP11840490.4A patent/EP2638046A4/en not_active Withdrawn
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