JP2014198737A5 - - Google Patents

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JP2014198737A5
JP2014198737A5 JP2014153222A JP2014153222A JP2014198737A5 JP 2014198737 A5 JP2014198737 A5 JP 2014198737A5 JP 2014153222 A JP2014153222 A JP 2014153222A JP 2014153222 A JP2014153222 A JP 2014153222A JP 2014198737 A5 JP2014198737 A5 JP 2014198737A5
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JP
Japan
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JP2014153222A
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JP5957043B2 (ja
JP2014198737A (ja
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JP2014153222A 2009-07-20 2014-07-28 増殖性疾患の相乗的処置のための抗ctla4抗体と多様な治療レジメンとの組み合わせ Active JP5957043B2 (ja)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US22691009P 2009-07-20 2009-07-20
US61/226,910 2009-07-20
US12/462,168 2009-07-30
USPCT/US2009/052209 2009-07-30
US12/462,168 US8119129B2 (en) 2008-08-01 2009-07-30 Combination of anti-CTLA4 antibody with dasatinib for the treatment of proliferative diseases
PCT/US2009/052209 WO2010014784A2 (en) 2008-08-01 2009-07-30 Combination of anti-ctla4 antibody with diverse therapeutic regimens for the synergistic treatment of proliferative diseases

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2014123960A Division JP5957036B2 (ja) 2009-07-20 2014-06-17 増殖性疾患の相乗的処置のための抗ctla4抗体と多様な治療レジメンとの組み合わせ

Publications (3)

Publication Number Publication Date
JP2014198737A JP2014198737A (ja) 2014-10-23
JP2014198737A5 true JP2014198737A5 (ja) 2015-04-02
JP5957043B2 JP5957043B2 (ja) 2016-07-27

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ID=43499324

Family Applications (3)

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JP2012521608A Active JP5589077B2 (ja) 2009-07-20 2009-10-29 増殖性疾患の相乗的処置のための抗ctla4抗体と多様な治療レジメンとの組み合わせ
JP2014123960A Active JP5957036B2 (ja) 2009-07-20 2014-06-17 増殖性疾患の相乗的処置のための抗ctla4抗体と多様な治療レジメンとの組み合わせ
JP2014153222A Active JP5957043B2 (ja) 2009-07-20 2014-07-28 増殖性疾患の相乗的処置のための抗ctla4抗体と多様な治療レジメンとの組み合わせ

Family Applications Before (2)

Application Number Title Priority Date Filing Date
JP2012521608A Active JP5589077B2 (ja) 2009-07-20 2009-10-29 増殖性疾患の相乗的処置のための抗ctla4抗体と多様な治療レジメンとの組み合わせ
JP2014123960A Active JP5957036B2 (ja) 2009-07-20 2014-06-17 増殖性疾患の相乗的処置のための抗ctla4抗体と多様な治療レジメンとの組み合わせ

Country Status (16)

Country Link
EP (4) EP3659596A1 (ja)
JP (3) JP5589077B2 (ja)
KR (1) KR101733255B1 (ja)
CN (1) CN102822200A (ja)
AU (1) AU2009350151B2 (ja)
CY (1) CY1119128T1 (ja)
DK (1) DK2769737T3 (ja)
ES (2) ES2768990T3 (ja)
HR (1) HRP20170785T1 (ja)
HU (1) HUE033312T2 (ja)
LT (1) LT2769737T (ja)
MX (1) MX2012000851A (ja)
PL (1) PL2769737T3 (ja)
PT (1) PT2769737T (ja)
SI (1) SI2769737T1 (ja)
WO (1) WO2011011027A1 (ja)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8119129B2 (en) 2008-08-01 2012-02-21 Bristol-Myers Squibb Company Combination of anti-CTLA4 antibody with dasatinib for the treatment of proliferative diseases
WO2010042433A1 (en) 2008-10-06 2010-04-15 Bristol-Myers Squibb Company Combination of cd137 antibody and ctla-4 antibody for the treatment of proliferative diseases
CN108997498A (zh) 2008-12-09 2018-12-14 霍夫曼-拉罗奇有限公司 抗-pd-l1抗体及它们用于增强t细胞功能的用途
JP6322413B2 (ja) 2011-03-10 2018-05-09 プロヴェクタス ファーマテック,インク. 改善されたがん治療のための局所および全身性免疫修飾療法の組み合わせ
WO2013022991A2 (en) * 2011-08-08 2013-02-14 Curelab Oncology, Inc. Methods and compositions relating to p62 for the treatment and prophylaxis of cancer
EP3563836A1 (en) * 2013-03-01 2019-11-06 Astex Pharmaceuticals, Inc. Drug combinations
US10570204B2 (en) 2013-09-26 2020-02-25 The Medical College Of Wisconsin, Inc. Methods for treating hematologic cancers
JOP20200094A1 (ar) 2014-01-24 2017-06-16 Dana Farber Cancer Inst Inc جزيئات جسم مضاد لـ pd-1 واستخداماتها
JOP20200096A1 (ar) 2014-01-31 2017-06-16 Children’S Medical Center Corp جزيئات جسم مضاد لـ tim-3 واستخداماتها
EP3116909B1 (en) 2014-03-14 2019-11-13 Novartis Ag Antibody molecules to lag-3 and uses thereof
US20150283237A1 (en) * 2014-04-02 2015-10-08 Mitchell S. Felder Ctla-4 blockade with metronomic chemotherapy for the treatment of cancer
EP3925622A1 (en) 2014-09-13 2021-12-22 Novartis AG Combination therapies
CA2963281A1 (en) * 2014-10-03 2016-04-07 Novartis Ag Combination therapies
EP4245376A3 (en) 2014-10-14 2023-12-13 Novartis AG Antibody molecules to pd-l1 and uses thereof
WO2016059602A2 (en) * 2014-10-16 2016-04-21 Glaxo Group Limited Methods of treating cancer and related compositions
US10806787B2 (en) 2015-02-16 2020-10-20 Pharma Foods International Co., Ltd. Anticancer agents or antimetastatic agents using FSTL1 and combination drug thereof
JP2018512397A (ja) * 2015-03-11 2018-05-17 プロビデンス ヘルス アンド サービシーズ−オレゴン 癌治療の有効性を高めるための組成物及び方法
US10144779B2 (en) * 2015-05-29 2018-12-04 Agenus Inc. Anti-CTLA-4 antibodies and methods of use thereof
SG10201913964QA (en) * 2015-06-25 2020-03-30 Advanced Accelerator Applications Method of treatment of neuroendocrine tumors that over-express somatostatatin receptors
EP3973988A1 (en) 2015-11-04 2022-03-30 Duke University Combination therapy of immunotoxin and checkpoint inhibitor
KR102281961B1 (ko) * 2016-01-08 2021-07-26 다이호야쿠힌고교 가부시키가이샤 면역 조절제를 함유하는 항종양제 및 항종양 효과 증강제
CA3015241A1 (en) * 2016-02-22 2017-08-31 Onxeo Combination therapies comprising immuno-oncology agents and belinostat
CN105560247B (zh) * 2016-03-04 2018-08-31 四川美大康华康药业有限公司 一种达沙替尼组合物片剂及其制备方法
CN109689056A (zh) * 2016-08-01 2019-04-26 亚尼塔公司 用于治疗癌症的组合
WO2018098352A2 (en) 2016-11-22 2018-05-31 Jun Oishi Targeting kras induced immune checkpoint expression
MX2019009660A (es) 2017-02-28 2019-10-02 Bristol Myers Squibb Co Uso de anticuerpos antigeno 4 del linfocito t (ctla-4) con citotoxicidad celular dependiente de anticuerpos (adcc) mejorada para mejorar la respuesta inmune a una vacuna.
CN106943380B (zh) * 2017-05-17 2021-02-05 杜楠 Vegf单抗联合纳米紫杉醇在制备治疗癌性腹腔粘连药物中的应用
WO2019005757A1 (en) * 2017-06-27 2019-01-03 Dana-Farber Cancer Institute, Inc. COMPOSITIONS AND METHODS FOR IDENTIFICATION AND TREATMENT OF CTLA4 ANTAGONIST RESISTANCE IN LEUKEMIA
JP7365694B2 (ja) * 2017-06-29 2023-10-20 信夫 塚本 抗腫瘍免疫療法増強剤
CN110960679A (zh) * 2018-09-28 2020-04-07 江苏康缘药业股份有限公司 一种抗肿瘤的药物组合物及其应用
US20230256092A1 (en) 2020-06-30 2023-08-17 Shionogi & Co., Ltd. Combined use of anti-ccr8 antibody and chemotherapeutic agent

Family Cites Families (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2532858B2 (ja) 1985-04-01 1996-09-11 セルテツク リミテツド 形質転換したミエロ―マ細胞系
US4676980A (en) 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
GB8601597D0 (en) 1986-01-23 1986-02-26 Wilson R H Nucleotide sequences
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
EP0307434B2 (en) 1987-03-18 1998-07-29 Scotgen Biopharmaceuticals, Inc. Altered antibodies
GB8717430D0 (en) 1987-07-23 1987-08-26 Celltech Ltd Recombinant dna product
US5336603A (en) 1987-10-02 1994-08-09 Genentech, Inc. CD4 adheson variants
KR900005995A (ko) 1988-10-31 1990-05-07 우메모또 요시마사 변형 인터류킨-2 및 그의 제조방법
US5112946A (en) 1989-07-06 1992-05-12 Repligen Corporation Modified pf4 compositions and methods of use
WO1991006570A1 (en) 1989-10-25 1991-05-16 The University Of Melbourne HYBRID Fc RECEPTOR MOLECULES
US5349053A (en) 1990-06-01 1994-09-20 Protein Design Labs, Inc. Chimeric ligand/immunoglobulin molecules and their uses
JP3242916B2 (ja) 1990-12-14 2001-12-25 セル ジェネシス,インコーポレイティド レセプター関連シグナル変換系のためのキメラ鎖
US5120805A (en) 1991-06-05 1992-06-09 The Dow Chemical Company Reactor with surface agitator for solution polymerization process
US5851795A (en) 1991-06-27 1998-12-22 Bristol-Myers Squibb Company Soluble CTLA4 molecules and uses thereof
US5622929A (en) 1992-01-23 1997-04-22 Bristol-Myers Squibb Company Thioether conjugates
US5447851B1 (en) 1992-04-02 1999-07-06 Univ Texas System Board Of Dna encoding a chimeric polypeptide comprising the extracellular domain of tnf receptor fused to igg vectors and host cells
US5618829A (en) 1993-01-28 1997-04-08 Mitsubishi Chemical Corporation Tyrosine kinase inhibitors and benzoylacrylamide derivatives
WO1995002420A2 (en) 1993-07-15 1995-01-26 Cancer Research Campaign Technology Ltd. Prodrugs of protein tyrosine kinase inhibitors
TW406020B (en) 1993-09-29 2000-09-21 Bristol Myers Squibb Co Stabilized pharmaceutical composition and its method for preparation and stabilizing solvent
CN1117155C (zh) 1994-07-29 2003-08-06 史密丝克莱恩比彻姆有限公司 新型化合物
US5804396A (en) 1994-10-12 1998-09-08 Sugen, Inc. Assay for agents active in proliferative disorders
US5639757A (en) 1995-05-23 1997-06-17 Pfizer Inc. 4-aminopyrrolo[2,3-d]pyrimidines as tyrosine kinase inhibitors
US5811097A (en) 1995-07-25 1998-09-22 The Regents Of The University Of California Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling
US6051227A (en) 1995-07-25 2000-04-18 The Regents Of The University Of California, Office Of Technology Transfer Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling
US5855887A (en) 1995-07-25 1999-01-05 The Regents Of The University Of California Blockade of lymphocyte down-regulation associated with CTLA-4 signaling
US6011029A (en) 1996-02-26 2000-01-04 Bristol-Myers Squibb Company Inhibitors of farnesyl protein transferase
AU5711196A (en) 1996-03-14 1997-10-01 Human Genome Sciences, Inc. Apoptosis inducing molecule i
CA2248868A1 (en) 1996-03-22 1997-09-25 Human Genome Sciences, Inc. Apoptosis inducing molecule ii
RO121900B1 (ro) 1996-04-12 2008-07-30 Warner-Lambert Company Compuşi inhibitori, ireversibili, ai tirozin kinazelor, compoziţie farmaceutică care îi conţine şi utilizarea acestora
US5898031A (en) 1996-06-06 1999-04-27 Isis Pharmaceuticals, Inc. Oligoribonucleotides for cleaving RNA
US6277381B1 (en) 1997-03-21 2001-08-21 Corixa Corporation Compounds and methods for the diagnosis and treatment of Ehrlichia infection
WO1998042752A1 (en) 1997-03-21 1998-10-01 Brigham And Women's Hospital Inc. Immunotherapeutic ctla-4 binding peptides
ZA986732B (en) 1997-07-29 1999-02-02 Warner Lambert Co Irreversible inhibitiors of tyrosine kinases
US6100254A (en) 1997-10-10 2000-08-08 Board Of Regents, The University Of Texas System Inhibitors of protein tyrosine kinases
EP1042343B1 (en) 1997-11-03 2008-01-23 Human Genome Sciences, Inc. Vegi, an inhibitor of angiogenesis and tumor growth
US6506559B1 (en) 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
US7115396B2 (en) 1998-12-10 2006-10-03 Compound Therapeutics, Inc. Protein scaffolds for antibody mimics and other binding proteins
EE05627B1 (et) 1998-12-23 2013-02-15 Pfizer Inc. CTLA-4 vastased inimese monoklonaalsed antikehad
US7109003B2 (en) 1998-12-23 2006-09-19 Abgenix, Inc. Methods for expressing and recovering human monoclonal antibodies to CTLA-4
CZ302706B6 (cs) 1998-12-23 2011-09-14 Pfizer Inc. Lidská monoklonální protilátka, farmaceutická kompozice tuto protilátku obsahující, bunecná linie produkující tuto protilátku, izolovaná molekula kódující težký nebo lehký retezec uvedené protilátky, hostitelská bunka obsahující tuto izolovanou molek
DE19956568A1 (de) 1999-01-30 2000-08-17 Roland Kreutzer Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens
US6740665B1 (en) 1999-02-10 2004-05-25 Ramachandran Murali Tyrosine kinase inhibitors and methods of using the same
PT1157023E (pt) 1999-02-22 2004-03-31 Bristol Myers Squibb Co Epotilonas modificadas em c-21
US6245759B1 (en) 1999-03-11 2001-06-12 Merck & Co., Inc. Tyrosine kinase inhibitors
AU5889100A (en) 1999-06-30 2001-01-31 Merck & Co., Inc. Src kinase inhibitor compounds
CA2376957A1 (en) 1999-06-30 2001-01-04 Merck & Co., Inc. Src kinase inhibitor compounds
JP2003523942A (ja) 1999-06-30 2003-08-12 メルク エンド カムパニー インコーポレーテッド Srcキナーゼ阻害剤化合物
US7605238B2 (en) 1999-08-24 2009-10-20 Medarex, Inc. Human CTLA-4 antibodies and their uses
MXPA02001911A (es) 1999-08-24 2003-07-21 Medarex Inc Anticuerpos ctla-4 humanos y sus usos.
PL355639A1 (en) 1999-09-10 2004-05-04 Merck & Co, Inc. Tyrosine kinase inhibitors
JP2003516124A (ja) 1999-10-15 2003-05-13 ユニバーシティー オブ マサチューセッツ 標的とした遺伝的干渉の手段としてのrna干渉経路遺伝子
DE60018782T2 (de) 1999-10-19 2006-04-06 Merck & Co., Inc. Tyrosin kinase inhibitoren
EE05107B1 (et) 1999-10-19 2008-12-15 Merck & Co., Inc. Türosiinkinaasi pärssiv ühend, seda sisaldav farmatseutiline kompositsioon ning ühendi kasutamine
US6794393B1 (en) 1999-10-19 2004-09-21 Merck & Co., Inc. Tyrosine kinase inhibitors
JP2003520828A (ja) 2000-01-27 2003-07-08 ジェネティクス インスティテュート,エルエルシー Ctla4(cd152)に対する抗体、これを含む結合体、およびその使用
US6313138B1 (en) 2000-02-25 2001-11-06 Merck & Co., Inc. Tyrosine kinase inhibitors
US6420382B2 (en) 2000-02-25 2002-07-16 Merck & Co., Inc. Tyrosine kinase inhibitors
AU2001249622B2 (en) 2000-03-30 2007-06-07 Massachusetts Institute Of Technology RNA sequence-specific mediators of RNA interference
HU230458B1 (hu) 2000-12-01 2016-07-28 Europäisches Laboratorium für Molekularbiologie (EMBL) Az RNS interferenciát közvetítő kis RNS molekulák
IL149701A0 (en) * 2001-05-23 2002-11-10 Pfizer Prod Inc Use of anti-ctla-4 antibodies
CA2450562A1 (en) 2001-06-22 2003-01-03 Merck & Co., Inc. Tyrosine kinase inhibitors
US6958340B2 (en) 2001-08-01 2005-10-25 Merck & Co., Inc. Tyrosine kinase inhibitors
WO2003020276A1 (en) 2001-08-30 2003-03-13 Merck & Co., Inc. Tyrosine kinase inhibitors
JP2005529873A (ja) * 2002-04-12 2005-10-06 メダレックス インコーポレイテッド Ctla−4抗体を使用した治療の方法
US7148342B2 (en) 2002-07-24 2006-12-12 The Trustees Of The University Of Pennyslvania Compositions and methods for sirna inhibition of angiogenesis
EP1534862A4 (en) 2002-08-07 2007-10-10 Exelixis Inc RABGGT MODULATORS AND METHODS OF USE THEREOF
WO2004035607A2 (en) 2002-10-17 2004-04-29 Genmab A/S Human monoclonal antibodies against cd20
US7465446B2 (en) * 2003-05-30 2008-12-16 Medarex, Inc. Surrogate therapeutic endpoint for anti-CTLA4-based immunotherapy of disease
US20050051208A1 (en) 2003-06-17 2005-03-10 Mount Robert L. System for transferring heat in a thermoelectric generator system
US20050009891A1 (en) * 2003-07-09 2005-01-13 Lee Francis Y. Combination of SRC Kinase inhibitors and chemotherapeutic agents for the treatment of proliferative diseases
US7576206B2 (en) 2003-08-14 2009-08-18 Cephalon, Inc. Proteasome inhibitors and methods of using the same
BRPI0509274A (pt) * 2004-03-26 2007-09-04 Pfizer Prod Inc usos de anticorpos anti-ctla-4
JP2008518902A (ja) * 2004-11-04 2008-06-05 ファイザー・プロダクツ・インク 乳癌のためのctla4抗体とアロマターゼ阻害剤の併用治療
CA2602316A1 (en) * 2005-03-23 2006-09-28 Pfizer Products Inc. Anti-ctla4 antibody and indolinone combination therapy for treatment of cancer
US20060235006A1 (en) * 2005-04-13 2006-10-19 Lee Francis Y Combinations, methods and compositions for treating cancer
EA200800268A1 (ru) * 2005-07-07 2008-06-30 Коли Фармасьютикал Груп, Инк. КОМБИНИРОВАННАЯ ТЕРАПИЯ АНТИТЕЛОМ ПРОТИВ CTLA-4 И СОДЕРЖАЩИМ CpG-МОТИВ СИНТЕТИЧЕСКИМ ОЛИГОДЕЗОКСИНУКЛЕОТИДОМ ДЛЯ ЛЕЧЕНИЯ ЗЛОКАЧЕСТВЕННОЙ ОПУХОЛИ
JP2009518446A (ja) * 2005-12-07 2009-05-07 メダレックス インコーポレーティッド Ctla−4抗体投与量漸増レジメン
CA2647282A1 (en) * 2006-04-05 2007-10-11 Pfizer Products Inc. Ctla4 antibody combination therapy
JP2008066402A (ja) 2006-09-05 2008-03-21 Fujifilm Corp 撮像素子および撮像装置
US9023356B2 (en) * 2007-03-15 2015-05-05 Ludwig Institute For Cancer Research Ltd Treatment method using EGFR antibodies and SRC inhibitors and related formulations
US8449886B2 (en) * 2008-01-08 2013-05-28 Bristol-Myers Squibb Company Combination of anti-CTLA4 antibody with tubulin modulating agents for the treatment of proliferative diseases
US8119129B2 (en) * 2008-08-01 2012-02-21 Bristol-Myers Squibb Company Combination of anti-CTLA4 antibody with dasatinib for the treatment of proliferative diseases

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