JP2014098004A5 - - Google Patents

Download PDF

Info

Publication number
JP2014098004A5
JP2014098004A5 JP2014010925A JP2014010925A JP2014098004A5 JP 2014098004 A5 JP2014098004 A5 JP 2014098004A5 JP 2014010925 A JP2014010925 A JP 2014010925A JP 2014010925 A JP2014010925 A JP 2014010925A JP 2014098004 A5 JP2014098004 A5 JP 2014098004A5
Authority
JP
Japan
Prior art keywords
kinase
inhibitor
active site
itk
interleukin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2014010925A
Other languages
English (en)
Japanese (ja)
Other versions
JP2014098004A (ja
Filing date
Publication date
Application filed filed Critical
Publication of JP2014098004A publication Critical patent/JP2014098004A/ja
Publication of JP2014098004A5 publication Critical patent/JP2014098004A5/ja
Pending legal-status Critical Current

Links

JP2014010925A 2006-05-18 2014-01-24 細胞内キナーゼ阻害剤 Pending JP2014098004A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US80107406P 2006-05-18 2006-05-18
US60/801,074 2006-05-18
US86966406P 2006-12-12 2006-12-12
US60/869,664 2006-12-12

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2009511099A Division JP5682051B2 (ja) 2006-05-18 2007-05-18 細胞内キナーゼ阻害剤

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015164169A Division JP2016040248A (ja) 2006-05-18 2015-08-21 細胞内キナーゼ阻害剤

Publications (2)

Publication Number Publication Date
JP2014098004A JP2014098004A (ja) 2014-05-29
JP2014098004A5 true JP2014098004A5 (OSRAM) 2015-01-15

Family

ID=38723876

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2009511099A Expired - Fee Related JP5682051B2 (ja) 2006-05-18 2007-05-18 細胞内キナーゼ阻害剤
JP2014010925A Pending JP2014098004A (ja) 2006-05-18 2014-01-24 細胞内キナーゼ阻害剤
JP2015164169A Pending JP2016040248A (ja) 2006-05-18 2015-08-21 細胞内キナーゼ阻害剤

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2009511099A Expired - Fee Related JP5682051B2 (ja) 2006-05-18 2007-05-18 細胞内キナーゼ阻害剤

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2015164169A Pending JP2016040248A (ja) 2006-05-18 2015-08-21 細胞内キナーゼ阻害剤

Country Status (7)

Country Link
US (4) US8604031B2 (OSRAM)
EP (2) EP2865381A1 (OSRAM)
JP (3) JP5682051B2 (OSRAM)
AU (1) AU2007254179B2 (OSRAM)
CA (2) CA2858520A1 (OSRAM)
MX (1) MX2008014450A (OSRAM)
WO (1) WO2007136790A2 (OSRAM)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7968574B2 (en) 2004-12-28 2011-06-28 Kinex Pharmaceuticals, Llc Biaryl compositions and methods for modulating a kinase cascade
BRPI0519424B8 (pt) 2004-12-28 2021-05-25 Athenex Inc compostos, composição e uso dos ditos compostos para a preparação de um medicamento para prevenção ou tratamento de um distúrbio de proliferação celular ou infecção microbiana
US8604031B2 (en) * 2006-05-18 2013-12-10 Mannkind Corporation Intracellular kinase inhibitors
CA2656564C (en) 2006-06-29 2015-06-16 Kinex Pharmaceuticals, Llc Biaryl compositions and methods for modulating a kinase cascade
PT2201840E (pt) 2006-09-22 2012-02-14 Pharmacyclics Inc Inibidores da tirosina quinase de bruton
US7935697B2 (en) 2006-12-28 2011-05-03 Kinex Pharmaceuticals, Llc Compositions for modulating a kinase cascade and methods of use thereof
US7939529B2 (en) 2007-05-17 2011-05-10 Kinex Pharmaceuticals, Llc Process for the preparation of compositions for modulating a kinase cascade and methods of use thereof
EA017865B1 (ru) * 2007-03-28 2013-03-29 Фармасайкликс, Инк. Ингибиторы тирозинкиназы брутона
US8809273B2 (en) 2007-03-28 2014-08-19 Pharmacyclics, Inc. Inhibitors of Bruton's tyrosine kinase
WO2009009041A2 (en) * 2007-07-06 2009-01-15 Kinex Pharmaceuticals, Llc Compositions and methods for modulating a kinase cascade
US20100298329A1 (en) * 2007-09-19 2010-11-25 Massachusette Institute Of Technology Tolperisone and tolperisone-like drugs for the treatment of k-ras associated cancers
EP3777832A1 (en) * 2007-10-20 2021-02-17 Athenex, Inc. Pharmaceutical compositions for modulating a kinase cascade and methods of use thereof
US11351168B1 (en) 2008-06-27 2022-06-07 Celgene Car Llc 2,4-disubstituted pyrimidines useful as kinase inhibitors
TWI458721B (zh) 2008-06-27 2014-11-01 Celgene Avilomics Res Inc 雜芳基化合物及其用途
US8338439B2 (en) 2008-06-27 2012-12-25 Celgene Avilomics Research, Inc. 2,4-disubstituted pyrimidines useful as kinase inhibitors
AU2009270856B2 (en) 2008-07-16 2013-07-25 Pharmacyclics Llc Inhibitors of Bruton's tyrosine kinase for the treatment of solid tumors
KR101705158B1 (ko) 2009-05-05 2017-02-09 다나-파버 캔서 인스티튜트 인크. Ｅｇｆｒ 억제제 및 질환 치료방법
EP2478361A4 (en) * 2009-09-16 2014-05-21 Celgene Avilomics Res Inc CONJUGATES AND INHIBITORS OF PROTEIN KINASE
US8299070B2 (en) * 2009-11-25 2012-10-30 Japan Tobacco Inc. Indole compounds and pharmaceutical use thereof
CN102812167A (zh) 2009-12-30 2012-12-05 阿维拉制药公司 蛋白的配体-介导的共价修饰
KR20130016244A (ko) 2010-03-10 2013-02-14 인게니움 파르마코이티칼스 게엠베하 단백질 키나아제의 억제제
CN107441097A (zh) 2010-04-16 2017-12-08 阿西纳斯公司 用于预防和治疗癌症的组合物以及方法
EA201890869A3 (ru) 2010-06-03 2019-03-29 Фармасайкликс, Инк. Применение ингибиторов тирозинкиназы брутона (btk)
RU2013109393A (ru) 2010-08-10 2014-09-20 Сэлджин Авиаломикс Ресеарч, Инк. Безилатная соль ингибитора втк
CA2815858C (en) 2010-11-01 2018-10-16 Celgene Avilomics Research, Inc. Heterocyclic compounds and uses thereof
EP2635285B1 (en) 2010-11-01 2017-05-03 Celgene Avilomics Research, Inc. Heteroaryl compounds and uses thereof
EP2637502B1 (en) 2010-11-10 2018-01-10 Celgene CAR LLC Mutant-selective egfr inhibitors and uses thereof
AU2012283775A1 (en) 2011-07-13 2014-01-23 Pharmacyclics Llc Inhibitors of Bruton's tyrosine kinase
CA2853498A1 (en) 2011-10-28 2013-05-02 Celgene Avilomics Research, Inc. Methods of treating a bruton's tyrosine kinase disease or disorder
US8377946B1 (en) 2011-12-30 2013-02-19 Pharmacyclics, Inc. Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors
IN2014DN07812A (OSRAM) * 2012-02-27 2015-05-15 British Columbia Cancer Agency
WO2013153539A1 (en) 2012-04-13 2013-10-17 Glenmark Pharmaceuticals S.A. Tricyclic compounds as tec kinase inhibitors
CA3218491A1 (en) 2012-06-04 2013-12-12 Pharmacyclics Llc Crystalline forms of a bruton's tyrosine kinase inhibitor
WO2014018567A1 (en) 2012-07-24 2014-01-30 Pharmacyclics, Inc. Mutations associated with resistance to inhibitors of bruton's tyrosine kinase (btk)
LT2890680T (lt) 2012-08-30 2018-05-10 Athenex, Inc. N-(3-fluorbenzil-2-(5-(4-morfolinofenil)piridin-2-il)acetamidas, kaip proteintirozinkinazės moduliatorius
AU2013323736A1 (en) 2012-09-26 2015-04-09 Mannkind Corporation Multiple kinase pathway inhibitors
JP2015537033A (ja) 2012-11-15 2015-12-24 ファーマサイクリックス，インク． キナーゼ阻害剤としてのピロロピリミジン化合物
WO2014100748A1 (en) 2012-12-21 2014-06-26 Celgene Avilomics Research, Inc. Heteroaryl compounds and uses thereof
EP2953457B1 (en) 2013-02-08 2020-04-08 Celgene CAR LLC Erk inhibitors and uses thereof
BR112015025260B1 (pt) 2013-04-25 2021-11-03 Beigene, Ltd Compostos heterocíclicos fundidos como inibidores da proteína quinase, sua composição, combinação e uso
AR097204A1 (es) 2013-08-02 2016-02-24 Pharmacyclics Inc Métodos de tratamiento de tumores sólidos
EP3033079B1 (en) 2013-08-12 2018-10-31 Pharmacyclics LLC Methods for the treatment of her2 amplified cancer
US9492471B2 (en) 2013-08-27 2016-11-15 Celgene Avilomics Research, Inc. Methods of treating a disease or disorder associated with Bruton'S Tyrosine Kinase
RS63571B9 (sr) 2013-09-13 2023-02-28 Beigene Switzerland Gmbh Anti-pd1 antitela i njihova primena kao terapeutska i dijagnostička sredstva
US9624224B2 (en) 2013-09-30 2017-04-18 Pharmacyclics Llc Inhibitors of Bruton's tyrosine kinase
CA2942528A1 (en) 2014-03-20 2015-09-24 Pharmacyclics Inc. Phospholipase c gamma 2 and resistance associated mutations
WO2015181633A2 (en) 2014-04-11 2015-12-03 Acerta Pharma B.V. Methods of blocking the cxcr-4/sdf-1 signaling pathway with inhibitors of bruton's tyrosine kinase
US10544225B2 (en) 2014-07-03 2020-01-28 Beigene, Ltd. Anti-PD-L1 antibodies and their use as therapeutics and diagnostics
WO2016019233A1 (en) 2014-08-01 2016-02-04 Pharmacyclics Llc Inhibitors of bruton's tyrosine kinase
MX2017001671A (es) 2014-08-07 2017-07-04 Pharmacyclics Llc Formulaciones novedosas de un inhibidor de la tirosina cinasa de bruton.
EP3179858B1 (en) 2014-08-13 2019-05-15 Celgene Car Llc Forms and compositions of an erk inhibitor
IL315294A (en) 2015-03-03 2024-10-01 Pharmacyclics Llc Pharmaceutical formulations of bruton's tyrosine kinase inhibitor
CN108135904A (zh) 2015-08-31 2018-06-08 药品循环有限责任公司 用于治疗多发性骨髓瘤的btk抑制剂组合
WO2018007885A1 (en) 2016-07-05 2018-01-11 Beigene, Ltd. COMBINATION OF A PD-l ANTAGONIST AND A RAF INHIBITOR FOR TREATING CANCER
JP7402685B2 (ja) 2016-08-16 2023-12-21 ベイジーン スウィッツァーランド ゲーエムベーハー （ｓ）－７－（１－アクリロイルピペリジン－４－イル）－２－（４－フェノキシフェニル）－４，５，６，７－テトラ－ヒドロピラゾロ［１，５－ａ］ピリミジン－３－カルボキサミドの結晶形、その調製、及びその使用
AU2017313085B2 (en) 2016-08-19 2024-06-20 Beone Medicines I Gmbh Use of a combination comprising a Btk inhibitor for treating cancers
BR112019005337A2 (pt) 2016-09-19 2019-08-27 Mei Pharma Inc terapia combinada
WO2018085731A2 (en) 2016-11-03 2018-05-11 Juno Therapeutics, Inc. Combination therapy of a t cell therapy and a btk inhibitor
CN110461847B (zh) 2017-01-25 2022-06-07 百济神州有限公司 (S)-7-(1-(丁-2-炔酰基)哌啶-4-基)-2-(4-苯氧基苯基)-4,5,6,7-四氢吡唑并[1,5-a]嘧啶-3-甲酰胺的结晶形式、其制备及用途
CA3062874A1 (en) 2017-05-10 2018-11-16 Iovance Biotherapeutics, Inc. Expansion of tumor infiltrating lymphocytes from liquid tumors and therapeutic uses thereof
WO2019001417A1 (en) 2017-06-26 2019-01-03 Beigene, Ltd. IMMUNOTHERAPY FOR HEPATOCELLULAR CARCINOMA
US11377449B2 (en) 2017-08-12 2022-07-05 Beigene, Ltd. BTK inhibitors with improved dual selectivity
CA3083118A1 (en) 2017-11-22 2019-05-31 Iovance Biotherapeutics, Inc. Expansion of peripheral blood lymphocytes (pbls) from peripheral blood
US11786529B2 (en) 2017-11-29 2023-10-17 Beigene Switzerland Gmbh Treatment of indolent or aggressive B-cell lymphomas using a combination comprising BTK inhibitors
EP3787751A1 (en) 2018-05-03 2021-03-10 Juno Therapeutics, Inc. Combination therapy of a chimeric antigen receptor (car) t cell therapy and a kinase inhibitor
WO2019217753A1 (en) 2018-05-10 2019-11-14 Iovance Biotherapeutics, Inc. Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy
AU2020233284A1 (en) 2019-03-01 2021-09-16 Iovance Biotherapeutics, Inc. Expansion of tumor infiltrating lymphocytes from liquid tumors and therapeutic uses thereof
WO2020249001A1 (zh) 2019-06-10 2020-12-17 百济神州瑞士有限责任公司 一种含有布鲁顿氏酪氨酸激酶抑制剂的口服固体片剂及其制备方法
WO2023220655A1 (en) 2022-05-11 2023-11-16 Celgene Corporation Methods to overcome drug resistance by re-sensitizing cancer cells to treatment with a prior therapy via treatment with a t cell therapy
US11786531B1 (en) 2022-06-08 2023-10-17 Beigene Switzerland Gmbh Methods of treating B-cell proliferative disorder
WO2024098024A1 (en) 2022-11-04 2024-05-10 Iovance Biotherapeutics, Inc. Expansion of tumor infiltrating lymphocytes from liquid tumors and therapeutic uses thereof
WO2024123175A1 (en) 2022-12-06 2024-06-13 Erasmus University Medical Center Rotterdam Compositions for treating immune checkpoint blockade therapy resistant cancers

Family Cites Families (219)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3314970A (en) * 1967-04-18 Pykrolidino ketones
US2282907A (en) * 1941-05-01 1942-05-12 Us Rubber Co Parasiticide
US2649444A (en) 1948-10-19 1953-08-18 Burroughs Wellcome Co Process for the preparation of amino ketones
US2778853A (en) * 1952-09-10 1957-01-22 Merck & Co Inc Deamination process
US2771391A (en) 1953-08-20 1956-11-20 Allied Lab Inc Physiologically active p-alkoxy-beta-piperidinopropiophenones causing cns depressantand anesthetic effects in animals
US2997479A (en) 1955-07-01 1961-08-22 Endo Lab 1, 1-diphenyl-1-hydroxy-4-(pyrrolidyl)-butanone-2
BE561320A (nl) 1956-10-04 1960-05-20 Lab Pharmaceutica Nv Werkwijze voor de bereiding van nieuwe 4-carbalkoxy-4-fenyl piperidine derivaten.
US3080372A (en) * 1960-03-25 1963-03-05 Res Lab Dr C Janssen 1-aroylalkyl-4-arylpiperidine derivatives
CH402859A (de) * 1960-05-24 1965-11-30 Wander Ag Dr A Verfahren zur Herstellung von a-Pyrrolidino-valerophenonen
US3252996A (en) * 1962-10-02 1966-05-24 Ciba Geigy Corp Alpha-pyrrolidinomethyl valero and caprophenones
US3151124A (en) 1961-11-20 1964-09-29 Ciba Geigy Corp Alpha oxy-beta alkyl-gamma tertiary amino-alpha phenyl propanes
BE633437A (OSRAM) * 1962-06-11
US3203962A (en) 1962-10-11 1965-08-31 Ciba Geigy Corp Alpha-phenyl-beta pyrrolidino-propiophenones
US3310566A (en) * 1963-11-18 1967-03-21 American Home Prod Substituted 4-piperidino-butyrophenone oximes
US3284453A (en) 1964-09-29 1966-11-08 American Cyanamid Co 4-(2-aroylethyl)-1-piperazinecarboxylic acid esters
US3364210A (en) 1964-10-05 1968-01-16 American Cyanamid Co Substituted 3-aminoacrylophenones and method of preparing the same
NL143925C (OSRAM) * 1965-03-09
US3816433A (en) * 1965-03-24 1974-06-11 Ferrosan Ab 4-fluoro-ypsilon-(4-methylpiperidino)-butyrophenone and its pharmaceutically acceptable salts
GB1079520A (en) * 1965-07-19 1967-08-16 Roche Products Ltd Novel tetrahydro-isoquinoline derivatives and a process for the manufacture thereof
US3317538A (en) * 1965-10-22 1967-05-02 American Home Prod 4, 4'-diamino-butyrophenones
US3417087A (en) 1965-12-27 1968-12-17 Research Corp 3(aminopropionyl)benzothiophenes
US3364120A (en) * 1966-01-24 1968-01-16 Babcock & Wilcox Co Nuclear control rod actuator
US3637704A (en) * 1967-10-18 1972-01-25 Dainippon Pharmaceutical Co 1gamma-(p-fluorobenzoyl)propyl-4-phenylalkyl piperazine
GB1186495A (en) * 1968-02-20 1970-04-02 Delalande Sa 0-[3-(4-Fluorobenzoyl) Proplyl]-4-Substituted Piperazines, their Acid Addition Salts and their method of preparation
GB1196721A (en) 1968-02-23 1970-07-01 Ici Ltd Piperazine Derivatives
CH503726A (de) 1968-04-29 1971-02-28 Ciba Geigy Ag Verfahren zur Herstellung von neuen Estern substituierter Phenylessigsäuren
US3465080A (en) 1968-10-07 1969-09-02 American Cyanamid Co Therapeutic compositions containing morpholinoalkylene - indoles and methods of administering such in the treatment of depression
FR2035749A1 (OSRAM) * 1969-02-06 1970-12-24 Bellon Labor Sa Roger
US3536809A (en) 1969-02-17 1970-10-27 Alza Corp Medication method
GB1262965A (en) 1969-03-21 1972-02-09 Ferrosan As Butyrophenones
US3598123A (en) 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
US3651085A (en) * 1969-04-14 1972-03-21 Robins Co Inc A H 1-(omega-benzoylalkyl)-3-substituted pyrrolidines
US3703527A (en) 1969-06-04 1972-11-21 Hoffmann La Roche Preparation of mannich-bases
US3907812A (en) 1969-07-16 1975-09-23 Sumitomo Chemical Co Butyrophenone derivatives
US3936468A (en) * 1969-10-27 1976-02-03 Sumitomo Chemical Company, Ltd. Phenylbutanol derivatives
US3799932A (en) * 1970-03-20 1974-03-26 Sumitomo Chemical Co Gamma-piperidinobutyrophenones
US3651067A (en) * 1970-04-15 1972-03-21 Usv Pharma Corp Styrene ethers of amino alcohols
DE2021470A1 (de) 1970-05-02 1971-11-25 Cassella Farbwerke Mainkur Ag Piperazinderivate
FR2092133B1 (OSRAM) 1970-05-06 1974-03-22 Orsymonde
US4029801A (en) 1970-09-03 1977-06-14 John Wyeth & Brother Limited Pharmaceutical compositions and methods of treating hypertension
US4148796A (en) * 1971-03-15 1979-04-10 Sumitomo Chemical Company, Limited γ-Piperidinobutyrophenones
US3794677A (en) * 1971-07-01 1974-02-26 American Home Prod Di(lower)alkylamino-and heteroamino-(lower)alkyl-alpha,alpha,alpha-trifluoro-m-toluic acid esters and derivatives
US3969356A (en) 1971-09-13 1976-07-13 Kali-Chemie Aktiengesellschaft N-[3-(p-f-benzoyl)-propyl]-N'-[2.(nitro,nitro-el, or methoxyphenyl)-ethyl]-p
US3850935A (en) 1971-10-16 1974-11-26 Sumitomo Chemical Co Process for producing piperidine derivatives by degrading quaternary piperidinium salts
JPS4948957B2 (OSRAM) * 1971-10-26 1974-12-24
US3806526A (en) * 1972-01-28 1974-04-23 Richardson Merrell Inc 1-aroylalkyl-4-diphenylmethyl piperidines
BE795671A (fr) 1972-02-21 1973-08-20 Ugine Kuhlmann Nouveaux medicaments antiuriques
US3951978A (en) * 1972-04-22 1976-04-20 Istituto Luso Farmaco D'italia S.R.L. 1,3-Disubstituted 3-aroylpropanes and process for the preparation thereof
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US3922266A (en) 1972-06-28 1975-11-25 Sumitomo Chemical Co Aryl ketones and production thereof
US3900478A (en) 1973-01-29 1975-08-19 Squibb & Sons Inc 2-methyl-2-piperidino-3'-(trifluoromethyl) propiophenone
CH602687A5 (OSRAM) 1973-03-12 1978-07-31 Kali Chemie Ag
US3916899A (en) 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
US3873539A (en) * 1973-10-03 1975-03-25 Sandoz Ag Substituted-4-aminoacetyl alkanoylphenones
US3992546A (en) 1973-10-18 1976-11-16 Ciba-Geigy Corporation 4-Piperidinobutyrophenones as neuroleptics
US4054570A (en) 1973-10-18 1977-10-18 Ciba-Geigy Corporation 4-Piperidinobutyrophenones
US3944064A (en) 1973-10-26 1976-03-16 Alza Corporation Self-monitored device for releasing agent at functional rate
US4181803A (en) * 1973-12-14 1980-01-01 Eisai Co., Ltd. Propiophenone derivatives and preparation thereof
US3995047A (en) 1973-12-14 1976-11-30 Eisai Co., Ltd. Propiophenone derivatives in the treatment of pathological muscular conditions
US3912755A (en) 1974-01-30 1975-10-14 Lilly Co Eli Preparation of pharmaceutical intermediates
US3931197A (en) * 1974-02-08 1976-01-06 Richardson-Merrell Inc. Substituted piperidine derivatives
US4069331A (en) * 1974-05-16 1978-01-17 Boehringer Ingelheim Gmbh N-(p-fluorobenzoyl-n-propyl)-4-piperidylamides and salts thereof
IL48319A0 (en) 1974-10-26 1975-12-31 Merck Patent Gmbh Araliphatic nitrogen compounds and a process for their preparation
US4028366A (en) 1975-01-20 1977-06-07 Sterling Drug Inc. 2-Naphthyl-lower-alkanoylamines
US4169892A (en) * 1975-04-03 1979-10-02 Innothera 1-(benzothien-2'-yl)-3-morpholino propanones and therapeutic compositions containing same
GB1498884A (en) 1975-04-15 1978-01-25 Wyeth John & Brother Ltd Aminoacetamide-pyridyl-tetrahydropyridyl and-piperidyl derivatives
FR2316939A1 (fr) 1975-07-08 1977-02-04 Troponwerke Dinklage & Co Derives de 2-benzopyranone et leur application comme medicaments
FI60559C (fi) * 1975-07-17 1982-02-10 Sumitomo Chemical Co Foerfarande foer framstaellning av ny-(tertiaer amino)-orto-aminobutyrofenonfoereningar
FR2325379A1 (fr) 1975-09-29 1977-04-22 Cerm Cent Europ Rech Mauvernay Nouveaux derives de 2-(2-hydroxyethyl)tetrahydro-1,4 oxazines substituees et leur application comme medicaments antispasmodique
DE2557341A1 (de) * 1975-12-19 1977-06-30 Hoechst Ag Basisch substituierte indolderivate und verfahren zu ihrer herstellung
US4333941A (en) 1975-12-22 1982-06-08 The Dow Chemical Company Inhibition of enveloped viruses with phenyl ketones
US4008719A (en) 1976-02-02 1977-02-22 Alza Corporation Osmotic system having laminar arrangement for programming delivery of active agent
FR2361883A2 (fr) 1976-04-09 1978-03-17 Fabre Sa Pierre Amides de la pyrrolidino ethyl amine utilisables en therapeutique pulmonaire
DE2718405A1 (de) * 1977-04-26 1978-11-02 Boehringer Sohn Ingelheim Neue n- eckige klammer auf 1-(3-benzoylpropyl)-4-piperidyl eckige klammer zu -sulfonsaeureamide und verfahren zu deren herstellung
JPS54125630A (en) * 1978-02-22 1979-09-29 Nippon Zoki Pharmaceutical Co Novel propanone derivative*its manufacture and medical composition containing it as active component
DE2933636A1 (de) 1978-08-30 1980-03-20 Sandoz Ag Neue n-phenylindolinderivate, ihre herstellung und pharmazeutische praeparate, welche diese verbindungen enthalten
FR2443246A1 (fr) 1978-12-05 1980-07-04 Pharmindustrie Nouveaux medicaments a base de derives de la phenyl-1 (piperidyl-4)-3 propanone-1
US4293561A (en) 1979-03-09 1981-10-06 Syntex (U.S.A.) Inc. 1-(Naphthyl-n-propyl)imidazole derivatives
US4283404A (en) 1979-09-04 1981-08-11 Richardson-Merrell Inc. Aroylethenylpiperidinobutyrophenone antipsychotic agents
DE2939292A1 (de) 1979-09-28 1981-04-09 Boehringer Mannheim Gmbh, 6800 Mannheim N-phenoxyalkylpiperidin-derivate, verfahrenn zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
DE3041199A1 (de) * 1979-11-14 1981-05-21 Sandoz-Patent-GmbH, 7850 Lörrach Neue stilbenverbindungen, deren herstellung und verwendung
FR2473518A1 (fr) 1980-01-16 1981-07-17 Unicler Derives du phenyl-1 morpholino-4 butene-1 ol-3, leur preparation et leur application en therapeutique
DE3019497A1 (de) 1980-05-22 1981-11-26 Bayer Ag, 5090 Leverkusen Aminopropiophenon-derivate, verfahren zu ihrer herstellung und ihre verwendung als fungizide
DE3019496A1 (de) * 1980-05-22 1981-11-26 Bayer Ag, 5090 Leverkusen Aminopropanol-derivate, verfahren zu ihrer herstellung und ihre verwendung als fungizide
US4400380A (en) 1980-07-02 1983-08-23 Merrell Dow Pharmaceuticals Inc. Antiviral 1-aryl-5-amino-1-penten-3-ones
US4397850A (en) 1981-10-07 1983-08-09 Sandoz, Inc. Isoxazolyl indolamines
JPS5944371A (ja) 1982-09-07 1984-03-12 Dainippon Pharmaceut Co Ltd １―フエニル―２―メチル―３―（１―ピロリジニル）―１―プロパノン誘導体
FR2534912B1 (fr) 1982-10-26 1985-06-28 Lafon Labor Nouveaux derives de (2,4,6-trimethoxyphenyl) - (3-piperidinopropyl) -cetone, utilisation en therapeutique et procede de preparation
EP0117233B1 (de) * 1983-02-18 1987-08-26 Ciba-Geigy Ag Photohärtbare gefärbte Massen
US4515793A (en) * 1983-07-27 1985-05-07 Edna Mcconnell Clark Foundation Phenylpiperazines which are useful in the treatment of schistosomiasis
DE3471486D1 (de) * 1983-08-15 1988-06-30 Ciba Geigy Ag Photocurable compositions
HU33131A (OSRAM) * 1984-01-26 1984-10-29
FR2560873B1 (fr) * 1984-03-09 1986-09-26 Rhone Poulenc Sante Medicaments a base de derives de la piperidine, nouveaux derives de la piperidine et leurs procedes de preparation
DE3413897A1 (de) * 1984-04-13 1985-10-17 Bayer Ag, 5090 Leverkusen (beta)-naphthylalkylamine
US4544663A (en) 1984-05-07 1985-10-01 Sandoz, Inc. Indolamine derivatives as anti-fertility agents
DE3436450A1 (de) 1984-10-05 1986-04-10 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von p-aminoethylketonen
US5057535A (en) 1985-04-11 1991-10-15 Nippon Kayaku Kabushiki Kaisha Derivatives of an aminoketone
FR2584715B1 (fr) 1985-07-10 1987-10-09 Lafon Labor Phenyl-(3-hexamethyleneiminopropyl)-cetone, procede de preparation et utilisation en therapeutique
EP0219756B1 (de) * 1985-10-09 1994-01-05 Shell Internationale Researchmaatschappij B.V. Neue Acrylsäureamide
DE3602016A1 (de) 1985-12-05 1987-06-11 Bayer Ag Pyri(mi)dyl-oxy- und thio-benzoesaeure-derivate
FR2597864B1 (fr) 1986-04-28 1990-11-16 Lafon Labor Nouveaux derives de la n-((trimethoxy-2,4,6-benzoyl)-3 propyl) piperidine, leurs procedes de preparation et leur application en therapeutique
KR910006138B1 (ko) * 1986-09-30 1991-08-16 에자이 가부시끼가이샤 환상아민 유도체
US4766118A (en) * 1986-12-22 1988-08-23 Ortho Pharmaceutical Corporation 6-benzoxazinyl- and 6-benzothiazinyl-2,3,4,5-tetrahydropyridazin-3-ones and pharmaceutical use
JPH0637389B2 (ja) * 1986-12-26 1994-05-18 北陸製薬株式会社 頻尿治療剤
US4965266A (en) 1987-01-20 1990-10-23 Dainippon Pharmaceutical Co., Ltd. Heteroarylcarboxamide derivatives, process for preparing the same and pharmaceutical composition containing the same
US4840950A (en) 1987-02-11 1989-06-20 Sterling Drug Inc. 4-arylcarbonyl-1-[(4-morpholinyl)-lower-alkyl]-1H-indoles
US4874761A (en) 1987-02-11 1989-10-17 Sterling Drug Inc. 4-arylcarbonyl-1-[(4-morpholinyl)-lower-alkyl]-1H-indoles
DE3880868D1 (en) 1987-03-26 1993-06-17 Ciba Geigy Ag Neue alpha-aminoacetophenone als photoinitiatoren.
US4870083A (en) 1987-11-24 1989-09-26 Merrell Dow Pharmaceuticals Inc. 1,4-Disubstituted-piperidinyl compounds useful as analgesics and muscle relaxants
US5196439A (en) * 1987-11-27 1993-03-23 Eisai Co., Ltd. Piperidine compounds useful to treat cerebrovascular diseases
US4791045A (en) 1988-01-25 1988-12-13 Minnesota Mining And Manufacturing Company Photosensitizers and polymerizable compositions with mannich bases and iodonium salts
IT1231260B (it) * 1988-11-16 1991-11-28 Sergio Bertini Curri Farmaco e metodo per aumentare volume e velocita' del flusso microcircolatorio capillare a livello cutaneo
JPH0660141B2 (ja) * 1989-09-12 1994-08-10 三井東圧化学株式会社 ジヒドロカフェイン酸誘導体およびそれを有効成分として含有する治療剤
US5182284A (en) * 1990-01-26 1993-01-26 Taiho Pharmaceutical Co., Ltd. Piperazine compounds, processes for preparation thereof and medical uses thereof
US5013837A (en) * 1990-03-08 1991-05-07 Sterling Drug Inc. 3-Arylcarbonyl-1H-indole-containing compounds
US5276035A (en) * 1990-07-26 1994-01-04 Novo Nordisk A/S 1,4-disubstituted piperazines
US5750542A (en) 1993-09-28 1998-05-12 Pfizer Benzisoxazole and benzisothizole derivatives as cholinesterase inhibitors
FR2680366B1 (fr) * 1991-08-13 1995-01-20 Adir Nouveaux derives d'arylethylamines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
JP3157882B2 (ja) 1991-11-15 2001-04-16 帝国臓器製薬株式会社 新規なベンゾチオフエン誘導体
US5643919A (en) 1992-06-22 1997-07-01 Boehringer Ingelheim Kg Anellated dihydropyridines and the use thereof for the production of pharmaceutical preparation
US5324483B1 (en) * 1992-10-08 1996-09-24 Warner Lambert Co Apparatus for multiple simultaneous synthesis
GB9301660D0 (en) * 1993-01-28 1993-03-17 Smithkline Beecham Plc Pharmaceuticals
US6127379A (en) 1993-02-01 2000-10-03 Smithkline Beecham P.L.C. Benzopyran, benzothiopyran and benzofuran derivatives as 5-HT4 antagonists
DK0612724T3 (da) * 1993-02-23 1997-06-16 Hoechst Ag Substituerede benzensulfonylurinstoffer og -thiourinstoffer, fremgangsmåde til deres fremstilling og deres anvendelse som farmaceutika
KR100238346B1 (ko) 1993-04-07 2000-03-02 오쓰까 아끼히꼬 피페리딘 유도체를 유효성분으로 하는 말초혈관확장제
US5350748A (en) 1993-08-18 1994-09-27 Warner-Lambert Company 3-thio or amino substituted-benzo[b]thiophene-2-carboxamides and 3-oxygen, thio, or amino substituted-benzofuran-2-carboxamides as inhibitors of cell adhesion
GB9324018D0 (en) * 1993-11-23 1994-01-12 Merck Sharp & Dohme Therapeutic agents
FR2713637B1 (fr) * 1993-12-15 1996-01-05 Cird Galderma Nouveaux composés bi-aromatiques dérivés d'amide, compositions pharmaceutiques et cosmétiques les contenant et utilisations.
DK139593D0 (da) 1993-12-16 1993-12-16 Lundbeck & Co As H Compounds
ES2152379T3 (es) 1993-12-21 2001-02-01 Boehringer Ingelheim Pharma Dihidropiridinas condensadas y su utilizacion para la produccion de preparados farmaceuticos.
GB9408185D0 (en) * 1994-04-25 1994-06-15 Fujisawa Pharmaceutical Co New benzamide derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same
US5552402A (en) 1994-05-19 1996-09-03 Merck, Sharp & Dohme Ltd. Five-membered heteroaromatic compounds as 5-HT receptor agonists
US5618819A (en) * 1994-07-07 1997-04-08 Adir Et Compagnie 1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one and oxazolo[4,5-b]pyridin-2-(3H)-one compounds
US6214994B1 (en) 1997-04-21 2001-04-10 Molecular Geriatrics Corporation Certain substituted 1-aryl-3-piperazin-1′-yl propanones
US5705501A (en) * 1994-11-17 1998-01-06 Molecular Geriatrics Corporation Certain substituted 1-aryl-3-morpholinopropanones to treat Alzheimer's Disease
GB9423460D0 (en) * 1994-11-21 1995-01-11 Merck Sharp & Dohme Therapeutic agents
WO1996040636A1 (en) * 1995-06-07 1996-12-19 Pfizer Inc. Catechol diethers derivatives useful as pharmaceutical agents
GB9511694D0 (en) * 1995-06-09 1995-08-02 Fujisawa Pharmaceutical Co Benzamide derivatives
DE69728138T2 (de) * 1996-03-29 2004-09-16 Pfizer Inc. 6-phenylpyridinderivate
PT892791E (pt) * 1996-04-12 2003-06-30 Searle & Co N-¬¬4-(5-metil-3-fenilisoxazol-4-il|fenil|sulfonil-propilamida e seu sal de sodio como pro-farmacos de inibidores de cox-2
NZ332340A (en) 1996-05-20 2000-04-28 Darwin Discovery Ltd 4-(aryl or heteroaryl) substituted benzofurancarboxamide derivatives and medicaments
US6555690B2 (en) * 1996-06-21 2003-04-29 Allergan, Inc. Alkyl or aryl substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity
US6184235B1 (en) 1996-08-14 2001-02-06 Warner-Lambert Company 2-phenyl benzimidazole derivatives as MCP-1 antagonists
TW452575B (en) * 1996-12-06 2001-09-01 Ciba Sc Holding Ag New Α-aminoacetophenone photoinitiators and photopolymerizable compositions comprising these photoinitiators
US5994398A (en) 1996-12-11 1999-11-30 Elan Pharmaceuticals, Inc. Arylsulfonamides as phospholipase A2 inhibitors
US6281227B1 (en) * 1996-12-13 2001-08-28 Aventis Pharma Deutschland Gmbh Sulfonic acid sulfonylamino n-(heteroaralkyl)-azaheterocyclylamide compounds
FR2761358B1 (fr) 1997-03-27 1999-05-07 Adir Nouveaux composes de n-aryl piperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US6207665B1 (en) * 1997-06-12 2001-03-27 Schering Aktiengesellschaft Piperazine derivatives and their use as anti-inflammatory agents
US20010049379A1 (en) * 1997-08-27 2001-12-06 Lowe John Adams 2-aminopyridines containing fused ring substituents
HN1998000125A (es) * 1997-08-28 1999-02-09 Pfizer Prod Inc 2-aminopiridinas con sustituyentes alcoxi ramificados
US5972986A (en) 1997-10-14 1999-10-26 G.D. Searle & Co. Method of using cyclooxygenase-2 inhibitors in the treatment and prevention of neoplasia
US6140349A (en) 1998-02-02 2000-10-31 Merck & Co., Inc. Cyclic amine modulators of chemokine receptor activity
US6528529B1 (en) * 1998-03-31 2003-03-04 Acadia Pharmaceuticals Inc. Compounds with activity on muscarinic receptors
US6462036B1 (en) * 1998-11-06 2002-10-08 Basf Aktiengesellschaft Tricyclic pyrazole derivatives
AR022338A1 (es) 1999-02-04 2002-09-04 Hokuriku Pharmaceutical Un compuesto de benzamida, medicamento que lo contiene, y uso para la manufactura de un medicamento para el tratamiento o prevencion de una enfermedad digestiva o para mejorar la movilidad del tracto gastrointestinal.
AUPP873799A0 (en) * 1999-02-17 1999-03-11 Fujisawa Pharmaceutical Co., Ltd. Pyridine compounds
ES2295009T3 (es) * 1999-03-25 2008-04-16 Mitsubishi Tanabe Pharma Corporation Inhibidores de rho quinasa para la profilaxis y el tratamiento de neumonia intersticial y fibrosis pulmonar.
US7361666B2 (en) * 1999-05-25 2008-04-22 Sepracor, Inc. Heterocyclic analgesic compounds and methods of use thereof
US6677332B1 (en) 1999-05-25 2004-01-13 Sepracor, Inc. Heterocyclic analgesic compounds and methods of use thereof
DE60024830T2 (de) 1999-07-09 2006-06-14 Boehringer Ingelheim Pharma Verfahren zur herstellung heteroarylsubstituierter ureaverbindungen
US7253165B2 (en) * 1999-09-14 2007-08-07 Aventis Pharmaceuticals Inc. Benzisoxazolyl-, pyridoisoxazolyl-and benzthienyl-phenoxy derivatives useful as D4 antagonists
CA2395520A1 (en) 1999-12-21 2001-06-28 Sugen, Inc. 4-substituted 7-aza-indolin-2-ones and their use as protein kinase inhibitors
CN1615873A (zh) * 1999-12-24 2005-05-18 阿文蒂斯药物有限公司 氮杂吲哚类化合物
GB0004149D0 (en) 2000-02-23 2000-04-12 Astrazeneca Uk Ltd Novel compounds
EP1339702A1 (en) * 2000-03-15 2003-09-03 Warner-Lambert Company 5-amide substituted diarylamines as mek inhibitors
US20030225036A1 (en) 2000-03-20 2003-12-04 Aleksandr Kolesnikov Non-amidine containing protease inhibitors
EP1268455A2 (en) * 2000-03-31 2003-01-02 Pfizer Products Inc. Piperazine derivatives
CN1195742C (zh) * 2000-06-05 2005-04-06 Fmc有限公司 磺酰胺的制备方法
US6537994B2 (en) * 2000-07-17 2003-03-25 Wyeth Heterocyclic β3 adrenergic receptor agonists
TWI262920B (en) 2000-10-27 2006-10-01 Elbion Ag New 7-azaindoles, their use as inhibitors of phosphodiesterase 4, and a method for synthesizing them
ATE286897T1 (de) * 2000-11-28 2005-01-15 Smithkline Beecham Plc Morpholinderivate als antagonisten an orexinrezeptoren
DK1347971T3 (da) 2000-12-21 2006-05-15 Bristol Myers Squibb Co Thiazolylinhibitorer af tyrosinkinaser fra Tec-familien
US20030105144A1 (en) * 2001-04-17 2003-06-05 Ping Gao Stabilized oral pharmaceutical composition
US6673818B2 (en) * 2001-04-20 2004-01-06 Pharmacia Corporation Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation
DE10123129A1 (de) 2001-05-02 2002-11-14 Berolina Drug Dev Ab Svedala Deuterierte 3-Piperidinopropiophenone sowie diese Verbindungen enthaltende Arzneimittel
MXPA03010269A (es) * 2001-05-11 2004-05-05 Vertex Pharma Derivados de 2,5-disubstituida piridina, pirimidina, piridazina y 1,2,4-triazina para usarse como inhibidores de p38.
GB0115109D0 (en) * 2001-06-21 2001-08-15 Aventis Pharma Ltd Chemical compounds
SE0102809D0 (sv) 2001-08-22 2001-08-22 Astrazeneca Ab Novel compounds
US20030236293A1 (en) 2001-09-18 2003-12-25 Pharmacia Corporation Compositions of tricyclic cyclooxygenase-2 selective inhibitors and acetaminophen for treatment and prevention of inflammation, inflammation-mediated disorders and pain
WO2003050102A1 (en) 2001-12-10 2003-06-19 Aryx Therapeutics Novel compounds for the treatment of cardiac arrhythmia, synthesis, and methods of use
DE10161644A1 (de) * 2001-12-14 2003-06-26 Gruenenthal Gmbh N,N'-disubstituierte Piperazin-Verbindungen
US7161008B2 (en) * 2002-05-03 2007-01-09 Sanofi - Aventis Deutschland GmbH Optically active β-aminoketones, optically active 1,3-amino alcohols and processes for preparing them
CN1150176C (zh) 2002-05-22 2004-05-19 上海医药工业研究院 芳烷酮哌嗪衍生物及其应用
US7259179B2 (en) * 2002-05-23 2007-08-21 Cytopia Research Pty Ltd Kinase inhibitors
US20040077529A1 (en) * 2002-06-10 2004-04-22 Per-Fredrik Lehmann Urotensin II receptor agents
US20040072839A1 (en) * 2002-06-14 2004-04-15 Amedeo Leonardi 1-Phenylalkylpiperazines
WO2004014905A1 (en) * 2002-08-08 2004-02-19 Boehringer Ingelheim Pharmaceuticals, Inc. Substituted benzimidazole compounds
SE0202463D0 (sv) 2002-08-14 2002-08-14 Astrazeneca Ab Novel compounds
JP4560483B2 (ja) 2002-10-03 2010-10-13 ターゲジェン インコーポレーティッド 血管静態化物質およびそれらの使用法
EP1562574A1 (en) * 2002-11-07 2005-08-17 Astrazeneca AB 2-oxo-ethanesulfonamide derivates
GB0227240D0 (en) * 2002-11-21 2002-12-31 Glaxo Group Ltd Compounds
US7741485B2 (en) 2003-04-08 2010-06-22 Basf Aktiengesellschaft Benzenesulphonamide derivatives as herbicides or desiccant/defoliant compounds
MXPA06001636A (es) 2003-08-13 2006-04-28 Amgen Inc Antagonista del receptor de la hormona concentradora de melanina.
US7160888B2 (en) 2003-08-22 2007-01-09 Warner Lambert Company Llc [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia
CN1897950A (zh) * 2003-10-14 2007-01-17 惠氏公司 稠合芳基和杂芳基衍生物及其使用方法
EP1716126B1 (en) * 2003-12-23 2009-02-25 Eli Lilly And Company Morpholine derivatives as norepinephrine reuptake inhibitors
EP1716151A1 (en) * 2004-01-26 2006-11-02 Vertex Pharmaceuticals Incorporated Compositions useful as inhibitors of protein kinases
PT1730146E (pt) * 2004-03-30 2011-07-11 Vertex Pharma Azaindoles úteis como inibidores de jak e outras proteínas quinases
US7498342B2 (en) * 2004-06-17 2009-03-03 Plexxikon, Inc. Compounds modulating c-kit activity
US7361764B2 (en) * 2004-07-27 2008-04-22 Sgx Pharmaceuticals, Inc. Pyrrolo-pyridine kinase modulators
KR20070053237A (ko) * 2004-07-27 2007-05-23 에스지엑스 파마슈티컬스, 인코포레이티드 피롤로-피리딘 키나제 조절제
BRPI0514094A (pt) 2004-08-02 2008-05-27 Osi Pharm Inc composto, composição, e, método de tratamento de distúrbio hiperproliferativo
WO2006034473A2 (en) * 2004-09-23 2006-03-30 Reddy Us Therapeutics, Inc. Novel pyrimidine compounds, process for their preparation and compositions containing them
JP2008523146A (ja) 2004-12-14 2008-07-03 ワイス 神経変性障害の処置および予防のための５−ｈｔ６アゴニストの使用
DE102004060659A1 (de) 2004-12-15 2006-07-06 Lanxess Deutschland Gmbh Neue substituierte 1H-Pyrrolo[2,3-b]pyridine und deren Herstellung
EP1856053A1 (en) 2005-01-14 2007-11-21 Millennium Pharmaceuticals, Inc. Cinnamide and hydrocinnamide derivatives with raf-kinase inhibitory activity
US20060246099A1 (en) 2005-04-21 2006-11-02 L'oreal Compositions containing piperazine compounds
NZ563444A (en) * 2005-05-17 2011-04-29 Plexxikon Inc Pyrrolo(2,3-b)pyridine derivatives as protein kinase inhibitors
EP1881983B1 (en) * 2005-05-20 2012-01-11 Vertex Pharmaceuticals, Inc. Pyrrolopyridines useful as inhibitors of protein kinase
EE05697B1 (et) * 2005-06-08 2014-02-17 Janssen Pharmaceutica N.V. Kinoliini derivaadid kui antibakteriaalsed toimeained
GB0516156D0 (en) * 2005-08-05 2005-09-14 Eisai London Res Lab Ltd JNK inhibitors
AR056544A1 (es) * 2005-09-29 2007-10-10 Wyeth Corp Derivados fenilaminopropanol y metodos de uso de los mismos
CA2629314A1 (en) * 2005-11-12 2007-05-24 Boehringer Ingelheim International Gmbh Tec kinase inhibitors
EP1968580A2 (en) * 2005-12-20 2008-09-17 Boehringer Ingelheim International Gmbh 2-(ih-thieno [3,2-c] pyrazol-3yl)-ih-indole derivatives and related compounds as tec kinase inhibitors for the treatment of inflammations and immunological disorders
CA2635899A1 (en) * 2006-01-19 2007-07-26 Osi Pharmaceuticals, Inc. Fused heterobicyclic kinase inhibitors
UY30121A1 (es) * 2006-02-03 2007-08-31 Glaxo Group Ltd Nuevos compuestos
US8604031B2 (en) * 2006-05-18 2013-12-10 Mannkind Corporation Intracellular kinase inhibitors
PT2201840E (pt) * 2006-09-22 2012-02-14 Pharmacyclics Inc Inibidores da tirosina quinase de bruton
SG171815A1 (en) * 2008-12-19 2011-07-28 Bristol Myers Squibb Co Carbazole carboxamide compounds useful as kinase inhibitors

Similar Documents

Publication Publication Date Title
JP2014098004A5 (OSRAM)
Nguyen et al. The FGFR1 inhibitor PD173074 induces mesenchymal–epithelial transition through the transcription factor AP-1
Cheah et al. Mantle cell lymphoma
Willmann et al. Impairment of prostate cancer cell growth by a selective and reversible lysine‐specific demethylase 1 inhibitor
Dyshlovoy et al. Proteomic profiling of germ cell cancer cells treated with aaptamine, a marine alkaloid with antiproliferative activity
CY1120637T1 (el) Πολυπεπτιδικα αντισωματα που ανταγωνιζονται cd40
JP2018516245A5 (OSRAM)
DOP2009000280A (es) Sales del inhibidor de janus cinasa (r)-3-(4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il)-3-ciclopentilpropanitrilo
HK1254861A1 (zh) 抗lag3抗体及其用途
BR112015022978A2 (pt) agente de ligação biespecífico, seu método de produção composição farmacêutica, proteína de fusão, uso, sequência de ácido nucleico, vetor, célula hospedeira, método de matar células tumorais e de inibir o crescimento tumoral
EP3736294A3 (en) Cd73 blockade
CN110382482A (zh) 稠合的杂-杂二环化合物及其使用方法
EP4302784A3 (en) Anti-ntb-a antibodies and related compositions and methods
JOP20160154B1 (ar) أجسام ضادة مضاد لل psma، وجزيئات رابطة لمستضد ثنائي النوعية الذي يربط psma و cd3، واستخداماتها
HRP20211976T1 (hr) Postupci liječenja bolesnika od raka inhibitorima farnezil transferaze
CL2008003366A1 (es) Compuestos derivados de heterociclos nitrogenados fusionados, inhibidores de proteinas quinasas mek y mapk/erk; proceso de preparacion de los compuestos; composicion farmaceutica que los comprende; conjunto que los comprende; y su uso en la preparacion de medicamentos para el tratamiento de trastornos hiperproliferativos.
JP2009537552A5 (OSRAM)
BR112014004239A2 (pt) inibidores de enzima ativadora de nedd8
HK1248133A1 (zh) 治疗神经母细胞瘤的方法
EA202091082A1 (ru) Композиция и способ лечения периферической т-клеточной лимфомы и кожной т-клеточной лимфомы
Wassmann et al. Efficacy and safety of imatinib mesylate (Glivec™) in combination with interferon-α (IFN-α) in Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL)
EP4268900A3 (en) Treatment paradigm for an anti-cd19 antibody and venetoclax combination treatment
MA37751A1 (fr) Procédé de préparation de composés d'acides aminés
AR090544A1 (es) Metodo para tratar selectivamente a un sujeto que tenga cancer
Zhang et al. Tim-3 expression in glioma cells is associated with drug resistance