JP2014036956A5 - - Google Patents

Download PDF

Info

Publication number
JP2014036956A5
JP2014036956A5 JP2013203694A JP2013203694A JP2014036956A5 JP 2014036956 A5 JP2014036956 A5 JP 2014036956A5 JP 2013203694 A JP2013203694 A JP 2013203694A JP 2013203694 A JP2013203694 A JP 2013203694A JP 2014036956 A5 JP2014036956 A5 JP 2014036956A5
Authority
JP
Japan
Prior art keywords
liquid
droplets
continuous phase
phase liquid
spacing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2013203694A
Other languages
English (en)
Japanese (ja)
Other versions
JP5973407B2 (ja
JP2014036956A (ja
Filing date
Publication date
Priority claimed from US11/082,187 external-priority patent/US7655470B2/en
Priority claimed from US11/174,298 external-priority patent/US9477233B2/en
Application filed filed Critical
Publication of JP2014036956A publication Critical patent/JP2014036956A/ja
Publication of JP2014036956A5 publication Critical patent/JP2014036956A5/ja
Application granted granted Critical
Publication of JP5973407B2 publication Critical patent/JP5973407B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2013203694A 2005-03-16 2013-09-30 マイクロフルイディックシステム Expired - Fee Related JP5973407B2 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11/082,187 2005-03-16
US11/082,187 US7655470B2 (en) 2004-10-29 2005-03-16 Method for manipulating a plurality of plugs and performing reactions therein in microfluidic systems
US11/174,298 2005-07-01
US11/174,298 US9477233B2 (en) 2004-07-02 2005-07-01 Microfluidic system with a plurality of sequential T-junctions for performing reactions in microdroplets

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2011231160A Division JP5671434B2 (ja) 2005-03-16 2011-10-20 マイクロフルイディックシステム

Publications (3)

Publication Number Publication Date
JP2014036956A JP2014036956A (ja) 2014-02-27
JP2014036956A5 true JP2014036956A5 (enExample) 2014-10-09
JP5973407B2 JP5973407B2 (ja) 2016-08-23

Family

ID=37024341

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013203694A Expired - Fee Related JP5973407B2 (ja) 2005-03-16 2013-09-30 マイクロフルイディックシステム

Country Status (4)

Country Link
US (5) US9477233B2 (enExample)
EP (2) EP3763442A1 (enExample)
JP (1) JP5973407B2 (enExample)
WO (1) WO2006101851A2 (enExample)

Families Citing this family (136)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7901939B2 (en) 2002-05-09 2011-03-08 University Of Chicago Method for performing crystallization and reactions in pressure-driven fluid plugs
JP2006507921A (ja) 2002-06-28 2006-03-09 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 流体分散のための方法および装置
US10533998B2 (en) 2008-07-18 2020-01-14 Bio-Rad Laboratories, Inc. Enzyme quantification
GB0307428D0 (en) * 2003-03-31 2003-05-07 Medical Res Council Compartmentalised combinatorial chemistry
US20060078893A1 (en) * 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
GB0307403D0 (en) * 2003-03-31 2003-05-07 Medical Res Council Selection by compartmentalised screening
WO2004091763A2 (en) 2003-04-10 2004-10-28 President And Fellows Of Harvard College Formation and control of fluidic species
EP2662136A3 (en) 2003-08-27 2013-12-25 President and Fellows of Harvard College Method for handling and mixing droplets
US20050221339A1 (en) * 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
US9477233B2 (en) 2004-07-02 2016-10-25 The University Of Chicago Microfluidic system with a plurality of sequential T-junctions for performing reactions in microdroplets
US7655470B2 (en) 2004-10-29 2010-02-02 University Of Chicago Method for manipulating a plurality of plugs and performing reactions therein in microfluidic systems
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
EP1861194A2 (en) 2005-03-04 2007-12-05 The President and Fellows of Harvard College Method and apparatus for forming multiple emulsions
US20060280029A1 (en) * 2005-06-13 2006-12-14 President And Fellows Of Harvard College Microfluidic mixer
WO2007024914A2 (en) 2005-08-22 2007-03-01 Applera Corporation Device and method for microfluidic control of a first fluid in contact with a second fluid, wherein the first and second fluids are immiscible
EP3913375A1 (en) 2006-01-11 2021-11-24 Bio-Rad Laboratories, Inc. Microfluidic devices and methods of use in the formation and control of nanoreactors
WO2008051265A2 (en) * 2006-02-03 2008-05-02 President And Fellows Of Harvard College Engineered cell growth on polymeric films and biotechnological applications there of
EP2021113A2 (en) 2006-05-11 2009-02-11 Raindance Technologies, Inc. Microfluidic devices
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
US9012390B2 (en) 2006-08-07 2015-04-21 Raindance Technologies, Inc. Fluorocarbon emulsion stabilizing surfactants
US20100196432A1 (en) * 2006-10-10 2010-08-05 Feinberg Adam W Biopolymer structures
US7918831B2 (en) * 2006-10-12 2011-04-05 Colorado Catheter Company, Inc. Catheter assembly having protective sheath
FR2907228B1 (fr) * 2006-10-13 2009-07-24 Rhodia Recherches & Tech Dispositif d'ecoulement fluidique,ensemble de determination d'au moins une caracteristique d'un systeme physico-chimique comprenant un tel dispositif,procede de determination et procede de criblage correspondants
FR2907227B1 (fr) * 2006-10-13 2009-04-10 Rhodia Recherches & Tech Procede et installation de determination d'au moins un parametre d'une transformation physique et/ou chimique,et procede de criblage correspondant
US8772046B2 (en) 2007-02-06 2014-07-08 Brandeis University Manipulation of fluids and reactions in microfluidic systems
JP5062399B2 (ja) * 2007-02-19 2012-10-31 セイコーインスツル株式会社 マイクロ流路およびマイクロリアクタ
US9152150B1 (en) * 2007-02-22 2015-10-06 Applied Biosystems, Llc Compositions, systems, and methods for immiscible fluid discrete volume manipulation
WO2008132309A2 (fr) * 2007-03-05 2008-11-06 Rhodia Operations Procede de suivi de la cristallisation d'une substance, dispositif microfluidique et procede de criblage correspondants
US7776927B2 (en) 2007-03-28 2010-08-17 President And Fellows Of Harvard College Emulsions and techniques for formation
WO2008130623A1 (en) 2007-04-19 2008-10-30 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
WO2009009021A1 (en) * 2007-07-06 2009-01-15 The Regents Of The University Of California Integrated microfluidics for highly parallel screening of chemical reactions
WO2009048673A2 (en) 2007-07-26 2009-04-16 University Of Chicago Stochastic confinement to detect, manipulate, and utilize molecules and organisms
EP2197583A2 (en) 2007-09-19 2010-06-23 Claros Diagnostics, Inc. Liquid containment for integrated assays
WO2009085067A2 (en) * 2007-09-26 2009-07-09 President And Fellows Of Harvard College Boundary conditions for the arrangement of cells and tissues
FR2928209B1 (fr) * 2008-03-03 2011-04-22 Rhodia Operations Procede et installation de determination d'au moins un parametre d'une transformation physique et/ou chimique
EP2285491A1 (en) 2008-04-25 2011-02-23 Claros Diagnostics, Inc. Flow control in microfluidic systems
WO2010011407A2 (en) * 2008-05-23 2010-01-28 President And Fellows Of Harvard College Methods of generating patterned soft substrates and uses thereof
US8622987B2 (en) * 2008-06-04 2014-01-07 The University Of Chicago Chemistrode, a plug-based microfluidic device and method for stimulation and sampling with high temporal, spatial, and chemical resolution
KR20110016479A (ko) 2008-06-06 2011-02-17 바이오나노매트릭스, 인크. 통합 나노유체 분석 장치, 제작 방법 및 분석 기술
US20100158772A1 (en) * 2008-06-13 2010-06-24 Decode Biostructures, Inc. Nanovolume microcapillary crystallization system
WO2009152520A2 (en) * 2008-06-13 2009-12-17 Decode Biostructures, Inc. Nanovolume microcapillary crystallization system
GB0810990D0 (en) * 2008-06-16 2008-07-23 Q Chip Ltd Device and method of making solid beads
WO2010009365A1 (en) 2008-07-18 2010-01-21 Raindance Technologies, Inc. Droplet libraries
US12038438B2 (en) 2008-07-18 2024-07-16 Bio-Rad Laboratories, Inc. Enzyme quantification
US8053239B2 (en) * 2008-10-08 2011-11-08 The Governing Council Of The University Of Toronto Digital microfluidic method for protein extraction by precipitation from heterogeneous mixtures
US9713802B2 (en) * 2009-01-13 2017-07-25 Kobe Steel, Ltd. Method and apparatus for manufacturing liquid microspheres
WO2010111231A1 (en) 2009-03-23 2010-09-30 Raindance Technologies, Inc. Manipulation of microfluidic droplets
WO2010111265A1 (en) 2009-03-24 2010-09-30 University Of Chicago Slip chip device and methods
US9447461B2 (en) 2009-03-24 2016-09-20 California Institute Of Technology Analysis devices, kits, and related methods for digital quantification of nucleic acids and other analytes
US9464319B2 (en) 2009-03-24 2016-10-11 California Institute Of Technology Multivolume devices, kits and related methods for quantification of nucleic acids and other analytes
US10196700B2 (en) 2009-03-24 2019-02-05 University Of Chicago Multivolume devices, kits and related methods for quantification and detection of nucleic acids and other analytes
US9012172B2 (en) 2009-05-01 2015-04-21 President And Fellows Of Harvard College Devices comprising muscle thin films and uses thereof in high throughput assays for determining contractile function
US20100294986A1 (en) * 2009-05-19 2010-11-25 Massachusetts Institute Of Technology Supercritical fluid facilitated particle formation in microfluidic systems
US20100298602A1 (en) * 2009-05-19 2010-11-25 Massachusetts Institute Of Technology Systems and methods for microfluidic crystallization
US9752964B1 (en) * 2009-06-22 2017-09-05 Stc.Unm Flow cytometry apparatus pulling sample stream through observation chamber
US8337783B2 (en) * 2009-06-23 2012-12-25 The United States of America as represented by the Secretary of Commerce, the National Institute of Standards and Technology Magnetic connectors for microfluidic applications
JP5841937B2 (ja) * 2009-06-26 2016-01-13 プレジデント アンド フェローズ オブ ハーバード カレッジ 流体注入
US11285494B2 (en) 2009-08-25 2022-03-29 Nanoshell Company, Llc Method and apparatus for continuous removal of sub-micron sized particles in a closed loop liquid flow system
US10099227B2 (en) 2009-08-25 2018-10-16 Nanoshell Company, Llc Method and apparatus for continuous removal of sub-micron sized particles in a closed loop liquid flow system
CN102655922A (zh) 2009-08-25 2012-09-05 艾格尼丝·奥斯塔芬 用于在闭环液流系统中连续除去亚微米尺寸的颗粒的方法和设备
US10751464B2 (en) 2009-08-25 2020-08-25 Nanoshell Company, Llc Therapeutic retrieval of targets in biological fluids
EP2473263B1 (en) 2009-09-02 2022-11-02 President and Fellows of Harvard College Multiple emulsions created using jetting and other techniques
FR2950544B1 (fr) * 2009-09-29 2011-12-09 Ecole Polytech Circuit microfluidique
WO2011042564A1 (en) 2009-10-09 2011-04-14 Universite De Strasbourg Labelled silica-based nanomaterial with enhanced properties and uses thereof
EP2517025B1 (en) 2009-12-23 2019-11-27 Bio-Rad Laboratories, Inc. Methods for reducing the exchange of molecules between droplets
US20110165037A1 (en) * 2010-01-07 2011-07-07 Ismagilov Rustem F Interfaces that eliminate non-specific adsorption, and introduce specific interactions
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
EP4484577A3 (en) 2010-02-12 2025-03-26 Bio-Rad Laboratories, Inc. Digital analyte analysis
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
WO2011139719A2 (en) 2010-04-26 2011-11-10 Rheosense, Inc. Portable viscometer
WO2012006320A1 (en) 2010-07-06 2012-01-12 President And Fellows Of Harvard College Photosensitive cardiac rhythm modulation systems
US9677979B2 (en) 2010-07-16 2017-06-13 Vanderbilt University Low resource processor using surface tension valves for extracting, concentrating and detecting molecular species
EP2622103B2 (en) 2010-09-30 2022-11-16 Bio-Rad Laboratories, Inc. Sandwich assays in droplets
IT1404074B1 (it) * 2010-12-17 2013-11-08 Alifax Holding S P A Dispositivo per realizzare test clinici su liquidi biologici e relativo procedimento
WO2012109600A2 (en) 2011-02-11 2012-08-16 Raindance Technologies, Inc. Methods for forming mixed droplets
US9150852B2 (en) 2011-02-18 2015-10-06 Raindance Technologies, Inc. Compositions and methods for molecular labeling
WO2012162296A2 (en) 2011-05-23 2012-11-29 President And Fellows Of Harvard College Control of emulsions, including multiple emulsions
US8841071B2 (en) 2011-06-02 2014-09-23 Raindance Technologies, Inc. Sample multiplexing
WO2013006661A2 (en) 2011-07-06 2013-01-10 President And Fellows Of Harvard College Multiple emulsions and techniques for the formation of multiple emulsions
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
CN103946712A (zh) * 2011-09-30 2014-07-23 不列颠哥伦比亚大学 用于流动控制润湿的方法和设备
JP5800195B2 (ja) * 2011-11-25 2015-10-28 国立研究開発法人産業技術総合研究所 結晶成長用容器、液滴調製器具および結晶取得方法
WO2013086512A2 (en) 2011-12-09 2013-06-13 President And Fellows Of Harvard College Muscle chips and methods of use thereof
WO2013159117A1 (en) 2012-04-20 2013-10-24 SlipChip, LLC Fluidic devices and systems for sample preparation or autonomous analysis
WO2013159116A1 (en) 2012-04-20 2013-10-24 University Of Chicago Fluidic devices for biospecimen preservation
US9803237B2 (en) 2012-04-24 2017-10-31 California Institute Of Technology Slip-induced compartmentalization
WO2014008490A1 (en) * 2012-07-05 2014-01-09 Nanoshell Company, Llc Therapeutic retrieval of targets in biological fluids
WO2014015251A2 (en) 2012-07-20 2014-01-23 President And Fellows Of Harvard College Tissue-engineered pumps and valves and uses thereof
US9869675B2 (en) 2013-03-13 2018-01-16 Vanderbilt University Low resource processor using surface tension valves for extracting, concentrating, and detecting whole cells
JP6164580B2 (ja) * 2013-03-13 2017-07-19 国立大学法人 筑波大学 マイクロ流路装置及びこれに関する方法
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
US11193176B2 (en) 2013-12-31 2021-12-07 Bio-Rad Laboratories, Inc. Method for detecting and quantifying latent retroviral RNA species
WO2015178980A2 (en) 2014-02-18 2015-11-26 President And Fellows Of Harvard College Anisotropic muscular tissue devices with integrated electrical force readouts
JP6090208B2 (ja) 2014-02-27 2017-03-08 マツダ株式会社 エンジンの排気装置
JP2017510822A (ja) 2014-04-11 2017-04-13 レオセンス，インコーポレイテッド 粘度計及びその使用方法
CN106573242B (zh) * 2014-08-06 2019-01-08 J·舒福莱企业公司 在微米流体设备或毫米流体设备中使反应剂液滴和试剂液滴融合或接触的方法
WO2016069142A2 (en) 2014-09-24 2016-05-06 President And Fellows Of Harvard College Contractile function measuring devices, systems, and methods of use thereof
US10018040B2 (en) 2014-10-24 2018-07-10 Schlumberger Technology Corporation System and methodology for chemical constituent sensing and analysis
WO2017004250A1 (en) 2015-06-29 2017-01-05 Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of Arizona State University Systems and methods for continuous flow digital droplet polymerase chain reaction bioanalysis
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions
US10357770B2 (en) * 2015-10-09 2019-07-23 International Business Machines Corporation Microfluidic probe for modulating insertion of liquid spacers
US11384328B2 (en) 2015-11-18 2022-07-12 President And Fellows Of Harvard College Cartridge-based system for long term culture of cell clusters
US10751685B2 (en) 2016-05-02 2020-08-25 Purdue Research Foundation Systems and methods for producing a chemical product
EP3269444A1 (en) * 2016-07-14 2018-01-17 Base4 Innovation Ltd Method of identifying droplets in a stack and an associated sequencer
GB201615320D0 (en) * 2016-09-09 2016-10-26 Invitron Ltd Point of care platform test
JP2020500517A (ja) 2016-11-28 2020-01-16 アリゾナ ボード オブ リージェンツ オン ビハーフ オブ アリゾナ ステート ユニバーシティ 連続流小滴反応に関連するシステムおよび方法
CA3062519A1 (en) 2017-05-11 2018-11-15 Emd Millipore Corporation Method of maintaining narrow residence time distributions in continuous flow systems using solid material packet interfaces
EP3621715A4 (en) 2017-05-11 2021-01-27 EMD Millipore Corporation MECHANICAL PROCEDURE FOR MAINTAINING TIGHT DISTRIBUTION OF DWELL TIME IN CONTINUOUS FLOW SYSTEMS
CN110799679A (zh) * 2017-06-20 2020-02-14 10X基因组学有限公司 用于改善液滴稳定的方法和系统
CN107328949B (zh) * 2017-06-27 2019-05-03 中国科学院长春光学精密机械与物理研究所 一种实现多份液体自发顺序流动的方法及装置
EP3645167A4 (en) 2017-06-28 2021-02-24 Bio-rad Laboratories, Inc. DROPLET DETECTION SYSTEM AND METHOD
US11166920B2 (en) * 2017-10-05 2021-11-09 Auburn University Microfluidics device for fabrication of large, uniform, injectable hydrogel microparticles for cell encapsulation
WO2019079681A1 (en) 2017-10-20 2019-04-25 President And Fellows Of Harvard College METHODS FOR PRODUCING MATURE ADIPOCYTES AND METHODS OF USE
US11045805B2 (en) 2017-11-01 2021-06-29 Bio-Rad Laboratories, Inc. Microfluidic system and method for arranging objects
WO2019195197A1 (en) 2018-04-02 2019-10-10 Dropworks, Inc. Systems and methods for serial flow emulsion processes
CN109012774B (zh) * 2018-08-10 2022-03-15 深圳先进技术研究院 液滴生成装置、液滴微流控芯片及应用
CN109622080B (zh) * 2019-01-08 2021-04-06 新羿制造科技（北京）有限公司 用于多指标分析的微液滴生成芯片
CN111434377B (zh) * 2019-01-11 2022-07-15 中国石油化工股份有限公司 一种盘管微反应器和一种微反应器系统
EP4041444B1 (en) 2019-10-02 2024-08-28 Piotr Jeuté A method and system for controlling drop collisions in a drop on demand printing apparatus
CN114829626A (zh) 2019-10-10 2022-07-29 1859公司 用于微流体筛选的方法和系统
CN115279495B (zh) * 2019-12-04 2024-09-20 阿斯特拉维斯公司 用于加工颗粒的微流控设备和方法
CN111135883B (zh) * 2019-12-31 2024-01-02 中山大学 一种用于筛选晶体生成条件的超高通量平台及筛选方法
EP4090987A4 (en) * 2020-01-17 2024-01-17 Zepto Life Technology, LLC SYSTEMS AND METHODS FOR MEASURING ANALYTES IN GMR-BASED DETECTION OF BIOMARRKERS
USD989342S1 (en) * 2020-02-04 2023-06-13 Ut-Battelle, Llc Microfluidic polymer chip interface bracket
USD993443S1 (en) * 2020-02-04 2023-07-25 Ut-Battelle, Llc Microfluidic glass chip interface bracket
US10953404B1 (en) 2020-04-24 2021-03-23 Pattern Bioscience, Inc. Apparatuses for contactless loading and imaging of microfluidic chips and related methods
CN112461768B (zh) * 2020-11-20 2021-11-05 武汉大学 海水硝酸盐检测装置
US12078582B2 (en) 2021-05-10 2024-09-03 Rheosense, Inc. Viscometer with reduced dead-volume and high dynamic range
DK4253965T3 (da) * 2022-04-01 2025-11-17 Hoffmann La Roche Fremgangsmåde til sensorkalibrering og in-vitro diagnostisk analysator
US20240085406A1 (en) * 2022-09-13 2024-03-14 Biological Mimetics, Inc. Multi-chamber device for detecting pathogens/molecules and methods of using same
JP2025535563A (ja) * 2022-11-07 2025-10-24 シェンノン バイオテクノロジーズ インコーポレイテッド 細胞－細胞相互作用のハイスループットスクリーニングのためのマイクロ流体デバイス
WO2024106872A1 (ko) * 2022-11-15 2024-05-23 고려대학교 산학협력단 초점도 유체의 액적화 장치
WO2024137351A1 (en) * 2022-12-19 2024-06-27 Anchorline Biolabs, Inc. Capillary partitioning microfluidics
WO2025052041A1 (en) * 2023-09-06 2025-03-13 Helsingin Yliopisto Microfluidic devices and methods for producing droplets for droplet-based assays

Family Cites Families (205)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2692800A (en) 1951-10-08 1954-10-26 Gen Electric Nozzle flow control
US3479141A (en) 1967-05-17 1969-11-18 Technicon Corp Method and apparatus for analysis
CH503985A (de) * 1968-09-19 1971-02-28 Ceskoslovenska Akademie Ved Verfahren und Einrichtung zur Trennung eines Hauptmediums von einem Strom, der durch einzelne Abschnitte des Hauptmediums und eines Trennmediums gebildet wird
BE788754A (enExample) * 1971-10-13 1973-03-13 Technicon Instr
US3816331A (en) 1972-07-05 1974-06-11 Ncr Continuous encapsulation and device therefor
CH564966A5 (enExample) 1974-02-25 1975-08-15 Sauter Fr Ag Fabrik Elektrisch
US4059552A (en) 1974-06-21 1977-11-22 The Dow Chemical Company Cross-linked water-swellable polymer particles
US3960187A (en) 1974-07-23 1976-06-01 Usm Corporation Method and device for metering and dispersing fluid materials
US3982541A (en) 1974-07-29 1976-09-28 Esperance Jr Francis A L Eye surgical instrument
FI52025C (fi) * 1976-04-08 1977-06-10 Osmo Antero Suovaniemi Menetelmä ja laitteisto nesteannosteluun, nesteen siirtoon ja laimennu ssarjoihin.
US4279345A (en) 1979-08-03 1981-07-21 Allred John C High speed particle sorter using a field emission electrode
US4346608A (en) * 1980-07-31 1982-08-31 The United States Of America As Represented By The Secretary Of The Army Float device for density gradient fractionation
GB2097692B (en) 1981-01-10 1985-05-22 Shaw Stewart P D Combining chemical reagents
JPS6057907B2 (ja) 1981-06-18 1985-12-17 工業技術院長 液体の混合噴霧化方法
DE3230289A1 (de) 1982-08-14 1984-02-16 Bayer Ag, 5090 Leverkusen Herstellung von pharmazeutischen oder kosmetischen dispersionen
US4853336A (en) 1982-11-15 1989-08-01 Technicon Instruments Corporation Single channel continuous flow system
US4618476A (en) 1984-02-10 1986-10-21 Eastman Kodak Company Capillary transport device having speed and meniscus control means
US4865444A (en) 1984-04-05 1989-09-12 Mobil Oil Corporation Apparatus and method for determining luminosity of hydrocarbon fuels
US4963498A (en) 1985-08-05 1990-10-16 Biotrack Capillary flow device
GB8604328D0 (en) 1986-02-21 1986-03-26 Ici Plc Producing spray of droplets of liquid
US4916070A (en) 1986-04-14 1990-04-10 The General Hospital Corporation Fibrin-specific antibodies and method of screening for the antibodies
US5204112A (en) 1986-06-16 1993-04-20 The Liposome Company, Inc. Induction of asymmetry in vesicles
US5149625A (en) 1987-08-11 1992-09-22 President And Fellows Of Harvard College Multiplex analysis of DNA
US4931225A (en) 1987-12-30 1990-06-05 Union Carbide Industrial Gases Technology Corporation Method and apparatus for dispersing a gas into a liquid
US5185099A (en) 1988-04-20 1993-02-09 Institut National De Recherche Chimique Appliquee Visco-elastic, isotropic materials based on water, fluorinate sufactants and fluorinated oils, process for their preparation, and their use in various fields, such as optics, pharmacology and electrodynamics
US5093602A (en) 1989-11-17 1992-03-03 Charged Injection Corporation Methods and apparatus for dispersing a fluent material utilizing an electron beam
US6149789A (en) 1990-10-31 2000-11-21 Fraunhofer Gesellschaft Zur Forderung Der Angewandten Forschung E.V. Process for manipulating microscopic, dielectric particles and a device therefor
DE4127405C2 (de) 1991-08-19 1996-02-29 Fraunhofer Ges Forschung Verfahren zur Trennung von Gemischen mikroskopisch kleiner, in einer Flüssigkeit oder einem Gel suspendierter dielektrischer Teilchen und Vorrichtung zur Durchführung des Verfahrens
SE500071C2 (sv) 1992-06-25 1994-04-11 Vattenfall Utveckling Ab Anordning för blandning av två fluider, i synnerhet vätskor med olika temperatur
US5512131A (en) 1993-10-04 1996-04-30 President And Fellows Of Harvard College Formation of microstamped patterns on surfaces and derivative articles
DE69519197T2 (de) 1994-06-13 2001-05-17 Praxair Technology, Inc. Zerstäuber für die Verbrennung von flüssigem Brennstoff mit kleinem Sprühwinkel
US5935331A (en) 1994-09-09 1999-08-10 Matsushita Electric Industrial Co., Ltd. Apparatus and method for forming films
US5762775A (en) 1994-09-21 1998-06-09 Lockheed Martin Energy Systems, Inc. Method for electrically producing dispersions of a nonconductive fluid in a conductive medium
AU708165B2 (en) 1995-06-06 1999-07-29 Interpore International Inc. Wound sealant preparation and application device and method
US20020022261A1 (en) 1995-06-29 2002-02-21 Anderson Rolfe C. Miniaturized genetic analysis systems and methods
US5872010A (en) 1995-07-21 1999-02-16 Northeastern University Microscale fluid handling system
US6130098A (en) 1995-09-15 2000-10-10 The Regents Of The University Of Michigan Moving microdroplets
US5851769A (en) 1995-09-27 1998-12-22 The Regents Of The University Of California Quantitative DNA fiber mapping
JP3759986B2 (ja) 1995-12-07 2006-03-29 フロイント産業株式会社 シームレスカプセルおよびその製造方法
US6740506B2 (en) 1995-12-07 2004-05-25 Diversa Corporation End selection in directed evolution
US5681600A (en) 1995-12-18 1997-10-28 Abbott Laboratories Stabilization of liquid nutritional products and method of making
US5868322A (en) 1996-01-31 1999-02-09 Hewlett-Packard Company Apparatus for forming liquid droplets having a mechanically fixed inner microtube
WO1997029508A2 (en) 1996-02-08 1997-08-14 Perseptive Biosystems, Inc. Interface between liquid flow and mass spectrometer
US6355198B1 (en) 1996-03-15 2002-03-12 President And Fellows Of Harvard College Method of forming articles including waveguides via capillary micromolding and microtransfer molding
EP0832436A1 (en) 1996-04-15 1998-04-01 Dade Behring Inc. Apparatus and method for analysis
US5942443A (en) 1996-06-28 1999-08-24 Caliper Technologies Corporation High throughput screening assay systems in microscale fluidic devices
US6248378B1 (en) 1998-12-16 2001-06-19 Universidad De Sevilla Enhanced food products
US6386463B1 (en) 1996-05-13 2002-05-14 Universidad De Sevilla Fuel injection nozzle and method of use
US6189803B1 (en) 1996-05-13 2001-02-20 University Of Seville Fuel injection nozzle and method of use
US6299145B1 (en) 1996-05-13 2001-10-09 Universidad De Sevilla Device and method for fluid aeration via gas forced through a liquid within an orifice of a pressure chamber
ES2140998B1 (es) 1996-05-13 2000-10-16 Univ Sevilla Procedimiento de atomizacion de liquidos.
US6196525B1 (en) 1996-05-13 2001-03-06 Universidad De Sevilla Device and method for fluid aeration via gas forced through a liquid within an orifice of a pressure chamber
US6187214B1 (en) 1996-05-13 2001-02-13 Universidad De Seville Method and device for production of components for microfabrication
US6405936B1 (en) 1996-05-13 2002-06-18 Universidad De Sevilla Stabilized capillary microjet and devices and methods for producing same
US6116516A (en) 1996-05-13 2000-09-12 Universidad De Sevilla Stabilized capillary microjet and devices and methods for producing same
EP0909385B1 (en) 1996-06-28 2008-09-10 Caliper Life Sciences, Inc. Method of transporting fluid samples within a microfluidic channel
NZ333346A (en) 1996-06-28 2000-03-27 Caliper Techn Corp High-throughput screening assay systems in microscale fluidic devices
US5800690A (en) 1996-07-03 1998-09-01 Caliper Technologies Corporation Variable control of electroosmotic and/or electrophoretic forces within a fluid-containing structure via electrical forces
DE69707288T2 (de) 1996-07-15 2002-07-18 Calcitech Ltd., Hamilton Herstellung von pulvern
US6252129B1 (en) 1996-07-23 2001-06-26 Electrosols, Ltd. Dispensing device and method for forming material
US6143248A (en) 1996-08-12 2000-11-07 Gamera Bioscience Corp. Capillary microvalve
AU4113297A (en) 1996-09-04 1998-03-26 Technical University Of Denmark A micro flow system for particle separation and analysis
US6221654B1 (en) 1996-09-25 2001-04-24 California Institute Of Technology Method and apparatus for analysis and sorting of polynucleotides based on size
US6120666A (en) 1996-09-26 2000-09-19 Ut-Battelle, Llc Microfabricated device and method for multiplexed electrokinetic focusing of fluid streams and a transport cytometry method using same
US6140053A (en) 1996-11-06 2000-10-31 Sequenom, Inc. DNA sequencing by mass spectrometry via exonuclease degradation
DE19717085C2 (de) 1997-04-23 1999-06-17 Bruker Daltonik Gmbh Verfahren und Geräte für extrem schnelle DNA-Vervielfachung durch Polymerase-Kettenreaktionen (PCR)
AU734957B2 (en) 1997-05-16 2001-06-28 Alberta Research Council Inc. Microfluidic system and methods of use
DK1801214T3 (da) 1997-07-07 2011-01-24 Medical Res Council In vitro sorteringsfremgangsmåde
US5980936A (en) 1997-08-07 1999-11-09 Alliance Pharmaceutical Corp. Multiple emulsions comprising a hydrophobic continuous phase
US6540895B1 (en) 1997-09-23 2003-04-01 California Institute Of Technology Microfabricated cell sorter for chemical and biological materials
US7214298B2 (en) 1997-09-23 2007-05-08 California Institute Of Technology Microfabricated cell sorter
JP3081880B2 (ja) 1998-03-30 2000-08-28 農林水産省食品総合研究所長 マイクロスフィアの連続製造装置
US5997636A (en) 1998-05-01 1999-12-07 Instrumentation Technology Associates, Inc. Method and apparatus for growing crystals
US6003794A (en) 1998-08-04 1999-12-21 Progressive Grower Technologies, Inc. Electrostatic spray module
KR20010089295A (ko) 1998-10-13 2001-09-29 마이클 알. 맥닐리 수동 유체 동역학에 의한 유체회로 및 유체회로내에서의방법
US6149787A (en) 1998-10-14 2000-11-21 Caliper Technologies Corp. External material accession systems and methods
US6614598B1 (en) 1998-11-12 2003-09-02 Institute Of Technology, California Microlensing particles and applications
US6450189B1 (en) 1998-11-13 2002-09-17 Universidad De Sevilla Method and device for production of components for microfabrication
US20030069601A1 (en) 1998-12-15 2003-04-10 Closys Corporation Clotting cascade initiating apparatus and methods of use
GB9900298D0 (en) 1999-01-07 1999-02-24 Medical Res Council Optical sorting method
US6565727B1 (en) 1999-01-25 2003-05-20 Nanolytics, Inc. Actuators for microfluidics without moving parts
US6294063B1 (en) 1999-02-12 2001-09-25 Board Of Regents, The University Of Texas System Method and apparatus for programmable fluidic processing
US7615373B2 (en) 1999-02-25 2009-11-10 Virginia Commonwealth University Intellectual Property Foundation Electroprocessed collagen and tissue engineering
US6633031B1 (en) 1999-03-02 2003-10-14 Advion Biosciences, Inc. Integrated monolithic microfabricated dispensing nozzle and liquid chromatography-electrospray system and method
DE19911777A1 (de) 1999-03-17 2000-09-21 Merck Patent Gmbh Verfahren zur Herstellung von kosmetischen Formulierungen
AU770678B2 (en) 1999-05-17 2004-02-26 Caliper Life Sciences, Inc. Focusing of microparticles in microfluidic systems
US6592821B1 (en) 1999-05-17 2003-07-15 Caliper Technologies Corp. Focusing of microparticles in microfluidic systems
EP1192009B1 (en) 1999-06-11 2013-05-01 Aradigm Corporation Method for producing an aerosol
US20060169800A1 (en) 1999-06-11 2006-08-03 Aradigm Corporation Aerosol created by directed flow of fluids and devices and methods for producing same
US6630006B2 (en) 1999-06-18 2003-10-07 The Regents Of The University Of California Method for screening microcrystallizations for crystal formation
US6296673B1 (en) 1999-06-18 2001-10-02 The Regents Of The University Of California Methods and apparatus for performing array microcrystallizations
US7195670B2 (en) 2000-06-27 2007-03-27 California Institute Of Technology High throughput screening of crystallization of materials
EP1065378B1 (en) 1999-06-28 2002-04-03 California Institute of Technology Microfabricated elastomeric valve and pump systems
US7244402B2 (en) 2001-04-06 2007-07-17 California Institute Of Technology Microfluidic protein crystallography
AU768135B2 (en) * 1999-08-12 2003-12-04 Ut-Battelle, Llc Microfluidic devices for the controlled manipulation of small volumes
US6524456B1 (en) 1999-08-12 2003-02-25 Ut-Battelle, Llc Microfluidic devices for the controlled manipulation of small volumes
US20010050881A1 (en) 1999-09-20 2001-12-13 Depaoli David W. Continuous flow, electrohydrodynamic micromixing apparatus and methods
US6890487B1 (en) 1999-09-30 2005-05-10 Science & Technology Corporation ©UNM Flow cytometry for high throughput screening
DE19961257C2 (de) 1999-12-18 2002-12-19 Inst Mikrotechnik Mainz Gmbh Mikrovermischer
US6790328B2 (en) 2000-01-12 2004-09-14 Ut-Battelle, Llc Microfluidic device and method for focusing, segmenting, and dispensing of a fluid stream
JP4753517B2 (ja) 2000-02-11 2011-08-24 アクララ バイオサイエンシーズ， インコーポレイテッド サンプル注入器を備えるマイクロ流体デバイスおよび方法
GB2359765B (en) 2000-03-02 2003-03-05 Univ Newcastle Capillary reactor distribution device and method
EP1263687A4 (en) 2000-03-10 2009-11-11 Flow Focusing Inc Method for producing optical fibers by focusing high viscosity liquids
US7485454B1 (en) 2000-03-10 2009-02-03 Bioprocessors Corp. Microreactor
US20020012971A1 (en) 2000-03-20 2002-01-31 Mehta Tammy Burd PCR compatible nucleic acid sieving medium
EP1285106A2 (en) 2000-03-31 2003-02-26 Micronics, Inc. Protein crystallization in microfluidic structures
EP1275005A1 (en) 2000-04-06 2003-01-15 Caliper Technologies Corporation Methods and devices for achieving long incubation times in high-throughput systems
AU2001255458A1 (en) 2000-04-18 2001-10-30 Waters Investments Limited Improved electrospray and other lc/ms interfaces
US20010048637A1 (en) 2000-05-24 2001-12-06 Weigl Bernhard H. Microfluidic system and method
US6686184B1 (en) 2000-05-25 2004-02-03 President And Fellows Of Harvard College Patterning of surfaces utilizing microfluidic stamps including three-dimensionally arrayed channel networks
US6645432B1 (en) 2000-05-25 2003-11-11 President & Fellows Of Harvard College Microfluidic systems including three-dimensionally arrayed channel networks
US6777450B1 (en) 2000-05-26 2004-08-17 Color Access, Inc. Water-thin emulsions with low emulsifier levels
US20060263888A1 (en) 2000-06-02 2006-11-23 Honeywell International Inc. Differential white blood count on a disposable card
US7351376B1 (en) 2000-06-05 2008-04-01 California Institute Of Technology Integrated active flux microfluidic devices and methods
AU8306901A (en) 2000-08-04 2002-02-18 Caliper Techn Corp Control of operation conditions within fluidic systems
US20040005582A1 (en) 2000-08-10 2004-01-08 Nanobiodynamics, Incorporated Biospecific desorption microflow systems and methods for studying biospecific interactions and their modulators
US6301055B1 (en) 2000-08-16 2001-10-09 California Institute Of Technology Solid immersion lens structures and methods for producing solid immersion lens structures
DE10041823C2 (de) 2000-08-25 2002-12-19 Inst Mikrotechnik Mainz Gmbh Verfahren und statischer Mikrovermischer zum Mischen mindestens zweier Fluide
US6610499B1 (en) 2000-08-31 2003-08-26 The Regents Of The University Of California Capillary array and related methods
AU2001290879A1 (en) 2000-09-15 2002-03-26 California Institute Of Technology Microfabricated crossflow devices and methods
EP1327132A4 (en) 2000-09-21 2004-03-31 Dna Sciences Inc METHOD AND SYSTEM FOR INJECTING A SPECIMEN
US6508988B1 (en) 2000-10-03 2003-01-21 California Institute Of Technology Combinatorial synthesis system
US6827095B2 (en) * 2000-10-12 2004-12-07 Nanostream, Inc. Modular microfluidic systems
US6778724B2 (en) 2000-11-28 2004-08-17 The Regents Of The University Of California Optical switching and sorting of biological samples and microparticles transported in a micro-fluidic device, including integrated bio-chip devices
AU2002243277A1 (en) 2000-12-07 2002-06-24 President And Fellows Of Harvard College Methods and compositions for encapsulating active agents
US20040096515A1 (en) 2001-12-07 2004-05-20 Bausch Andreas R. Methods and compositions for encapsulating active agents
ES2180405B1 (es) 2001-01-31 2004-01-16 Univ Sevilla Dispositivo y procedimiento para producir chorros liquidos compuestos multicomponentes estacionarios y capsulas multicomponente y/o multicapa de tamaño micro y nanometrico.
TW593122B (en) 2001-02-13 2004-06-21 Qinetiq Ltd Microchannel device
JP3746766B2 (ja) 2001-02-23 2006-02-15 独立行政法人科学技術振興機構 エマルションの製造方法およびその装置
EP1741482B1 (en) 2001-02-23 2008-10-15 Japan Science and Technology Agency Process and apparatus for producing microcapsules
US20040134854A1 (en) 2001-02-23 2004-07-15 Toshiro Higuchi Small liquid particle handling method, and device therefor
US7037417B2 (en) 2001-03-19 2006-05-02 Ecole Polytechnique Federale De Lausanne Mechanical control of fluids in micro-analytical devices
US20030064414A1 (en) 2001-03-30 2003-04-03 Benecky Michael J. Rapid assessment of coagulation activity in whole blood
US6752922B2 (en) 2001-04-06 2004-06-22 Fluidigm Corporation Microfluidic chromatography
EP1399580B1 (en) 2001-05-26 2008-10-08 One Cell Systems, Inc. Secretion of proteins by encapsulated cells
US6797056B2 (en) 2001-06-08 2004-09-28 Syrrx, Inc. Microfluidic method employing delivery of plural different fluids to same lumen
US6719840B2 (en) 2001-06-08 2004-04-13 Syrrx, Inc. In situ crystal growth and crystallization
GB0114854D0 (en) 2001-06-18 2001-08-08 Medical Res Council Selective gene amplification
US20030015425A1 (en) 2001-06-20 2003-01-23 Coventor Inc. Microfluidic system including a virtual wall fluid interface port for interfacing fluids with the microfluidic system
US7704728B2 (en) * 2001-07-18 2010-04-27 The University Of Michigan Microfluidic gravity pump with constant flow rate
US6766817B2 (en) 2001-07-25 2004-07-27 Tubarc Technologies, Llc Fluid conduction utilizing a reversible unsaturated siphon with tubarc porosity action
WO2003011443A2 (en) 2001-07-27 2003-02-13 President And Fellows Of Harvard College Laminar mixing apparatus and methods
US6520425B1 (en) 2001-08-21 2003-02-18 The University Of Akron Process and apparatus for the production of nanofibers
AU2002360282A1 (en) 2001-10-19 2003-06-10 West Virginia University Research Corporation Microflludic system for proteome analysis
EP1485191B1 (en) 2002-03-05 2012-08-01 Caliper Life Sciences, Inc. Mixed mode microfluidic system and method
US7101467B2 (en) 2002-03-05 2006-09-05 Caliper Life Sciences, Inc. Mixed mode microfluidic systems
US7147763B2 (en) 2002-04-01 2006-12-12 Palo Alto Research Center Incorporated Apparatus and method for using electrostatic force to cause fluid movement
US7312085B2 (en) 2002-04-01 2007-12-25 Fluidigm Corporation Microfluidic particle-analysis systems
US6976590B2 (en) 2002-06-24 2005-12-20 Cytonome, Inc. Method and apparatus for sorting particles
US7901939B2 (en) 2002-05-09 2011-03-08 University Of Chicago Method for performing crystallization and reactions in pressure-driven fluid plugs
EP2278337B1 (en) 2002-05-09 2019-06-26 The University of Chicago Device and method for pressure-driven plug transport and reaction
US7266587B2 (en) * 2002-05-15 2007-09-04 Broadcom Corporation System having interfaces, switch, and memory bridge for CC-NUMA operation
JP2006507921A (ja) 2002-06-28 2006-03-09 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 流体分散のための方法および装置
US7329545B2 (en) 2002-09-24 2008-02-12 Duke University Methods for sampling a liquid flow
US6911132B2 (en) 2002-09-24 2005-06-28 Duke University Apparatus for manipulating droplets by electrowetting-based techniques
GB2395196B (en) 2002-11-14 2006-12-27 Univ Cardiff Microfluidic device and methods for construction and application
KR101216828B1 (ko) 2002-12-30 2013-01-04 더 리전트 오브 더 유니버시티 오브 캘리포니아 병원균 검출과 분석을 위한 방법과 기구
WO2004071638A2 (en) 2003-02-11 2004-08-26 Regents Of The University Of California, The Microfluidic devices and method for controlled viscous shearing and formation of amphiphilic vesicles
WO2004075734A2 (en) 2003-02-25 2004-09-10 Inlight Solutions, Inc. DETERMINATION OF pH INCLUDING HEMOGLOBIN CORRECTION
JP2006527093A (ja) * 2003-03-10 2006-11-30 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン プログラム可能な触覚アクチュエータを用いた集積化したマイクロ流体コントロール
US7041481B2 (en) 2003-03-14 2006-05-09 The Regents Of The University Of California Chemical amplification based on fluid partitioning
US7045040B2 (en) 2003-03-20 2006-05-16 Asm Nutool, Inc. Process and system for eliminating gas bubbles during electrochemical processing
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
US20040223874A1 (en) 2003-03-31 2004-11-11 Canon Kabushiki Kaisha Biochemical reaction cartridge
WO2004091763A2 (en) 2003-04-10 2004-10-28 President And Fellows Of Harvard College Formation and control of fluidic species
US7262059B2 (en) 2003-05-06 2007-08-28 Thrombodyne, Inc. Systems and methods for measuring fluid properties
AU2004239599A1 (en) 2003-05-16 2004-11-25 Global Technologies (Nz) Ltd Method and apparatus for mixing sample and reagent in a suspension fluid
WO2004103565A2 (de) 2003-05-19 2004-12-02 Hans-Knöll-Institut für Naturstoff-Forschung e.V. Vorrichtung und verfahren zur strukturierung von flüssigkeiten und zum zudosieren von reaktionsflüssigkeiten zu in separationsmedium eingebetteten flüssigkeitskompartimenten
US7115230B2 (en) 2003-06-26 2006-10-03 Intel Corporation Hydrodynamic focusing devices
GB0315438D0 (en) 2003-07-02 2003-08-06 Univ Manchester Analysis of mixed cell populations
US20050032238A1 (en) 2003-08-07 2005-02-10 Nanostream, Inc. Vented microfluidic separation devices and methods
EP2662136A3 (en) * 2003-08-27 2013-12-25 President and Fellows of Harvard College Method for handling and mixing droplets
CA2536360C (en) 2003-08-28 2013-08-06 Celula, Inc. Methods and apparatus for sorting cells using an optical switch in a microfluidic channel network
US7204431B2 (en) 2003-10-31 2007-04-17 Agilent Technologies, Inc. Electrospray ion source for mass spectroscopy
US20050103690A1 (en) 2003-11-19 2005-05-19 Aisin Seiki Kabushiki Kaisha Micro liquid control system
EP1691792A4 (en) 2003-11-24 2008-05-28 Yeda Res & Dev COMPOSITIONS AND PROCESSES FOR SORTING IN VITRO OF MOLECULE AND CELL LIBRARIES
WO2005059512A2 (en) * 2003-12-10 2005-06-30 Northeastern University Method for efficient transport of small liquid volumes to, from or within microfluidic devices
US20050221339A1 (en) 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
WO2005103106A1 (en) 2004-04-23 2005-11-03 Eugenia Kumacheva Method of producing polymeric particles with selected size, shape, morphology and composition
US7655470B2 (en) 2004-10-29 2010-02-02 University Of Chicago Method for manipulating a plurality of plugs and performing reactions therein in microfluidic systems
US9477233B2 (en) 2004-07-02 2016-10-25 The University Of Chicago Microfluidic system with a plurality of sequential T-junctions for performing reactions in microdroplets
US7759111B2 (en) 2004-08-27 2010-07-20 The Regents Of The University Of California Cell encapsulation microfluidic device
JP5885901B2 (ja) 2004-09-09 2016-03-16 アンスティテュート キュリー マイクロチャネルまたは他のマイクロ容器中でパケットを操作するためのデバイス
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
US20080004436A1 (en) 2004-11-15 2008-01-03 Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science Directed Evolution and Selection Using in Vitro Compartmentalization
US7604938B2 (en) * 2005-02-18 2009-10-20 Canon U.S. Life Sciences, Inc. Devices and methods for monitoring genomic DNA of organisms
EP1861194A2 (en) 2005-03-04 2007-12-05 The President and Fellows of Harvard College Method and apparatus for forming multiple emulsions
US20070054119A1 (en) 2005-03-04 2007-03-08 Piotr Garstecki Systems and methods of forming particles
FR2882939B1 (fr) 2005-03-11 2007-06-08 Centre Nat Rech Scient Dispositif de separation fluidique
CN101351542A (zh) 2005-07-15 2009-01-21 阿普尔拉公司 液体加工装置和方法
US8734003B2 (en) 2005-09-15 2014-05-27 Alcatel Lucent Micro-chemical mixing
US7274191B2 (en) * 2005-12-29 2007-09-25 Intel Corporation Integrated on-chip NMR and ESR device and method for making and using the same
EP3913375A1 (en) 2006-01-11 2021-11-24 Bio-Rad Laboratories, Inc. Microfluidic devices and methods of use in the formation and control of nanoreactors
US7537897B2 (en) 2006-01-23 2009-05-26 Population Genetics Technologies, Ltd. Molecular counting
DE602007009811D1 (de) 2006-01-27 2010-11-25 Harvard College Koaleszenz fluider tröpfchen
EP2021113A2 (en) 2006-05-11 2009-02-11 Raindance Technologies, Inc. Microfluidic devices
US7776927B2 (en) 2007-03-28 2010-08-17 President And Fellows Of Harvard College Emulsions and techniques for formation
WO2008134153A1 (en) 2007-04-23 2008-11-06 Advanced Liquid Logic, Inc. Bead-based multiplexed analytical methods and instrumentation
EP2175999B1 (en) 2007-06-21 2017-01-04 Gen-Probe Incorporated Receptacles for use in performing processes
US20090068170A1 (en) 2007-07-13 2009-03-12 President And Fellows Of Harvard College Droplet-based selection
US8622987B2 (en) * 2008-06-04 2014-01-07 The University Of Chicago Chemistrode, a plug-based microfluidic device and method for stimulation and sampling with high temporal, spatial, and chemical resolution
WO2010009365A1 (en) 2008-07-18 2010-01-21 Raindance Technologies, Inc. Droplet libraries
US9156010B2 (en) 2008-09-23 2015-10-13 Bio-Rad Laboratories, Inc. Droplet-based assay system
US8061187B2 (en) * 2009-04-27 2011-11-22 Battelle Memorial Institute Lossless droplet transfer of droplet-based microfluidic analysis
US10434970B2 (en) 2016-12-08 2019-10-08 Toyota Jidosha Kabushiki Kaisha Vehicle side section structure

Similar Documents

Publication Publication Date Title
JP2014036956A5 (enExample)
WO2014186440A3 (en) Apparatus and method for the rapid production of droplets
ES2552392R1 (es) Un método para producir negro de humo mediante un fluido diluyente
PH12015501787A1 (en) Systems and methods for ocular surgery
EP3005652A4 (en) DEVICE AND METHOD FOR MAINTAINING A MESSAGE TREAD WITH OPTIONAL ENROLLMENT OF ENTRIES
WO2011146156A3 (en) Generating fluid flow in a fluidic network
WO2015044454A3 (en) A microfluidic device, use and methods
WO2013160408A3 (en) Microfluidic device for performing operations on microdroplets
DK3004527T3 (da) Choker
EP2947167A4 (en) SEAMLESS STAINLESS STEEL TUBE FOR USE IN OIL BOILERS AND MANUFACTURING METHOD THEREFOR
Lastra et al. Summability in general Carleman ultraholomorphic classes
EP2505499A3 (en) Landing gear system
AR098410A1 (es) Optimización de las propiedades de dispositivos de control de flujo tanto en pozos productores como inyectores en sistemas de inundación de líquidos de inyector y productor conectados
MX2016011740A (es) Red integrada de flujo fluidico para la gestion de fluidos.
CA2900708C (en) Mixing of fluids in fluidic systems
WO2015014432A8 (de) Filtervorrichtung für fluide
WO2014204597A3 (en) Fluid dispensing system
Qi et al. Electroosmotic flow of a power-law fluid in a slit microchannel with gradually varying channel height and wall potential
HK1208256A1 (en) Microfluidic pump
MX391361B (es) Metodo y dispositivo para la separacion de liquidos inmiscibles para aislar de modo efectivo al menos uno de los liquidos.
EP3329983A4 (en) CLEANSING AGENT, CLEANING SOLUTION AND CLEANSING PROCESS FOR REVERSE OSMOSEMBRBRANE
WO2019067319A3 (en) Microfluidic technique for detection of multi-contact miscibility
CO2017010800A2 (es) Desgasificador y método de gas para la extracción de un liquido
GB2529598A (en) Fluid dispensing apparatus and method
EP2977815A4 (en) ALIGNMENT PROCESS FOR LIQUID CRYSTALS WITH MICRO / NANOREGIONS AND SYSTEM THEREOF BASED ON DIRECT LASER DISCS