JP2014036956A5 - - Google Patents

Download PDF

Info

Publication number
JP2014036956A5
JP2014036956A5 JP2013203694A JP2013203694A JP2014036956A5 JP 2014036956 A5 JP2014036956 A5 JP 2014036956A5 JP 2013203694 A JP2013203694 A JP 2013203694A JP 2013203694 A JP2013203694 A JP 2013203694A JP 2014036956 A5 JP2014036956 A5 JP 2014036956A5
Authority
JP
Japan
Prior art keywords
liquid
droplets
continuous phase
phase liquid
spacing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2013203694A
Other languages
English (en)
Japanese (ja)
Other versions
JP2014036956A (ja
JP5973407B2 (ja
Filing date
Publication date
Priority claimed from US11/082,187 external-priority patent/US7655470B2/en
Priority claimed from US11/174,298 external-priority patent/US9477233B2/en
Application filed filed Critical
Publication of JP2014036956A publication Critical patent/JP2014036956A/ja
Publication of JP2014036956A5 publication Critical patent/JP2014036956A5/ja
Application granted granted Critical
Publication of JP5973407B2 publication Critical patent/JP5973407B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2013203694A 2005-03-16 2013-09-30 マイクロフルイディックシステム Expired - Fee Related JP5973407B2 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11/082,187 2005-03-16
US11/082,187 US7655470B2 (en) 2004-10-29 2005-03-16 Method for manipulating a plurality of plugs and performing reactions therein in microfluidic systems
US11/174,298 2005-07-01
US11/174,298 US9477233B2 (en) 2004-07-02 2005-07-01 Microfluidic system with a plurality of sequential T-junctions for performing reactions in microdroplets

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2011231160A Division JP5671434B2 (ja) 2005-03-16 2011-10-20 マイクロフルイディックシステム

Publications (3)

Publication Number Publication Date
JP2014036956A JP2014036956A (ja) 2014-02-27
JP2014036956A5 true JP2014036956A5 (enExample) 2014-10-09
JP5973407B2 JP5973407B2 (ja) 2016-08-23

Family

ID=37024341

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013203694A Expired - Fee Related JP5973407B2 (ja) 2005-03-16 2013-09-30 マイクロフルイディックシステム

Country Status (4)

Country Link
US (5) US9477233B2 (enExample)
EP (2) EP1866092B1 (enExample)
JP (1) JP5973407B2 (enExample)
WO (1) WO2006101851A2 (enExample)

Families Citing this family (136)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7901939B2 (en) 2002-05-09 2011-03-08 University Of Chicago Method for performing crystallization and reactions in pressure-driven fluid plugs
JP2006507921A (ja) 2002-06-28 2006-03-09 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 流体分散のための方法および装置
US20100022414A1 (en) 2008-07-18 2010-01-28 Raindance Technologies, Inc. Droplet Libraries
GB0307428D0 (en) * 2003-03-31 2003-05-07 Medical Res Council Compartmentalised combinatorial chemistry
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
GB0307403D0 (en) * 2003-03-31 2003-05-07 Medical Res Council Selection by compartmentalised screening
EP2266687A3 (en) 2003-04-10 2011-06-29 The President and Fellows of Harvard College Formation and control of fluidic species
WO2005021151A1 (en) 2003-08-27 2005-03-10 President And Fellows Of Harvard College Electronic control of fluidic species
US20050221339A1 (en) * 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
US9477233B2 (en) 2004-07-02 2016-10-25 The University Of Chicago Microfluidic system with a plurality of sequential T-junctions for performing reactions in microdroplets
US7655470B2 (en) 2004-10-29 2010-02-02 University Of Chicago Method for manipulating a plurality of plugs and performing reactions therein in microfluidic systems
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
EP2248578B1 (en) 2005-03-04 2012-06-06 President and Fellows of Harvard College Method for forming multiple emulsions
US20060280029A1 (en) * 2005-06-13 2006-12-14 President And Fellows Of Harvard College Microfluidic mixer
US20070141593A1 (en) 2005-08-22 2007-06-21 Lee Linda G Apparatus, system, and method using immiscible-fluid-discrete-volumes
US20100137163A1 (en) * 2006-01-11 2010-06-03 Link Darren R Microfluidic Devices and Methods of Use in The Formation and Control of Nanoreactors
AU2007309701B2 (en) * 2006-02-03 2012-09-27 President And Fellows Of Harvard College Engineered cell growth on polymeric films and biotechnological applications there of
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
US20080014589A1 (en) 2006-05-11 2008-01-17 Link Darren R Microfluidic devices and methods of use thereof
EP3536396B1 (en) 2006-08-07 2022-03-30 The President and Fellows of Harvard College Fluorocarbon emulsion stabilizing surfactants
WO2008045506A2 (en) * 2006-10-10 2008-04-17 President And Fellows Of Harvard College Biopolymer structures
US7918831B2 (en) * 2006-10-12 2011-04-05 Colorado Catheter Company, Inc. Catheter assembly having protective sheath
FR2907228B1 (fr) * 2006-10-13 2009-07-24 Rhodia Recherches & Tech Dispositif d'ecoulement fluidique,ensemble de determination d'au moins une caracteristique d'un systeme physico-chimique comprenant un tel dispositif,procede de determination et procede de criblage correspondants
FR2907227B1 (fr) * 2006-10-13 2009-04-10 Rhodia Recherches & Tech Procede et installation de determination d'au moins un parametre d'une transformation physique et/ou chimique,et procede de criblage correspondant
US8772046B2 (en) 2007-02-06 2014-07-08 Brandeis University Manipulation of fluids and reactions in microfluidic systems
JP5062399B2 (ja) * 2007-02-19 2012-10-31 セイコーインスツル株式会社 マイクロ流路およびマイクロリアクタ
US9152150B1 (en) * 2007-02-22 2015-10-06 Applied Biosystems, Llc Compositions, systems, and methods for immiscible fluid discrete volume manipulation
JP5148635B2 (ja) * 2007-03-05 2013-02-20 ロディア オペレーションズ 物質の結晶化を追跡する方法と対応する微小流体装置およびスクリーニング方法
US7776927B2 (en) 2007-03-28 2010-08-17 President And Fellows Of Harvard College Emulsions and techniques for formation
WO2008130623A1 (en) 2007-04-19 2008-10-30 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
WO2009009021A1 (en) * 2007-07-06 2009-01-15 The Regents Of The University Of California Integrated microfluidics for highly parallel screening of chemical reactions
US9090885B2 (en) 2007-07-26 2015-07-28 The University Of Chicago Co-incubating confined microbial communities
WO2009038628A2 (en) * 2007-09-19 2009-03-26 Claros Diagnostics, Inc. Liquid containment for integrated assays
WO2009085067A2 (en) * 2007-09-26 2009-07-09 President And Fellows Of Harvard College Boundary conditions for the arrangement of cells and tissues
FR2928209B1 (fr) * 2008-03-03 2011-04-22 Rhodia Operations Procede et installation de determination d'au moins un parametre d'une transformation physique et/ou chimique
WO2009131677A1 (en) 2008-04-25 2009-10-29 Claros Diagnostics, Inc. Flow control in microfluidic systems
WO2010011407A2 (en) * 2008-05-23 2010-01-28 President And Fellows Of Harvard College Methods of generating patterned soft substrates and uses thereof
WO2009149257A1 (en) * 2008-06-04 2009-12-10 The University Of Chicago The chemistrode: a plug-based microfluidic device and method for stimulation and sampling with high temporal, spatial, and chemical resolution
CA2727095C (en) 2008-06-06 2020-01-07 Bionanomatrix, Inc. Integrated analysis devices and related fabrication methods and analysis techniques
EP2352591A4 (en) * 2008-06-13 2013-01-23 Emerald Biostructures Inc NANOVOLUMIC MICROKAPILLAR CRYSTALLIZATION SYSTEM
US8475747B1 (en) * 2008-06-13 2013-07-02 U.S. Department Of Energy Processing fissile material mixtures containing zirconium and/or carbon
GB0810990D0 (en) * 2008-06-16 2008-07-23 Q Chip Ltd Device and method of making solid beads
US12038438B2 (en) 2008-07-18 2024-07-16 Bio-Rad Laboratories, Inc. Enzyme quantification
US8053239B2 (en) * 2008-10-08 2011-11-08 The Governing Council Of The University Of Toronto Digital microfluidic method for protein extraction by precipitation from heterogeneous mixtures
US9713802B2 (en) * 2009-01-13 2017-07-25 Kobe Steel, Ltd. Method and apparatus for manufacturing liquid microspheres
WO2010111231A1 (en) 2009-03-23 2010-09-30 Raindance Technologies, Inc. Manipulation of microfluidic droplets
US9447461B2 (en) 2009-03-24 2016-09-20 California Institute Of Technology Analysis devices, kits, and related methods for digital quantification of nucleic acids and other analytes
US9415392B2 (en) 2009-03-24 2016-08-16 The University Of Chicago Slip chip device and methods
US10196700B2 (en) 2009-03-24 2019-02-05 University Of Chicago Multivolume devices, kits and related methods for quantification and detection of nucleic acids and other analytes
US9464319B2 (en) 2009-03-24 2016-10-11 California Institute Of Technology Multivolume devices, kits and related methods for quantification of nucleic acids and other analytes
US9012172B2 (en) 2009-05-01 2015-04-21 President And Fellows Of Harvard College Devices comprising muscle thin films and uses thereof in high throughput assays for determining contractile function
US20100298602A1 (en) * 2009-05-19 2010-11-25 Massachusetts Institute Of Technology Systems and methods for microfluidic crystallization
US20100294986A1 (en) * 2009-05-19 2010-11-25 Massachusetts Institute Of Technology Supercritical fluid facilitated particle formation in microfluidic systems
US9752964B1 (en) * 2009-06-22 2017-09-05 Stc.Unm Flow cytometry apparatus pulling sample stream through observation chamber
US8337783B2 (en) * 2009-06-23 2012-12-25 The United States of America as represented by the Secretary of Commerce, the National Institute of Standards and Technology Magnetic connectors for microfluidic applications
EP4019977B1 (en) 2009-06-26 2024-11-20 President and Fellows of Harvard College Fluid injection
US10099227B2 (en) 2009-08-25 2018-10-16 Nanoshell Company, Llc Method and apparatus for continuous removal of sub-micron sized particles in a closed loop liquid flow system
EP2470282A4 (en) 2009-08-25 2015-07-29 Agnes Ostafin METHOD AND APPARATUS FOR CONTINUOUS REMOVAL OF SUBMICRONIC PARTICLES PRESENT IN A CLOSED-CIRCUIT FLUID FLOW SYSTEM
US10751464B2 (en) 2009-08-25 2020-08-25 Nanoshell Company, Llc Therapeutic retrieval of targets in biological fluids
US11285494B2 (en) 2009-08-25 2022-03-29 Nanoshell Company, Llc Method and apparatus for continuous removal of sub-micron sized particles in a closed loop liquid flow system
CN102574078B (zh) 2009-09-02 2016-05-18 哈佛学院院长等 使用喷射和其它技术产生的多重乳液
FR2950544B1 (fr) * 2009-09-29 2011-12-09 Ecole Polytech Circuit microfluidique
WO2011042564A1 (en) 2009-10-09 2011-04-14 Universite De Strasbourg Labelled silica-based nanomaterial with enhanced properties and uses thereof
EP2517025B1 (en) 2009-12-23 2019-11-27 Bio-Rad Laboratories, Inc. Methods for reducing the exchange of molecules between droplets
US20110165037A1 (en) * 2010-01-07 2011-07-07 Ismagilov Rustem F Interfaces that eliminate non-specific adsorption, and introduce specific interactions
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
US8535889B2 (en) 2010-02-12 2013-09-17 Raindance Technologies, Inc. Digital analyte analysis
WO2011139719A2 (en) 2010-04-26 2011-11-10 Rheosense, Inc. Portable viscometer
WO2012006320A1 (en) 2010-07-06 2012-01-12 President And Fellows Of Harvard College Photosensitive cardiac rhythm modulation systems
CN103153467A (zh) * 2010-07-16 2013-06-12 范德比尔特大学 用于提取、浓缩和检测分子物类的使用表面张力阀的低资源处理器
WO2012045012A2 (en) 2010-09-30 2012-04-05 Raindance Technologies, Inc. Sandwich assays in droplets
IT1404074B1 (it) * 2010-12-17 2013-11-08 Alifax Holding S P A Dispositivo per realizzare test clinici su liquidi biologici e relativo procedimento
US9364803B2 (en) 2011-02-11 2016-06-14 Raindance Technologies, Inc. Methods for forming mixed droplets
EP3736281A1 (en) 2011-02-18 2020-11-11 Bio-Rad Laboratories, Inc. Compositions and methods for molecular labeling
WO2012162296A2 (en) 2011-05-23 2012-11-29 President And Fellows Of Harvard College Control of emulsions, including multiple emulsions
WO2012167142A2 (en) 2011-06-02 2012-12-06 Raindance Technolgies, Inc. Enzyme quantification
US8841071B2 (en) 2011-06-02 2014-09-23 Raindance Technologies, Inc. Sample multiplexing
CN106268389A (zh) 2011-07-06 2017-01-04 哈佛学院院长等 多重乳剂和用于配制多重乳剂的技术
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
EP2761306A4 (en) * 2011-09-30 2015-07-01 Univ British Columbia METHOD AND DEVICE FOR FLOW-CONTROLLED FURNITURE
JP5800195B2 (ja) * 2011-11-25 2015-10-28 国立研究開発法人産業技術総合研究所 結晶成長用容器、液滴調製器具および結晶取得方法
US9857356B2 (en) 2011-12-09 2018-01-02 President And Fellows Of Havard College Muscle chips and methods of use thereof
WO2013159117A1 (en) 2012-04-20 2013-10-24 SlipChip, LLC Fluidic devices and systems for sample preparation or autonomous analysis
US9808798B2 (en) 2012-04-20 2017-11-07 California Institute Of Technology Fluidic devices for biospecimen preservation
US9803237B2 (en) 2012-04-24 2017-10-31 California Institute Of Technology Slip-induced compartmentalization
WO2014008490A1 (en) * 2012-07-05 2014-01-09 Nanoshell Company, Llc Therapeutic retrieval of targets in biological fluids
US9669141B2 (en) 2012-07-20 2017-06-06 President And Fellows Of Harvard College Tissue-engineered pumps and valves and uses thereof
JP6164580B2 (ja) * 2013-03-13 2017-07-19 国立大学法人 筑波大学 マイクロ流路装置及びこれに関する方法
US9869675B2 (en) 2013-03-13 2018-01-16 Vanderbilt University Low resource processor using surface tension valves for extracting, concentrating, and detecting whole cells
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
US11193176B2 (en) 2013-12-31 2021-12-07 Bio-Rad Laboratories, Inc. Method for detecting and quantifying latent retroviral RNA species
US10591458B2 (en) 2014-02-18 2020-03-17 President And Fellows Of Harvard College Anisotropic muscular tissue devices with integrated electrical force readouts
JP6090208B2 (ja) 2014-02-27 2017-03-08 マツダ株式会社 エンジンの排気装置
JP2017510822A (ja) 2014-04-11 2017-04-13 レオセンス,インコーポレイテッド 粘度計及びその使用方法
US9908118B2 (en) * 2014-08-06 2018-03-06 Etablissements J. Soufflet Method for fusing or contacting reactor and reagent droplets in a microfluidic or millifluidic device
WO2016069142A2 (en) 2014-09-24 2016-05-06 President And Fellows Of Harvard College Contractile function measuring devices, systems, and methods of use thereof
US10018040B2 (en) 2014-10-24 2018-07-10 Schlumberger Technology Corporation System and methodology for chemical constituent sensing and analysis
US11123740B2 (en) 2015-06-29 2021-09-21 Arizona Board Of Regents On Behalf Of Arizona State University Systems and methods for continuous flow digital droplet polymerase chain reaction bioanalysis
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions
US10357770B2 (en) * 2015-10-09 2019-07-23 International Business Machines Corporation Microfluidic probe for modulating insertion of liquid spacers
US11384328B2 (en) 2015-11-18 2022-07-12 President And Fellows Of Harvard College Cartridge-based system for long term culture of cell clusters
US10751685B2 (en) 2016-05-02 2020-08-25 Purdue Research Foundation Systems and methods for producing a chemical product
EP3269444A1 (en) * 2016-07-14 2018-01-17 Base4 Innovation Ltd Method of identifying droplets in a stack and an associated sequencer
GB201615320D0 (en) * 2016-09-09 2016-10-26 Invitron Ltd Point of care platform test
WO2018098438A1 (en) 2016-11-28 2018-05-31 Arizona Board Of Regents On Behalf Of Arizona State University Systems and methods related to continuous flow droplet reaction
KR102286411B1 (ko) 2017-05-11 2021-08-05 이엠디 밀리포어 코포레이션 연속 유동 시스템에서 좁은 체류 시간 분포를 유지하기 위한 방법
EP3621715A4 (en) 2017-05-11 2021-01-27 EMD Millipore Corporation MECHANICAL PROCEDURE FOR MAINTAINING TIGHT DISTRIBUTION OF DWELL TIME IN CONTINUOUS FLOW SYSTEMS
CN110799679A (zh) * 2017-06-20 2020-02-14 10X基因组学有限公司 用于改善液滴稳定的方法和系统
CN107328949B (zh) * 2017-06-27 2019-05-03 中国科学院长春光学精密机械与物理研究所 一种实现多份液体自发顺序流动的方法及装置
WO2019006190A1 (en) 2017-06-28 2019-01-03 Bio-Rad Laboratories, Inc. SYSTEM AND METHOD FOR DROPLELET DETECTION
US11166920B2 (en) * 2017-10-05 2021-11-09 Auburn University Microfluidics device for fabrication of large, uniform, injectable hydrogel microparticles for cell encapsulation
US11629318B2 (en) 2017-10-20 2023-04-18 President And Fellows Of Harvard College Methods for producing mature adipocytes and methods of use thereof
WO2019089979A1 (en) 2017-11-01 2019-05-09 Bio-Rad Laboratories, Inc. Microfluidic system and method for arranging objects
AU2019249846C1 (en) 2018-04-02 2024-09-12 Dropworks, Inc. Systems and methods for serial flow emulsion processes
CN109012774B (zh) * 2018-08-10 2022-03-15 深圳先进技术研究院 液滴生成装置、液滴微流控芯片及应用
CN109622080B (zh) * 2019-01-08 2021-04-06 新羿制造科技(北京)有限公司 用于多指标分析的微液滴生成芯片
CN111434377B (zh) * 2019-01-11 2022-07-15 中国石油化工股份有限公司 一种盘管微反应器和一种微反应器系统
EP4041444B1 (en) * 2019-10-02 2024-08-28 Piotr Jeuté A method and system for controlling drop collisions in a drop on demand printing apparatus
US11919000B2 (en) 2019-10-10 2024-03-05 1859, Inc. Methods and systems for microfluidic screening
EP4069423A1 (en) * 2019-12-04 2022-10-12 Astraveus Microfluidic device and method for processing particles
CN111135883B (zh) * 2019-12-31 2024-01-02 中山大学 一种用于筛选晶体生成条件的超高通量平台及筛选方法
US20230085052A1 (en) * 2020-01-17 2023-03-16 Zepto Life Technology, LLC Systems and methods for sensing analytes in gmr-based detection of biomarkers
USD993443S1 (en) * 2020-02-04 2023-07-25 Ut-Battelle, Llc Microfluidic glass chip interface bracket
USD989342S1 (en) * 2020-02-04 2023-06-13 Ut-Battelle, Llc Microfluidic polymer chip interface bracket
US10953404B1 (en) 2020-04-24 2021-03-23 Pattern Bioscience, Inc. Apparatuses for contactless loading and imaging of microfluidic chips and related methods
CN112461768B (zh) * 2020-11-20 2021-11-05 武汉大学 海水硝酸盐检测装置
WO2022240899A1 (en) 2021-05-10 2022-11-17 Rheosense, Inc. Viscometer with reduced dead-volume and high dynamic range
EP4253965B1 (en) * 2022-04-01 2025-09-10 F. Hoffmann-La Roche AG Method for sensor calibration and in-vitro diagnostic analyzer
US20240085406A1 (en) * 2022-09-13 2024-03-14 Biological Mimetics, Inc. Multi-chamber device for detecting pathogens/molecules and methods of using same
EP4615951A2 (en) * 2022-11-07 2025-09-17 Shennon Biotechnologies Inc. Microfluidic devices for high throughput screening of cell-cell interactions
WO2024106872A1 (ko) * 2022-11-15 2024-05-23 고려대학교 산학협력단 초점도 유체의 액적화 장치
US20240198336A1 (en) * 2022-12-19 2024-06-20 Anchorline Biolabs, Inc. Capillary partitioning microfluidics
WO2025052041A1 (en) * 2023-09-06 2025-03-13 Helsingin Yliopisto Microfluidic devices and methods for producing droplets for droplet-based assays

Family Cites Families (205)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2692800A (en) 1951-10-08 1954-10-26 Gen Electric Nozzle flow control
US3479141A (en) 1967-05-17 1969-11-18 Technicon Corp Method and apparatus for analysis
CH503985A (de) * 1968-09-19 1971-02-28 Ceskoslovenska Akademie Ved Verfahren und Einrichtung zur Trennung eines Hauptmediums von einem Strom, der durch einzelne Abschnitte des Hauptmediums und eines Trennmediums gebildet wird
BE788754A (enExample) * 1971-10-13 1973-03-13 Technicon Instr
US3816331A (en) 1972-07-05 1974-06-11 Ncr Continuous encapsulation and device therefor
CH564966A5 (enExample) 1974-02-25 1975-08-15 Sauter Fr Ag Fabrik Elektrisch
US4059552A (en) 1974-06-21 1977-11-22 The Dow Chemical Company Cross-linked water-swellable polymer particles
US3960187A (en) 1974-07-23 1976-06-01 Usm Corporation Method and device for metering and dispersing fluid materials
US3982541A (en) 1974-07-29 1976-09-28 Esperance Jr Francis A L Eye surgical instrument
FI52025C (fi) * 1976-04-08 1977-06-10 Osmo Antero Suovaniemi Menetelmä ja laitteisto nesteannosteluun, nesteen siirtoon ja laimennu ssarjoihin.
US4279345A (en) 1979-08-03 1981-07-21 Allred John C High speed particle sorter using a field emission electrode
US4346608A (en) * 1980-07-31 1982-08-31 The United States Of America As Represented By The Secretary Of The Army Float device for density gradient fractionation
GB2097692B (en) 1981-01-10 1985-05-22 Shaw Stewart P D Combining chemical reagents
JPS6057907B2 (ja) 1981-06-18 1985-12-17 工業技術院長 液体の混合噴霧化方法
DE3230289A1 (de) 1982-08-14 1984-02-16 Bayer Ag, 5090 Leverkusen Herstellung von pharmazeutischen oder kosmetischen dispersionen
US4853336A (en) 1982-11-15 1989-08-01 Technicon Instruments Corporation Single channel continuous flow system
US4618476A (en) 1984-02-10 1986-10-21 Eastman Kodak Company Capillary transport device having speed and meniscus control means
US4865444A (en) 1984-04-05 1989-09-12 Mobil Oil Corporation Apparatus and method for determining luminosity of hydrocarbon fuels
US4963498A (en) 1985-08-05 1990-10-16 Biotrack Capillary flow device
GB8604328D0 (en) 1986-02-21 1986-03-26 Ici Plc Producing spray of droplets of liquid
US4916070A (en) 1986-04-14 1990-04-10 The General Hospital Corporation Fibrin-specific antibodies and method of screening for the antibodies
US5204112A (en) 1986-06-16 1993-04-20 The Liposome Company, Inc. Induction of asymmetry in vesicles
US5149625A (en) 1987-08-11 1992-09-22 President And Fellows Of Harvard College Multiplex analysis of DNA
US4931225A (en) 1987-12-30 1990-06-05 Union Carbide Industrial Gases Technology Corporation Method and apparatus for dispersing a gas into a liquid
US5185099A (en) 1988-04-20 1993-02-09 Institut National De Recherche Chimique Appliquee Visco-elastic, isotropic materials based on water, fluorinate sufactants and fluorinated oils, process for their preparation, and their use in various fields, such as optics, pharmacology and electrodynamics
US5093602A (en) 1989-11-17 1992-03-03 Charged Injection Corporation Methods and apparatus for dispersing a fluent material utilizing an electron beam
US6149789A (en) 1990-10-31 2000-11-21 Fraunhofer Gesellschaft Zur Forderung Der Angewandten Forschung E.V. Process for manipulating microscopic, dielectric particles and a device therefor
DE4127405C2 (de) 1991-08-19 1996-02-29 Fraunhofer Ges Forschung Verfahren zur Trennung von Gemischen mikroskopisch kleiner, in einer Flüssigkeit oder einem Gel suspendierter dielektrischer Teilchen und Vorrichtung zur Durchführung des Verfahrens
SE500071C2 (sv) 1992-06-25 1994-04-11 Vattenfall Utveckling Ab Anordning för blandning av två fluider, i synnerhet vätskor med olika temperatur
US5512131A (en) 1993-10-04 1996-04-30 President And Fellows Of Harvard College Formation of microstamped patterns on surfaces and derivative articles
CA2151541C (en) 1994-06-13 1999-06-08 William Thoru Kobayashi Narrow spray angle liquid fuel atomizers for combustion
US5935331A (en) 1994-09-09 1999-08-10 Matsushita Electric Industrial Co., Ltd. Apparatus and method for forming films
US5762775A (en) 1994-09-21 1998-06-09 Lockheed Martin Energy Systems, Inc. Method for electrically producing dispersions of a nonconductive fluid in a conductive medium
EP0957772A2 (en) 1995-06-06 1999-11-24 Quantic Biomedical Partners Wound sealant preparation and application device and method
US20020022261A1 (en) 1995-06-29 2002-02-21 Anderson Rolfe C. Miniaturized genetic analysis systems and methods
US5872010A (en) 1995-07-21 1999-02-16 Northeastern University Microscale fluid handling system
US6130098A (en) 1995-09-15 2000-10-10 The Regents Of The University Of Michigan Moving microdroplets
US5851769A (en) 1995-09-27 1998-12-22 The Regents Of The University Of California Quantitative DNA fiber mapping
JP3759986B2 (ja) 1995-12-07 2006-03-29 フロイント産業株式会社 シームレスカプセルおよびその製造方法
US6740506B2 (en) 1995-12-07 2004-05-25 Diversa Corporation End selection in directed evolution
US5681600A (en) 1995-12-18 1997-10-28 Abbott Laboratories Stabilization of liquid nutritional products and method of making
US5868322A (en) 1996-01-31 1999-02-09 Hewlett-Packard Company Apparatus for forming liquid droplets having a mechanically fixed inner microtube
US5917184A (en) 1996-02-08 1999-06-29 Perseptive Biosystems Interface between liquid flow and mass spectrometer
US6355198B1 (en) 1996-03-15 2002-03-12 President And Fellows Of Harvard College Method of forming articles including waveguides via capillary micromolding and microtransfer molding
WO1997039359A1 (en) 1996-04-15 1997-10-23 Dade International Inc. Apparatus and method for analysis
US5942443A (en) 1996-06-28 1999-08-24 Caliper Technologies Corporation High throughput screening assay systems in microscale fluidic devices
US6248378B1 (en) 1998-12-16 2001-06-19 Universidad De Sevilla Enhanced food products
ES2140998B1 (es) 1996-05-13 2000-10-16 Univ Sevilla Procedimiento de atomizacion de liquidos.
US6405936B1 (en) 1996-05-13 2002-06-18 Universidad De Sevilla Stabilized capillary microjet and devices and methods for producing same
US6189803B1 (en) 1996-05-13 2001-02-20 University Of Seville Fuel injection nozzle and method of use
US6386463B1 (en) 1996-05-13 2002-05-14 Universidad De Sevilla Fuel injection nozzle and method of use
US6187214B1 (en) 1996-05-13 2001-02-13 Universidad De Seville Method and device for production of components for microfabrication
US6299145B1 (en) 1996-05-13 2001-10-09 Universidad De Sevilla Device and method for fluid aeration via gas forced through a liquid within an orifice of a pressure chamber
US6196525B1 (en) 1996-05-13 2001-03-06 Universidad De Sevilla Device and method for fluid aeration via gas forced through a liquid within an orifice of a pressure chamber
US6116516A (en) 1996-05-13 2000-09-12 Universidad De Sevilla Stabilized capillary microjet and devices and methods for producing same
US6547942B1 (en) 1996-06-28 2003-04-15 Caliper Technologies Corp. Electropipettor and compensation means for electrophoretic bias
NZ333346A (en) 1996-06-28 2000-03-27 Caliper Techn Corp High-throughput screening assay systems in microscale fluidic devices
US5800690A (en) 1996-07-03 1998-09-01 Caliper Technologies Corporation Variable control of electroosmotic and/or electrophoretic forces within a fluid-containing structure via electrical forces
US6458335B1 (en) 1996-07-15 2002-10-01 Calcitech Ltd. Production of powders
US6252129B1 (en) 1996-07-23 2001-06-26 Electrosols, Ltd. Dispensing device and method for forming material
US6143248A (en) 1996-08-12 2000-11-07 Gamera Bioscience Corp. Capillary microvalve
AU4113297A (en) 1996-09-04 1998-03-26 Technical University Of Denmark A micro flow system for particle separation and analysis
US6221654B1 (en) 1996-09-25 2001-04-24 California Institute Of Technology Method and apparatus for analysis and sorting of polynucleotides based on size
US6120666A (en) 1996-09-26 2000-09-19 Ut-Battelle, Llc Microfabricated device and method for multiplexed electrokinetic focusing of fluid streams and a transport cytometry method using same
US6140053A (en) 1996-11-06 2000-10-31 Sequenom, Inc. DNA sequencing by mass spectrometry via exonuclease degradation
DE19717085C2 (de) 1997-04-23 1999-06-17 Bruker Daltonik Gmbh Verfahren und Geräte für extrem schnelle DNA-Vervielfachung durch Polymerase-Kettenreaktionen (PCR)
CA2286601A1 (en) 1997-05-16 1998-11-26 Alberta Research Council Microfluidic system and methods of use
WO1999002671A1 (en) 1997-07-07 1999-01-21 Medical Research Council In vitro sorting method
US5980936A (en) 1997-08-07 1999-11-09 Alliance Pharmaceutical Corp. Multiple emulsions comprising a hydrophobic continuous phase
US7214298B2 (en) 1997-09-23 2007-05-08 California Institute Of Technology Microfabricated cell sorter
US6540895B1 (en) 1997-09-23 2003-04-01 California Institute Of Technology Microfabricated cell sorter for chemical and biological materials
JP3081880B2 (ja) 1998-03-30 2000-08-28 農林水産省食品総合研究所長 マイクロスフィアの連続製造装置
US5997636A (en) 1998-05-01 1999-12-07 Instrumentation Technology Associates, Inc. Method and apparatus for growing crystals
US6003794A (en) 1998-08-04 1999-12-21 Progressive Grower Technologies, Inc. Electrostatic spray module
WO2000022436A1 (en) 1998-10-13 2000-04-20 Biomicro Systems, Inc. Fluid circuit components based upon passive fluid dynamics
US6149787A (en) 1998-10-14 2000-11-21 Caliper Technologies Corp. External material accession systems and methods
US6614598B1 (en) 1998-11-12 2003-09-02 Institute Of Technology, California Microlensing particles and applications
US6450189B1 (en) 1998-11-13 2002-09-17 Universidad De Sevilla Method and device for production of components for microfabrication
US20030069601A1 (en) 1998-12-15 2003-04-10 Closys Corporation Clotting cascade initiating apparatus and methods of use
GB9900298D0 (en) 1999-01-07 1999-02-24 Medical Res Council Optical sorting method
US6565727B1 (en) 1999-01-25 2003-05-20 Nanolytics, Inc. Actuators for microfluidics without moving parts
US6294063B1 (en) 1999-02-12 2001-09-25 Board Of Regents, The University Of Texas System Method and apparatus for programmable fluidic processing
US7615373B2 (en) 1999-02-25 2009-11-10 Virginia Commonwealth University Intellectual Property Foundation Electroprocessed collagen and tissue engineering
US6633031B1 (en) 1999-03-02 2003-10-14 Advion Biosciences, Inc. Integrated monolithic microfabricated dispensing nozzle and liquid chromatography-electrospray system and method
DE19911777A1 (de) 1999-03-17 2000-09-21 Merck Patent Gmbh Verfahren zur Herstellung von kosmetischen Formulierungen
US6592821B1 (en) 1999-05-17 2003-07-15 Caliper Technologies Corp. Focusing of microparticles in microfluidic systems
CA2373347A1 (en) 1999-05-17 2000-11-23 Caliper Technologies Corporation Focusing of microparticles in microfluidic systems
US20060169800A1 (en) 1999-06-11 2006-08-03 Aradigm Corporation Aerosol created by directed flow of fluids and devices and methods for producing same
JP2003501257A (ja) 1999-06-11 2003-01-14 アラディジム コーポレーション エーロゾルを生成する方法
US6296673B1 (en) 1999-06-18 2001-10-02 The Regents Of The University Of California Methods and apparatus for performing array microcrystallizations
US6630006B2 (en) 1999-06-18 2003-10-07 The Regents Of The University Of California Method for screening microcrystallizations for crystal formation
US7195670B2 (en) 2000-06-27 2007-03-27 California Institute Of Technology High throughput screening of crystallization of materials
US7244402B2 (en) 2001-04-06 2007-07-17 California Institute Of Technology Microfluidic protein crystallography
ATE215673T1 (de) 1999-06-28 2002-04-15 California Inst Of Techn Elastomerische mikropumpen- und mikroventilsysteme
MXPA02001437A (es) * 1999-08-12 2002-07-02 Ut Battelle Llc Aparatos microfluidicos para la manipulacion controlada de volumenes pequenos.
US6524456B1 (en) 1999-08-12 2003-02-25 Ut-Battelle, Llc Microfluidic devices for the controlled manipulation of small volumes
US20010050881A1 (en) 1999-09-20 2001-12-13 Depaoli David W. Continuous flow, electrohydrodynamic micromixing apparatus and methods
US6890487B1 (en) 1999-09-30 2005-05-10 Science & Technology Corporation ©UNM Flow cytometry for high throughput screening
DE19961257C2 (de) 1999-12-18 2002-12-19 Inst Mikrotechnik Mainz Gmbh Mikrovermischer
AU2001232805A1 (en) 2000-01-12 2001-07-24 Ut-Battelle, Llc A microfluidic device and method for focusing, segmenting, and dispensing of a fluid stream
AU3499701A (en) 2000-02-11 2001-08-20 Aclara Biosciences Inc Microfluidic device with sample injector and method
GB2359765B (en) 2000-03-02 2003-03-05 Univ Newcastle Capillary reactor distribution device and method
US7485454B1 (en) 2000-03-10 2009-02-03 Bioprocessors Corp. Microreactor
JP2003527299A (ja) 2000-03-10 2003-09-16 フロー・フォーカシング・インコーポレーテッド 高粘性液体を収束させることにより光ファイバを製作する方法
US20020012971A1 (en) 2000-03-20 2002-01-31 Mehta Tammy Burd PCR compatible nucleic acid sieving medium
US6409832B2 (en) 2000-03-31 2002-06-25 Micronics, Inc. Protein crystallization in microfluidic structures
WO2001077683A1 (en) 2000-04-06 2001-10-18 Caliper Technologies Corp. Methods and devices for achieving long incubation times in high-throughput systems
EP1282910B1 (en) 2000-04-18 2017-04-05 Waters Technologies Corporation Improved electrospray and other lc/ms interfaces
US20010048637A1 (en) 2000-05-24 2001-12-06 Weigl Bernhard H. Microfluidic system and method
US6686184B1 (en) 2000-05-25 2004-02-03 President And Fellows Of Harvard College Patterning of surfaces utilizing microfluidic stamps including three-dimensionally arrayed channel networks
US6645432B1 (en) 2000-05-25 2003-11-11 President & Fellows Of Harvard College Microfluidic systems including three-dimensionally arrayed channel networks
US6777450B1 (en) 2000-05-26 2004-08-17 Color Access, Inc. Water-thin emulsions with low emulsifier levels
US20060263888A1 (en) 2000-06-02 2006-11-23 Honeywell International Inc. Differential white blood count on a disposable card
US7351376B1 (en) 2000-06-05 2008-04-01 California Institute Of Technology Integrated active flux microfluidic devices and methods
WO2002012856A1 (en) 2000-08-04 2002-02-14 Caliper Technologies Corp. Control of operation conditions within fluidic systems
US20040005582A1 (en) 2000-08-10 2004-01-08 Nanobiodynamics, Incorporated Biospecific desorption microflow systems and methods for studying biospecific interactions and their modulators
US6301055B1 (en) 2000-08-16 2001-10-09 California Institute Of Technology Solid immersion lens structures and methods for producing solid immersion lens structures
DE10041823C2 (de) 2000-08-25 2002-12-19 Inst Mikrotechnik Mainz Gmbh Verfahren und statischer Mikrovermischer zum Mischen mindestens zweier Fluide
US6610499B1 (en) 2000-08-31 2003-08-26 The Regents Of The University Of California Capillary array and related methods
AU2001290879A1 (en) 2000-09-15 2002-03-26 California Institute Of Technology Microfabricated crossflow devices and methods
WO2002025243A1 (en) 2000-09-21 2002-03-28 Dna Sciences, Inc. Sample injector system and method
US6508988B1 (en) 2000-10-03 2003-01-21 California Institute Of Technology Combinatorial synthesis system
US6827095B2 (en) * 2000-10-12 2004-12-07 Nanostream, Inc. Modular microfluidic systems
US6778724B2 (en) 2000-11-28 2004-08-17 The Regents Of The University Of California Optical switching and sorting of biological samples and microparticles transported in a micro-fluidic device, including integrated bio-chip devices
WO2002047665A2 (en) 2000-12-07 2002-06-20 President And Fellows Of Harvard College Methods and compositions for encapsulating active agents
US20040096515A1 (en) 2001-12-07 2004-05-20 Bausch Andreas R. Methods and compositions for encapsulating active agents
ES2180405B1 (es) 2001-01-31 2004-01-16 Univ Sevilla Dispositivo y procedimiento para producir chorros liquidos compuestos multicomponentes estacionarios y capsulas multicomponente y/o multicapa de tamaño micro y nanometrico.
TW593122B (en) 2001-02-13 2004-06-21 Qinetiq Ltd Microchannel device
EP1741482B1 (en) 2001-02-23 2008-10-15 Japan Science and Technology Agency Process and apparatus for producing microcapsules
CA2438955C (en) 2001-02-23 2008-12-09 Japan Science And Technology Corporation Method and device for handling liquid particulates
EP1510251B1 (en) 2001-02-23 2006-09-06 Japan Science and Technology Agency Process and apparatus for producing microcapsules
US7037417B2 (en) 2001-03-19 2006-05-02 Ecole Polytechnique Federale De Lausanne Mechanical control of fluids in micro-analytical devices
US20030064414A1 (en) 2001-03-30 2003-04-03 Benecky Michael J. Rapid assessment of coagulation activity in whole blood
US6752922B2 (en) 2001-04-06 2004-06-22 Fluidigm Corporation Microfluidic chromatography
JP4194934B2 (ja) 2001-05-26 2008-12-10 ワン セル システムズ インコーポレイテッド カプセル化細胞によるタンパク質の分泌法
US6797056B2 (en) 2001-06-08 2004-09-28 Syrrx, Inc. Microfluidic method employing delivery of plural different fluids to same lumen
US6719840B2 (en) 2001-06-08 2004-04-13 Syrrx, Inc. In situ crystal growth and crystallization
GB0114854D0 (en) 2001-06-18 2001-08-08 Medical Res Council Selective gene amplification
US20030015425A1 (en) 2001-06-20 2003-01-23 Coventor Inc. Microfluidic system including a virtual wall fluid interface port for interfacing fluids with the microfluidic system
US7704728B2 (en) * 2001-07-18 2010-04-27 The University Of Michigan Microfluidic gravity pump with constant flow rate
US6766817B2 (en) 2001-07-25 2004-07-27 Tubarc Technologies, Llc Fluid conduction utilizing a reversible unsaturated siphon with tubarc porosity action
EP1412065A2 (en) 2001-07-27 2004-04-28 President And Fellows Of Harvard College Laminar mixing apparatus and methods
US6520425B1 (en) 2001-08-21 2003-02-18 The University Of Akron Process and apparatus for the production of nanofibers
JP2005509872A (ja) 2001-10-19 2005-04-14 ウエスト バージニア ユニバーシティ リサーチ コーポレーション プロテオーム解析のための微小流体システム
EP2581739B1 (en) 2002-03-05 2015-11-04 Caliper Life Sciences, Inc. Microfluidic separation method with combined pressure and voltage control
US7101467B2 (en) 2002-03-05 2006-09-05 Caliper Life Sciences, Inc. Mixed mode microfluidic systems
US7147763B2 (en) 2002-04-01 2006-12-12 Palo Alto Research Center Incorporated Apparatus and method for using electrostatic force to cause fluid movement
US7312085B2 (en) 2002-04-01 2007-12-25 Fluidigm Corporation Microfluidic particle-analysis systems
US6976590B2 (en) 2002-06-24 2005-12-20 Cytonome, Inc. Method and apparatus for sorting particles
US7901939B2 (en) 2002-05-09 2011-03-08 University Of Chicago Method for performing crystallization and reactions in pressure-driven fluid plugs
EP2283918B1 (en) 2002-05-09 2022-10-05 The University of Chicago Device and method for pressure-driven plug transport and reaction
US7266587B2 (en) * 2002-05-15 2007-09-04 Broadcom Corporation System having interfaces, switch, and memory bridge for CC-NUMA operation
JP2006507921A (ja) 2002-06-28 2006-03-09 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 流体分散のための方法および装置
US7329545B2 (en) 2002-09-24 2008-02-12 Duke University Methods for sampling a liquid flow
US6911132B2 (en) 2002-09-24 2005-06-28 Duke University Apparatus for manipulating droplets by electrowetting-based techniques
GB2395196B (en) 2002-11-14 2006-12-27 Univ Cardiff Microfluidic device and methods for construction and application
AU2003303594A1 (en) 2002-12-30 2004-07-29 The Regents Of The University Of California Methods and apparatus for pathogen detection and analysis
WO2004071638A2 (en) 2003-02-11 2004-08-26 Regents Of The University Of California, The Microfluidic devices and method for controlled viscous shearing and formation of amphiphilic vesicles
EP1605817A2 (en) 2003-02-25 2005-12-21 Inlight Solutions, Inc. DETERMINATION OF pH INCLUDING HEMOGLOBIN CORRECTION
ES2327231T3 (es) * 2003-03-10 2009-10-27 The Regents Of The University Of Michigan Control microfluidico integrado que emplea accionadores tactiles programables.
US20100022414A1 (en) 2008-07-18 2010-01-28 Raindance Technologies, Inc. Droplet Libraries
US7041481B2 (en) 2003-03-14 2006-05-09 The Regents Of The University Of California Chemical amplification based on fluid partitioning
US7045040B2 (en) 2003-03-20 2006-05-16 Asm Nutool, Inc. Process and system for eliminating gas bubbles during electrochemical processing
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
EP1473084B1 (en) 2003-03-31 2015-07-29 Canon Kabushiki Kaisha Biochemical reaction cartridge
EP2266687A3 (en) 2003-04-10 2011-06-29 The President and Fellows of Harvard College Formation and control of fluidic species
US7262059B2 (en) 2003-05-06 2007-08-28 Thrombodyne, Inc. Systems and methods for measuring fluid properties
WO2004102204A1 (en) 2003-05-16 2004-11-25 Global Technologies (Nz) Ltd Method and apparatus for mixing sample and reagent in a suspension fluid
WO2004103565A2 (de) 2003-05-19 2004-12-02 Hans-Knöll-Institut für Naturstoff-Forschung e.V. Vorrichtung und verfahren zur strukturierung von flüssigkeiten und zum zudosieren von reaktionsflüssigkeiten zu in separationsmedium eingebetteten flüssigkeitskompartimenten
US7115230B2 (en) 2003-06-26 2006-10-03 Intel Corporation Hydrodynamic focusing devices
GB0315438D0 (en) 2003-07-02 2003-08-06 Univ Manchester Analysis of mixed cell populations
US20050032238A1 (en) 2003-08-07 2005-02-10 Nanostream, Inc. Vented microfluidic separation devices and methods
WO2005021151A1 (en) 2003-08-27 2005-03-10 President And Fellows Of Harvard College Electronic control of fluidic species
JP4533382B2 (ja) 2003-08-28 2010-09-01 セルラ・インコーポレイテッド マイクロ流体分析およびソーティング用の一体化された構造物
US7204431B2 (en) 2003-10-31 2007-04-17 Agilent Technologies, Inc. Electrospray ion source for mass spectroscopy
US20050103690A1 (en) 2003-11-19 2005-05-19 Aisin Seiki Kabushiki Kaisha Micro liquid control system
EP1691792A4 (en) 2003-11-24 2008-05-28 Yeda Res & Dev COMPOSITIONS AND PROCESSES FOR SORTING IN VITRO OF MOLECULE AND CELL LIBRARIES
US7687269B2 (en) * 2003-12-10 2010-03-30 Northeastern University Method for efficient transport of small liquid volumes to, from or within microfluidic devices
US20050221339A1 (en) 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
CA2563836C (en) 2004-04-23 2011-06-14 Eugenia Kumacheva Method of producing polymeric particles with selected size, shape, morphology and composition
US9477233B2 (en) 2004-07-02 2016-10-25 The University Of Chicago Microfluidic system with a plurality of sequential T-junctions for performing reactions in microdroplets
US7655470B2 (en) 2004-10-29 2010-02-02 University Of Chicago Method for manipulating a plurality of plugs and performing reactions therein in microfluidic systems
US7759111B2 (en) 2004-08-27 2010-07-20 The Regents Of The University Of California Cell encapsulation microfluidic device
US9566558B2 (en) 2004-09-09 2017-02-14 Institut Curie Device for manipulation of packets in micro-containers, in particular in microchannels
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
WO2006051552A2 (en) 2004-11-15 2006-05-18 Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science Directed evolution and selection using in vitro compartmentalization
AU2006214085A1 (en) * 2005-02-18 2006-08-24 Canon U.S. Life Sciences, Inc. Devices and methods for identifying genomic DNA of organisms
EP2248578B1 (en) 2005-03-04 2012-06-06 President and Fellows of Harvard College Method for forming multiple emulsions
US20070054119A1 (en) 2005-03-04 2007-03-08 Piotr Garstecki Systems and methods of forming particles
FR2882939B1 (fr) 2005-03-11 2007-06-08 Centre Nat Rech Scient Dispositif de separation fluidique
CN101351542A (zh) 2005-07-15 2009-01-21 阿普尔拉公司 液体加工装置和方法
US8734003B2 (en) 2005-09-15 2014-05-27 Alcatel Lucent Micro-chemical mixing
US7274191B2 (en) * 2005-12-29 2007-09-25 Intel Corporation Integrated on-chip NMR and ESR device and method for making and using the same
US20100137163A1 (en) 2006-01-11 2010-06-03 Link Darren R Microfluidic Devices and Methods of Use in The Formation and Control of Nanoreactors
US7537897B2 (en) 2006-01-23 2009-05-26 Population Genetics Technologies, Ltd. Molecular counting
EP2004316B8 (en) 2006-01-27 2011-04-13 President and Fellows of Harvard College Fluidic droplet coalescence
US20080014589A1 (en) 2006-05-11 2008-01-17 Link Darren R Microfluidic devices and methods of use thereof
US7776927B2 (en) 2007-03-28 2010-08-17 President And Fellows Of Harvard College Emulsions and techniques for formation
US20100130369A1 (en) 2007-04-23 2010-05-27 Advanced Liquid Logic, Inc. Bead-Based Multiplexed Analytical Methods and Instrumentation
CN103418295B (zh) 2007-06-21 2015-11-18 简.探针公司 用于混合检测腔室的内容物的仪器和方法
US20090068170A1 (en) 2007-07-13 2009-03-12 President And Fellows Of Harvard College Droplet-based selection
WO2009149257A1 (en) * 2008-06-04 2009-12-10 The University Of Chicago The chemistrode: a plug-based microfluidic device and method for stimulation and sampling with high temporal, spatial, and chemical resolution
US9156010B2 (en) 2008-09-23 2015-10-13 Bio-Rad Laboratories, Inc. Droplet-based assay system
US8061187B2 (en) * 2009-04-27 2011-11-22 Battelle Memorial Institute Lossless droplet transfer of droplet-based microfluidic analysis
US10434970B2 (en) 2016-12-08 2019-10-08 Toyota Jidosha Kabushiki Kaisha Vehicle side section structure

Similar Documents

Publication Publication Date Title
JP2014036956A5 (enExample)
WO2014186440A3 (en) Apparatus and method for the rapid production of droplets
ES2552392R1 (es) Un método para producir negro de humo mediante un fluido diluyente
PH12015501787A1 (en) Systems and methods for ocular surgery
EP3005652A4 (en) DEVICE AND METHOD FOR MAINTAINING A MESSAGE TREAD WITH OPTIONAL ENROLLMENT OF ENTRIES
WO2011146156A3 (en) Generating fluid flow in a fluidic network
BR112017002945A2 (pt) composições de fluido de serviço de poço e método para usar microemulsões como auxiliares de fluido de retorno
WO2015044454A3 (en) A microfluidic device, use and methods
WO2013160408A3 (en) Microfluidic device for performing operations on microdroplets
DK3004527T3 (da) Choker
Lastra et al. Summability in general Carleman ultraholomorphic classes
MX2016011740A (es) Red integrada de flujo fluidico para la gestion de fluidos.
AR098410A1 (es) Optimización de las propiedades de dispositivos de control de flujo tanto en pozos productores como inyectores en sistemas de inundación de líquidos de inyector y productor conectados
CL2018000572A1 (es) Jeringa filtrante
CA2900708C (en) Mixing of fluids in fluidic systems
WO2015014432A8 (de) Filtervorrichtung für fluide
WO2014204597A3 (en) Fluid dispensing system
Qi et al. Electroosmotic flow of a power-law fluid in a slit microchannel with gradually varying channel height and wall potential
HK1208256A1 (en) Microfluidic pump
MX391361B (es) Metodo y dispositivo para la separacion de liquidos inmiscibles para aislar de modo efectivo al menos uno de los liquidos.
EP3329983A4 (en) CLEANSING AGENT, CLEANING SOLUTION AND CLEANSING PROCESS FOR REVERSE OSMOSEMBRBRANE
CO2017010800A2 (es) Desgasificador y método de gas para la extracción de un liquido
GB2529598A (en) Fluid dispensing apparatus and method
EP2977815A4 (en) ALIGNMENT PROCESS FOR LIQUID CRYSTALS WITH MICRO / NANOREGIONS AND SYSTEM THEREOF BASED ON DIRECT LASER DISCS
WO2014110522A3 (en) Ball seat apparatus and method