FR2950544B1 - Circuit microfluidique - Google Patents

Circuit microfluidique

Info

Publication number
FR2950544B1
FR2950544B1 FR0904639A FR0904639A FR2950544B1 FR 2950544 B1 FR2950544 B1 FR 2950544B1 FR 0904639 A FR0904639 A FR 0904639A FR 0904639 A FR0904639 A FR 0904639A FR 2950544 B1 FR2950544 B1 FR 2950544B1
Authority
FR
France
Prior art keywords
fluid
microchannel
microfluidic circuit
drops
bubbles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR0904639A
Other languages
English (en)
Other versions
FR2950544A1 (fr
Inventor
Charles Baroud
Remi Dangla
Francois Gallaire
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Ecole Polytechnique
Original Assignee
Ecole Polytechnique
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0904639A priority Critical patent/FR2950544B1/fr
Application filed by Ecole Polytechnique filed Critical Ecole Polytechnique
Priority to JP2012531479A priority patent/JP5752694B2/ja
Priority to KR1020127011313A priority patent/KR101720683B1/ko
Priority to EP19201464.5A priority patent/EP3632566B1/fr
Priority to US13/498,927 priority patent/US9452432B2/en
Priority to PCT/FR2010/052051 priority patent/WO2011039475A1/fr
Priority to ES10778686T priority patent/ES2803402T3/es
Priority to EP10778686.5A priority patent/EP2482983B1/fr
Priority to ES19201464T priority patent/ES2906718T3/es
Priority to DE10778686.5T priority patent/DE10778686T1/de
Publication of FR2950544A1 publication Critical patent/FR2950544A1/fr
Application granted granted Critical
Publication of FR2950544B1 publication Critical patent/FR2950544B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0652—Sorting or classification of particles or molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/089—Virtual walls for guiding liquids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Micromachines (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

Circuit microfluidique comprenant au moins un microcanal (2) dans lequel s'écoule un premier fluide servant au déplacement de gouttes (5) ou de bulles d'au moins un deuxième fluide, la hauteur (h) du microcanal (2) étant dimensionnée pour écraser les gouttes (5) ou les bulles lors de leur déplacement, le microcanal (2) comportant au moins un chenal (3) de hauteur (hc) plus importante, s'étendant au moins en partie dans la direction d'écoulement (A) du premier fluide, de façon à ce qu'au moins certaines des gouttes (5) ou des bulles du deuxième fluide soient attirées et guidées dans le chenal (3).
FR0904639A 2009-09-29 2009-09-29 Circuit microfluidique Active FR2950544B1 (fr)

Priority Applications (10)

Application Number Priority Date Filing Date Title
FR0904639A FR2950544B1 (fr) 2009-09-29 2009-09-29 Circuit microfluidique
ES19201464T ES2906718T3 (es) 2009-09-29 2010-09-29 Procedimiento de tratamiento de gotas o de burbujas en un circuito microfluídico
EP19201464.5A EP3632566B1 (fr) 2009-09-29 2010-09-29 Procédé de traitement de gouttes ou de bulles dans un circuit microfluidique
US13/498,927 US9452432B2 (en) 2009-09-29 2010-09-29 Microfluidic circuit
PCT/FR2010/052051 WO2011039475A1 (fr) 2009-09-29 2010-09-29 Circuit microfluidique
ES10778686T ES2803402T3 (es) 2009-09-29 2010-09-29 Circuito microfluídico
JP2012531479A JP5752694B2 (ja) 2009-09-29 2010-09-29 マイクロ流体回路
KR1020127011313A KR101720683B1 (ko) 2009-09-29 2010-09-29 마이크로유체성 회로
DE10778686.5T DE10778686T1 (de) 2009-09-29 2010-09-29 Mikrofluidischer schaltkreis
EP10778686.5A EP2482983B1 (fr) 2009-09-29 2010-09-29 Circuit microfluidique

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0904639A FR2950544B1 (fr) 2009-09-29 2009-09-29 Circuit microfluidique

Publications (2)

Publication Number Publication Date
FR2950544A1 FR2950544A1 (fr) 2011-04-01
FR2950544B1 true FR2950544B1 (fr) 2011-12-09

Family

ID=42199939

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0904639A Active FR2950544B1 (fr) 2009-09-29 2009-09-29 Circuit microfluidique

Country Status (8)

Country Link
US (1) US9452432B2 (fr)
EP (2) EP2482983B1 (fr)
JP (1) JP5752694B2 (fr)
KR (1) KR101720683B1 (fr)
DE (1) DE10778686T1 (fr)
ES (2) ES2803402T3 (fr)
FR (1) FR2950544B1 (fr)
WO (1) WO2011039475A1 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100392316C (zh) * 2006-03-27 2008-06-04 博奥生物有限公司 控制液体在微管路中连续流动的流路结构
EP2608878A4 (fr) 2010-08-23 2017-11-15 President and Fellows of Harvard College Ondes acoustiques en microfluidique
FR2996545B1 (fr) 2012-10-08 2016-03-25 Ecole Polytech Procede microfluidique de traitement et d'analyse d'une solution contenant un materiel biologique, et circuit microfluidique correspondant.
FR2996544B1 (fr) * 2012-10-08 2015-03-13 Ecole Polytech Circuit microfluidique permettant la mise en contact de gouttes de plusieurs fluides, et procede microfluidique correspondant.
KR101410129B1 (ko) * 2012-12-11 2014-06-25 서강대학교산학협력단 액적 병합장치
EP3271058B1 (fr) 2015-03-16 2021-10-06 Luminex Corporation Appareil et procédés pour émulsification dans un canal à gradins multiples
LT3341116T (lt) * 2015-08-27 2022-05-25 President And Fellows Of Harvard College Rūšiavimo naudojant akustines bangas būdas
CN108698814A (zh) 2015-12-30 2018-10-23 伯克利之光生命科技公司 用于光学驱动的对流和移位的微流体设备、试剂盒及其方法
FR3056927B1 (fr) 2016-09-30 2021-07-09 Ecole Polytech Procede microfluidique de manipulation de microgouttes
KR102043161B1 (ko) * 2018-06-07 2019-11-11 한양대학교 산학협력단 미세 액적 병합을 위한 미세 유체 제어 장치 및 이를 이용한 미세 액적의 병합 방법
US10486155B1 (en) 2018-10-22 2019-11-26 Klaris Corporation Vacuum-loaded, droplet-generating microfluidic chips and related methods
CN109825417B (zh) * 2019-03-10 2023-12-29 新羿制造科技（北京）有限公司 一种液滴引导装置
CN116174068A (zh) 2019-04-30 2023-05-30 伯克利之光生命科技公司 用于包封和测定细胞的方法
FR3098128B1 (fr) 2019-07-05 2023-11-17 Commissariat Energie Atomique Dispositif microfluidique comportant une microgoutte présentant une matrice sol-gel.
US11701658B2 (en) 2019-08-09 2023-07-18 President And Fellows Of Harvard College Systems and methods for microfluidic particle selection, encapsulation, and injection using surface acoustic waves
US10953404B1 (en) 2020-04-24 2021-03-23 Pattern Bioscience, Inc. Apparatuses for contactless loading and imaging of microfluidic chips and related methods

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4233029A (en) * 1978-10-25 1980-11-11 Eastman Kodak Company Liquid transport device and method
DE10120035B4 (de) * 2001-04-24 2005-07-07 Advalytix Ag Verfahren und Vorrichtung zur Manipulation kleiner Flüssigkeitsmengen auf Oberflächen
AU2003216175A1 (en) * 2002-02-04 2003-09-02 Colorado School Of Mines Laminar flow-based separations of colloidal and cellular particles
US6877528B2 (en) * 2002-04-17 2005-04-12 Cytonome, Inc. Microfluidic system including a bubble valve for regulating fluid flow through a microchannel
AU2003254637A1 (en) * 2002-08-15 2004-03-03 Memsflow Aps Micro liquid handling device and methods for using it
US9477233B2 (en) * 2004-07-02 2016-10-25 The University Of Chicago Microfluidic system with a plurality of sequential T-junctions for performing reactions in microdroplets
FR2873171B1 (fr) 2004-07-19 2007-12-07 Centre Nat Rech Scient Cnrse Circuit microfluidique a composant actif
JP2006058031A (ja) * 2004-08-17 2006-03-02 Hitachi High-Technologies Corp 化学分析装置
US7918244B2 (en) * 2005-05-02 2011-04-05 Massachusetts Institute Of Technology Microfluidic bubble logic devices
US8936945B2 (en) * 2005-11-17 2015-01-20 The Regents Of The University Of Michigan Compositions and methods for liquid metering in microchannels
FR2901717A1 (fr) * 2006-05-30 2007-12-07 Centre Nat Rech Scient Procede de traitement de gouttes dans un circuit microfluidique.
JP2010524002A (ja) * 2007-04-10 2010-07-15 アドヴァンスト リキッド ロジック インコーポレイテッド 液滴分配装置および方法
BRPI0907148B1 (pt) * 2008-02-27 2021-01-12 Boehringer Ingelheim Microparts Gmbh dispositivo para a separação do plasma
US8340913B2 (en) * 2008-03-03 2012-12-25 Schlumberger Technology Corporation Phase behavior analysis using a microfluidic platform

Also Published As

Publication number Publication date
ES2803402T3 (es) 2021-01-26
EP3632566B1 (fr) 2021-11-10
DE10778686T1 (de) 2019-12-19
WO2011039475A1 (fr) 2011-04-07
EP3632566A1 (fr) 2020-04-08
US9452432B2 (en) 2016-09-27
JP2013505827A (ja) 2013-02-21
JP5752694B2 (ja) 2015-07-22
EP2482983B1 (fr) 2020-04-29
KR20120082015A (ko) 2012-07-20
ES2906718T3 (es) 2022-04-20
US20120315203A1 (en) 2012-12-13
FR2950544A1 (fr) 2011-04-01
EP2482983A1 (fr) 2012-08-08
KR101720683B1 (ko) 2017-03-28

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Legal Events

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TQ Partial transmission of property

Owner name: ECOLE POLYTECHNIQUE, FR

Effective date: 20150202

Owner name: CENTRE NATIONAL DELA RECHERCHE SCIENTIFIQUE (C, FR

Effective date: 20150202

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