JP2013505827A - マイクロ流体回路 - Google Patents
マイクロ流体回路 Download PDFInfo
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- JP2013505827A JP2013505827A JP2012531479A JP2012531479A JP2013505827A JP 2013505827 A JP2013505827 A JP 2013505827A JP 2012531479 A JP2012531479 A JP 2012531479A JP 2012531479 A JP2012531479 A JP 2012531479A JP 2013505827 A JP2013505827 A JP 2013505827A
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
- B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
- B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
- B01L2200/0652—Sorting or classification of particles or molecules
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/089—Virtual walls for guiding liquids
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/08—Regulating or influencing the flow resistance
- B01L2400/084—Passive control of flow resistance
- B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions
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Abstract
【選択図】図1
Description
Claims (12)
- 少なくとも1種類の第2の流体の滴もしくは泡(5)を搬送する第1の流体の流れのための少なくとも1つマイクロチャンネル(2)を具備するマイクロ流体回路(1)において、
前記マイクロチャンネル(2)の高さ(h)が、前記滴もしくは泡(5)を、滴もしくは泡(5)の移動の間に押し潰すように設定されていることと、前記マイクロチャンネル(2)は、前記第1の流体の流れ(F)の方向に少なくとも部分的に延びている少なくとも1つの流路、もしくは、滴もしくは泡を捕らえるためのトラップ領域を有しており、前記トラップ領域(28)もしくは前記流路(3)は、前記マイクロチャンネル(2)中の前記第2の流体の少なくとも一定の滴もしくは泡が前記流路(3)もしくは前記トラップ領域中に引っ張られて案内されるように、前記マイクロチャンネル(2)の高さより高い高さ(hc)を有していることとを特徴とする、マイクロ流体回路。 - 前記マイクロチャンネル(2)は、2つの平行した壁(4、8)によって規定されており、前記流路は、前記マイクロチャンネル(2)の少なくとも一方の前記壁(4)の流路(3)によって、もしくは前記マイクロチャンネル(2)の前記一方の壁の2つの平行なリブ(6)間に、形成されていることを特徴とする、請求項1に記載の回路。
- 少なくとも2つの異なる種類の泡もしくは滴(14、15)が、前記第1の流体によって搬送されることと、
前記流路(3)は、第1の種類の泡もしくは滴(15)のみが前記流路(3)中に案内されるように、泡もしくは滴を分別即ち分類するための手段を構成していることとを特徴とする、請求項1又は2に記載の回路。 - 前記異なる種類の泡もしくは滴(5)は、異なる大きさ、もしくは粘性、もしくは表面張力を有することを特徴とする、請求項3に記載の回路。
- 前記流路(3)は、異なる高さ及び/もしくは幅の少なくとも2つの連続した部分(17、18、19、20)を有しており、これらの部分のうち、大きい高さ及び/幅の部分が、小さい高さ及び/もしくは幅の部分より、前記第1の流体の流れの方向で、前に配置されていることを特徴とする、請求項1乃至4のいずれか1に記載の回路。
- 前記第1の流体の流れに対して異なる幅、及び/もしくは異なる傾斜の複数の流路(3)を具備することを特徴とする、請求項1乃至5のいずれか1に記載の回路。
- 前記マイクロチャンネル(2)もしくは前記流路(3)中の滴もしくは泡(5)の通路の断面の拡大によって、又は、前記マイクロチャンネル(2)及び/もしくは前記流路(3)の表面エネルギーの部分的な変更によって、形成されている、滴もしくは泡(5)を捕らえるための複数のトラップ領域(28)を具備することを特徴とする、請求項1乃至6のいずれか1に記載の回路。
- 前記トラップ領域(28)の少なくともいくつかは、互いに独立していることを特徴とする、請求項7に記載の回路。
- 前記トラップ領域(28)の少なくともいくつかは、前記マイクロチャンネル(2)によって、もしくは前記流路(3)によって、直列に、もしくは並列に接続されていることを特徴とする、請求項7に記載の回路。
- 障害物(32)が、前記トラップ領域中に引き込まれた泡もしくは滴を前記トラップ領域中に保持するように、一定のトラップ領域の下流に形成されていることを特徴とする、請求項7乃至9のいずれか1に記載の回路。
- 前記少なくとも1つの流路(3)は、前記流路(3)中に存在する泡もしくは滴(5)を減速させるための手段(25)、もしくは加速させるための手段(26)を有しており、前記減速させるための手段(25)、もしくは前記加速させるための手段(26)は、前記流路(3)の幅もしくは高さの変形によって、もしくは、減速もしくは加速のための所定の領域に沿って形成された、対応した前記マイクロチャンネルの壁のレールもしくはリブによって、形成されていることを特徴とする、請求項1乃至10のいずれか1に記載の回路。
- 異なる性質の滴もしくは泡(21、22、23、24)の平行な流れをマイクロチャンネル(2)中に供給するための手段(38)と、異なる性質の滴もしくは泡を前記マイクロチャンネル(2)中に導入するための平行手段(39)と、
前記導入するための手段(39)の各々から出た滴もしくは泡を、前記導入するための手段(39)によって前記マイクロチャンネル(2)の所定の領域まで案内するように、このマイクロチャンネル中に形成されている流路(3)と、
を具備することを特徴とする請求項1乃至11のいずれか1に記載の回路。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0904639A FR2950544B1 (fr) | 2009-09-29 | 2009-09-29 | Circuit microfluidique |
FR0904639 | 2009-09-29 | ||
PCT/FR2010/052051 WO2011039475A1 (fr) | 2009-09-29 | 2010-09-29 | Circuit microfluidique |
Publications (2)
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JP2013505827A true JP2013505827A (ja) | 2013-02-21 |
JP5752694B2 JP5752694B2 (ja) | 2015-07-22 |
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JP2012531479A Active JP5752694B2 (ja) | 2009-09-29 | 2010-09-29 | マイクロ流体回路 |
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US (1) | US9452432B2 (ja) |
EP (2) | EP3632566B1 (ja) |
JP (1) | JP5752694B2 (ja) |
KR (1) | KR101720683B1 (ja) |
DE (1) | DE10778686T1 (ja) |
ES (2) | ES2906718T3 (ja) |
FR (1) | FR2950544B1 (ja) |
WO (1) | WO2011039475A1 (ja) |
Cited By (1)
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JP2015534072A (ja) * | 2012-10-08 | 2015-11-26 | エコール ポリテクニック | 複数の流体の液滴を接触させることを可能にするマイクロ流体回路および対応するマイクロ流体方法 |
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CN100392316C (zh) * | 2006-03-27 | 2008-06-04 | 博奥生物有限公司 | 控制液体在微管路中连续流动的流路结构 |
WO2012027366A2 (en) | 2010-08-23 | 2012-03-01 | President And Fellows Of Harvard College | Acoustic waves in microfluidics |
FR2996545B1 (fr) | 2012-10-08 | 2016-03-25 | Ecole Polytech | Procede microfluidique de traitement et d'analyse d'une solution contenant un materiel biologique, et circuit microfluidique correspondant. |
KR101410129B1 (ko) * | 2012-12-11 | 2014-06-25 | 서강대학교산학협력단 | 액적 병합장치 |
WO2016149241A1 (en) | 2015-03-16 | 2016-09-22 | Luminex Corporation | Apparatus and methods for multi-step channel emulsification |
CA3004347A1 (en) * | 2015-08-27 | 2017-03-02 | President And Fellows Of Harvard College | Acoustic wave sorting |
JP6964590B2 (ja) | 2015-12-30 | 2021-11-10 | バークレー ライツ,インコーポレイテッド | 光学的に駆動される対流及び変位のマイクロ流体デバイス、そのキット及び方法 |
FR3056927B1 (fr) | 2016-09-30 | 2021-07-09 | Ecole Polytech | Procede microfluidique de manipulation de microgouttes |
KR102043161B1 (ko) * | 2018-06-07 | 2019-11-11 | 한양대학교 산학협력단 | 미세 액적 병합을 위한 미세 유체 제어 장치 및 이를 이용한 미세 액적의 병합 방법 |
US10486155B1 (en) | 2018-10-22 | 2019-11-26 | Klaris Corporation | Vacuum-loaded, droplet-generating microfluidic chips and related methods |
CN109825417B (zh) * | 2019-03-10 | 2023-12-29 | 新羿制造科技(北京)有限公司 | 一种液滴引导装置 |
EP3962652A4 (en) | 2019-04-30 | 2023-01-18 | Berkeley Lights, Inc. | METHODS FOR ENCAPSULATION AND TESTING OF CELLS |
FR3098128B1 (fr) | 2019-07-05 | 2023-11-17 | Commissariat Energie Atomique | Dispositif microfluidique comportant une microgoutte présentant une matrice sol-gel. |
US11701658B2 (en) | 2019-08-09 | 2023-07-18 | President And Fellows Of Harvard College | Systems and methods for microfluidic particle selection, encapsulation, and injection using surface acoustic waves |
US10953404B1 (en) | 2020-04-24 | 2021-03-23 | Pattern Bioscience, Inc. | Apparatuses for contactless loading and imaging of microfluidic chips and related methods |
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- 2010-09-29 WO PCT/FR2010/052051 patent/WO2011039475A1/fr active Application Filing
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JP2006058031A (ja) * | 2004-08-17 | 2006-03-02 | Hitachi High-Technologies Corp | 化学分析装置 |
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Publication number | Publication date |
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EP3632566B1 (fr) | 2021-11-10 |
EP2482983A1 (fr) | 2012-08-08 |
FR2950544A1 (fr) | 2011-04-01 |
EP2482983B1 (fr) | 2020-04-29 |
DE10778686T1 (de) | 2019-12-19 |
KR101720683B1 (ko) | 2017-03-28 |
ES2906718T3 (es) | 2022-04-20 |
ES2803402T3 (es) | 2021-01-26 |
US20120315203A1 (en) | 2012-12-13 |
KR20120082015A (ko) | 2012-07-20 |
JP5752694B2 (ja) | 2015-07-22 |
EP3632566A1 (fr) | 2020-04-08 |
US9452432B2 (en) | 2016-09-27 |
WO2011039475A1 (fr) | 2011-04-07 |
FR2950544B1 (fr) | 2011-12-09 |
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