JP2013545489A5 - - Google Patents
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- Publication number
- JP2013545489A5 JP2013545489A5 JP2013543905A JP2013543905A JP2013545489A5 JP 2013545489 A5 JP2013545489 A5 JP 2013545489A5 JP 2013543905 A JP2013543905 A JP 2013543905A JP 2013543905 A JP2013543905 A JP 2013543905A JP 2013545489 A5 JP2013545489 A5 JP 2013545489A5
- Authority
- JP
- Japan
- Prior art keywords
- culture medium
- cell culture
- item
- lipid
- trace mineral
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000006143 cell culture medium Substances 0.000 claims description 27
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims description 12
- 102000003974 Fibroblast growth factor 2 Human genes 0.000 claims description 10
- 108090000379 Fibroblast growth factor 2 Proteins 0.000 claims description 10
- 239000000758 substrate Substances 0.000 claims description 9
- 150000002632 lipids Chemical class 0.000 claims description 8
- 239000011573 trace mineral Substances 0.000 claims description 8
- 235000013619 trace mineral Nutrition 0.000 claims description 8
- 102000004877 Insulin Human genes 0.000 claims description 6
- 108090001061 Insulin Proteins 0.000 claims description 6
- 229940125396 insulin Drugs 0.000 claims description 6
- 239000003102 growth factor Substances 0.000 claims description 5
- 102000009027 Albumins Human genes 0.000 claims description 4
- 108010088751 Albumins Proteins 0.000 claims description 4
- 102000004338 Transferrin Human genes 0.000 claims description 4
- 108090000901 Transferrin Proteins 0.000 claims description 4
- KWGKDLIKAYFUFQ-UHFFFAOYSA-M lithium chloride Chemical compound [Li+].[Cl-] KWGKDLIKAYFUFQ-UHFFFAOYSA-M 0.000 claims description 4
- 239000012581 transferrin Substances 0.000 claims description 4
- 150000001413 amino acids Chemical class 0.000 claims description 3
- 229910017053 inorganic salt Inorganic materials 0.000 claims description 3
- 210000001778 pluripotent stem cell Anatomy 0.000 claims description 3
- 235000013343 vitamin Nutrition 0.000 claims description 3
- 239000011782 vitamin Substances 0.000 claims description 3
- 229940088594 vitamin Drugs 0.000 claims description 3
- 229930003231 vitamin Natural products 0.000 claims description 3
- 150000003722 vitamin derivatives Chemical class 0.000 claims description 3
- 102000000905 Cadherin Human genes 0.000 claims description 2
- 108050007957 Cadherin Proteins 0.000 claims description 2
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 claims description 2
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims description 2
- 229930182816 L-glutamine Natural products 0.000 claims description 2
- HXEACLLIILLPRG-YFKPBYRVSA-N L-pipecolic acid Chemical compound [O-]C(=O)[C@@H]1CCCC[NH2+]1 HXEACLLIILLPRG-YFKPBYRVSA-N 0.000 claims description 2
- 229940050528 albumin Drugs 0.000 claims description 2
- 239000003797 essential amino acid Substances 0.000 claims description 2
- 235000020776 essential amino acid Nutrition 0.000 claims description 2
- 229960003692 gamma aminobutyric acid Drugs 0.000 claims description 2
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 claims description 2
- HXEACLLIILLPRG-RXMQYKEDSA-N l-pipecolic acid Natural products OC(=O)[C@H]1CCCCN1 HXEACLLIILLPRG-RXMQYKEDSA-N 0.000 claims description 2
- 229940073577 lithium chloride Drugs 0.000 claims description 2
- 210000000130 stem cell Anatomy 0.000 claims description 2
- 108010038862 laminin 10 Proteins 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201061424273P | 2010-12-17 | 2010-12-17 | |
| US61/424,273 | 2010-12-17 | ||
| US201161488353P | 2011-05-20 | 2011-05-20 | |
| US61/488,353 | 2011-05-20 | ||
| US201161533063P | 2011-09-09 | 2011-09-09 | |
| US61/533,063 | 2011-09-09 | ||
| US201161537940P | 2011-09-22 | 2011-09-22 | |
| US61/537,940 | 2011-09-22 | ||
| US201161565380P | 2011-11-30 | 2011-11-30 | |
| US61/565,380 | 2011-11-30 | ||
| US201161565849P | 2011-12-01 | 2011-12-01 | |
| US61/565,849 | 2011-12-01 | ||
| PCT/IB2011/003265 WO2012080844A1 (en) | 2010-12-17 | 2011-12-16 | Cell culture medium |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013545489A JP2013545489A (ja) | 2013-12-26 |
| JP2013545489A5 true JP2013545489A5 (enExample) | 2015-02-05 |
| JP6002675B2 JP6002675B2 (ja) | 2016-10-05 |
Family
ID=45755415
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013543904A Active JP5990531B2 (ja) | 2010-12-17 | 2011-12-16 | 組換えラミニン−５２１ |
| JP2013543905A Active JP6002675B2 (ja) | 2010-12-17 | 2011-12-16 | 細胞培養培地 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013543904A Active JP5990531B2 (ja) | 2010-12-17 | 2011-12-16 | 組換えラミニン−５２１ |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US8415156B2 (enExample) |
| EP (2) | EP2651974B1 (enExample) |
| JP (2) | JP5990531B2 (enExample) |
| KR (3) | KR101921350B1 (enExample) |
| CN (2) | CN103384679B (enExample) |
| AU (1) | AU2011342904B2 (enExample) |
| BR (2) | BR112013017629A2 (enExample) |
| CA (2) | CA2826252C (enExample) |
| IL (2) | IL226971B (enExample) |
| MX (2) | MX345861B (enExample) |
| SG (3) | SG191216A1 (enExample) |
| WO (2) | WO2012080842A1 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2008307633C1 (en) | 2007-09-28 | 2015-04-30 | Celularity Inc. | Tumor suppression using human placental perfusate and human placenta-derived intermediate natural killer cells |
| WO2011063005A2 (en) | 2009-11-17 | 2011-05-26 | Advanced Cell Technology, Inc. | Methods of producing human rpe cells and pharmaceutical preparations of human rpe cells |
| WO2012009422A1 (en) | 2010-07-13 | 2012-01-19 | Anthrogenesis Corporation | Methods of generating natural killer cells |
| US8415156B2 (en) * | 2010-12-17 | 2013-04-09 | Biolamina Ab | Recombinant laminin-521 |
| KR102048464B1 (ko) * | 2011-09-22 | 2019-11-25 | 칼 트리그베이슨 | 라미닌 및 카데린를 포함하는 세포 배양 기질 |
| WO2013080051A2 (en) | 2011-11-30 | 2013-06-06 | Biolamina Ab | Methods of enhancing genetic diagnosis |
| DK2838992T3 (en) | 2012-04-20 | 2018-02-05 | Biolamina Ab | Maintaining differentiated cells with laminins |
| US20130330825A1 (en) * | 2012-06-07 | 2013-12-12 | City Of Hope | Attachment substrates for directed differentiation of human embryonic stem cells in culture |
| WO2014037807A2 (en) * | 2012-09-07 | 2014-03-13 | Biolamina Ab | Stem cell bank |
| EP2925856B1 (en) | 2012-12-03 | 2018-03-07 | Biolamina AB | Methods of producing rpe cells |
| WO2014123879A1 (en) | 2013-02-05 | 2014-08-14 | Anthrogenesis Corporation | Natural killer cells from placenta |
| ES2742444T3 (es) * | 2013-07-02 | 2020-02-14 | Nat Univ Singapore | Diferenciación de células madre pluripotentes y células progenitoras cardíacas en fibras de cardiomiocito estriadas usando laminianas LN-15, LN-521 y LN-221 |
| SG11201508796SA (en) * | 2013-11-01 | 2015-11-27 | Bbhc Co Ltd | Method for producing induced pluripotent stem cell from mesenchymal stem cell and induced pluripotent stem cell produced by the method |
| RU2704984C1 (ru) | 2013-11-27 | 2019-11-01 | Киото Прифекчурал Паблик Юниверсити Корпорэйшн | Применение ламинина в культуре клеток эндотелия роговицы |
| CN113559246A (zh) | 2014-10-31 | 2021-10-29 | 京都府公立大学法人 | 使用层粘连蛋白的新的角膜的治疗 |
| WO2016067629A1 (ja) * | 2014-10-31 | 2016-05-06 | 京都府公立大学法人 | ラミニンによる網膜および神経の新規治療 |
| DK3059307T5 (da) * | 2015-02-20 | 2022-08-29 | Inst Nat Sante Rech Med | Anvendelse af et laminin til differentiering af pluripotente celler i hepatocytcellelinier |
| US20190359939A1 (en) * | 2015-08-23 | 2019-11-28 | Diamyd Medical Ab | New use |
| ES2896548T3 (es) * | 2015-10-30 | 2022-02-24 | Biolamina Ab | Métodos de producción de hepatocitos |
| JP6605618B2 (ja) * | 2015-11-10 | 2019-11-20 | 日機装株式会社 | 細胞支持複合体および細胞支持複合体の製造方法 |
| US11920155B2 (en) | 2016-03-30 | 2024-03-05 | Asterias Biotherapeutics, Inc. | Oligodendrocyte progenitor cell compositions |
| US20190211305A1 (en) * | 2016-08-25 | 2019-07-11 | Kyoto University | Method for Culturing Pluripotent Stem Cells on Specific Laminin |
| CA3042562C (en) * | 2016-11-16 | 2023-02-28 | Cynata Therapeutics Limited | Pluripotent stem cell assay |
| CN106591295B (zh) * | 2016-12-31 | 2019-10-25 | 贵州北科生物科技有限公司 | 一种多功能干细胞培养方法及所用培养基 |
| CN110914407A (zh) | 2017-05-05 | 2020-03-24 | 新加坡国立大学 | 人角质形成细胞的培养方法 |
| US12365872B2 (en) | 2018-09-19 | 2025-07-22 | Lineage Cell Therapeutics, Inc. | Methods for differentiating pluripotent stem cells in dynamic suspension culture |
| US11603518B2 (en) | 2019-01-23 | 2023-03-14 | Asterias Biotherapeutics, Inc. | Dorsally-derived oligodendrocyte progenitor cells from human pluripotent stem cells |
| CN111621473A (zh) * | 2019-04-03 | 2020-09-04 | 成熙(上海)生物科技有限公司 | 一种新型人源脂肪干细胞制剂的制备方法 |
| CN111617105A (zh) * | 2019-04-03 | 2020-09-04 | 成熙(上海)生物科技有限公司 | 一种脂肪干细胞多细胞活性因子冻干粉的制备方法 |
| WO2021233116A1 (zh) * | 2020-05-21 | 2021-11-25 | 北京大学 | 多能干细胞的成分明确、无异源的培养系统 |
| CN111569048B (zh) * | 2020-05-22 | 2023-04-18 | 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 | LamG5肽在制备修复睾丸中支持细胞损伤的药物中的应用 |
| WO2025067551A1 (zh) * | 2024-05-16 | 2025-04-03 | 北京百普赛斯生物科技股份有限公司 | 活性增强的改造型Laminin 521蛋白及应用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7005252B1 (en) * | 2000-03-09 | 2006-02-28 | Wisconsin Alumni Research Foundation | Serum free cultivation of primate embryonic stem cells |
| EP2457999B1 (en) | 2002-12-16 | 2018-10-17 | Technion Research & Development Foundation Ltd. | Culture medium for pluripotent stem cells |
| ES2383813T3 (es) * | 2004-09-08 | 2012-06-26 | Wisconsin Alumni Research Foundation | Método de cultivo y cultivo de células madre embrionarias |
| JP2006087396A (ja) | 2004-09-27 | 2006-04-06 | National Institute For Environmental Studies | 細胞培養基質及びその製造方法 |
| JP2009506785A (ja) * | 2005-11-18 | 2009-02-19 | イムジェン カンパニー リミテッド | 胚芽幹細胞の未分化増殖を誘導するオカダ酸含有培地組成物 |
| EP1994141B1 (en) * | 2006-02-23 | 2017-11-15 | ViaCyte, Inc. | Compositions and methods useful for culturing differentiable cells |
| DK2137295T3 (en) | 2007-01-04 | 2018-06-25 | Karl Tryggvason | Use of a composition and method for enabling proliferation of pluripotent stem cells |
| US10829733B2 (en) | 2007-01-04 | 2020-11-10 | Biolamina Ab | Composition and method for enabling proliferation of pluripotent human stem cells |
| US8951799B2 (en) * | 2007-01-04 | 2015-02-10 | Biolamina Ab | Composition and method for enabling proliferation of pluripotent stem cells |
| WO2009006399A1 (en) | 2007-07-01 | 2009-01-08 | Lifescan | Single pluripotent stem cell culture |
| ES2690554T3 (es) * | 2008-03-17 | 2018-11-21 | The Scripps Research Institute | Enfoques químicos y genéticos combinados para la generación de células madre pluripotentes inducidas |
| US20110117645A1 (en) * | 2008-03-31 | 2011-05-19 | Oriental Yeast Co., Ltd. | Method for proliferation of pluripotent stem cells |
| US20110318730A1 (en) | 2008-07-07 | 2011-12-29 | The Rockefeller University | Micropatterned co-culture systems as infectious disease analysis platforms |
| JP5765714B2 (ja) | 2009-05-29 | 2015-08-19 | 国立大学法人京都大学 | 人工多能性幹細胞の製造方法および培養方法 |
| WO2010140698A1 (ja) * | 2009-06-03 | 2010-12-09 | 国立大学法人東北大学 | 多能性幹細胞からの神経堤細胞群の分化誘導方法 |
| CA2707296A1 (en) | 2009-06-12 | 2010-12-12 | Richard T. Scott, Jr. | Method for relative quantitation of chromosomal dna copy number in a single or few cells |
| US8415156B2 (en) | 2010-12-17 | 2013-04-09 | Biolamina Ab | Recombinant laminin-521 |
-
2011
- 2011-12-16 US US13/328,145 patent/US8415156B2/en active Active
- 2011-12-16 EP EP11820801.6A patent/EP2651974B1/en active Active
- 2011-12-16 KR KR1020137018840A patent/KR101921350B1/ko active Active
- 2011-12-16 MX MX2013006959A patent/MX345861B/es active IP Right Grant
- 2011-12-16 CN CN201180067474.2A patent/CN103384679B/zh active Active
- 2011-12-16 KR KR1020197003578A patent/KR101966033B1/ko active Active
- 2011-12-16 KR KR1020137018841A patent/KR20140012047A/ko not_active Abandoned
- 2011-12-16 SG SG2013046727A patent/SG191216A1/en unknown
- 2011-12-16 SG SG10201510405PA patent/SG10201510405PA/en unknown
- 2011-12-16 EP EP11820800.8A patent/EP2651973B1/en active Active
- 2011-12-16 WO PCT/IB2011/003258 patent/WO2012080842A1/en not_active Ceased
- 2011-12-16 CA CA2826252A patent/CA2826252C/en active Active
- 2011-12-16 US US13/328,156 patent/US10138292B2/en active Active
- 2011-12-16 CA CA2828794A patent/CA2828794C/en active Active
- 2011-12-16 JP JP2013543904A patent/JP5990531B2/ja active Active
- 2011-12-16 JP JP2013543905A patent/JP6002675B2/ja active Active
- 2011-12-16 WO PCT/IB2011/003265 patent/WO2012080844A1/en not_active Ceased
- 2011-12-16 SG SG2013046701A patent/SG191215A1/en unknown
- 2011-12-16 AU AU2011342904A patent/AU2011342904B2/en active Active
- 2011-12-16 CN CN201180067656.XA patent/CN103384680B/zh active Active
- 2011-12-16 BR BR112013017629A patent/BR112013017629A2/pt not_active Application Discontinuation
- 2011-12-16 MX MX2013006958A patent/MX343462B/es active IP Right Grant
- 2011-12-16 BR BR112013017632A patent/BR112013017632A2/pt not_active Application Discontinuation
-
2013
- 2013-06-16 IL IL226971A patent/IL226971B/en active IP Right Grant
-
2019
- 2019-10-26 IL IL270186A patent/IL270186B/en active IP Right Grant
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