KR101921350B1 - 인간 다능성 줄기세포를 유지하기 위한 시스템 - Google Patents

인간 다능성 줄기세포를 유지하기 위한 시스템 Download PDF

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KR101921350B1
KR101921350B1 KR1020137018840A KR20137018840A KR101921350B1 KR 101921350 B1 KR101921350 B1 KR 101921350B1 KR 1020137018840 A KR1020137018840 A KR 1020137018840A KR 20137018840 A KR20137018840 A KR 20137018840A KR 101921350 B1 KR101921350 B1 KR 101921350B1
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KR20140016881A (ko
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칼 트리그베이슨
세르게이 로딘
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바이오라미나 에이비
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors
    • C12N2501/602—Sox-2
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors
    • C12N2501/603—Oct-3/4
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors
    • C12N2501/605—Nanog
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors
    • C12N2501/608—Lin28
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/52—Fibronectin; Laminin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/13—Hollow or container type article [e.g., tube, vase, etc.]

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
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  • Developmental Biology & Embryology (AREA)
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  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • General Engineering & Computer Science (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Transplantation (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020137018840A 2010-12-17 2011-12-16 인간 다능성 줄기세포를 유지하기 위한 시스템 Active KR101921350B1 (ko)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US201061424273P 2010-12-17 2010-12-17
US61/424,273 2010-12-17
US201161488353P 2011-05-20 2011-05-20
US61/488,353 2011-05-20
US201161533063P 2011-09-09 2011-09-09
US61/533,063 2011-09-09
US201161537940P 2011-09-22 2011-09-22
US61/537,940 2011-09-22
US201161565380P 2011-11-30 2011-11-30
US61/565,380 2011-11-30
US201161565849P 2011-12-01 2011-12-01
US61/565,849 2011-12-01
PCT/IB2011/003265 WO2012080844A1 (en) 2010-12-17 2011-12-16 Cell culture medium

Publications (2)

Publication Number Publication Date
KR20140016881A KR20140016881A (ko) 2014-02-10
KR101921350B1 true KR101921350B1 (ko) 2018-11-22

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KR1020137018840A Active KR101921350B1 (ko) 2010-12-17 2011-12-16 인간 다능성 줄기세포를 유지하기 위한 시스템
KR1020197003578A Active KR101966033B1 (ko) 2010-12-17 2011-12-16 재조합 라미닌-521
KR1020137018841A Abandoned KR20140012047A (ko) 2010-12-17 2011-12-16 재조합 라미닌-521

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KR1020197003578A Active KR101966033B1 (ko) 2010-12-17 2011-12-16 재조합 라미닌-521
KR1020137018841A Abandoned KR20140012047A (ko) 2010-12-17 2011-12-16 재조합 라미닌-521

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US (2) US8415156B2 (enExample)
EP (2) EP2651974B1 (enExample)
JP (2) JP5990531B2 (enExample)
KR (3) KR101921350B1 (enExample)
CN (2) CN103384679B (enExample)
AU (1) AU2011342904B2 (enExample)
BR (2) BR112013017629A2 (enExample)
CA (2) CA2826252C (enExample)
IL (2) IL226971B (enExample)
MX (2) MX345861B (enExample)
SG (3) SG191216A1 (enExample)
WO (2) WO2012080842A1 (enExample)

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WO2011063005A2 (en) 2009-11-17 2011-05-26 Advanced Cell Technology, Inc. Methods of producing human rpe cells and pharmaceutical preparations of human rpe cells
WO2012009422A1 (en) 2010-07-13 2012-01-19 Anthrogenesis Corporation Methods of generating natural killer cells
US8415156B2 (en) * 2010-12-17 2013-04-09 Biolamina Ab Recombinant laminin-521
KR102048464B1 (ko) * 2011-09-22 2019-11-25 칼 트리그베이슨 라미닌 및 카데린를 포함하는 세포 배양 기질
WO2013080051A2 (en) 2011-11-30 2013-06-06 Biolamina Ab Methods of enhancing genetic diagnosis
DK2838992T3 (en) 2012-04-20 2018-02-05 Biolamina Ab Maintaining differentiated cells with laminins
US20130330825A1 (en) * 2012-06-07 2013-12-12 City Of Hope Attachment substrates for directed differentiation of human embryonic stem cells in culture
WO2014037807A2 (en) * 2012-09-07 2014-03-13 Biolamina Ab Stem cell bank
EP2925856B1 (en) 2012-12-03 2018-03-07 Biolamina AB Methods of producing rpe cells
WO2014123879A1 (en) 2013-02-05 2014-08-14 Anthrogenesis Corporation Natural killer cells from placenta
ES2742444T3 (es) * 2013-07-02 2020-02-14 Nat Univ Singapore Diferenciación de células madre pluripotentes y células progenitoras cardíacas en fibras de cardiomiocito estriadas usando laminianas LN-15, LN-521 y LN-221
SG11201508796SA (en) * 2013-11-01 2015-11-27 Bbhc Co Ltd Method for producing induced pluripotent stem cell from mesenchymal stem cell and induced pluripotent stem cell produced by the method
RU2704984C1 (ru) 2013-11-27 2019-11-01 Киото Прифекчурал Паблик Юниверсити Корпорэйшн Применение ламинина в культуре клеток эндотелия роговицы
CN113559246A (zh) 2014-10-31 2021-10-29 京都府公立大学法人 使用层粘连蛋白的新的角膜的治疗
WO2016067629A1 (ja) * 2014-10-31 2016-05-06 京都府公立大学法人 ラミニンによる網膜および神経の新規治療
DK3059307T5 (da) * 2015-02-20 2022-08-29 Inst Nat Sante Rech Med Anvendelse af et laminin til differentiering af pluripotente celler i hepatocytcellelinier
US20190359939A1 (en) * 2015-08-23 2019-11-28 Diamyd Medical Ab New use
ES2896548T3 (es) * 2015-10-30 2022-02-24 Biolamina Ab Métodos de producción de hepatocitos
JP6605618B2 (ja) * 2015-11-10 2019-11-20 日機装株式会社 細胞支持複合体および細胞支持複合体の製造方法
US11920155B2 (en) 2016-03-30 2024-03-05 Asterias Biotherapeutics, Inc. Oligodendrocyte progenitor cell compositions
US20190211305A1 (en) * 2016-08-25 2019-07-11 Kyoto University Method for Culturing Pluripotent Stem Cells on Specific Laminin
CA3042562C (en) * 2016-11-16 2023-02-28 Cynata Therapeutics Limited Pluripotent stem cell assay
CN106591295B (zh) * 2016-12-31 2019-10-25 贵州北科生物科技有限公司 一种多功能干细胞培养方法及所用培养基
CN110914407A (zh) 2017-05-05 2020-03-24 新加坡国立大学 人角质形成细胞的培养方法
US12365872B2 (en) 2018-09-19 2025-07-22 Lineage Cell Therapeutics, Inc. Methods for differentiating pluripotent stem cells in dynamic suspension culture
US11603518B2 (en) 2019-01-23 2023-03-14 Asterias Biotherapeutics, Inc. Dorsally-derived oligodendrocyte progenitor cells from human pluripotent stem cells
CN111621473A (zh) * 2019-04-03 2020-09-04 成熙(上海)生物科技有限公司 一种新型人源脂肪干细胞制剂的制备方法
CN111617105A (zh) * 2019-04-03 2020-09-04 成熙(上海)生物科技有限公司 一种脂肪干细胞多细胞活性因子冻干粉的制备方法
WO2021233116A1 (zh) * 2020-05-21 2021-11-25 北京大学 多能干细胞的成分明确、无异源的培养系统
CN111569048B (zh) * 2020-05-22 2023-04-18 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 LamG5肽在制备修复睾丸中支持细胞损伤的药物中的应用
WO2025067551A1 (zh) * 2024-05-16 2025-04-03 北京百普赛斯生物科技股份有限公司 活性增强的改造型Laminin 521蛋白及应用

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SG191215A1 (en) 2013-07-31
JP2014501101A (ja) 2014-01-20
EP2651973B1 (en) 2016-08-31
JP2013545489A (ja) 2013-12-26
SG10201510405PA (en) 2016-01-28
CN103384680A (zh) 2013-11-06
MX2013006959A (es) 2013-12-06
MX2013006958A (es) 2013-12-16
MX345861B (es) 2017-02-20
BR112013017632A2 (pt) 2016-10-11
CA2826252C (en) 2018-12-04
SG191216A1 (en) 2013-07-31
CN103384679B (zh) 2015-08-26
CN103384680B (zh) 2015-08-26
MX343462B (es) 2016-11-07
IL270186B (en) 2020-08-31
EP2651974A1 (en) 2013-10-23
WO2012080844A1 (en) 2012-06-21
US10138292B2 (en) 2018-11-27
US8415156B2 (en) 2013-04-09
IL226971B (en) 2018-04-30
JP5990531B2 (ja) 2016-09-14
US20120156782A1 (en) 2012-06-21
WO2012080842A1 (en) 2012-06-21
KR20140016881A (ko) 2014-02-10
CN103384679A (zh) 2013-11-06
EP2651973A1 (en) 2013-10-23
JP6002675B2 (ja) 2016-10-05
KR101966033B1 (ko) 2019-04-04
KR20140012047A (ko) 2014-01-29
BR112013017629A2 (pt) 2017-04-18
CA2828794C (en) 2021-07-13
CA2826252A1 (en) 2012-06-21
US20120156254A1 (en) 2012-06-21
AU2011342904B2 (en) 2016-05-12
KR20190018024A (ko) 2019-02-20
EP2651974B1 (en) 2015-09-16
CA2828794A1 (en) 2012-06-21

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